Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 490


Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.

Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, Chen JJ, Chen N, Frohn MJ, Goodman G, Kopecky DJ, Liu L, Lopez P, Low JD, Ma V, Minatti AE, Nguyen TT, Nishimura N, Pickrell AJ, Reed AB, Shin Y, Siegmund AC, Tamayo NA, Tegley CM, Walton MC, Wang HL, Wurz RP, Xue M, Yang KC, Achanta P, Bartberger MD, Canon J, Hollis LS, McCarter JD, Mohr C, Rex K, Saiki AY, San Miguel T, Volak LP, Wang KH, Whittington DA, Zech SG, Lipford JR, Cee VJ.

J Med Chem. 2020 Jan 9;63(1):52-65. doi: 10.1021/acs.jmedchem.9b01180. Epub 2019 Dec 24.


GABA-A receptor and mitochondrial TSPO signaling act in parallel to regulate melanocyte stem cell quiescence in larval zebrafish.

Allen JR, Skeath JB, Johnson SL.

Pigment Cell Melanoma Res. 2019 Oct 23. doi: 10.1111/pcmr.12836. [Epub ahead of print]


Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.

Pettus LH, Bourbeau MP, Bradley J, Bartberger MD, Chen K, Hickman D, Johnson M, Liu Q, Manning JR, Nanez A, Siegmund AC, Wen PH, Whittington DA, Allen JR, Wood S.

J Med Chem. 2019 Oct 18. doi: 10.1021/acs.jmedchem.9b01034. [Epub ahead of print]


Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish.

Allen JR, Skeath JB, Johnson SL.

Genetics. 2019 Oct;213(2):555-566. doi: 10.1534/genetics.119.302416. Epub 2019 Aug 23.


Correction to "Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction".

Allen JR, Bahamonde A, Furukawa Y, Sigman MS.

J Am Chem Soc. 2019 Aug 7;141(31):12420. doi: 10.1021/jacs.9b07380. Epub 2019 Jul 26. No abstract available.


To Harness the Power of Cultural Support, We Must Differentiate Between the Culture of Health Concept and Traditional Wellness Programming.

Safeer RS, Allen JR.

J Occup Environ Med. 2019 May;61(5):e232-e233. doi: 10.1097/JOM.0000000000001576. No abstract available.


Enantioselective Markovnikov Addition of Carbamates to Allylic Alcohols for the Construction of α-Secondary and α-Tertiary Amines.

Bahamonde A, Al Rifaie B, Martín-Heras V, Allen JR, Sigman MS.

J Am Chem Soc. 2019 Jun 5;141(22):8708-8711. doi: 10.1021/jacs.9b03438. Epub 2019 May 24.


Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction.

Allen JR, Bahamonde A, Furukawa Y, Sigman MS.

J Am Chem Soc. 2019 Jun 5;141(22):8670-8674. doi: 10.1021/jacs.9b01476. Epub 2019 May 24. Erratum in: J Am Chem Soc. 2019 Aug 7;141(31):12420.


Low Stroke Volume during Exercise with Hot Skin Is Due to Elevated Heart Rate.

Chou TH, Akins JD, Crawford CK, Allen JR, Coyle EF.

Med Sci Sports Exerc. 2019 Oct;51(10):2025-2032. doi: 10.1249/MSS.0000000000002029.


Daily Heart Rate Variability before and after Concussion in an American College Football Player.

Flatt AA, Wilkerson GB, Allen JR, Keith CM, Esco MR.

Sports (Basel). 2019 Apr 27;7(5). pii: E97. doi: 10.3390/sports7050097.


Recurrent Depression and Borderline Personality Disorder in a Patient with Ehlers-Danlos Syndrome.

Espiridion ED, Daniel A, Van Allen JR.

Cureus. 2018 Dec 21;10(12):e3760. doi: 10.7759/cureus.3760.


TIMP-1 Promotes the Immune Response in Influenza-Induced Acute Lung Injury.

Allen JR, Ge L, Huang Y, Brauer R, Parimon T, Cassel SL, Sutterwala FS, Chen P.

Lung. 2018 Dec;196(6):737-743. doi: 10.1007/s00408-018-0154-2. Epub 2018 Aug 30.


Past and future global transformation of terrestrial ecosystems under climate change.

