Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 120


Natural Tolerance to Ischemia and Hypoxemia in Diving Mammals: A Review.

Allen KN, Vázquez-Medina JP.

Front Physiol. 2019 Sep 20;10:1199. doi: 10.3389/fphys.2019.01199. eCollection 2019. Review.


Muscular apoptosis but not oxidative stress increases with old age in a long-lived diver, the Weddell seal.

Allen KN, Vázquez-Medina JP, Lawler JM, Mellish JE, Horning M, Hindle AG.

J Exp Biol. 2019 Jun 25;222(Pt 12). pii: jeb200246. doi: 10.1242/jeb.200246.


A Central Region of NF-κB Essential Modulator Is Required for IKKβ-Induced Conformational Change and for Signal Propagation.

Shaffer R, DeMaria AM, Kagermazova L, Liu Y, Babaei M, Caban-Penix S, Cervantes A, Jehle S, Makowski L, Gilmore TD, Whitty A, Allen KN.

Biochemistry. 2019 Jul 2;58(26):2906-2920. doi: 10.1021/acs.biochem.8b01316. Epub 2019 Jun 18.


Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces.

Allen KN, Imperiali B.

Curr Opin Struct Biol. 2019 Apr 16;59:81-90. doi: 10.1016/ [Epub ahead of print] Review.


Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving.

Hindle AG, Allen KN, Batten AJ, Hückstädt LA, Turner-Maier J, Schulberg SA, Johnson J, Karlsson E, Lindblad-Toh K, Costa DP, Bloch DB, Zapol WM, Buys ES.

Am J Physiol Regul Integr Comp Physiol. 2019 Jun 1;316(6):R704-R715. doi: 10.1152/ajpregu.00283.2018. Epub 2019 Mar 20.


Monotopic Membrane Proteins Join the Fold.

Allen KN, Entova S, Ray LC, Imperiali B.

Trends Biochem Sci. 2019 Jan;44(1):7-20. doi: 10.1016/j.tibs.2018.09.013. Epub 2018 Oct 15. Review.


X-ray Fluorescence Nanotomography of Single Bacteria with a Sub-15 nm Beam.

Victor TW, Easthon LM, Ge M, O'Toole KH, Smith RJ, Huang X, Yan H, Allen KN, Chu YS, Miller LM.

Sci Rep. 2018 Sep 7;8(1):13415. doi: 10.1038/s41598-018-31461-y.



Allen KN.

Methods Enzymol. 2018;607:xv-xviii. doi: 10.1016/S0076-6879(18)30315-X. No abstract available.


Crystallization of Liganded Phosphatases in the HAD Superfamily.

Harvey CM, O'Toole KH, Allen KN.

Methods Enzymol. 2018;607:157-184. doi: 10.1016/bs.mie.2018.06.011. Epub 2018 Aug 9.


Mechanism of Substrate Recognition and Catalysis of the Haloalkanoic Acid Dehalogenase Family Member α-Phosphoglucomutase.

Zhang C, Allen KN, Dunaway-Mariano D.

Biochemistry. 2018 Jul 31;57(30):4504-4517. doi: 10.1021/acs.biochem.8b00396. Epub 2018 Jul 13.


Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.

Tararina MA, Xue S, Smith LC, Muellers SN, Miranda PO, Janda KD, Allen KN.

Biochemistry. 2018 Jul 3;57(26):3741-3751. doi: 10.1021/acs.biochem.8b00384. Epub 2018 Jun 13.


Membrane association of monotopic phosphoglycosyl transferase underpins function.

Ray LC, Das D, Entova S, Lukose V, Lynch AJ, Imperiali B, Allen KN.

Nat Chem Biol. 2018 Jun;14(6):538-541. doi: 10.1038/s41589-018-0054-z. Epub 2018 May 16.


Intrinsic anti-inflammatory properties in the serum of two species of deep-diving seal.

Bagchi A, Batten AJ, Levin M, Allen KN, Fitzgerald ML, Hückstädt LA, Costa DP, Buys ES, Hindle AG.

