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Cognitive impairment, brain ischemia and shorter telomeres are predictors of mortality in the Japanese elderly: A 13-year prospective community-based study.

Igari R, Davy P, Sato H, Takahashi Y, Iseki C, Kato H, Sato H, Koyama S, Ishizawa K, Allsopp R, Kato T.

J Neurol Sci. 2019 Feb 15;397:129-134. doi: 10.1016/j.jns.2018.12.038. Epub 2018 Dec 31.


Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele.

Davy PMC, Willcox DC, Shimabukuro M, Donlon TA, Torigoe T, Suzuki M, Higa M, Masuzaki H, Sata M, Chen R, Murkofsky RL, Morris BJ, Lim E, Allsopp RC, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1448-1452. doi: 10.1093/gerona/gly071. Erratum in: J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):192.


Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.

Allsopp RC, Dayl S, Bin Dayel A, Schmid R, Evans RJ.

Mol Pharmacol. 2018 May;93(5):553-562. doi: 10.1124/mol.117.111021. Epub 2018 Mar 13.


FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.

Davy PMC, Allsopp RC, Donlon TA, Morris BJ, Willcox DC, Willcox BJ.

Curr Top Dev Biol. 2018;127:193-212. doi: 10.1016/bs.ctdb.2017.10.001.


Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity.

Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tiirikainen M, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1459-1464. doi: 10.1093/gerona/glx247.


FOXO3 longevity interactome on chromosome 6.

Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, Elliott A, Willcox BJ.

Aging Cell. 2017 Oct;16(5):1016-1025. doi: 10.1111/acel.12625. Epub 2017 Jul 19.


Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.

Allsopp RC, Dayl S, Schmid R, Evans RJ.

Sci Rep. 2017 Apr 7;7(1):725. doi: 10.1038/s41598-017-00732-5.


Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation.

Broady AJ, Loichinger MH, Ahn HJ, Davy PM, Allsopp RC, Bryant-Greenwood GD.

Placenta. 2017 Feb;50:44-52. doi: 10.1016/j.placenta.2016.12.018. Epub 2016 Dec 18.


Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations.

Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Gerschenson M, Davy PMC, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Donlon TA.

J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):724-728. doi: 10.1093/gerona/glw196.


Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity.

Donlon TA, Morris BJ, He Q, Chen R, Masaki KH, Allsopp RC, Willcox DC, Tranah GJ, Parimi N, Evans DS, Flachsbart F, Nebel A, Kim DH, Park J, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1038-1044. doi: 10.1093/gerona/glw116.


Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle.

Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC.

PLoS One. 2016 May 5;11(5):e0154309. doi: 10.1371/journal.pone.0154309. eCollection 2016.


Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue - Evaluations on Monocyte-Based Delivery System for the Central Nervous System.

Tong HI, Kang W, Davy PM, Shi Y, Sun S, Allsopp RC, Lu Y.

PLoS One. 2016 Apr 26;11(4):e0154022. doi: 10.1371/journal.pone.0154022. eCollection 2016.


The FoxO3 gene and cause-specific mortality.

Willcox BJ, Tranah GJ, Chen R, Morris BJ, Masaki KH, He Q, Willcox DC, Allsopp RC, Moisyadi S, Poon LW, Rodriguez B, Newman AB, Harris TB, Cummings SR, Liu Y, Parimi N, Evans DS, Davy P, Gerschenson M, Donlon TA.

Aging Cell. 2016 Aug;15(4):617-24. doi: 10.1111/acel.12452. Epub 2016 Apr 13.


Stem cells, telomerase regulation and the hypoxic state.

Mathews J, Davy PM, Gardner LH, Allsopp RC.

Front Biosci (Landmark Ed). 2016 Jan 1;21:303-15. Review.


Human adipose stem cell and ASC-derived cardiac progenitor cellular therapy improves outcomes in a murine model of myocardial infarction.

Davy PM, Lye KD, Mathews J, Owens JB, Chow AY, Wong L, Moisyadi S, Allsopp RC.

