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Items: 24


Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS.

Zheng N, Catlett IM, Taylor K, Gu H, Pattoli MA, Neely RJ, Li W, Allentoff A, Yuan X, Ciccimaro E, Yao M, Warrack BM, Burke JR, Zhang YJ, Pillutla R, Zeng J.

Anal Chem. 2019 Jul 2;91(13):8443-8452. doi: 10.1021/acs.analchem.9b01462. Epub 2019 Jun 19.


Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Watterson SH, Liu Q, Beaudoin Bertrand M, Batt DG, Li L, Pattoli MA, Skala S, Cheng L, Obermeier MT, Moore R, Yang Z, Vickery R, Elzinga PA, Discenza L, D'Arienzo C, Gillooly KM, Taylor TL, Pulicicchio C, Zhang Y, Heimrich E, McIntyre KW, Ruan Q, Westhouse RA, Catlett IM, Zheng N, Chaudhry C, Dai J, Galella MA, Tebben AJ, Pokross M, Li J, Zhao R, Smith D, Rampulla R, Allentoff A, Wallace MA, Mathur A, Salter-Cid L, Macor JE, Carter PH, Fura A, Burke JR, Tino JA.

J Med Chem. 2019 Apr 11;62(7):3228-3250. doi: 10.1021/acs.jmedchem.9b00167. Epub 2019 Mar 29.


Direct Carbon Isotope Exchange through Decarboxylative Carboxylation.

Kingston C, Wallace MA, Allentoff AJ, deGruyter JN, Chen JS, Gong SX, Bonacorsi S Jr, Baran PS.

J Am Chem Soc. 2019 Jan 16;141(2):774-779. doi: 10.1021/jacs.8b12035. Epub 2019 Jan 3.


A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study.

Yuan L, Huang C, Liu-Kreyche P, Voronin K, Fancher RM, Allentoff A, Zheng N, Iyer R, Zhu L, Pillutla R, Ji QC.

J Pharm Biomed Anal. 2019 Feb 20;165:198-206. doi: 10.1016/j.jpba.2018.12.014. Epub 2018 Dec 10.


Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors.

Lipovšek D, Carvajal I, Allentoff AJ, Barros A Jr, Brailsford J, Cong Q, Cotter P, Gangwar S, Hollander C, Lafont V, Lau WL, Li W, Moreta M, O'Neil S, Pinckney J, Smith MJ, Su J, Terragni C, Wallace MA, Wang L, Wright M, Marsh HN, Bryson JW.

Protein Eng Des Sel. 2018 May 1;31(5):159-171. doi: 10.1093/protein/gzy013.


Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.

Nelp MT, Kates PA, Hunt JT, Newitt JA, Balog A, Maley D, Zhu X, Abell L, Allentoff A, Borzilleri R, Lewis HA, Lin Z, Seitz SP, Yan C, Groves JT.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3249-3254. doi: 10.1073/pnas.1719190115. Epub 2018 Mar 12.


Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics.

Zheng N, Zeng J, Manney A, Williams L, Aubry AF, Voronin K, Buzescu A, Zhang YJ, Allentoff A, Xu C, Shen H, Warner W, Arnold ME.

Anal Chim Acta. 2016 Apr 15;916:42-51. doi: 10.1016/j.aca.2016.02.017. Epub 2016 Feb 20.


Synthesis of 2-(14)C-iminothiolane and 2-(13)C,(15)N-iminothiolane (Traut's reagent).

Wallace M, Allentoff AJ, Brailsford J, Gong S, Bonacorsi S Jr, Rinaldi F.

J Labelled Comp Radiopharm. 2015 Sep-Oct;58(11-12):429-32. doi: 10.1002/jlcr.3345. Epub 2015 Sep 14.


Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples.

Fung EN, Aubry AF, Allentoff A, Ji QC.

AAPS J. 2015 Sep;17(5):1168-76. doi: 10.1208/s12248-015-9783-z. Epub 2015 May 15.


Development and validation of an LC-MS/MS assay for the quantitation of a PEGylated anti-CD28 domain antibody in human serum: overcoming interference from antidrug antibodies and soluble target.

Gong C, Zeng J, Akinsanya B, Jiang H, Mora J, Chilewski S, Gambardella J, Allentoff A, Gleason C, Aubry AF, DeSilva BS, Arnold ME.

Bioanalysis. 2014 Sep;6(18):2371-83. doi: 10.4155/bio.14.181.


Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates.

