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Dynamic Histone H3 Incorporation Fuels Metastatic Progression.

Simeonova I, Almouzni G.

Trends Mol Med. 2019 Nov;25(11):933-935. doi: 10.1016/j.molmed.2019.09.003. Epub 2019 Oct 14.


Combining epigenetic drugs with other therapies for solid tumours - past lessons and future promise.

Morel D, Jeffery D, Aspeslagh S, Almouzni G, Postel-Vinay S.

Nat Rev Clin Oncol. 2019 Sep 30. doi: 10.1038/s41571-019-0267-4. [Epub ahead of print] Review.


Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.

Bakail M, Gaubert A, Andreani J, Moal G, Pinna G, Boyarchuk E, Gaillard MC, Courbeyrette R, Mann C, Thuret JY, Guichard B, Murciano B, Richet N, Poitou A, Frederic C, Le Du MH, Agez M, Roelants C, Gurard-Levin ZA, Almouzni G, Cherradi N, Guerois R, Ochsenbein F.

Cell Chem Biol. 2019 Nov 21;26(11):1573-1585.e10. doi: 10.1016/j.chembiol.2019.09.002. Epub 2019 Sep 19.


Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity.

Gemble S, Simon A, Pennetier C, Dumont M, Hervé S, Meitinger F, Oegema K, Rodriguez R, Almouzni G, Fachinetti D, Basto R.

Curr Biol. 2019 Sep 23;29(18):3072-3080.e5. doi: 10.1016/j.cub.2019.07.052. Epub 2019 Sep 5.


The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.

Ng C, Aichinger M, Nguyen T, Au C, Najar T, Wu L, Mesa KR, Liao W, Quivy JP, Hubert B, Almouzni G, Zuber J, Littman DR.

Genes Dev. 2019 Jun 1;33(11-12):669-683. doi: 10.1101/gad.322024.118. Epub 2019 Apr 11.


Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure.

El-Daher MT, Cagnard N, Gil M, Da Cruz MC, Leveau C, Sepulveda F, Zarhrate M, Tores F, Legoix P, Baulande S, de Villartay JP, Almouzni G, Quivy JP, Fischer A, de Saint Basile G.

Cell Discov. 2018 Nov 13;4:61. doi: 10.1038/s41421-018-0061-y. eCollection 2018.


Challenges and guidelines toward 4D nucleome data and model standards.

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME.

Nat Genet. 2018 Oct;50(10):1352-1358. doi: 10.1038/s41588-018-0236-3. Epub 2018 Sep 27. Review.


Chromatin plasticity: A versatile landscape that underlies cell fate and identity.

Yadav T, Quivy JP, Almouzni G.

Science. 2018 Sep 28;361(6409):1332-1336. doi: 10.1126/science.aat8950. Review.


Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle.

Mendiratta S, Gatto A, Almouzni G.

J Cell Biol. 2019 Jan 7;218(1):39-54. doi: 10.1083/jcb.201807179. Epub 2018 Sep 26. Review.


POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.

Bellelli R, Belan O, Pye VE, Clement C, Maslen SL, Skehel JM, Cherepanov P, Almouzni G, Boulton SJ.

Mol Cell. 2018 Oct 4;72(1):112-126.e5. doi: 10.1016/j.molcel.2018.08.043. Epub 2018 Sep 11.


High-resolution visualization of H3 variants during replication reveals their controlled recycling.

Clément C, Orsi GA, Gatto A, Boyarchuk E, Forest A, Hajj B, Miné-Hattab J, Garnier M, Gurard-Levin ZA, Quivy JP, Almouzni G.

Nat Commun. 2018 Aug 9;9(1):3181. doi: 10.1038/s41467-018-05697-1.


Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.

Ray-Gallet D, Ricketts MD, Sato Y, Gupta K, Boyarchuk E, Senda T, Marmorstein R, Almouzni G.

Nat Commun. 2018 Aug 6;9(1):3103. doi: 10.1038/s41467-018-05581-y.


Imaging Newly Synthesized and Old Histone Variant Dynamics Dependent on Chaperones Using the SNAP-Tag System.

Torné J, Orsi GA, Ray-Gallet D, Almouzni G.

