Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 332

1.

Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity.

Shrestha R, Garrett SC, Almo SC, Fiser A.

Structure. 2019 May 7;27(5):829-836.e3. doi: 10.1016/j.str.2019.03.006. Epub 2019 Mar 28.

PMID:
30930066
2.

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells.

Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, De Larrea CF, Olson E, Peguero E, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Wendel HG, Riviere I, Liu C, Sather B, Brentjens RJ.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaau7746. doi: 10.1126/scitranslmed.aau7746.

PMID:
30918115
3.

Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells.

Ng SL, Leno-Duran E, Samanta D, Almo SC, Strominger JL.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2634-2639. doi: 10.1073/pnas.1811984116. Epub 2019 Jan 25.

PMID:
30683721
4.

Substrate Profile of the Phosphotriesterase Homology Protein from Escherichia coli.

Nemmara VV, Xiang DF, Fedorov AA, Fedorov EV, Bonanno JB, Almo SC, Raushel FM.

Biochemistry. 2018 Oct 30;57(43):6219-6227. doi: 10.1021/acs.biochem.8b00935. Epub 2018 Oct 16.

PMID:
30277746
5.

Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria.

Bouvier JT, Sernova NV, Ghasempur S, Rodionova IA, Vetting MW, Al-Obaidi NF, Almo SC, Gerlt JA, Rodionov DA.

J Bacteriol. 2018 Dec 20;201(2). pii: e00431-18. doi: 10.1128/JB.00431-18. Print 2019 Jan 15.

6.

Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine.

Ryu H, Grove TL, Almo SC, Kim J.

Nucleic Acids Res. 2018 Sep 28;46(17):9160-9169. doi: 10.1093/nar/gky592.

7.

Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Oct;562(7725):E3. doi: 10.1038/s41586-018-0355-0.

PMID:
29980769
8.

A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Jun;558(7711):610-614. doi: 10.1038/s41586-018-0238-4. Epub 2018 Jun 20. Erratum in: Nature. 2018 Oct;562(7725):E3.

9.

Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells That Enhance Protective Immunity in Tuberculosis.

Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR Jr, Sette A, Almo SC, Porcelli SA.

Infect Immun. 2018 Aug 22;86(9). pii: e00009-18. doi: 10.1128/IAI.00009-18. Print 2018 Sep.

10.

Functional assignment of multiple catabolic pathways for D-apiose.

Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA.

Nat Chem Biol. 2018 Jul;14(7):696-705. doi: 10.1038/s41589-018-0067-7. Epub 2018 Jun 4.

11.

Comparison of Alicyclobacillus acidocaldarius o-Succinylbenzoate Synthase to Its Promiscuous N-Succinylamino Acid Racemase/ o-Succinylbenzoate Synthase Relatives.

Odokonyero D, McMillan AW, Ramagopal UA, Toro R, Truong DP, Zhu M, Lopez MS, Somiari B, Herman M, Aziz A, Bonanno JB, Hull KG, Burley SK, Romo D, Almo SC, Glasner ME.

Biochemistry. 2018 Jul 3;57(26):3676-3689. doi: 10.1021/acs.biochem.8b00088. Epub 2018 May 30.

PMID:
29767960
12.

Development and Evaluation of an Optimal Human Single-Chain Variable Fragment-Derived BCMA-Targeted CAR T Cell Vector.

Smith EL, Staehr M, Masakayan R, Tatake IJ, Purdon TJ, Wang X, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Riviere I, Liu C, Brentjens RJ.

Mol Ther. 2018 Jun 6;26(6):1447-1456. doi: 10.1016/j.ymthe.2018.03.016. Epub 2018 Mar 28.

13.

Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.

14.

The biosynthesis of methanobactin.

Kenney GE, Dassama LMK, Pandelia ME, Gizzi AS, Martinie RJ, Gao P, DeHart CJ, Schachner LF, Skinner OS, Ro SY, Zhu X, Sadek M, Thomas PM, Almo SC, Bollinger JM Jr, Krebs C, Kelleher NL, Rosenzweig AC.