Voronin K, Allentoff AJ, Bonacorsi SJ Jr, Mapelli C, Gong SX, Lee V, Riexinger D, Sanghvi N, Jiang H, Zeng J.

J Labelled Comp Radiopharm. 2014 Jul;57(9):579-83. doi: 10.1002/jlcr.3218. Epub 2014 Aug 4.


Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

Jiang H, Xu W, Titsch CA, Furlong MT, Dodge R, Voronin K, Allentoff A, Zeng J, Aubry AF, DeSilva BS, Arnold ME.

Anal Chem. 2014 Mar 4;86(5):2673-80. doi: 10.1021/ac5001465. Epub 2014 Feb 17.


Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Jiang H, Zeng J, Titsch C, Voronin K, Akinsanya B, Luo L, Shen H, Desai DD, Allentoff A, Aubry AF, Desilva BS, Arnold ME.

Anal Chem. 2013 Oct 15;85(20):9859-67. doi: 10.1021/ac402420v. Epub 2013 Sep 26.


Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.

Zhang D, Flint O, Wang L, Gupta A, Westhouse RA, Zhao W, Raghavan N, Caceres-Cortes J, Marathe P, Shen G, Zhang Y, Allentoff A, Josephs J, Gan J, Borzilleri R, Humphreys WG.

Chem Res Toxicol. 2012 Mar 19;25(3):556-71. doi: 10.1021/tx200524d. Epub 2012 Mar 2.


Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans.

Gong J, Gan J, Caceres-Cortes J, Christopher LJ, Arora V, Masson E, Williams D, Pursley J, Allentoff A, Lago M, Tran SB, Iyer RA.

Drug Metab Dispos. 2011 May;39(5):891-903. doi: 10.1124/dmd.110.037341. Epub 2011 Feb 2.


Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans.

Christopher LJ, Hong H, Vakkalagadda BJ, Clemens PL, Su H, Roongta V, Allentoff A, Sun H, Heller K, Harbison CT, Iyer RA, Humphreys WG, Wong T, Zhang S.

Drug Metab Dispos. 2010 Nov;38(11):2049-59. doi: 10.1124/dmd.110.034850. Epub 2010 Jul 28.


Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs.

Hong H, Su H, Sun H, Allentoff A, Ekhato IV, Chando T, Caceres-Cortes J, Roongta V, Iyer RA, Humphreys WG, Christopher LJ.

Drug Metab Dispos. 2010 Jul;38(7):1189-201. doi: 10.1124/dmd.110.032755. Epub 2010 Apr 2.


Metabolism and disposition of dasatinib after oral administration to humans.

Christopher LJ, Cui D, Wu C, Luo R, Manning JA, Bonacorsi SJ, Lago M, Allentoff A, Lee FY, McCann B, Galbraith S, Reitberg DP, He K, Barros A Jr, Blackwood-Chirchir A, Humphreys WG, Iyer RA.

Drug Metab Dispos. 2008 Jul;36(7):1357-64. doi: 10.1124/dmd.107.018267. Epub 2008 Apr 17.


Understanding the cellular uptake of phosphopeptides.

Allentoff AJ, Mandiyan S, Liang H, Yuryev A, Vlattas I, Duelfer T, Sytwu II, Wennogle LP.

Cell Biochem Biophys. 1999;31(2):129-40.


Comparison of recombinant cyclooxygenase-2 to native isoforms: aspirin labeling of the active site.

Wennogle LP, Liang H, Quintavalla JC, Bowen BR, Wasvary J, Miller DB, Allentoff A, Boyer W, Kelly M, Marshall P.

FEBS Lett. 1995 Sep 11;371(3):315-20.


Interactions of peroxyquinols with cytochromes P450 2B1, 3A1, and 3A5: influence of the apoprotein on heterolytic versus homolytic O-O bond cleavage.

Correia MA, Yao K, Allentoff AJ, Wrighton SA, Thompson JA.

Arch Biochem Biophys. 1995 Mar 10;317(2):471-8.


Metabolic activation of butylated hydroxytoluene by mouse bronchiolar Clara cells.

Bolton JL, Thompson JA, Allentoff AJ, Miley FB, Malkinson AM.

Toxicol Appl Pharmacol. 1993 Nov;123(1):43-9.


Analysis of trimethylsilylperoxy derivatives of thermally labile hydroperoxides by gas chromatography-mass spectrometry.

Turnipseed SB, Allentoff AJ, Thompson JA.

Anal Biochem. 1993 Sep;213(2):218-25. Erratum in: Anal Biochem 1994 Jan;216(1):241.


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