Methods Mol Biol. 2018;1832:207-221. doi: 10.1007/978-1-4939-8663-7_11.


KAP1 facilitates reinstatement of heterochromatin after DNA replication.

Jang SM, Kauzlaric A, Quivy JP, Pontis J, Rauwel B, Coluccio A, Offner S, Duc J, Turelli P, Almouzni G, Trono D.

Nucleic Acids Res. 2018 Sep 28;46(17):8788-8802. doi: 10.1093/nar/gky580.


Vision 2030 for the optimal approach to cancer research and care in Europe: A mission or a network of networks?

Philip T, Almouzni G, Poortmans P.

Tumori. 2019 Jun;105(3):265-270. doi: 10.1177/0300891618783655. Epub 2018 Jun 17.


Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2.

Mendez-Bermudez A, Lototska L, Bauwens S, Giraud-Panis MJ, Croce O, Jamet K, Irizar A, Mowinckel M, Koundrioukoff S, Nottet N, Almouzni G, Teulade-Fichou MP, Schertzer M, Perderiset M, Londoño-Vallejo A, Debatisse M, Gilson E, Ye J.

Mol Cell. 2018 May 3;70(3):449-461.e5. doi: 10.1016/j.molcel.2018.03.036.


The epigenetic control of stemness in CD8+ T cell fate commitment.

Pace L, Goudot C, Zueva E, Gueguen P, Burgdorf N, Waterfall JJ, Quivy JP, Almouzni G, Amigorena S.

Science. 2018 Jan 12;359(6372):177-186. doi: 10.1126/science.aah6499.


Shaping Chromatin in the Nucleus: The Bricks and the Architects.

Sitbon D, Podsypanina K, Yadav T, Almouzni G.

Cold Spring Harb Symp Quant Biol. 2017;82:1-14. doi: 10.1101/sqb.2017.82.033753. Epub 2017 Dec 5.


PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4.

Saavedra F, Rivera C, Rivas E, Merino P, Garrido D, Hernández S, Forné I, Vassias I, Gurard-Levin ZA, Alfaro IE, Imhof A, Almouzni G, Loyola A.

Nucleic Acids Res. 2017 Nov 16;45(20):11700-11710. doi: 10.1093/nar/gkx775.


Targeting chromatin defects in selected solid tumors based on oncogene addiction, synthetic lethality and epigenetic antagonism.

Morel D, Almouzni G, Soria JC, Postel-Vinay S.

Ann Oncol. 2017 Feb 1;28(2):254-269. doi: 10.1093/annonc/mdw552. Review.


Essential role for centromeric factors following p53 loss and oncogenic transformation.

Filipescu D, Naughtin M, Podsypanina K, Lejour V, Wilson L, Gurard-Levin ZA, Orsi GA, Simeonova I, Toufektchan E, Attardi LD, Toledo F, Almouzni G.

Genes Dev. 2017 Mar 1;31(5):463-480. doi: 10.1101/gad.290924.116. Epub 2017 Mar 29.


Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1.

Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Mücke N, Langowski J, Ochsenbein F, Almouzni G, Panne D.

Elife. 2017 Mar 18;6. pii: e23474. doi: 10.7554/eLife.23474.


Chromatin dynamics during the cell cycle at centromeres.

Müller S, Almouzni G.

Nat Rev Genet. 2017 Mar;18(3):192-208. doi: 10.1038/nrg.2016.157. Epub 2017 Jan 31. Review.


Suv39h1 links the SUMO pathway to constitutive heterochromatin.

Maison C, Quivy JP, Almouzni G.

Mol Cell Oncol. 2016 Aug 26;3(6):e1225546. doi: 10.1080/23723556.2016.1225546. eCollection 2016.


The Epigenome and Cancer Stem Cell Fate: Connected by a Linker Histone Variant.

Orsi GA, Naughtin M, Almouzni G.

Cell Stem Cell. 2016 Nov 3;19(5):567-568. doi: 10.1016/j.stem.2016.10.010.


Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage.

Adam S, Dabin J, Chevallier O, Leroy O, Baldeyron C, Corpet A, Lomonte P, Renaud O, Almouzni G, Polo SE.

Mol Cell. 2016 Oct 6;64(1):65-78. doi: 10.1016/j.molcel.2016.08.019. Epub 2016 Sep 15.