Science. 2018 Mar 23;359(6382):1411-1416. doi: 10.1126/science.aap9437.

15.

X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.

Barr I, Stich TA, Gizzi AS, Grove TL, Bonanno JB, Latham JA, Chung T, Wilmot CM, Britt RD, Almo SC, Klinman JP.

Biochemistry. 2018 Feb 27;57(8):1306-1315. doi: 10.1021/acs.biochem.7b01097. Epub 2018 Feb 6.

16.

Prediction of enzymatic pathways by integrative pathway mapping.

Calhoun S, Korczynska M, Wichelecki DJ, San Francisco B, Zhao S, Rodionov DA, Vetting MW, Al-Obaidi NF, Lin H, O'Meara MJ, Scott DA, Morris JH, Russel D, Almo SC, Osterman AL, Gerlt JA, Jacobson MP, Shoichet BK, Sali A.

Elife. 2018 Jan 29;7. pii: e31097. doi: 10.7554/eLife.31097.

17.

Mechanism and Structure of γ-Resorcylate Decarboxylase.

Sheng X, Patskovsky Y, Vladimirova A, Bonanno JB, Almo SC, Himo F, Raushel FM.

Biochemistry. 2018 Jun 5;57(22):3167-3175. doi: 10.1021/acs.biochem.7b01213. Epub 2018 Jan 19.

18.

Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.

Ghosh A, Ramagopal UA, Bonanno JB, Brenowitz M, Almo SC.

Biochemistry. 2018 Feb 27;57(8):1293-1305. doi: 10.1021/acs.biochem.7b01074. Epub 2018 Feb 7.

19.

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells.

Ohaegbulam KC, Liu W, Jeon H, Almo SC, Zang X.

Oncotarget. 2017 Sep 20;8(47):82740-82753. doi: 10.18632/oncotarget.21098. eCollection 2017 Oct 10.

20.

General principles of binding between cell surface receptors and multi-specific ligands: A computational study.

Chen J, Almo SC, Wu Y.

PLoS Comput Biol. 2017 Oct 10;13(10):e1005805. doi: 10.1371/journal.pcbi.1005805. eCollection 2017 Oct.

21.

PD-L1 is an activation-independent marker of brown adipocytes.

Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL.

Nat Commun. 2017 Sep 21;8(1):647. doi: 10.1038/s41467-017-00799-8.

22.

Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.

Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilchéze C, Arcos J, Chen Y, Bi L, Mehta S, Porcelli SA, Almo SC, Yeh SR, Jacobs WR Jr, Torrelles JB, Chan J.

PLoS Pathog. 2017 Jul 28;13(7):e1006515. doi: 10.1371/journal.ppat.1006515. eCollection 2017 Jul.

23.

Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.

Grove TL, Himes PM, Hwang S, Yumerefendi H, Bonanno JB, Kuhlman B, Almo SC, Bowers AA.

J Am Chem Soc. 2017 Aug 30;139(34):11734-11744. doi: 10.1021/jacs.7b01283. Epub 2017 Aug 21.

24.

Can the propensity of protein crystallization be increased by using systematic screening with metals?

Hegde RP, Pavithra GC, Dey D, Almo SC, Ramakumar S, Ramagopal UA.

Protein Sci. 2017 Sep;26(9):1704-1713. doi: 10.1002/pro.3214. Epub 2017 Jun 29. Review.

25.

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.

Ramagopal UA, Liu W, Garrett-Thomson SC, Bonanno JB, Yan Q, Srinivasan M, Wong SC, Bell A, Mankikar S, Rangan VS, Deshpande S, Korman AJ, Almo SC.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4223-E4232. doi: 10.1073/pnas.1617941114. Epub 2017 May 8.

26.

The hidden treasure in your data: phasing with unexpected weak anomalous scatterers from routine data sets.

Hegde RP, Fedorov AA, Sauder JM, Burley SK, Almo SC, Ramagopal UA.