Nolan C, Overpeck JT, Allen JRM, Anderson PM, Betancourt JL, Binney HA, Brewer S, Bush MB, Chase BM, Cheddadi R, Djamali M, Dodson J, Edwards ME, Gosling WD, Haberle S, Hotchkiss SC, Huntley B, Ivory SJ, Kershaw AP, Kim SH, Latorre C, Leydet M, Lézine AM, Liu KB, Liu Y, Lozhkin AV, McGlone MS, Marchant RA, Momohara A, Moreno PI, Müller S, Otto-Bliesner BL, Shen C, Stevenson J, Takahara H, Tarasov PE, Tipton J, Vincens A, Weng C, Xu Q, Zheng Z, Jackson ST.

Science. 2018 Aug 31;361(6405):920-923. doi: 10.1126/science.aan5360.


Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.

Horne DB, Biswas K, Brown J, Bartberger MD, Clarine J, Davis CD, Gore VK, Harried S, Horner M, Kaller MR, Lehto SG, Liu Q, Ma VV, Monenschein H, Nguyen TT, Yuan CC, Youngblood BD, Zhang M, Zhong W, Allen JR, Chen JJ, Gavva NR.

J Med Chem. 2018 Sep 27;61(18):8186-8201. doi: 10.1021/acs.jmedchem.8b00518. Epub 2018 Sep 10.


Cardiovascular responses to exercise when increasing skin temperature with narrowing of the core-to-skin temperature gradient.

Chou TH, Allen JR, Hahn D, Leary BK, Coyle EF.

J Appl Physiol (1985). 2018 Sep 1;125(3):697-705. doi: 10.1152/japplphysiol.00965.2017. Epub 2018 May 10.


Cardiac-Autonomic Responses to In-Season Training Among Division-1 College Football Players.

Flatt AA, Esco MR, Allen JR, Robinson JB, Bragg A, Keith CM, Fedewa MV, Earley RL.

J Strength Cond Res. 2018 Feb 14. doi: 10.1519/JSC.0000000000002475. [Epub ahead of print]


Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation.

Low JD, Bartberger MD, Cheng Y, Whittington D, Xue Q, Wood S, Allen JR, Minatti AE.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):1111-1115. doi: 10.1016/j.bmcl.2018.01.056. Epub 2018 Feb 1.


Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction.

Ross SL, Biswas K, Rottman J, Allen JR, Long J, Miranda LP, Winters A, Arvedson TL.

Front Pharmacol. 2017 Nov 21;8:838. doi: 10.3389/fphar.2017.00838. eCollection 2017.


Progressive structural modification to a zinc-actuated photoinduced electron transfer (PeT) switch in the context of intracellular zinc imaging.

Macias-Contreras M, Daykin KL, Simmons JT, Allen JR, Hooper ZS, Davidson MW, Zhu L.

Org Biomol Chem. 2017 Nov 7;15(43):9139-9148. doi: 10.1039/c7ob02235b.


Heart Rate Variability and Training Load Among National Collegiate Athletic Association Division 1 College Football Players Throughout Spring Camp.

Flatt AA, Esco MR, Allen JR, Robinson JB, Earley RL, Fedewa MV, Bragg A, Keith CM, Wingo JE.

J Strength Cond Res. 2018 Nov;32(11):3127-3134. doi: 10.1519/JSC.0000000000002241.


Role of branchiomotor neurons in controlling food intake of zebrafish larvae.

Allen JR, Bhattacharyya KD, Asante E, Almadi B, Schafer K, Davis J, Cox J, Voigt M, Viator JA, Chandrasekhar A.

J Neurogenet. 2017 Sep;31(3):128-137. doi: 10.1080/01677063.2017.1358270. Epub 2017 Aug 16.


Ovarian hormones, age and pubertal development and their association with days of headache onset in girls with migraine: An observational cohort study.

Martin VT, Allen JR, Houle TT, Powers SW, Kabbouche MA, O'Brien HL, Kacperski J, LeCates SL, White S, Vaughan P, Mandell K, Hershey AD.

Cephalalgia. 2018 Apr;38(4):707-717. doi: 10.1177/0333102417706980. Epub 2017 May 5.


Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial.

Kroon Van Diest AM, Ramsey RR, Kashikar-Zuck S, Slater S, Hommel K, Kroner JW, LeCates S, Kabbouche MA, O'Brien HL, Kacperski J, Allen JR, Peugh J, Hershey AD, Powers SW.

