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Items: 1 to 50 of 132

1.

Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver.

Ayyar VS, Sukumaran S, DuBois DC, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2018 Aug 7. pii: jpet.118.251959. doi: 10.1124/jpet.118.251959. [Epub ahead of print]

2.

Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.

Mavroudis PD, DuBois DC, Almon RR, Jusko WJ.

PLoS One. 2018 Jun 12;13(6):e0197534. doi: 10.1371/journal.pone.0197534. eCollection 2018.

3.

Daily variation of gene expression in diverse rat tissues.

Mavroudis PD, DuBois DC, Almon RR, Jusko WJ.

PLoS One. 2018 May 10;13(5):e0197258. doi: 10.1371/journal.pone.0197258. eCollection 2018.

4.

Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver.

Ayyar VS, Sukumaran S, DuBois DC, Almon RR, Qu J, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2018 Aug;45(4):557-575. doi: 10.1007/s10928-018-9585-x. Epub 2018 Apr 27.

PMID:
29704219
5.

Mechanistic Multi-Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics.

Ayyar VS, DuBois DC, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2017 Oct;363(1):45-57. doi: 10.1124/jpet.117.242990. Epub 2017 Jul 20.

PMID:
28729456
6.

Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats.

Nie J, DuBois DC, Xue B, Jusko WJ, Almon RR.

Gene Regul Syst Bio. 2017 May 29;11:1177625017710009. doi: 10.1177/1177625017710009. eCollection 2017.

7.

Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen.

Li X, DuBois DC, Song D, Almon RR, Jusko WJ, Chen X.

Drug Metab Dispos. 2017 Jul;45(7):834-845. doi: 10.1124/dmd.117.075614. Epub 2017 Apr 17.

8.

Interrelationships between Infliximab and Recombinant Tumor Necrosis Factor-α in Plasma Using Minimal Physiologically Based Pharmacokinetic Models.

Chen X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 Jul;45(7):790-797. doi: 10.1124/dmd.116.074807. Epub 2017 Apr 14.

9.

Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models.

Chen X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 Jul;45(7):798-806. doi: 10.1124/dmd.116.074799. Epub 2017 Apr 14.

10.

Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.

Ayyar VS, Almon RR, DuBois DC, Sukumaran S, Qu J, Jusko WJ.

J Proteomics. 2017 May 8;160:84-105. doi: 10.1016/j.jprot.2017.03.007. Epub 2017 Mar 14.

11.

Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels.

Kamisoglu K, Acevedo A, Almon RR, Coyle S, Corbett S, Dubois DC, Nguyen TT, Jusko WJ, Androulakis IP.

Front Pharmacol. 2017 Feb 27;8:91. doi: 10.3389/fphar.2017.00091. eCollection 2017.

12.

Modeling Sex Differences in Pharmacokinetics, Pharmacodynamics, and Disease Progression Effects of Naproxen in Rats with Collagen-Induced Arthritis.

Li X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 May;45(5):484-491. doi: 10.1124/dmd.116.074526. Epub 2017 Feb 28.

13.

Effect of Disease-Related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats.

Li X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2017 May;45(5):476-483. doi: 10.1124/dmd.116.074500. Epub 2017 Feb 28.

14.

Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats.

Lon HK, DuBois DC, Earp JC, Almon RR, Jusko WJ.

Pharmacol Res Perspect. 2015 Oct;3(5):e00169. doi: 10.1002/prp2.169. Epub 2015 Aug 3.

15.

Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats.

Xue B, Nie J, Wang X, DuBois DC, Jusko WJ, Almon RR.

Gene Regul Syst Bio. 2015 Aug 10;9:15-26. doi: 10.4137/GRSB.S25172. eCollection 2015.

16.

Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids.

Ayyar VS, Almon RR, Jusko WJ, DuBois DC.

Physiol Rep. 2015 Jun;3(6). pii: e12382. doi: 10.14814/phy2.12382.

17.

Biodistribution of etanercept to tissues and sites of inflammation in arthritic rats.

Chen X, DuBois DC, Almon RR, Jusko WJ.

Drug Metab Dispos. 2015 Jun;43(6):898-907. doi: 10.1124/dmd.114.062901. Epub 2015 Apr 1.

18.

Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: a systems approach to liver function in pharmacogenomics.

Kamisoglu K, Sukumaran S, Nouri-Nigjeh E, Tu C, Li J, Shen X, Duan X, Qu J, Almon RR, DuBois DC, Jusko WJ, Androulakis IP.

