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Items: 41


Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele.

Davy PMC, Willcox DC, Shimabukuro M, Donlon TA, Torigoe T, Suzuki M, Higa M, Masuzaki H, Sata M, Chen R, Murkofsky RL, Morris BJ, Lim E, Allsopp RC, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1448-1452. doi: 10.1093/gerona/gly071. Erratum in: J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):192.


Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.

Allsopp RC, Dayl S, Bin Dayel A, Schmid R, Evans RJ.

Mol Pharmacol. 2018 May;93(5):553-562. doi: 10.1124/mol.117.111021. Epub 2018 Mar 13.


FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.

Davy PMC, Allsopp RC, Donlon TA, Morris BJ, Willcox DC, Willcox BJ.

Curr Top Dev Biol. 2018;127:193-212. doi: 10.1016/bs.ctdb.2017.10.001.


Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity.

Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tiirikainen M, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1459-1464. doi: 10.1093/gerona/glx247.


FOXO3 longevity interactome on chromosome 6.

Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, Elliott A, Willcox BJ.

Aging Cell. 2017 Oct;16(5):1016-1025. doi: 10.1111/acel.12625. Epub 2017 Jul 19.


Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.

Allsopp RC, Dayl S, Schmid R, Evans RJ.

Sci Rep. 2017 Apr 7;7(1):725. doi: 10.1038/s41598-017-00732-5.


Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation.

Broady AJ, Loichinger MH, Ahn HJ, Davy PM, Allsopp RC, Bryant-Greenwood GD.

Placenta. 2017 Feb;50:44-52. doi: 10.1016/j.placenta.2016.12.018. Epub 2016 Dec 18.


Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations.

Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA.

J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):724-728. doi: 10.1093/gerona/glw196.


Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity.

Donlon TA, Morris BJ, He Q, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tranah GJ, Parimi N, Evans DS, Flachsbart F, Nebel A, Kim DH, Park J, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1038-1044. doi: 10.1093/gerona/glw116.


Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle.

Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC.

PLoS One. 2016 May 5;11(5):e0154309. doi: 10.1371/journal.pone.0154309. eCollection 2016.


Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue - Evaluations on Monocyte-Based Delivery System for the Central Nervous System.

Tong HI, Kang W, Davy PM, Shi Y, Sun S, Allsopp RC, Lu Y.

PLoS One. 2016 Apr 26;11(4):e0154022. doi: 10.1371/journal.pone.0154022. eCollection 2016.


The FoxO3 gene and cause-specific mortality.

Willcox BJ, Tranah GJ, Chen R, Morris BJ, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Davy P, Gerschenson M, Donlon TA.

Aging Cell. 2016 Aug;15(4):617-24. doi: 10.1111/acel.12452. Epub 2016 Apr 13.


Stem cells, telomerase regulation and the hypoxic state.

Mathews J, Davy PM, Gardner LH, Allsopp RC.

Front Biosci (Landmark Ed). 2016 Jan 1;21:303-15. Review.


Human adipose stem cell and ASC-derived cardiac progenitor cellular therapy improves outcomes in a murine model of myocardial infarction.

Davy PM, Lye KD, Mathews J, Owens JB, Chow AY, Wong L, Moisyadi S, Allsopp RC.

Stem Cells Cloning. 2015 Oct 29;8:135-48. doi: 10.2147/SCCAA.S86925. eCollection 2015.


Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels.

Allsopp RC, Evans RJ.

J Biol Chem. 2015 Jun 5;290(23):14556-66. doi: 10.1074/jbc.M115.642033. Epub 2015 Apr 22.


Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.

Roberts JA, Allsopp RC, El Ajouz S, Vial C, Schmid R, Young MT, Evans RJ.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4663-7. doi: 10.1073/pnas.1201872109. Epub 2012 Mar 5.


The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels.

Allsopp RC, Evans RJ.

J Biol Chem. 2011 Dec 30;286(52):44691-701. doi: 10.1074/jbc.M111.303917. Epub 2011 Oct 25.


Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating.

Allsopp RC, El Ajouz S, Schmid R, Evans RJ.

J Biol Chem. 2011 Aug 19;286(33):29207-17. doi: 10.1074/jbc.M111.260364. Epub 2011 Jun 20.


Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop.

El-Ajouz S, Ray D, Allsopp RC, Evans RJ.

Br J Pharmacol. 2012 Jan;165(2):390-400. doi: 10.1111/j.1476-5381.2011.01534.x.


P2X1 receptor mobility and trafficking; regulation by receptor insertion and activation.

Lalo U, Allsopp RC, Mahaut-Smith MP, Evans RJ.

J Neurochem. 2010 Jun;113(5):1177-87. doi: 10.1111/j.1471-4159.2010.06730.x. Epub 2010 Apr 2.


Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimer's disease patients and aged controls.

Hainsworth AH, Allsopp RC, Jim A, Potter JF, Lowe J, Talbot CJ, Prettyman RJ.

Neuropathol Appl Neurobiol. 2010 Feb;36(1):17-24. doi: 10.1111/j.1365-2990.2009.01035.x. Epub 2009 Jul 14.


Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.

Roberts JA, Valente M, Allsopp RC, Watt D, Evans RJ.

J Neurochem. 2009 May;109(4):1042-52. doi: 10.1111/j.1471-4159.2009.06035.x. Epub 2009 Mar 13.


SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity.

Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H.

Mol Biol Cell. 2008 Mar;19(3):1210-9. doi: 10.1091/mbc.E07-09-0965. Epub 2008 Jan 9.


Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells.

Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL.

Nat Med. 2003 Apr;9(4):369-71. No abstract available.


Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.

Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL.

Blood. 2003 Jul 15;102(2):517-20. Epub 2003 Mar 27.


Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.

Greenberg RA, Allsopp RC, Chin L, Morin GB, DePinho RA.

Oncogene. 1998 Apr 2;16(13):1723-30.


ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH, Poirier GG, Benchimol S.

EMBO J. 1997 Oct 1;16(19):6018-33.


Models of initiation of replicative senescence by loss of telomeric DNA.

Allsopp RC.

Exp Gerontol. 1996 Jan-Apr;31(1-2):235-43. Review.


Telomere shortening is associated with cell division in vitro and in vivo.

Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, Harley CB.

Exp Cell Res. 1995 Sep;220(1):194-200.


The RNA component of human telomerase.

Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al.

Science. 1995 Sep 1;269(5228):1236-41.


Evidence for a critical telomere length in senescent human fibroblasts.

Allsopp RC, Harley CB.

Exp Cell Res. 1995 Jul;219(1):130-6.


Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM.

Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9857-60.


Telomere length predicts replicative capacity of human fibroblasts.

Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB.

Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10114-8.


The telomere hypothesis of cellular aging.

Harley CB, Vaziri H, Counter CM, Allsopp RC.

Exp Gerontol. 1992 Jul-Aug;27(4):375-82. No abstract available.


Telomere end-replication problem and cell aging.

Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB.

J Mol Biol. 1992 Jun 20;225(4):951-60.


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