Acta Crystallogr F Struct Biol Commun. 2017 Apr 1;73(Pt 4):184-195. doi: 10.1107/S2053230X17002680. Epub 2017 Mar 22.

27.

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.

Metcalf B, Chuang C, Dufu K, Patel MP, Silva-Garcia A, Johnson C, Lu Q, Partridge JR, Patskovska L, Patskovsky Y, Almo SC, Jacobson MP, Hua L, Xu Q, Gwaltney SL 2nd, Yee C, Harris J, Morgan BP, James J, Xu D, Hutchaleelaha A, Paulvannan K, Oksenberg D, Li Z.

ACS Med Chem Lett. 2017 Jan 23;8(3):321-326. doi: 10.1021/acsmedchemlett.6b00491. eCollection 2017 Mar 9.

28.

Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis.

Park HB, Sampathkumar P, Perez CE, Lee JH, Tran J, Bonanno JB, Hallem EA, Almo SC, Crawford JM.

J Biol Chem. 2017 Apr 21;292(16):6680-6694. doi: 10.1074/jbc.M116.762542. Epub 2017 Feb 28.

29.

Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.

Lázár-Molnár E, Scandiuzzi L, Basu I, Quinn T, Sylvestre E, Palmieri E, Ramagopal UA, Nathenson SG, Guha C, Almo SC.

EBioMedicine. 2017 Mar;17:30-44. doi: 10.1016/j.ebiom.2017.02.004. Epub 2017 Feb 6.

30.

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.

Upla P, Kim SJ, Sampathkumar P, Dutta K, Cahill SM, Chemmama IE, Williams R, Bonanno JB, Rice WJ, Stokes DL, Cowburn D, Almo SC, Sali A, Rout MP, Fernandez-Martinez J.

Structure. 2017 Mar 7;25(3):434-445. doi: 10.1016/j.str.2017.01.006. Epub 2017 Feb 2.

31.

A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea.

Rodionova IA, Vetting MW, Li X, Almo SC, Osterman AL, Rodionov DA.

Nucleic Acids Res. 2017 Apr 20;45(7):3785-3799. doi: 10.1093/nar/gkw1331.

32.

Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.

Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC.

Mol Immunol. 2017 Jan;81:151-159. doi: 10.1016/j.molimm.2016.12.003. Epub 2016 Dec 12.

33.

Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.

Liu W, Ramagopal U, Cheng H, Bonanno JB, Toro R, Bhosle R, Zhan C, Almo SC.

Structure. 2016 Nov 1;24(11):2016-2023. doi: 10.1016/j.str.2016.09.009.

34.

Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go?

Liu W, Almo SC, Zang X.

Immunol Invest. 2016 Nov;45(8):813-831. Epub 2016 Jul 15. Review.

PMID:
27419268
35.

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.

Wang Y, Wach JY, Sheehan P, Zhong C, Zhan C, Harris R, Almo SC, Bishop J, Haggarty SJ, Ramek A, Berry KN, O'Herin C, Koehler AN, Hung AW, Young DW.

ACS Med Chem Lett. 2016 Jul 14;7(9):852-6. doi: 10.1021/acsmedchemlett.6b00230. eCollection 2016 Sep 8.

36.

A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals.

McClelland EE, Ramagopal UA, Rivera J, Cox J, Nakouzi A, Prabu MM, Almo SC, Casadevall A.

PLoS Pathog. 2016 Sep 1;12(9):e1005849. doi: 10.1371/journal.ppat.1005849. eCollection 2016 Sep.

37.

Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.

Zhang X, Carter MS, Vetting MW, San Francisco B, Zhao S, Al-Obaidi NF, Solbiati JO, Thiaville JJ, de Crécy-Lagard V, Jacobson MP, Almo SC, Gerlt JA.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4161-9. doi: 10.1073/pnas.1605546113. Epub 2016 Jul 11.

38.

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.

