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Items: 1 to 50 of 138

1.

Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.

Tang YJ, Huang J, Tsushima H, Ban GI, Zhang H, Oristian KM, Puviindran V, Williams N, Ding X, Ou J, Jung SH, Lee CL, Jiao Y, Chen BJ, Kirsch DG, Alman BA.

Cell Rep. 2019 Sep 10;28(11):2837-2850.e5. doi: 10.1016/j.celrep.2019.08.029.

2.

Pharmacologic targeting of β-catenin improves fracture healing in old mice.

Kwak YH, Barrientos T, Furman B, Zhang H, Puviindran V, Cutcliffe H, Herfarth J, Nwankwo E, Alman BA.

Sci Rep. 2019 Jun 21;9(1):9005. doi: 10.1038/s41598-019-45339-0.

3.

Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma.

Zhang H, Wei Q, Tsushima H, Puviindran V, Tang YJ, Pathmanapan S, Poon R, Ramu E, Al-Jazrawe M, Wunder J, Alman BA.

JCI Insight. 2019 Apr 30;5. pii: 127232. doi: 10.1172/jci.insight.127232.

4.

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.

Vi L, Baht GS, Soderblom EJ, Whetstone H, Wei Q, Furman B, Puviindran V, Nadesan P, Foster M, Poon R, White JP, Yahara Y, Ng A, Barrientos T, Grynpas M, Mosely MA, Alman BA.

Nat Commun. 2018 Dec 5;9(1):5191. doi: 10.1038/s41467-018-07666-0.

5.

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.

Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA.

Development. 2018 Jul 9;145(13). pii: dev162396. doi: 10.1242/dev.162396.

6.

The Role of the Immune Cells in Fracture Healing.

Baht GS, Vi L, Alman BA.

Curr Osteoporos Rep. 2018 Apr;16(2):138-145. doi: 10.1007/s11914-018-0423-2. Review.

7.

Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management.

Birnkrant DJ, Bushby K, Bann CM, Alman BA, Apkon SD, Blackwell A, Case LE, Cripe L, Hadjiyannakis S, Olson AK, Sheehan DW, Bolen J, Weber DR, Ward LM; DMD Care Considerations Working Group.

Lancet Neurol. 2018 Apr;17(4):347-361. doi: 10.1016/S1474-4422(18)30025-5. Epub 2018 Feb 3. Review.

8.

Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.

Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA.

J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051. Epub 2017 Dec 1.

9.

The Fourth Year of Medical School: Time for Reassessment: AOA Critical Issues.

Alman BA, Purtill JJ, Pellegrini VD, Scoles P.

J Bone Joint Surg Am. 2017 Jul 5;99(13):e72. doi: 10.2106/JBJS.16.01094.

PMID:
28678133
10.

Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair.

Baht GS, Nadesan P, Silkstone D, Alman BA.

Bone. 2017 May;98:31-36. doi: 10.1016/j.bone.2017.02.012. Epub 2017 Feb 22.

PMID:
28254468
11.

Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.

MacParland SA, Tsoi KM, Ouyang B, Ma XZ, Manuel J, Fawaz A, Ostrowski MA, Alman BA, Zilman A, Chan WC, McGilvray ID.

ACS Nano. 2017 Mar 28;11(3):2428-2443. doi: 10.1021/acsnano.6b06245. Epub 2017 Jan 17.

PMID:
28040885
12.

Mechanism of hard-nanomaterial clearance by the liver.

Tsoi KM, MacParland SA, Ma XZ, Spetzler VN, Echeverri J, Ouyang B, Fadel SM, Sykes EA, Goldaracena N, Kaths JM, Conneely JB, Alman BA, Selzner M, Ostrowski MA, Adeyi OA, Zilman A, McGilvray ID, Chan WC.

Nat Mater. 2016 Nov;15(11):1212-1221. doi: 10.1038/nmat4718. Epub 2016 Aug 15.

13.

Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.

