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Items: 28

1.

Absence of functional compensation between coagulation factor VIII and plasminogen in double-knockout mice.

Stagaard R, Ley CD, Almholt K, Olsen LH, Knudsen T, Flick MJ.

Blood Adv. 2018 Nov 27;2(22):3126-3136. doi: 10.1182/bloodadvances.2018024851.

2.

Preclinical pharmacokinetics and biodistribution of subcutaneously administered glycoPEGylated recombinant factor VIII (N8-GP) and development of a human pharmacokinetic prediction model.

Rode F, Almholt K, Petersen M, Kreilgaard M, Kjalke M, Karpf DM, Groth AV, Johansen PB, Larsen LF, Loftager M, Haaning J.

J Thromb Haemost. 2018 Jun;16(6):1141-1152. doi: 10.1111/jth.14013. Epub 2018 May 10.

PMID:
29582559
3.

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells.

Thornton S, Raghu H, Cruz C, Frederick MD, Palumbo JS, Mullins ES, Almholt K, Usher PA, Flick MJ.

Blood Adv. 2017 Mar 21;1(9):545-556. doi: 10.1182/bloodadvances.2016004002. eCollection 2017 Mar 28.

4.

Antibody-Mediated Neutralization of uPA Proteolytic Function Reduces Disease Progression in Mouse Arthritis Models.

Almholt K, Hebsgaard JB, Nansen A, Andersson C, Pass J, Rønø B, Thygesen P, Pelzer H, Loftager M, Lund IK, Høyer-Hansen G, Frisch T, Jensen CH, Otte KS, Søe NH, Bartels EM, Andersen M, Bliddal H, Usher PA.

J Immunol. 2018 Feb 1;200(3):957-965. doi: 10.4049/jimmunol.1701317. Epub 2017 Dec 27.

5.

Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR.

Almholt K, Lærum OD, Nielsen BS, Lund IK, Lund LR, Rømer J, Jögi A.

Clin Exp Metastasis. 2015 Aug;32(6):543-54. doi: 10.1007/s10585-015-9726-1. Epub 2015 Jun 4.

PMID:
26040548
6.

Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer.

Thurison T, Almholt K, Gårdsvoll H, Ploug M, Høyer-Hansen G, Lund IK.

Mol Carcinog. 2016 May;55(5):717-31. doi: 10.1002/mc.22316. Epub 2015 Mar 25.

PMID:
25809119
7.

Sensitive and specific in situ hybridization for early drug discovery.

Usher PA, Galsgaard ED, Kruse K, Wang J, Krogh BO, Mandelbaum J, Almholt K.

Methods Mol Biol. 2014;1211:103-23. doi: 10.1007/978-1-4939-1459-3_10.

PMID:
25218381
8.

Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion.

Fleetwood AJ, Achuthan A, Schultz H, Nansen A, Almholt K, Usher P, Hamilton JA.

J Immunol. 2014 Apr 15;192(8):3540-7. doi: 10.4049/jimmunol.1302864. Epub 2014 Mar 10.

9.

Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz-type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor.

Hansen L, Petersen LC, Lauritzen B, Clausen JT, Grell SN, Agersø H, Sørensen BB, Hilden I, Almholt K.

Thromb Res. 2014 Mar;133(3):464-71. doi: 10.1016/j.thromres.2013.12.015. Epub 2013 Dec 17.

PMID:
24393663
10.

Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation.

Almholt K, Juncker-Jensen A, Lærum OD, Johnsen M, Rømer J, Lund LR.

Clin Exp Metastasis. 2013 Mar;30(3):277-88. doi: 10.1007/s10585-012-9534-9. Epub 2012 Sep 21.

PMID:
22996753
11.

Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling.

Lund IK, Nielsen BS, Almholt K, Rønø B, Hald A, Illemann M, Green KA, Christensen IJ, Rømer J, Lund LR.

Dev Biol. 2011 Oct 1;358(1):56-67. doi: 10.1016/j.ydbio.2011.07.021. Epub 2011 Jul 22.

12.

Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.

Bjerre Knudsen L, Madsen LW, Andersen S, Almholt K, de Boer AS, Drucker DJ, Gotfredsen C, Egerod FL, Hegelund AC, Jacobsen H, Jacobsen SD, Moses AC, Mølck AM, Nielsen HS, Nowak J, Solberg H, Thi TD, Zdravkovic M, Moerch U.