OMICS. 2015 Feb;19(2):80-91. doi: 10.1089/omi.2014.0130. Epub 2015 Jan 22.

19.

Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals.

Wang X, DuBois DC, Sukumaran S, Ayyar V, Jusko WJ, Almon RR.

Diabetes Metab Syndr Obes. 2014 Nov 11;7:531-41. doi: 10.2147/DMSO.S69891. eCollection 2014.

20.

Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment.

Wang X, DuBois DC, Cao Y, Jusko WJ, Almon RR.

Diabetes Metab Syndr Obes. 2014 Aug 1;7:381-9. doi: 10.2147/DMSO.S65818. eCollection 2014.

21.

Highly multiplexed and reproducible ion-current-based strategy for large-scale quantitative proteomics and the application to protein expression dynamics induced by methylprednisolone in 60 rats.

Nouri-Nigjeh E, Sukumaran S, Tu C, Li J, Shen X, Duan X, DuBois DC, Almon RR, Jusko WJ, Qu J.

Anal Chem. 2014 Aug 19;86(16):8149-57. doi: 10.1021/ac501380s. Epub 2014 Aug 6.

22.

Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration.

Nguyen TT, Almon RR, Dubois DC, Sukumaran S, Jusko WJ, Androulakis IP.

Gene Regul Syst Bio. 2014 Mar 10;8:75-87. doi: 10.4137/GRSB.S13134. eCollection 2014.

23.

Meta-modeling of methylprednisolone effects on glucose regulation in rats.

Fang J, Sukumaran S, Dubois DC, Almon RR, Jusko WJ.

PLoS One. 2013 Dec 2;8(12):e81679. doi: 10.1371/journal.pone.0081679. eCollection 2013.

24.
25.

Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats.

Liu DY, Lon HK, Wang YL, DuBois DC, Almon RR, Jusko WJ.

Biopharm Drug Dispos. 2013 May;34(4):203-14. doi: 10.1002/bdd.1838. Epub 2013 Apr 7.

26.

Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver.

DuBois DC, Sukumaran S, Jusko WJ, Almon RR.

Steroids. 2013 Feb;78(2):312-20. doi: 10.1016/j.steroids.2012.11.014. Epub 2012 Dec 19.

27.

Effects of high fat feeding on liver gene expression in diabetic goto-kakizaki rats.

Almon RR, Dubois DC, Sukumaran S, Wang X, Xue B, Nie J, Jusko WJ.

Gene Regul Syst Bio. 2012;6:151-68. doi: 10.4137/GRSB.S10371. Epub 2012 Nov 28.

28.

Glucocorticoid effects on adiponectin expression.

Sukumaran S, Dubois DC, Jusko WJ, Almon RR.

Vitam Horm. 2012;90:163-86. doi: 10.1016/B978-0-12-398313-8.00007-5. Review.

29.

Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats.

Cao Y, DuBois DC, Almon RR, Jusko WJ.

Biopharm Drug Dispos. 2012 Sep;33(6):285-91. doi: 10.1002/bdd.1797. Epub 2012 Jul 26.

30.

Pharmacokinetic/pharmacodynamic modeling of methylprednisolone effects on iNOS mRNA expression and nitric oxide during LPS-induced inflammation in rats.

Sukumaran S, Lepist EI, DuBois DC, Almon RR, Jusko WJ.

Pharm Res. 2012 Aug;29(8):2060-9. doi: 10.1007/s11095-012-0733-5. Epub 2012 Mar 16.

31.

Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis.

Liu D, Lon HK, Dubois DC, Almon RR, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2011 Dec;38(6):769-86. doi: 10.1007/s10928-011-9219-z. Epub 2011 Oct 16.

32.

Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.

Cao Y, Dubois DC, Sun H, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2011 Dec;339(3):896-904. doi: 10.1124/jpet.111.185686. Epub 2011 Sep 8.

33.

Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action.

Sukumaran S, Jusko WJ, Dubois DC, Almon RR.

J Appl Physiol (1985). 2011 Jun;110(6):1732-47. doi: 10.1152/japplphysiol.00079.2011. Epub 2011 Mar 24.

34.

Mechanistic modeling of the effects of glucocorticoids and circadian rhythms on adipokine expression.

Sukumaran S, Jusko WJ, DuBois DC, Almon RR.

J Pharmacol Exp Ther. 2011 Jun;337(3):734-46. doi: 10.1124/jpet.111.179960. Epub 2011 Mar 11.