Oksenberg D, Dufu K, Patel MP, Chuang C, Li Z, Xu Q, Silva-Garcia A, Zhou C, Hutchaleelaha A, Patskovska L, Patskovsky Y, Almo SC, Sinha U, Metcalf BW, Archer DR.

Br J Haematol. 2016 Oct;175(1):141-53. doi: 10.1111/bjh.14214. Epub 2016 Jul 5.

PMID:
27378309
39.

Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.

Yadava U, Vetting MW, Al Obaidi N, Carter MS, Gerlt JA, Almo SC.

Acta Crystallogr F Struct Biol Commun. 2016 Jun;72(Pt 6):467-72. doi: 10.1107/S2053230X16007500. Epub 2016 May 23.

40.

Durable antitumor responses to CD47 blockade require adaptive immune stimulation.

Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2646-54. doi: 10.1073/pnas.1604268113. Epub 2016 Apr 18.

41.

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.

Boskovic ZV, Kemp MM, Freedy AM, Viswanathan VS, Pop MS, Fuller JH, Martinez NM, Figueroa Lazú SO, Hong JA, Lewis TA, Calarese D, Love JD, Vetere A, Almo SC, Schreiber SL, Koehler AN.

ACS Chem Biol. 2016 Jul 15;11(7):1844-51. doi: 10.1021/acschembio.6b00012. Epub 2016 Apr 29.

PMID:
27064299
42.

Correction to "A General Strategy for the Discovery of Metabolic Pathways: D-Threitol, L-Threitol, and Erythritol Utilization in Mycobacterium smegmatis".

Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA.

J Am Chem Soc. 2016 Mar 30;138(12):4267. doi: 10.1021/jacs.6b01906. Epub 2016 Mar 15. No abstract available.

PMID:
26978037
43.

Biochemical characterization of two haloalkane dehalogenases: DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea.

Carlucci L, Zhou E, Malashkevich VN, Almo SC, Mundorff EC.

Protein Sci. 2016 Apr;25(4):877-86. doi: 10.1002/pro.2895. Epub 2016 Feb 21.

44.

Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation.

Vetting MW, Bouvier JT, Gerlt JA, Almo SC.

Acta Crystallogr F Struct Biol Commun. 2016 Jan;72(Pt 1):36-41. doi: 10.1107/S2053230X15023286. Epub 2016 Jan 1.

45.

Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase.

Vladimirova A, Patskovsky Y, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Hillerich B, Seidel RD, Richards NG, Almo SC, Raushel FM.

J Am Chem Soc. 2016 Jan 27;138(3):826-36. doi: 10.1021/jacs.5b08251. Epub 2016 Jan 12.

46.

A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.

Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA.

J Am Chem Soc. 2015 Nov 25;137(46):14570-3. doi: 10.1021/jacs.5b08968. Epub 2015 Nov 12. Erratum in: J Am Chem Soc. 2016 Mar 30;138(12):4267.

PMID:
26560079
47.

Analysis of the Structure and Function of FOX-4 Cephamycinase.

Lefurgy ST, Malashkevich VN, Aguilan JT, Nieves E, Mundorff EC, Biju B, Noel MA, Toro R, Baiwir D, Papp-Wallace KM, Almo SC, Frere JM, Bou G, Bonomo RA.

Antimicrob Agents Chemother. 2015 Nov 2;60(2):717-28. doi: 10.1128/AAC.01887-15. Print 2016 Feb.

48.

ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.

Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA.

J Biol Chem. 2015 Nov 27;290(48):28963-76. doi: 10.1074/jbc.M115.686857. Epub 2015 Oct 15.

49.

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.

Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD.

ACS Cent Sci. 2015;1(2):77-82.

50.

Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM.

Liu W, Vigdorovich V, Zhan C, Patskovsky Y, Bonanno JB, Nathenson SG, Almo SC.

Mol Biotechnol. 2015 Oct;57(10):914-22. doi: 10.1007/s12033-015-9881-2.

PMID:
26202493

Supplemental Content

Support Center