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Items: 1 to 50 of 188

1.

Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.

Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02071-18. doi: 10.1128/AAC.02071-18. Print 2019 Apr.

2.

Wildlife diseases in New Zealand: recent findings and future challenges.

Alley MR, Gartrell BD.

N Z Vet J. 2019 Jan;67(1):1-11. doi: 10.1080/00480169.2018.1520656. Epub 2018 Oct 1. Review.

PMID:
30198397
3.

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9616-9621. doi: 10.1073/pnas.1807915115. Epub 2018 Sep 5.

4.

The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.

Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T.

Tuberculosis (Edinb). 2018 Jan;108:96-98. doi: 10.1016/j.tube.2017.11.003. Epub 2017 Nov 7.

5.

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung KF, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang YK, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC.

PLoS Pathog. 2018 Feb 9;14(2):e1006850. doi: 10.1371/journal.ppat.1006850. eCollection 2018 Feb.

6.

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

Li X, Hernandez V, Rock FL, Choi W, Mak YSL, Mohan M, Mao W, Zhou Y, Easom EE, Plattner JJ, Zou W, Pérez-Herrán E, Giordano I, Mendoza-Losana A, Alemparte C, Rullas J, Angulo-Barturen I, Crouch S, Ortega F, Barros D, Alley MRK.

J Med Chem. 2017 Oct 12;60(19):8011-8026. doi: 10.1021/acs.jmedchem.7b00631. Epub 2017 Sep 27.

PMID:
28953378
7.

A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.

Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e01205-17. doi: 10.1128/AAC.01205-17. Print 2017 Sep.

8.

Description of four new species of coccidia (Apicomplexa: Eimeriidae) from brown kiwi, Apteryx mantelli, in New Zealand.

Morgan KJ, Pomroy WE, Howe L, Alley MR, Castro I.

Parasitol Res. 2017 May;116(5):1433-1441. doi: 10.1007/s00436-017-5414-1. Epub 2017 Apr 3.

PMID:
28374109
9.

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.

Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ.

Nat Commun. 2017 Mar 6;8:14574. doi: 10.1038/ncomms14574.

10.

Adenomatous hyperplasia of the mucous glands in captive Archey's frogs (Leiopelma archeyi).

Shaw SD, Berger L, Harvey C, Alley MR, Bishop PJ, Speare R.

N Z Vet J. 2017 May;65(3):140-146. doi: 10.1080/00480169.2016.1255158. Epub 2016 Nov 30. Erratum in: N Z Vet J. 2017 May;65(3):iii.

PMID:
27855564
11.

DIPHTHERITIC STOMATITIS IN YELLOW-EYED PENGUINS (MEGADYPTES ANTIPODES) IN NEW ZEALAND.

Alley MR, Suepaul RB, McKinlay B, Young MJ, Wang J, Morgan KJ, Hunter SA, Gartrell BD.

J Wildl Dis. 2017 Jan;53(1):102-110. doi: 10.7589/2015-07-195. Epub 2016 Oct 27.

PMID:
27788054
12.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.

13.

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5817-27. doi: 10.1128/AAC.00873-16. Print 2016 Oct.

14.

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4886-95. doi: 10.1128/AAC.00820-16. Print 2016 Aug.

15.

Tavaborole topical solution, 5% for the treatment of toenail onychomycosis.

Zane LT, Plattner J, Chanda S, Coronado D, Merchant T, Alley MR, Gupta AK.

Drugs Today (Barc). 2015 Oct;51(10):599-607. doi: 10.1358/dot.2015.51.10.2401004. Review.

PMID:
26583302
16.

Efficacy of anthelmintic treatment in captive-reared black stilts (Himantopus novaezelandiae) released to the wild.

Robertson LM, Alley MR, Gartrell BD, Castro IC, Lopez-Villalobos N, Sancha E.

N Z Vet J. 2016 Mar;64(2):82-9. doi: 10.1080/00480169.2015.1073636. Epub 2015 Aug 27.

PMID:
26208464
17.

Investigation of mortalities associated with Salmonella spp. infection in wildlife on Tiritiri Matangi Island in the Hauraki Gulf of New Zealand.

van Andel M, Jackson BH, Midwinter AC, Alley MR, Ewen JG, McInnes K, Jakob Hoff R, Reynolds AD, French N.

N Z Vet J. 2015 Jul;63(4):235-9. doi: 10.1080/00480169.2014.990065. Epub 2015 May 15.

PMID:
25482376
18.

Prevalence of and risk factors for coccidiosis in kiwi between 1977 and 2011.

Morgan KJ, Castro I, Lopez-Villalobos N, Pomroy WE, Alley MR, Gartrell BD, Hunter S, Howe L.

N Z Vet J. 2014 Nov;62(6):315-20. doi: 10.1080/00480169.2014.932657. Epub 2014 Sep 26.