Stem Cells Cloning. 2015 Oct 29;8:135-48. doi: 10.2147/SCCAA.S86925. eCollection 2015.


Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels.

Allsopp RC, Evans RJ.

J Biol Chem. 2015 Jun 5;290(23):14556-66. doi: 10.1074/jbc.M115.642033. Epub 2015 Apr 22.


Genetic variation in the raptor gene is associated with overweight but not hypertension in American men of Japanese ancestry.

Morris BJ, Carnes BA, Chen R, Donlon TA, He Q, Grove JS, Masaki KH, Elliott A, Willcox DC, Allsopp R, Willcox BJ.

Am J Hypertens. 2015 Apr;28(4):508-17. doi: 10.1093/ajh/hpu188. Epub 2014 Sep 22.


Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry.

Morris BJ, Donlon TA, He Q, Grove JS, Masaki KH, Elliott A, Willcox DC, Allsopp R, Willcox BJ.

J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):133-42. doi: 10.1093/gerona/glu021. Epub 2014 Mar 3.


Effective Targeted Gene Knockdown in Mammalian Cells Using the piggyBac Transposase-based Delivery System.

Owens JB, Mathews J, Davy P, Stoytchev I, Moisyadi S, Allsopp R.

Mol Ther Nucleic Acids. 2013 Dec 10;2:e137. doi: 10.1038/mtna.2013.61.


Short telomeres flirt with stem cell commitment.

Allsopp R.

Cell Stem Cell. 2013 Apr 4;12(4):383-4. doi: 10.1016/j.stem.2013.03.011.


A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

Le Saux CJ, Davy P, Brampton C, Ahuja SS, Fauce S, Shivshankar P, Nguyen H, Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R.

PLoS One. 2013;8(3):e58423. doi: 10.1371/journal.pone.0058423. Epub 2013 Mar 14.


Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting.

Schmitt J, Spuls P, Boers M, Thomas K, Chalmers J, Roekevisch E, Schram M, Allsopp R, Aoki V, Apfelbacher C, Bruijnzeel-Koomen C, Bruin-Weller M, Charman C, Cohen A, Dohil M, Flohr C, Furue M, Gieler U, Hooft L, Humphreys R, Ishii HA, Katayama I, Kouwenhoven W, Langan S, Lewis-Jones S, Merhand S, Murota H, Murrell DF, Nankervis H, Ohya Y, Oranje A, Otsuka H, Paul C, Rosenbluth Y, Saeki H, Schuttelaar ML, Stalder JF, Svensson A, Takaoka R, Wahlgren CF, Weidinger S, Wollenberg A, Williams H.

Allergy. 2012 Sep;67(9):1111-7. doi: 10.1111/j.1398-9995.2012.02874.x. Epub 2012 Jul 30.


Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.

Roberts JA, Allsopp RC, El Ajouz S, Vial C, Schmid R, Young MT, Evans RJ.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4663-7. doi: 10.1073/pnas.1201872109. Epub 2012 Mar 5.


Telomere length and iPSC re-programming: survival of the longest.

Allsopp R.

Cell Res. 2012 Apr;22(4):614-5. doi: 10.1038/cr.2012.6. Epub 2012 Jan 3. No abstract available.


The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels.

Allsopp RC, Evans RJ.

J Biol Chem. 2011 Dec 30;286(52):44691-701. doi: 10.1074/jbc.M111.303917. Epub 2011 Oct 25.


Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating.

Allsopp RC, El Ajouz S, Schmid R, Evans RJ.

J Biol Chem. 2011 Aug 19;286(33):29207-17. doi: 10.1074/jbc.M111.260364. Epub 2011 Jun 20.


Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop.

El-Ajouz S, Ray D, Allsopp RC, Evans RJ.

Br J Pharmacol. 2012 Jan;165(2):390-400. doi: 10.1111/j.1476-5381.2011.01534.x.


Hypoxia: are stem cells in it for the long run?

Davy P, Allsopp R.

Cell Cycle. 2011 Jan 15;10(2):206-11. Epub 2011 Jan 15.


Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?

Chang E, Forsberg EC, Wu J, Bingyin Wang, Prohaska SS, Allsopp R, Weissman IL, Cooke JP.