J Exp Biol. 2018 Jul 9;221(Pt 13). pii: jeb178491. doi: 10.1242/jeb.178491.


Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions.

Ji T, Zhang C, Zheng L, Dunaway-Mariano D, Allen KN.

Biochemistry. 2018 Jun 26;57(25):3480-3492. doi: 10.1021/acs.biochem.8b00223. Epub 2018 May 11.


Exploring the structural origins of cryptic sites on proteins.

Beglov D, Hall DR, Wakefield AE, Luo L, Allen KN, Kozakov D, Whitty A, Vajda S.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3416-E3425. doi: 10.1073/pnas.1711490115. Epub 2018 Mar 26.


The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase.

Muenster S, Lieb WS, Fabry G, Allen KN, Kamat SS, Guy AH, Dordea AC, Teixeira L, Tainsh RE, Yu B, Zhu W, Ashpole NE, Malhotra R, Brouckaert P, Bloch DB, Scherrer-Crosbie M, Stamer WD, Kuehn MH, Pasquale LR, Buys ES.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4826-4835. doi: 10.1167/iovs.17-22168.


Catalytic Mechanism of the Hotdog-Fold Thioesterase PA1618 Revealed by X-ray Structure Determination of a Substrate-Bound Oxygen Ester Analogue Complex.

Latham JA, Ji T, Matthews K, Mariano PS, Allen KN, Dunaway-Mariano D.

Chembiochem. 2017 Oct 5;18(19):1935-1943. doi: 10.1002/cbic.201700322. Epub 2017 Aug 30.


Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.

Jacobson AR, Adler M, Silvaggi NR, Allen KN, Smith GM, Fredenburg RA, Stein RL, Park JB, Feng X, Shoemaker CB, Deshpande SS, Goodnough MC, Malizio CJ, Johnson EA, Pellett S, Tepp WH, Tzipori S.

Toxicon. 2017 Oct;137:36-47. doi: 10.1016/j.toxicon.2017.06.016. Epub 2017 Jul 8.


Conformational dynamics and alignment properties of loop lanthanide-binding-tags (LBTs) studied in interleukin-1β.

Barthelmes D, Barthelmes K, Schnorr K, Jonker HRA, Bodmer B, Allen KN, Imperiali B, Schwalbe H.

J Biomol NMR. 2017 Jul;68(3):187-194. doi: 10.1007/s10858-017-0118-5. Epub 2017 May 22.


Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

Bremer PT, Pellett S, Carolan JP, Tepp WH, Eubanks LM, Allen KN, Johnson EA, Janda KD.

J Am Chem Soc. 2017 May 31;139(21):7264-7272. doi: 10.1021/jacs.7b01084. Epub 2017 May 19.


Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.

Koo BM, Kritikos G, Farelli JD, Todor H, Tong K, Kimsey H, Wapinski I, Galardini M, Cabal A, Peters JM, Hachmann AB, Rudner DZ, Allen KN, Typas A, Gross CA.

Cell Syst. 2017 Mar 22;4(3):291-305.e7. doi: 10.1016/j.cels.2016.12.013. Epub 2017 Feb 8.


Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.

Tararina MA, Janda KD, Allen KN.

Biochemistry. 2016 Dec 6;55(48):6595-6598. Epub 2016 Nov 18.


Catalytic scaffolds for phosphoryl group transfer.

Allen KN, Dunaway-Mariano D.

Curr Opin Struct Biol. 2016 Dec;41:172-179. doi: 10.1016/ Epub 2016 Aug 13. Review.


Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase.

Zhu W, Easthon LM, Reinhardt LA, Tu C, Cohen SE, Silverman DN, Allen KN, Richards NG.

Biochemistry. 2016 Apr 12;55(14):2163-73. doi: 10.1021/acs.biochem.6b00043. Epub 2016 Apr 4.


Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core.

Lukose V, Luo L, Kozakov D, Vajda S, Allen KN, Imperiali B.

Biochemistry. 2015 Dec 22;54(50):7326-34. doi: 10.1021/acs.biochem.5b01086. Epub 2015 Dec 4.