Clin J Pain. 2017 Oct;33(10):892-898. doi: 10.1097/AJP.0000000000000481.


Trajectory of Improvement in Children and Adolescents With Chronic Migraine: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial.

Kroner JW, Peugh J, Kashikar-Zuck SM, LeCates SL, Allen JR, Slater SK, Zafar M, Kabbouche MA, O'Brien HL, Shenk CE, Kroon Van Diest AM, Hershey AD, Powers SW.

J Pain. 2017 Jun;18(6):637-644. doi: 10.1016/j.jpain.2017.01.002. Epub 2017 Jan 18.


Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies.

Hu E, Chen N, Kunz RK, Hwang DR, Michelsen K, Davis C, Ma J, Shi J, Lester-Zeiner D, Hungate R, Treanor J, Chen H, Allen JR.

ACS Med Chem Lett. 2016 May 19;7(7):719-23. doi: 10.1021/acsmedchemlett.6b00185. eCollection 2016 Jul 14.


Quantitative assessment of fluorescent proteins.

Cranfill PJ, Sell BR, Baird MA, Allen JR, Lavagnino Z, de Gruiter HM, Kremers GJ, Davidson MW, Ustione A, Piston DW.

Nat Methods. 2016 Jul;13(7):557-62. doi: 10.1038/nmeth.3891. Epub 2016 May 30.


Adherence to Biobehavioral Recommendations in Pediatric Migraine as Measured by Electronic Monitoring: The Adherence in Migraine (AIM) Study.

Kroon Van Diest AM, Ramsey R, Aylward B, Kroner JW, Sullivan SM, Nause K, Allen JR, Chamberlin LA, Slater S, Hommel K, LeCates SL, Kabbouche MA, O'Brien HL, Kacperski J, Hershey AD, Powers SW.

Headache. 2016 Jul;56(7):1137-46. doi: 10.1111/head.12836. Epub 2016 May 11.


Quantitative neuromagnetic signatures of aberrant cortical excitability in pediatric chronic migraine.

Leiken KA, Xiang J, Curry E, Fujiwara H, Rose DF, Allen JR, Kacperski JE, O'Brien HL, Kabbouche MA, Powers SW, Hershey AD.

J Headache Pain. 2016;17:46. doi: 10.1186/s10194-016-0641-x. Epub 2016 Apr 26.


Cognitive Behavioral Therapy plus Amitriptyline for Children and Adolescents with Chronic Migraine Reduces Headache Days to ≤4 Per Month.

Kroner JW, Hershey AD, Kashikar-Zuck SM, LeCates SL, Allen JR, Slater SK, Zafar M, Kabbouche MA, O'Brien HL, Shenk CE, Rausch JR, Kroon Van Diest AM, Powers SW.

Headache. 2016 Apr;56(4):711-6. doi: 10.1111/head.12795. Epub 2016 Mar 18.


Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals.

Xiang J, Leiken K, Degrauw X, Kay B, Fujiwara H, Rose DF, Allen JR, Kacperski JE, O'Brien HL, Kabbouche MA, Powers SW, Hershey AD.

J Pain. 2016 Jun;17(6):694-706. doi: 10.1016/j.jpain.2016.02.009. Epub 2016 Mar 10.


Utilization of Practice Session Average Inertial Load to Quantify College Football Injury Risk.

Wilkerson GB, Gupta A, Allen JR, Keith CM, Colston MA.

J Strength Cond Res. 2016 Sep;30(9):2369-74. doi: 10.1519/JSC.0000000000001370.


Health promotion contrarians: Luther Terry, Halbert L. Dunn, Robert F. Allen, and Edward M. Kennedy.

Manley M, Ardell DB, Allen JR, Heinen L.

Am J Health Promot. 2015 Nov-Dec;30(2):TAHP8-9. No abstract available.


Communication: Fragment-based Hamiltonian model of electronic charge-excitation gaps and gap closure.

Valone SM, Pilania G, Liu XY, Allen JR, Wu TC, Atlas SR, Dunlap DH.

J Chem Phys. 2015 Nov 14;143(18):181104. doi: 10.1063/1.4935931.


Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.

Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC.

Curr Biol. 2015 Dec 7;25(23):3048-57. doi: 10.1016/j.cub.2015.10.018. Epub 2015 Nov 5.


Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists.