Sato S, Tang YJ, Wei Q, Hirata M, Weng A, Han I, Okawa A, Takeda S, Whetstone H, Nadesan P, Kirsch DG, Wunder JS, Alman BA.

Cell Rep. 2016 Jul 26;16(4):917-927. doi: 10.1016/j.celrep.2016.06.058. Epub 2016 Jul 14.

14.

β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications.

Ghadakzadeh S, Kannu P, Whetstone H, Howard A, Alman BA.

FASEB J. 2016 Sep;30(9):3227-37. doi: 10.1096/fj.201500190RR. Epub 2016 Jun 15.

PMID:
27306335
15.

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.

Rockel JS, Yu C, Whetstone H, Craft AM, Reilly K, Ma H, Tsushima H, Puviindran V, Al-Jazrawe M, Keller GM, Alman BA.

J Clin Invest. 2016 May 2;126(5):1649-63. doi: 10.1172/JCI80205. Epub 2016 Mar 28.

16.

Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.

Gray MJ, Kannu P, Sharma S, Neyt C, Zhang D, Paria N, Daniel PB, Whetstone H, Sprenger HG, Hammerschmidt P, Weng A, Dupuis L, Jobling R, Mendoza-Londono R, Dray M, Su P, Wilson MJ, Kapur RP, McCarthy EF, Alman BA, Howard A, Somers GR, Marshall CR, Manners S, Flanagan AM, Rathjen KE, Karol LA, Crawford H, Markie DM, Rios JJ, Wise CA, Robertson SP.

Am J Hum Genet. 2015 Dec 3;97(6):837-47. doi: 10.1016/j.ajhg.2015.11.001.

17.

Construct validity and reliability of a real-time multidimensional smartphone app to assess pain in children and adolescents with cancer.

Stinson JN, Jibb LA, Nguyen C, Nathan PC, Maloney AM, Dupuis LL, Gerstle JT, Hopyan S, Alman BA, Strahlendorf C, Portwine C, Johnston DL.

Pain. 2015 Dec;156(12):2607-15. doi: 10.1097/j.pain.0000000000000385.

PMID:
26580680
18.

Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma.

Wei Q, Tang YJ, Voisin V, Sato S, Hirata M, Whetstone H, Han I, Ailles L, Bader GD, Wunder J, Alman BA.

Oncotarget. 2015 Nov 24;6(37):40283-94. doi: 10.18632/oncotarget.5375.

19.

Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix.

Ng AH, Omelon S, Variola F, Allo B, Willett TL, Alman BA, Grynpas MD.

J Bone Miner Res. 2016 Feb;31(2):369-79. doi: 10.1002/jbmr.2702. Epub 2015 Oct 6.

20.

Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.

Ali SA, Al-Jazrawe M, Ma H, Whetstone H, Poon R, Farr S, Naples M, Adeli K, Alman BA.

Arthritis Rheumatol. 2016 Jan;68(1):127-37. doi: 10.1002/art.39337.

21.

Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin.

Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, Wei Q, Alman BA.

Nat Commun. 2015 Aug 26;6:7761. doi: 10.1038/ncomms8761. No abstract available.

22.

Bone Marrow Stress Decreases Osteogenic Progenitors.

Ng AH, Baht GS, Alman BA, Grynpas MD.

Calcif Tissue Int. 2015 Nov;97(5):476-86. doi: 10.1007/s00223-015-0032-3. Epub 2015 Jul 29.

PMID:
26220824
23.

The role of hedgehog signalling in skeletal health and disease.

Alman BA.

Nat Rev Rheumatol. 2015 Sep;11(9):552-60. doi: 10.1038/nrrheum.2015.84. Epub 2015 Jun 16. Review.

PMID:
26077918
24.

Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.

Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, Wei Q, Alman BA.

Nat Commun. 2015 May 19;6:7131. doi: 10.1038/ncomms8131. Erratum in: Nat Commun. 2015;6:7761.

25.

Generation of articular chondrocytes from human pluripotent stem cells.