Enzyme Substrate Specificity Conferred by Distinct Conformational Pathways.

Rago F, Saltzberg D, Allen KN, Tolan DR.

J Am Chem Soc. 2015 Nov 4;137(43):13876-86. doi: 10.1021/jacs.5b08149. Epub 2015 Oct 21.


Encoded loop-lanthanide-binding tags for long-range distance measurements in proteins by NMR and EPR spectroscopy.

Barthelmes D, Gränz M, Barthelmes K, Allen KN, Imperiali B, Prisner T, Schwalbe H.

J Biomol NMR. 2015 Nov;63(3):275-82. doi: 10.1007/s10858-015-9984-x. Epub 2015 Sep 4.


Accounting for observed small angle X-ray scattering profile in the protein-protein docking server ClusPro.

Xia B, Mamonov A, Leysen S, Allen KN, Strelkov SV, Paschalidis ICh, Vajda S, Kozakov D.

J Comput Chem. 2015 Jul 30;36(20):1568-72. doi: 10.1002/jcc.23952. Epub 2015 Jun 10.


Ligand deconstruction: Why some fragment binding positions are conserved and others are not.

Kozakov D, Hall DR, Jehle S, Luo L, Ochiana SO, Jones EV, Pollastri M, Allen KN, Whitty A, Vajda S.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2585-94. doi: 10.1073/pnas.1501567112. Epub 2015 Apr 27. Erratum in: Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3749. Jehle, Sefan [corrected to Jehle, Stefan].


Panoramic view of a superfamily of phosphatases through substrate profiling.

Huang H, Pandya C, Liu C, Al-Obaidi NF, Wang M, Zheng L, Toews Keating S, Aono M, Love JD, Evans B, Seidel RD, Hillerich BS, Garforth SJ, Almo SC, Mariano PS, Dunaway-Mariano D, Allen KN, Farelli JD.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1974-83. doi: 10.1073/pnas.1423570112. Epub 2015 Apr 6.


Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases.

London N, Farelli JD, Brown SD, Liu C, Huang H, Korczynska M, Al-Obaidi NF, Babbitt PC, Almo SC, Allen KN, Shoichet BK.

Biochemistry. 2015 Jan 20;54(2):528-37. doi: 10.1021/bi501140k. Epub 2015 Jan 5.


Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).

Zhou L, Yeo AT, Ballarano C, Weber U, Allen KN, Gilmore TD, Whitty A.

Biochemistry. 2014 Dec 23;53(50):7929-44. doi: 10.1021/bi500920n. Epub 2014 Dec 8.


Enzyme promiscuity: engine of evolutionary innovation.

Pandya C, Farelli JD, Dunaway-Mariano D, Allen KN.

J Biol Chem. 2014 Oct 31;289(44):30229-36. doi: 10.1074/jbc.R114.572990. Epub 2014 Sep 10. Review.


Structure and catalysis in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.

Wu R, Latham JA, Chen D, Farelli J, Zhao H, Matthews K, Allen KN, Dunaway-Mariano D.

Biochemistry. 2014 Jul 29;53(29):4788-805. doi: 10.1021/bi500334v. Epub 2014 Jul 18.


Divergence of substrate specificity and function in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.

Latham JA, Chen D, Allen KN, Dunaway-Mariano D.

Biochemistry. 2014 Jul 29;53(29):4775-87. doi: 10.1021/bi500333m. Epub 2014 Jul 18.


Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.

Farelli JD, Galvin BD, Li Z, Liu C, Aono M, Garland M, Hallett OE, Causey TB, Ali-Reynolds A, Saltzberg DJ, Carlow CK, Dunaway-Mariano D, Allen KN.

PLoS Pathog. 2014 Jul 3;10(7):e1004245. doi: 10.1371/journal.ppat.1004245. eCollection 2014 Jul.


Substrate deconstruction and the nonadditivity of enzyme recognition.

Barelier S, Cummings JA, Rauwerdink AM, Hitchcock DS, Farelli JD, Almo SC, Raushel FM, Allen KN, Shoichet BK.