The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.

Maison C, Bailly D, Quivy JP, Almouzni G.

Nat Commun. 2016 Jul 18;7:12224. doi: 10.1038/ncomms12224.


Functional Characterization of Histone Chaperones Using SNAP-Tag-Based Imaging to Assess De Novo Histone Deposition.

Clément C, Vassias I, Ray-Gallet D, Almouzni G.

Methods Enzymol. 2016;573:97-117. doi: 10.1016/bs.mie.2016.04.004. Epub 2016 May 27.


The CENP-T/-W complex is a binding partner of the histone chaperone FACT.

Prendergast L, Müller S, Liu Y, Huang H, Dingli F, Loew D, Vassias I, Patel DJ, Sullivan KF, Almouzni G.

Genes Dev. 2016 Jun 1;30(11):1313-26. doi: 10.1101/gad.275073.115. Epub 2016 Jun 9.


Chromatin Regulators as a Guide for Cancer Treatment Choice.

Gurard-Levin ZA, Wilson LO, Pancaldi V, Postel-Vinay S, Sousa FG, Reyes C, Marangoni E, Gentien D, Valencia A, Pommier Y, Cottu P, Almouzni G.

Mol Cancer Ther. 2016 Jul;15(7):1768-77. doi: 10.1158/1535-7163.MCT-15-1008. Epub 2016 May 16.


Maintenance of Epigenetic Information.

Almouzni G, Cedar H.

Cold Spring Harb Perspect Biol. 2016 May 2;8(5). pii: a019372. doi: 10.1101/cshperspect.a019372. Review.


The histone chaperone CAF-1 safeguards somatic cell identity.

Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K.

Nature. 2015 Dec 10;528(7581):218-24. doi: 10.1038/nature15749.


Chromatin dynamics after DNA damage: The legacy of the access-repair-restore model.

Polo SE, Almouzni G.

DNA Repair (Amst). 2015 Dec;36:114-121. doi: 10.1016/j.dnarep.2015.09.014. Epub 2015 Sep 15. Review.


Methylation of histone H3 lysine 9 occurs during translation.

Rivera C, Saavedra F, Alvarez F, Díaz-Celis C, Ugalde V, Li J, Forné I, Gurard-Levin ZA, Almouzni G, Imhof A, Loyola A.

Nucleic Acids Res. 2015 Oct 30;43(19):9097-106. doi: 10.1093/nar/gkv929. Epub 2015 Sep 24.


MCM2 binding to histones H3-H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork.

Clément C, Almouzni G.

Nat Struct Mol Biol. 2015 Aug;22(8):587-9. doi: 10.1038/nsmb.3067. No abstract available.


HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.

Tachiwana H, Müller S, Blümer J, Klare K, Musacchio A, Almouzni G.

Cell Rep. 2015 Apr 7;11(1):22-32. doi: 10.1016/j.celrep.2015.03.013. Epub 2015 Apr 2.


Epigenomics: Roadmap for regulation.

Romanoski CE, Glass CK, Stunnenberg HG, Wilson L, Almouzni G.

Nature. 2015 Feb 19;518(7539):314-6. doi: 10.1038/518314a. No abstract available.


The SENP7 SUMO-Protease Presents a Module of Two HP1 Interaction Motifs that Locks HP1 Protein at Pericentric Heterochromatin.

Romeo K, Louault Y, Cantaloube S, Loiodice I, Almouzni G, Quivy JP.

Cell Rep. 2015 Feb 10;10(5):771-782. doi: 10.1016/j.celrep.2015.01.004. Epub 2015 Feb 5.


Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork.

Richet N, Liu D, Legrand P, Velours C, Corpet A, Gaubert A, Bakail M, Moal-Raisin G, Guerois R, Compper C, Besle A, Guichard B, Almouzni G, Ochsenbein F.

Nucleic Acids Res. 2015 Feb 18;43(3):1905-17. doi: 10.1093/nar/gkv021. Epub 2015 Jan 23.


The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma.

Montes de Oca R, Gurard-Levin ZA, Berger F, Rehman H, Martel E, Corpet A, de Koning L, Vassias I, Wilson LO, Meseure D, Reyal F, Savignoni A, Asselain B, Sastre-Garau X, Almouzni G.