PMID:
25145793
19.

Investigation of an outbreak of craniofacial deformity in yellow-eyed penguin (Megadyptes antipodes) chicks.

Buckle KN, Young MJ, Alley MR.

N Z Vet J. 2014 Sep;62(5):250-7. doi: 10.1080/00480169.2014.906332. Epub 2014 May 20.

PMID:
24841759
20.

Avian malaria in New Zealand.

Schoener ER, Banda M, Howe L, Castro IC, Alley MR.

N Z Vet J. 2014 Jul;62(4):189-98. doi: 10.1080/00480169.2013.871195. Epub 2014 Feb 26. Review.

PMID:
24313228
21.

The anatomy of the bill tip of kiwi and associated somatosensory regions of the brain: comparisons with shorebirds.

Cunningham SJ, Corfield JR, Iwaniuk AN, Castro I, Alley MR, Birkhead TR, Parsons S.

PLoS One. 2013 Nov 14;8(11):e80036. doi: 10.1371/journal.pone.0080036. eCollection 2013.

23.

Extra-intestinal coccidiosis in the kiwi (Apteryx spp.).

Morgan KJ, Alley MR, Pomroy WE, Gartrell BD, Castro I, Howe L.

Avian Pathol. 2013 Apr;42(2):137-46. doi: 10.1080/03079457.2013.776665.

PMID:
23581440
24.

Potency and spectrum of activity of AN3365, a novel boron-containing protein synthesis inhibitor, tested against clinical isolates of Enterobacteriaceae and nonfermentative Gram-negative bacilli.

Mendes RE, Alley MR, Sader HS, Biedenbach DJ, Jones RN.

Antimicrob Agents Chemother. 2013 Jun;57(6):2849-57. doi: 10.1128/AAC.00160-13. Epub 2013 Mar 18.

25.

Coccidia species in endemic and native New Zealand passerines.

Schoener ER, Alley MR, Howe L, Castro I.

Parasitol Res. 2013 May;112(5):2027-36. doi: 10.1007/s00436-013-3361-z. Epub 2013 Mar 7.

PMID:
23468142
26.

Avian polyomavirus identified in a nestling Gouldian finch (Erythrura gouldiae) in New Zealand.

Alley MR, Rasiah I, Lee EA, Howe L, Gartrell BD.

N Z Vet J. 2013 Nov;61(6):359-61. doi: 10.1080/00480169.2012.760393. Epub 2013 Feb 28.

PMID:
23445119
27.

High prevalence of Leucocytozoon spp. in the endangered yellow-eyed penguin (Megadyptes antipodes) in the sub-Antarctic regions of New Zealand.

Argilla LS, Howe L, Gartrell BD, Alley MR.

Parasitology. 2013 Apr;140(5):672-82. doi: 10.1017/S0031182012002089. Epub 2013 Jan 29.

PMID:
23361092
28.

Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone.

Li X, Zhang YK, Plattner JJ, Mao W, Alley MR, Xia Y, Hernandez V, Zhou Y, Ding CZ, Li J, Shao Z, Zhang H, Xu M.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):963-6. doi: 10.1016/j.bmcl.2012.12.045. Epub 2012 Dec 21.

PMID:
23312945
29.

Traumatic ventriculitis following consumption of introduced insect prey (Hymenoptera) in nestling hihi (Notiomystis cincta).

Rippon RJ, Alley MR, Castro I.

J Wildl Dis. 2013 Jan;49(1):80-90. doi: 10.7589/2010-03-048.

PMID:
23307374
30.

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ.

Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7.

31.

Coccidiosis in hihi/stitchbirds (Notiomystis cincta) due to coccidia of the Eimeriidae.

Schoener ER, Alley MR, Twentyman CM, Howe L, Barta JR, Charleston WA, Castro I.

N Z Vet J. 2013 Mar;61(2):68-76. doi: 10.1080/00480169.2012.716361. Epub 2012 Sep 20.

PMID:
22992170
32.

Avipoxvirus infections in brown kiwi (Apteryx mantelli).

Ha HJ, Alley M, Howe L, Castro I, Gartrell B.

N Z Vet J. 2013 Jan;61(1):49-52. doi: 10.1080/00480169.2012.700629. Epub 2012 Sep 18.

PMID:
22984886
33.

Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.

Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y.

FEBS Lett. 2012 Sep 21;586(19):3410-4. doi: 10.1016/j.febslet.2012.07.058. Epub 2012 Jul 25.

34.

Enteric coccidiosis in the brown kiwi (Apteryx mantelli).

Morgan KJ, Alley MR, Pomroy WE, Castro I, Howe L.

Parasitol Res. 2012 Oct;111(4):1689-99. Epub 2012 Jul 27.

PMID:
22837099
35.

Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap.

Sarkar J, Mao W, Lincecum TL Jr, Alley MR, Martinis SA.

