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Items: 33

1.

Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.

Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernández-Zapico ME, Iliopoulos D.

Gut. 2018 Oct 18. pii: gutjnl-2017-315690. doi: 10.1136/gutjnl-2017-315690. [Epub ahead of print]

PMID:
30337373
2.

CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations.

McWilliams RR, Wieben ED, Chaffee KG, Antwi SO, Raskin L, Olopade OI, Li D, Highsmith WE Jr, Colon-Otero G, Khanna LG, Permuth JB, Olson JE, Frucht H, Genkinger J, Zheng W, Blot WJ, Wu L, Almada LL, Fernandez-Zapico ME, Sicotte H, Pedersen KS, Petersen GM.

Cancer Epidemiol Biomarkers Prev. 2018 Nov;27(11):1364-1370. doi: 10.1158/1055-9965.EPI-17-1065. Epub 2018 Jul 23.

PMID:
30038052
3.

Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells.

Li Q, Alsaidan OA, Rai S, Wu M, Shen H, Beharry Z, Almada LL, Fernandez-Zapico ME, Wang L, Cai H.

J Biol Chem. 2018 Jul 6;293(27):10547-10560. doi: 10.1074/jbc.RA118.003255. Epub 2018 May 17.

PMID:
29773652
4.

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion.

Jalan-Sakrikar N, De Assuncao TM, Lu J, Almada LL, Lomberk G, Fernandez-Zapico ME, Urrutia R, Huebert RC.

PLoS One. 2016 Dec 9;11(12):e0168266. doi: 10.1371/journal.pone.0168266. eCollection 2016.

5.

Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma.

Chen G, Nakamura I, Dhanasekaran R, Iguchi E, Tolosa EJ, Romecin PA, Vera RE, Almada LL, Miamen AG, Chaiteerakij R, Zhou M, Asiedu MK, Moser CD, Han S, Hu C, Banini BA, Oseini AM, Chen Y, Fang Y, Yang D, Shaleh HM, Wang S, Wu D, Song T, Lee JS, Thorgeirsson SS, Chevet E, Shah VH, Fernandez-Zapico ME, Roberts LR.

Cancer Res. 2017 Feb 1;77(3):632-645. doi: 10.1158/0008-5472.CAN-15-2556. Epub 2016 Nov 21.

6.

4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.

Yun S, Vincelette ND, Knorr KL, Almada LL, Schneider PA, Peterson KL, Flatten KS, Dai H, Pratz KW, Hess AD, Smith BD, Karp JE, Hendrickson AE, Fernandez-Zapico ME, Kaufmann SH.

Blood. 2016 Jun 2;127(22):2711-22. doi: 10.1182/blood-2015-02-629485. Epub 2016 Feb 25.

7.

Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid.

Comba A, Almada LL, Tolosa EJ, Iguchi E, Marks DL, Vara Messler M, Silva R, Fernandez-Barrena MG, Enriquez-Hesles E, Vrabel AL, Botta B, Di Marcotulio L, Ellenrieder V, Eynard AR, Pasqualini ME, Fernandez-Zapico ME.

J Biol Chem. 2016 Jan 22;291(4):1933-47. doi: 10.1074/jbc.M115.691972. Epub 2015 Nov 24.

8.

Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells.

Jackson DA, Smith TD, Amarsaikhan N, Han W, Neil MS, Boi SK, Vrabel AM, Tolosa EJ, Almada LL, Fernandez-Zapico ME, Elsawa SF.

J Immunol. 2015 Sep 15;195(6):2908-16. doi: 10.4049/jimmunol.1402974. Epub 2015 Aug 3.

9.

Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.

Razidlo GL, Magnine C, Sletten AC, Hurley RM, Almada LL, Fernandez-Zapico ME, Ji B, McNiven MA.

Cancer Res. 2015 Jul 15;75(14):2907-15. doi: 10.1158/0008-5472.CAN-14-3103. Epub 2015 May 14.

10.

Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.

Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M.