Mol Oncol. 2015 Mar;9(3):657-74. doi: 10.1016/j.molonc.2014.11.002. Epub 2014 Nov 20.


Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.

Arimura Y, Shirayama K, Horikoshi N, Fujita R, Taguchi H, Kagawa W, Fukagawa T, Almouzni G, Kurumizaka H.

Sci Rep. 2014 Nov 19;4:7115. doi: 10.1038/srep07115.


Histone modifications and a choice of variant: a language that helps the genome express itself.

Gurard-Levin ZA, Almouzni G.

F1000Prime Rep. 2014 Sep 4;6:76. doi: 10.12703/P6-76. eCollection 2014. Review.


Histone H3 variants and their chaperones during development and disease: contributing to epigenetic control.

Filipescu D, Müller S, Almouzni G.

Annu Rev Cell Dev Biol. 2014;30:615-46. doi: 10.1146/annurev-cellbio-100913-013311. Review.


Assembly of telomeric chromatin to create ALTernative endings.

O'Sullivan RJ, Almouzni G.

Trends Cell Biol. 2014 Nov;24(11):675-85. doi: 10.1016/j.tcb.2014.07.007. Epub 2014 Aug 26. Review.


Phosphorylation and DNA binding of HJURP determine its centromeric recruitment and function in CenH3(CENP-A) loading.

Müller S, Montes de Oca R, Lacoste N, Dingli F, Loew D, Almouzni G.

Cell Rep. 2014 Jul 10;8(1):190-203. doi: 10.1016/j.celrep.2014.06.002. Epub 2014 Jul 4.


Relationship between genome and epigenome--challenges and requirements for future research.

Almouzni G, Altucci L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S, Bressac-de Paillerets B, Bussemakers M, Clarke L, Conesa A, Estivill X, Fazeli A, Grgurević N, Gut I, Heijmans BT, Hermouet S, Houwing-Duistermaat J, Iacobucci I, Ilaš J, Kandimalla R, Krauss-Etschmann S, Lasko P, Lehmann S, Lindroth A, Majdič G, Marcotte E, Martinelli G, Martinet N, Meyer E, Miceli C, Mills K, Moreno-Villanueva M, Morvan G, Nickel D, Niesler B, Nowacki M, Nowak J, Ossowski S, Pelizzola M, Pochet R, Potočnik U, Radwanska M, Raes J, Rattray M, Robinson MD, Roelen B, Sauer S, Schinzer D, Slagboom E, Spector T, Stunnenberg HG, Tiligada E, Torres-Padilla ME, Tsonaka R, Van Soom A, Vidaković M, Widschwendter M.

BMC Genomics. 2014 Jun 18;15:487. doi: 10.1186/1471-2164-15-487.


The histone variant composition of centromeres is controlled by the pericentric heterochromatin state during the cell cycle.

Boyarchuk E, Filipescu D, Vassias I, Cantaloube S, Almouzni G.

J Cell Sci. 2014 Aug 1;127(Pt 15):3347-59. doi: 10.1242/jcs.148189. Epub 2014 Jun 6.


Histone chaperones: assisting histone traffic and nucleosome dynamics.

Gurard-Levin ZA, Quivy JP, Almouzni G.

Annu Rev Biochem. 2014;83:487-517. doi: 10.1146/annurev-biochem-060713-035536. Review.


The survival gene MED4 explains low penetrance retinoblastoma in patients with large RB1 deletion.

Dehainault C, Garancher A, Castéra L, Cassoux N, Aerts I, Doz F, Desjardins L, Lumbroso L, Montes de Oca R, Almouzni G, Stoppa-Lyonnet D, Pouponnot C, Gauthier-Villars M, Houdayer C.

Hum Mol Genet. 2014 Oct 1;23(19):5243-50. doi: 10.1093/hmg/ddu245. Epub 2014 May 23.


Histone lysine methylation and chromatin replication.

Rivera C, Gurard-Levin ZA, Almouzni G, Loyola A.

Biochim Biophys Acta. 2014 Dec;1839(12):1433-9. doi: 10.1016/j.bbagrm.2014.03.009. Epub 2014 Mar 28. Review.

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