35.

Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats.

Fang J, DuBois DC, He Y, Almon RR, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2011 Jun;38(3):293-316. doi: 10.1007/s10928-011-9194-4. Epub 2011 Mar 11.

36.

Adipose tissue deficiency and chronic inflammation in diabetic Goto-Kakizaki rats.

Xue B, Sukumaran S, Nie J, Jusko WJ, Dubois DC, Almon RR.

PLoS One. 2011 Feb 25;6(2):e17386. doi: 10.1371/journal.pone.0017386.

37.

Pharmacokinetic-pharmacodynamic disease progression model for effect of etanercept in Lewis rats with collagen-induced arthritis.

Lon HK, Liu D, Zhang Q, DuBois DC, Almon RR, Jusko WJ.

Pharm Res. 2011 Jul;28(7):1622-30. doi: 10.1007/s11095-011-0396-7. Epub 2011 Mar 1.

38.

Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats.

Nie J, Xue B, Sukumaran S, Jusko WJ, Dubois DC, Almon RR.

Mol Cell Endocrinol. 2011 May 16;338(1-2):10-7. doi: 10.1016/j.mce.2011.02.016. Epub 2011 Feb 26.

39.

Assessment of pharmacologic area under the curve when baselines are variable.

Scheff JD, Almon RR, Dubois DC, Jusko WJ, Androulakis IP.

Pharm Res. 2011 May;28(5):1081-9. doi: 10.1007/s11095-010-0363-8. Epub 2011 Jan 14.

40.

Mechanistic population modeling of diabetes disease progression in Goto-Kakizaki rat muscle.

Nie J, DuBois DC, Jusko WJ, Almon RR.

Biopharm Drug Dispos. 2011 Jan;32(1):50-63. doi: 10.1002/bdd.738. Epub 2010 Dec 5.

41.

Mechanism-based disease progression modeling of type 2 diabetes in Goto-Kakizaki rats.

Gao W, Bihorel S, DuBois DC, Almon RR, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2011 Feb;38(1):143-62. doi: 10.1007/s10928-010-9182-0. Epub 2010 Dec 3.

42.

Circadian signatures in rat liver: from gene expression to pathways.

Ovacik MA, Sukumaran S, Almon RR, DuBois DC, Jusko WJ, Androulakis IP.

BMC Bioinformatics. 2010 Nov 1;11:540. doi: 10.1186/1471-2105-11-540.

43.

Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: transcriptional dynamics and regulatory structures.

Nguyen TT, Almon RR, Dubois DC, Jusko WJ, Androulakis IP.

BMC Bioinformatics. 2010 Oct 14;11:515. doi: 10.1186/1471-2105-11-515.

44.

Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology.

Sukumaran S, Xue B, Jusko WJ, Dubois DC, Almon RR.

Physiol Genomics. 2010 Oct;42A(2):141-52. doi: 10.1152/physiolgenomics.00106.2010. Epub 2010 Aug 3.

45.

Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action.

Sukumaran S, Almon RR, DuBois DC, Jusko WJ.

Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):904-17. doi: 10.1016/j.addr.2010.05.009. Epub 2010 Jun 11. Review.

46.

Importance of replication in analyzing time-series gene expression data: corticosteroid dynamics and circadian patterns in rat liver.

Nguyen TT, Almon RR, DuBois DC, Jusko WJ, Androulakis IP.

BMC Bioinformatics. 2010 May 26;11:279. doi: 10.1186/1471-2105-11-279.

47.

A new symbolic representation for the identification of informative genes in replicated microarray experiments.

Scheff JD, Almon RR, DuBois DC, Jusko WJ, Androulakis IP.

OMICS. 2010 Jun;14(3):239-48. doi: 10.1089/omi.2010.0005.

48.

Identification of global transcriptional dynamics.

Yang EH, Almon RR, Dubois DC, Jusko WJ, Androulakis IP.

PLoS One. 2009 Jul 10;4(7):e5992. doi: 10.1371/journal.pone.0005992.

49.

Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats.

Almon RR, DuBois DC, Lai W, Xue B, Nie J, Jusko WJ.

J Endocrinol. 2009 Mar;200(3):331-46. doi: 10.1677/JOE-08-0404. Epub 2008 Dec 12.

50.

Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats.

Landersdorfer CB, DuBois DC, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):644-51. doi: 10.1124/jpet.108.144766. Epub 2008 Oct 29.

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