Carcinogenesis. 2015 Jul;36(7):730-8. doi: 10.1093/carcin/bgv058. Epub 2015 May 4.

11.

The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma.

Boddicker RL, Kip NS, Xing X, Zeng Y, Yang ZZ, Lee JH, Almada LL, Elsawa SF, Knudson RA, Law ME, Ketterling RP, Cunningham JM, Wu Y, Maurer MJ, O'Byrne MM, Cerhan JR, Slager SL, Link BK, Porcher JC, Grote DM, Jelinek DF, Dogan A, Ansell SM, Fernandez-Zapico ME, Feldman AL.

Blood. 2015 May 14;125(20):3118-27. doi: 10.1182/blood-2014-05-578575. Epub 2015 Apr 1.

12.

Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6).

Mazzone A, Gibbons SJ, Bernard CE, Nowsheen S, Middha S, Almada LL, Ordog T, Kendrick ML, Reid Lombardo KM, Shen KR, Galietta LJ, Fernandez-Zapico ME, Farrugia G.

FASEB J. 2015 Jan;29(1):152-63. doi: 10.1096/fj.14-258541. Epub 2014 Oct 28.

13.

The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner.

Nye MD, Almada LL, Fernandez-Barrena MG, Marks DL, Elsawa SF, Vrabel A, Tolosa EJ, Ellenrieder V, Fernandez-Zapico ME.

J Biol Chem. 2014 May 30;289(22):15495-506. doi: 10.1074/jbc.M113.545194. Epub 2014 Apr 16.

14.

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration.

Nakamura I, Fernandez-Barrena MG, Ortiz-Ruiz MC, Almada LL, Hu C, Elsawa SF, Mills LD, Romecin PA, Gulaid KH, Moser CD, Han JJ, Vrabel A, Hanse EA, Akogyeram NA, Albrecht JH, Monga SP, Sanderson SO, Prieto J, Roberts LR, Fernandez-Zapico ME.

J Biol Chem. 2013 Jul 19;288(29):21389-98. doi: 10.1074/jbc.M112.443440. Epub 2013 Jun 5.

15.

Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.

Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME.

J Biol Chem. 2013 Apr 26;288(17):11786-94. doi: 10.1074/jbc.M112.438846. Epub 2013 Mar 12.

16.

The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.

Zheng X, Vittar NB, Gai X, Fernandez-Barrena MG, Moser CD, Hu C, Almada LL, McCleary-Wheeler AL, Elsawa SF, Vrabel AM, Shire AM, Comba A, Thorgeirsson SS, Kim Y, Liu Q, Fernandez-Zapico ME, Roberts LR.

PLoS One. 2012;7(11):e49581. doi: 10.1371/journal.pone.0049581. Epub 2012 Nov 19.

17.

Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.

Lo Ré AE, Fernández-Barrena MG, Almada LL, Mills LD, Elsawa SF, Lund G, Ropolo A, Molejon MI, Vaccaro MI, Fernandez-Zapico ME.

J Biol Chem. 2012 Jul 20;287(30):25325-34. doi: 10.1074/jbc.M112.370809. Epub 2012 Apr 25.

18.

GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells.

Joost S, Almada LL, Rohnalter V, Holz PS, Vrabel AM, Fernandez-Barrena MG, McWilliams RR, Krause M, Fernandez-Zapico ME, Lauth M.

Cancer Res. 2012 Jan 1;72(1):88-99. doi: 10.1158/0008-5472.CAN-10-4621. Epub 2011 Nov 15.

19.

Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity.

Elsawa SF, Novak AJ, Ziesmer SC, Almada LL, Hodge LS, Grote DM, Witzig TE, Fernandez-Zapico ME, Ansell SM.

Blood. 2011 Nov 17;118(20):5540-9. doi: 10.1182/blood-2011-04-351742. Epub 2011 Sep 14.

20.

The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened.

Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fernández-Zapico ME, Manning DR.