FEBS Lett. 2011 Oct 3;585(19):2986-91. doi: 10.1016/j.febslet.2011.08.010. Epub 2011 Aug 16.

36.

Fibrous osteodystrophy in two Northern Royal albatross chicks (Diomedea sanfordi).

Morgan KJ, Alley MR, Gartrell BD, Thompson KG, Perriman L.

N Z Vet J. 2011 Sep;59(5):248-52. doi: 10.1080/00480169.2011.596265.

PMID:
21851303
37.

Malaria parasites (Plasmodium spp.) infecting introduced, native and endemic New Zealand birds.

Howe L, Castro IC, Schoener ER, Hunter S, Barraclough RK, Alley MR.

Parasitol Res. 2012 Feb;110(2):913-23. doi: 10.1007/s00436-011-2577-z. Epub 2011 Aug 14.

38.

Bilateral coxofemoral degenerative joint disease in a juvenile male yellow-eyed penguin (Megadyptes antipodes).

Buckle KN, Alley MR.

Avian Pathol. 2011 Aug;40(4):371-5. doi: 10.1080/03079457.2011.586020.

PMID:
21812716
39.

Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.

Xia Y, Cao K, Zhou Y, Alley MR, Rock F, Mohan M, Meewan M, Baker SJ, Lux S, Ding CZ, Jia G, Kully M, Plattner JJ.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2533-6. doi: 10.1016/j.bmcl.2011.02.024. Epub 2011 Feb 12.

PMID:
21392987
40.

Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.

Ding D, Meng Q, Gao G, Zhao Y, Wang Q, Nare B, Jacobs R, Rock F, Alley MR, Plattner JJ, Chen G, Li D, Zhou H.

J Med Chem. 2011 Mar 10;54(5):1276-87. doi: 10.1021/jm101225g. Epub 2011 Feb 15.

PMID:
21322634
41.

Candida albicans infection in free-living populations of hihi (stitchbird; Notiomystis cincta).

Rippon RJ, Alley MR, Castro I.

N Z Vet J. 2010 Dec;58(6):299-306. doi: 10.1080/00480169.2010.69760.

PMID:
21151216
42.

Facial bristle feather histology and morphology in New Zealand birds: implications for function.

Cunningham SJ, Alley MR, Castro I.

J Morphol. 2011 Jan;272(1):118-28. doi: 10.1002/jmor.10908. Epub 2010 Nov 10.

PMID:
21069752
43.

Concurrent avian malaria and avipox virus infection in translocated South Island saddlebacks (Philesturnus carunculatus carunculatus).

Alley MR, Hale KA, Cash W, Ha HJ, Howe L.

N Z Vet J. 2010 Aug;58(4):218-23. doi: 10.1080/00480169.2010.68868.

PMID:
20676161
44.

Prevalence of Leucocytozoon spp, in the endangered yellow-eyed penguin Megadyptes antipodes.

Hill AG, Howe L, Gartrell BD, Alley MR.

Parasitology. 2010 Sep;137(10):1477-85. doi: 10.1017/S0031182009991910. Epub 2010 Jun 17.

PMID:
20557665
45.
46.

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.

Seiradake E, Mao W, Hernandez V, Baker SJ, Plattner JJ, Alley MR, Cusack S.

J Mol Biol. 2009 Jul 10;390(2):196-207. doi: 10.1016/j.jmb.2009.04.073. Epub 2009 May 6.

PMID:
19426743
47.

The prevalence of psittacine beak and feather disease virus infection in native parrots in New Zealand.

Ha HJ, Alley MR, Cahill JI, Howe L, Gartrell BD.

N Z Vet J. 2009 Feb;57(1):50-2. doi: 10.1080/00480169.2009.36868.

PMID:
19252543
48.

An outbreak of avian malaria in captive yellowheads/mohua (Mohoua ochrocephala).

Alley MR, Fairley RA, Martin DG, Howe L, Atkinson T.

N Z Vet J. 2008 Oct;56(5):247-51. doi: 10.1080/00480169.2008.36842. Erratum in: N Z Vet J. 2008 Dec;56(6):345.

PMID:
18836507
49.

Hyperplastic goitre and mortality in captive-reared black stilts ( Himantopus novaezelandiae ).

Alley MR, Twentyman CM, Sancha SE, Clark P, Maloney RF.

N Z Vet J. 2008 Jun;56(3):139-44. doi: 10.1080/00480169.2008.36822.

PMID:
18536773
50.

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.

Xu H, Sullivan TJ, Sekiguchi J, Kirikae T, Ojima I, Stratton CF, Mao W, Rock FL, Alley MR, Johnson F, Walker SG, Tonge PJ.

Biochemistry. 2008 Apr 8;47(14):4228-36. doi: 10.1021/bi800023a. Epub 2008 Mar 13.

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