J Am Chem Soc. 2014 May 21;136(20):7374-82. doi: 10.1021/ja501354q. Epub 2014 May 12.


Structure-guided approach for detecting large domain inserts in protein sequences as illustrated using the haloacid dehalogenase superfamily.

Pandya C, Dunaway-Mariano D, Xia Y, Allen KN.

Proteins. 2014 Sep;82(9):1896-906. doi: 10.1002/prot.24543. Epub 2014 May 2.


Assigning the EPR fine structure parameters of the Mn(II) centers in Bacillus subtilis oxalate decarboxylase by site-directed mutagenesis and DFT/MM calculations.

Campomanes P, Kellett WF, Easthon LM, Ozarowski A, Allen KN, Angerhofer A, Rothlisberger U, Richards NG.

J Am Chem Soc. 2014 Feb 12;136(6):2313-23. doi: 10.1021/ja408138f. Epub 2014 Jan 28.


Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

Cote SM, Gilmore TD, Shaffer R, Weber U, Bollam R, Golden MS, Glover K, Herscovitch M, Ennis T, Allen KN, Whitty A.

Biochemistry. 2013 Dec 23;52(51):9141-54. doi: 10.1021/bi401368r. Epub 2013 Dec 10.


Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase.

Bryan T, González JM, Bacik JP, DeNunzio NJ, Unkefer CJ, Schrader TE, Ostermann A, Dunaway-Mariano D, Allen KN, Fisher SZ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):1015-9. doi: 10.1107/S1744309113021386. Epub 2013 Aug 19.


Consequences of domain insertion on sequence-structure divergence in a superfold.

Pandya C, Brown S, Pieper U, Sali A, Dunaway-Mariano D, Babbitt PC, Xia Y, Allen KN.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3381-7. doi: 10.1073/pnas.1305519110. Epub 2013 Aug 19.


Co-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.

Wang M, Song F, Wu R, Allen KN, Mariano PS, Dunaway-Mariano D.

FEBS Lett. 2013 Sep 2;587(17):2851-9. doi: 10.1016/j.febslet.2013.07.009. Epub 2013 Jul 10.


Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis.

Daughtry KD, Huang H, Malashkevich V, Patskovsky Y, Liu W, Ramagopal U, Sauder JM, Burley SK, Almo SC, Dunaway-Mariano D, Allen KN.

Biochemistry. 2013 Aug 13;52(32):5372-86. doi: 10.1021/bi400659k. Epub 2013 Jul 29.


Reflections: neurology and the humanities. Quoth the doctors.

Allen KN.

Neurology. 2013 Feb 12;80(7):687. No abstract available.


Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.

Šilhár P, Silvaggi NR, Pellett S, Čapková K, Johnson EA, Allen KN, Janda KD.

Bioorg Med Chem. 2013 Mar 1;21(5):1344-8. doi: 10.1016/j.bmc.2012.12.001. Epub 2012 Dec 20.


Tailoring encodable lanthanide-binding tags as MRI contrast agents.

Daughtry KD, Martin LJ, Sarraju A, Imperiali B, Allen KN.

Chembiochem. 2012 Nov 26;13(17):2567-74. doi: 10.1002/cbic.201200448. Epub 2012 Nov 13.


A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase.

Saylor BT, Reinhardt LA, Lu Z, Shukla MS, Nguyen L, Cleland WW, Angerhofer A, Allen KN, Richards NG.

Biochemistry. 2012 Apr 3;51(13):2911-20. doi: 10.1021/bi300001q. Epub 2012 Mar 19.


Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase.

Daughtry KD, Xiao Y, Stoner-Ma D, Cho E, Orville AM, Liu P, Allen KN.

J Am Chem Soc. 2012 Feb 8;134(5):2823-34. doi: 10.1021/ja2111898. Epub 2012 Jan 26.


Ritual and performance in domestic violence healing: from survivor to thriver through rites of passage.

Wozniak DF, Allen KN.

Cult Med Psychiatry. 2012 Mar;36(1):80-101. doi: 10.1007/s11013-011-9236-9.


Supplemental Content

Loading ...
Support Center