Endocrinology. 2010 Apr;151(4):1473-86. doi: 10.1210/en.2009-1272. Epub 2010 Mar 4. Erratum in: Endocrinology. 2012 Feb;153(2):1000. Moerch, Ulrik [added].

PMID:
20203154
13.

Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors.

Grum-Schwensen B, Klingelhöfer J, Grigorian M, Almholt K, Nielsen BS, Lukanidin E, Ambartsumian N.

Cancer Res. 2010 Feb 1;70(3):936-47. doi: 10.1158/0008-5472.CAN-09-3220. Epub 2010 Jan 26.

14.

Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.

Juncker-Jensen A, Rømer J, Pennington CJ, Lund LR, Almholt K.

Mol Carcinog. 2009 Jul;48(7):618-25. doi: 10.1002/mc.20503.

PMID:
19058297
15.

Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo.

Lund IK, Jögi A, Rønø B, Rasch MG, Lund LR, Almholt K, Gårdsvoll H, Behrendt N, Rømer J, Høyer-Hansen G.

J Biol Chem. 2008 Nov 21;283(47):32506-15. doi: 10.1074/jbc.M801924200. Epub 2008 Sep 17.

16.

Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model.

Almholt K, Juncker-Jensen A, Laerum OD, Danø K, Johnsen M, Lund LR, Rømer J.

Mol Cancer Ther. 2008 Sep;7(9):2758-67. doi: 10.1158/1535-7163.MCT-08-0251.

17.

Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.

Green KA, Almholt K, Ploug M, Rønø B, Castellino FJ, Johnsen M, Bugge TH, Rømer J, Lund LR.

J Invest Dermatol. 2008 Aug;128(8):2092-101. doi: 10.1038/jid.2008.54. Epub 2008 Mar 13.

18.

Extracellular proteolysis in transgenic mouse models of breast cancer.

Almholt K, Green KA, Juncker-Jensen A, Nielsen BS, Lund LR, Rømer J.

J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):83-97. Review.

19.

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J.

EMBO J. 2006 Jun 21;25(12):2686-97. Epub 2006 Jun 8.

20.

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

Vasiljeva O, Papazoglou A, Krüger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, Peters C, Reinheckel T.

Cancer Res. 2006 May 15;66(10):5242-50.

21.

Indication of a role of plasminogen activator inhibitor type I in protecting murine fibrosarcoma cells against apoptosis.

Rømer MU, Kirkebjerg Due A, Knud Larsen J, Hofland KF, Christensen IJ, Buhl-Jensen P, Almholt K, Lerberg Nielsen O, Brünner N, Lademann U.

Thromb Haemost. 2005 Oct;94(4):859-66.

PMID:
16270643
22.

Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.

Pedersen TX, Pennington CJ, Almholt K, Christensen IJ, Nielsen BS, Edwards DR, Rømer J, Danø K, Johnsen M.

Carcinogenesis. 2005 Jul;26(7):1233-40. Epub 2005 Mar 10.

PMID:
15760918
23.

Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice.

Almholt K, Lund LR, Rygaard J, Nielsen BS, Danø K, Rømer J, Johnsen M.

Int J Cancer. 2005 Feb 10;113(4):525-32.

24.

Changes in intracellular cAMP reported by a Redistribution assay using a cAMP-dependent protein kinase-green fluorescent protein chimera.

Almholt K, Tullin S, Skyggebjerg O, Scudder K, Thastrup O, Terry R.

Cell Signal. 2004 Aug;16(8):907-20.

PMID:
15157670
25.

Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice.

Almholt K, Nielsen BS, Frandsen TL, Brünner N, Danø K, Johnsen M.

Oncogene. 2003 Jul 10;22(28):4389-97.

PMID:
12853975
26.

Stromal cell involvement in cancer.

Almholt K, Johnsen M.

Recent Results Cancer Res. 2003;162:31-42. Review.

PMID:
12790319
27.
28.

Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation.

Johnsen M, Lund LR, Rømer J, Almholt K, Danø K.

Curr Opin Cell Biol. 1998 Oct;10(5):667-71. Review.

PMID:
9818179

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