Craft AM, Rockel JS, Nartiss Y, Kandel RA, Alman BA, Keller GM.

Nat Biotechnol. 2015 Jun;33(6):638-45. doi: 10.10.38/nbt.3210. Epub 2015 May 11.

PMID:
25961409
26.

Mutant IDH is sufficient to initiate enchondromatosis in mice.

Hirata M, Sasaki M, Cairns RA, Inoue S, Puviindran V, Li WY, Snow BE, Jones LD, Wei Q, Sato S, Tang YJ, Nadesan P, Rockel J, Whetstone H, Poon R, Weng A, Gross S, Straley K, Gliser C, Xu Y, Wunder J, Mak TW, Alman BA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34. doi: 10.1073/pnas.1424400112. Epub 2015 Feb 17.

27.

Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.

Vi L, Baht GS, Whetstone H, Ng A, Wei Q, Poon R, Mylvaganam S, Grynpas M, Alman BA.

J Bone Miner Res. 2015 Jun;30(6):1090-102. doi: 10.1002/jbmr.2422.

28.

Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents.

Bernick J, Wang Y, Sigal IA, Alman BA, Whyne CM, Nam D.

J Bone Joint Surg Am. 2014 Dec 3;96(23):1990-8. doi: 10.2106/JBJS.N.00057.

29.

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation.

Klingberg F, Chow ML, Koehler A, Boo S, Buscemi L, Quinn TM, Costell M, Alman BA, Genot E, Hinz B.

J Cell Biol. 2014 Oct 27;207(2):283-97. doi: 10.1083/jcb.201402006. Epub 2014 Oct 20.

30.

Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD).

Ng AH, Willett TL, Alman BA, Grynpas MD.

Bone. 2014 Nov;68:57-66. doi: 10.1016/j.bone.2014.07.037. Epub 2014 Aug 8.

PMID:
25111968
31.

Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease.

Gordon JA, Lisle JW, Alman BA, Lian JB.

J Cell Physiol. 2014 Dec;229(12):1884-6. doi: 10.1002/jcp.24692.

32.

β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.

Amini-Nik S, Cambridge E, Yu W, Guo A, Whetstone H, Nadesan P, Poon R, Hinz B, Alman BA.

J Clin Invest. 2014 Jun;124(6):2599-610. doi: 10.1172/JCI62059. Epub 2014 May 16.

33.

Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.

Campbell VT, Nadesan P, Ali SA, Wang CY, Whetstone H, Poon R, Wei Q, Keilty J, Proctor J, Wang LW, Apte SS, McGovern K, Alman BA, Wunder JS.

Mol Cancer Ther. 2014 May;13(5):1259-69. doi: 10.1158/1535-7163.MCT-13-0731. Epub 2014 Mar 14.

34.

Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.

Baht GS, Silkstone D, Nadesan P, Whetstone H, Alman BA.

J Orthop Res. 2014 Apr;32(4):581-6. doi: 10.1002/jor.22562. Epub 2013 Dec 17.

35.

Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.

Lo WW, Wunder JS, Dickson BC, Campbell V, McGovern K, Alman BA, Andrulis IL.

Cancer. 2014 Feb 15;120(4):537-47. doi: 10.1002/cncr.28439. Epub 2013 Oct 21.

36.

Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling.

Ghanbari-Azarnier R, Sato S, Wei Q, Al-Jazrawe M, Alman BA.

Neoplasia. 2013 Jul;15(7):712-9.

37.

Glucocorticoid treatment for the prevention of scoliosis in children with Duchenne muscular dystrophy: long-term follow-up.

Lebel DE, Corston JA, McAdam LC, Biggar WD, Alman BA.

J Bone Joint Surg Am. 2013 Jun 19;95(12):1057-61. doi: 10.2106/JBJS.L.01577.

PMID:
23783200
38.

Specification of chondrocytes and cartilage tissues from embryonic stem cells.

Craft AM, Ahmed N, Rockel JS, Baht GS, Alman BA, Kandel RA, Grigoriadis AE, Keller GM.