J Biol Chem. 2011 Sep 2;286(35):30714-22. doi: 10.1074/jbc.M111.219279. Epub 2011 Jul 11.

21.

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.

Beltran E, Fresquet V, Martinez-Useros J, Richter-Larrea JA, Sagardoy A, Sesma I, Almada LL, Montes-Moreno S, Siebert R, Gesk S, Calasanz MJ, Malumbres R, Rieger M, Prosper F, Lossos IS, Piris MA, Fernandez-Zapico ME, Martinez-Climent JA.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12461-6. doi: 10.1073/pnas.1018941108. Epub 2011 Jul 11.

22.

GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.

Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME.

J Biol Chem. 2011 Jun 17;286(24):21524-34. doi: 10.1074/jbc.M111.234146. Epub 2011 Mar 18.

23.

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth.

Fernandez-Zapico ME, Lomberk GA, Tsuji S, DeMars CJ, Bardsley MR, Lin YH, Almada LL, Han JJ, Mukhopadhyay D, Ordog T, Buttar NS, Urrutia R.

Biochem J. 2011 Apr 15;435(2):529-37. doi: 10.1042/BJ20100773.

24.

Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis.

Rizvi S, Demars CJ, Comba A, Gainullin VG, Rizvi Z, Almada LL, Wang K, Lomberk G, Fernández-Zapico ME, Buttar NS.

Cancer Res. 2010 Sep 1;70(17):6787-96. doi: 10.1158/0008-5472.CAN-10-0197. Epub 2010 Jul 20.

25.

GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis.

Kurita S, Mott JL, Almada LL, Bronk SF, Werneburg NW, Sun SY, Roberts LR, Fernandez-Zapico ME, Gores GJ.

Oncogene. 2010 Aug 26;29(34):4848-58. doi: 10.1038/onc.2010.235. Epub 2010 Jun 21.

26.

Primers on molecular pathways - cycling toward pancreatic cancer.

Liu Y, Elsawa SF, Almada LL.

Pancreatology. 2010;10(1):6-13. doi: 10.1159/000283646. Epub 2010 Mar 19. Review.

PMID:
20299817
27.

Subzero nonfreezing storage of rat hepatocytes using UW solution and 1,4-butanediol. II- functional testing on rewarming and gene expression of urea cycle enzymes.

Guibert EE, Almada LL, Mamprin ME, Bellarosa C, Pizarro MD, Tiribelli C, Rodriguez JV.

Ann Hepatol. 2009 Apr-Jun;8(2):129-33.

PMID:
19502656
28.
29.

Construction and performance of a minibioreactor suitable as experimental bioartificial liver.

Rodriguez JV, Pizarro MD, Scandizzi AL, Guibert EE, Almada LL, Mamprin ME.

Artif Organs. 2008 Apr;32(4):323-8. doi: 10.1111/j.1525-1594.2007.00435.x.

PMID:
18370948
30.

The assessment of viability in isolated rat hepatocytes subjected to cold or subzero non-freezing preservation protocols using a propidium iodide modified test.

Giraudi PJ, Almada LL, Mamprin ME, Guibert EE, Furno G, Rodriguez JV.

Cryo Letters. 2005 May-Jun;26(3):169-84.

PMID:
16082443
31.

Effect of S-nitrosoglutathione (GSNO) added to the University of Wisconsin solution (UW): II) Functional response to cold preservation/reperfusion of rat liver.

Quintana AB, Lenzi HL, Almada LL, Scandizzi AL, Furno G, Rodríguez JV, Guibert EE.

Ann Hepatol. 2002 Oct-Dec;1(4):183-91.

PMID:
15280805
32.
33.

Ammonium detoxifying activity is maintained after 72 hours of cold preservation of rat hepatocytes in University of Wisconsin (UW) solution.

Calligaris SD, Almada LL, Guibert EE, Tiribelli C, Rodriguez JV.

Cryo Letters. 2002 Jul-Aug;23(4):245-54.

PMID:
12391485

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