Vasc Med. 2010 Oct;15(5):375-85. doi: 10.1177/1358863X10378377.


RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cells.

Coussens M, Davy P, Brown L, Foster C, Andrews WH, Nagata M, Allsopp R.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13842-7. doi: 10.1073/pnas.0913834107. Epub 2010 Jul 19.


Quality of life and health-related utility analysis of adults with moderate and severe atopic dermatitis treated with tacrolimus ointment vs. topical corticosteroids.

Poole CD, Chambers C, Allsopp R, Currie CJ.

J Eur Acad Dermatol Venereol. 2010 Jun;24(6):674-8. doi: 10.1111/j.1468-3083.2009.03485.x.


P2X1 receptor mobility and trafficking; regulation by receptor insertion and activation.

Lalo U, Allsopp RC, Mahaut-Smith MP, Evans RJ.

J Neurochem. 2010 Jun;113(5):1177-87. doi: 10.1111/j.1471-4159.2010.06730.x. Epub 2010 Apr 2.


Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.

Meznikova M, Erdmann N, Allsopp R, Harrington LA.

Dis Model Mech. 2009 Nov-Dec;2(11-12):620-6. doi: 10.1242/dmm.004069. Epub 2009 Oct 19.


Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimer's disease patients and aged controls.

Hainsworth AH, Allsopp RC, Jim A, Potter JF, Lowe J, Talbot CJ, Prettyman RJ.

Neuropathol Appl Neurobiol. 2010 Feb;36(1):17-24. doi: 10.1111/j.1365-2990.2009.01035.x. Epub 2009 Jul 14.


Attenuated expression of SECIS binding protein 2 causes loss of telomeric reserve without affecting telomerase.

Squires JE, Davy P, Berry MJ, Allsopp R.

Exp Gerontol. 2009 Sep;44(9):619-23. doi: 10.1016/j.exger.2009.06.005. Epub 2009 Jun 27.


Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.

Roberts JA, Valente M, Allsopp RC, Watt D, Evans RJ.

J Neurochem. 2009 May;109(4):1042-52. doi: 10.1111/j.1471-4159.2009.06035.x. Epub 2009 Mar 13.


Fetal growth restriction is associated with accelerated telomere shortening and increased expression of cell senescence markers in the placenta.

Davy P, Nagata M, Bullard P, Fogelson NS, Allsopp R.

Placenta. 2009 Jun;30(6):539-42. doi: 10.1016/j.placenta.2009.03.005. Epub 2009 Apr 8.


Balancing out the ends during iPSC nuclear reprogramming.

Davy P, Allsopp R.

Cell Stem Cell. 2009 Feb 6;4(2):95-6. doi: 10.1016/j.stem.2009.01.004.


Sirt1 deficiency attenuates spermatogenesis and germ cell function.

Coussens M, Maresh JG, Yanagimachi R, Maeda G, Allsopp R.

PLoS One. 2008 Feb 13;3(2):e1571. doi: 10.1371/journal.pone.0001571.


SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity.

Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H.

Mol Biol Cell. 2008 Mar;19(3):1210-9. doi: 10.1091/mbc.E07-09-0965. Epub 2008 Jan 9.


Regulation and effects of modulation of telomerase reverse transcriptase expression in primordial germ cells during development.

Coussens M, Yamazaki Y, Moisyadi S, Suganuma R, Yanagimachi R, Allsopp R.

Biol Reprod. 2006 Nov;75(5):785-91. Epub 2006 Aug 9.


Long telomeres in the mature human placenta.

Allsopp R, Shimoda J, Easa D, Ward K.

Placenta. 2007 Apr;28(4):324-7. Epub 2006 Jun 23.


The two faces of telomerase.

Allsopp R.

Hawaii Med J. 2005 Feb;64(2):50-1. No abstract available.


Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells.

Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL.

Nat Med. 2003 Apr;9(4):369-71. No abstract available.


Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.

Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL.

Blood. 2003 Jul 15;102(2):517-20. Epub 2003 Mar 27.


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