Development. 2013 Jun;140(12):2597-610. doi: 10.1242/dev.087890.

39.

Competency-based education: a new model for teaching orthopaedics.

Alman BA, Ferguson P, Kraemer W, Nousiainen MT, Reznick RK.

Instr Course Lect. 2013;62:565-9.

PMID:
23395058
40.

Patients' views on surgeons' financial conflicts of interest.

Camp MW, Mattingly DA, Gross AE, Nousiainen MT, Alman BA, McKneally MF.

J Bone Joint Surg Am. 2013 Jan 16;95(2):e9 1-8. doi: 10.2106/JBJS.L.00270.

PMID:
23324970
41.

Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes.

Ho L, Ali SA, Al-Jazrawe M, Kandel R, Wunder JS, Alman BA.

Oncogene. 2013 Nov 21;32(47):5388-96. doi: 10.1038/onc.2012.588. Epub 2012 Dec 17.

42.

Cutaneous wound healing: recruiting developmental pathways for regeneration.

Bielefeld KA, Amini-Nik S, Alman BA.

Cell Mol Life Sci. 2013 Jun;70(12):2059-81. doi: 10.1007/s00018-012-1152-9. Epub 2012 Oct 4. Review.

43.

Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.

Hsu SH, Zhang X, Cheng S, Wunder JS, Hui CC, Alman BA.

J Biol Chem. 2012 Oct 19;287(43):36222-8. doi: 10.1074/jbc.M112.382275. Epub 2012 Aug 28.

44.

Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies.

Tsoi KM, Dai Q, Alman BA, Chan WC.

Acc Chem Res. 2013 Mar 19;46(3):662-71. doi: 10.1021/ar300040z. Epub 2012 Aug 1.

PMID:
22853558
45.

Orthopaedic resident education--it's a whole new game: "If I'm going to be a spine surgeon, why do I need to learn how to reconstruct an anterior cruciate ligament?": AOA critical issues.

Black KP, Alman BA, Levine WN, Nestler SP, Pinney SJ.

J Bone Joint Surg Am. 2012 Jul 3;94(13):e96. doi: 10.2106/JBJS.K.01214. No abstract available.

PMID:
22760397
46.

A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.

Poon R, Hong H, Wei X, Pan J, Alman BA.

PLoS One. 2012;7(5):e37940. doi: 10.1371/journal.pone.0037940. Epub 2012 May 30.

47.

The Canadian experience with long-term deflazacort treatment in Duchenne muscular dystrophy.

McAdam LC, Mayo AL, Alman BA, Biggar WD.

Acta Myol. 2012 May;31(1):16-20.

48.

A mechanism for gene-environment interaction in the etiology of congenital scoliosis.

Sparrow DB, Chapman G, Smith AJ, Mattar MZ, Major JA, O'Reilly VC, Saga Y, Zackai EH, Dormans JP, Alman BA, McGregor L, Kageyama R, Kusumi K, Dunwoodie SL.

Cell. 2012 Apr 13;149(2):295-306. doi: 10.1016/j.cell.2012.02.054. Epub 2012 Apr 5.

49.

Abnormal fatty acid metabolism in spinal muscular atrophy may predispose to perioperative risks.

Zolkipli Z, Sherlock M, Biggar WD, Taylor G, Hutchison JS, Peliowski A, Alman BA, Ling SC, Tein I.

Eur J Paediatr Neurol. 2012 Sep;16(5):549-53. doi: 10.1016/j.ejpn.2012.01.004. Epub 2012 Jan 20.

PMID:
22264649
50.

Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas.

Wang CY, Wei Q, Han I, Sato S, Ghanbari-Azarnier R, Whetstone H, Poon R, Hu J, Zheng F, Zhang P, Wang W, Wunder JS, Alman BA.

Cancer Res. 2012 Feb 15;72(4):1013-22. doi: 10.1158/0008-5472.CAN-11-2531. Epub 2012 Jan 9.

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