Liu B, Croy CH, Hitchcock SA, Allen JR, Rao Z, Evans D, Bures MG, McKinzie DL, Watt ML, Stuart Gregory G, Hansen MM, Hoogestraat PJ, Jamison JA, Okha-Mokube FM, Stratford RE, Turner W, Bymaster F, Felder CC.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4158-63. doi: 10.1016/j.bmcl.2015.08.011. Epub 2015 Aug 8.


A naturally monomeric infrared fluorescent protein for protein labeling in vivo.

Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X.

Nat Methods. 2015 Aug;12(8):763-5. doi: 10.1038/nmeth.3447. Epub 2015 Jun 22.


Enhancing the Photostability of Arylvinylenebipyridyl Compounds as Fluorescent Indicators for Intracellular Zinc(II) Ions.

Yuan Z, Younes AH, Allen JR, Davidson MW, Zhu L.

J Org Chem. 2015 Jun 5;80(11):5600-10. doi: 10.1021/acs.joc.5b00503. Epub 2015 May 20.


Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18F]AMG 580 in non-human primates.

Hwang DR, Hu E, Allen JR, Davis C, Treanor J, Miller S, Chen H, Shi B, Narayanan TK, Barret O, Alagille D, Yu Z, Slifstein M.

Nucl Med Biol. 2015 Aug;42(8):654-63. doi: 10.1016/j.nucmedbio.2015.04.004. Epub 2015 Apr 16.


The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.

Willet AH, McDonald NA, Bohnert KA, Baird MA, Allen JR, Davidson MW, Gould KL.

J Cell Biol. 2015 Feb 16;208(4):391-9. doi: 10.1083/jcb.201411097.


To suppress, or not to suppress? That is repression: controlling intrusive thoughts in addictive behaviour.

Moss AC, Erskine JA, Albery IP, Allen JR, Georgiou GJ.

Addict Behav. 2015 May;44:65-70. doi: 10.1016/j.addbeh.2015.01.029. Epub 2015 Jan 22. Review.


N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells.

Badisa RB, Kumar SS, Mazzio E, Haughbrook RD, Allen JR, Davidson MW, Fitch-Pye CA, Goodman CB.

PLoS One. 2015 Jan 24;10(1):e0114285. doi: 10.1371/journal.pone.0114285. eCollection 2015.


Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.

Harrington PE, Biswas K, Malwitz D, Tasker AS, Mohr C, Andrews KL, Dellamaggiore K, Kendall R, Beckmann H, Jaeckel P, Materna-Reichelt S, Allen JR, Lipford JR.

ACS Med Chem Lett. 2014 Sep 24;6(1):68-72. doi: 10.1021/ml500315b. eCollection 2015 Jan 8.


Fixation-resistant photoactivatable fluorescent proteins for CLEM.

Paez-Segala MG, Sun MG, Shtengel G, Viswanathan S, Baird MA, Macklin JJ, Patel R, Allen JR, Howe ES, Piszczek G, Hess HF, Davidson MW, Wang Y, Looger LL.

Nat Methods. 2015 Mar;12(3):215-8, 4 p following 218. doi: 10.1038/nmeth.3225. Epub 2015 Jan 12. Erratum in: Nat Methods. 2015 Jul;12(7):692.


Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS.

Taylor-Harding B, Aspuria PJ, Agadjanian H, Cheon DJ, Mizuno T, Greenberg D, Allen JR, Spurka L, Funari V, Spiteri E, Wang Q, Orsulic S, Walsh C, Karlan BY, Wiedemeyer WR.

Oncotarget. 2015 Jan 20;6(2):696-714.


AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.

Chen H, Lester-Zeiner D, Shi J, Miller S, Glaus C, Hu E, Chen N, Able J, Biorn C, Wong J, Ma J, Michelsen K, Hill Della Puppa G, Kazules T, Dou HH, Talreja S, Zhao X, Chen A, Rumfelt S, Kunz RK, Ye H, Thiel OR, Williamson T, Davis C, Porter A, Immke D, Allen JR, Treanor J.

J Pharmacol Exp Ther. 2015 Feb;352(2):327-37. doi: 10.1124/jpet.114.220517. Epub 2014 Dec 11.


Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.

Rzasa RM, Frohn MJ, Andrews KL, Chmait S, Chen N, Clarine JG, Davis C, Eastwood HA, Horne DB, Hu E, Jones AD, Kaller MR, Kunz RK, Miller S, Monenschein H, Nguyen T, Pickrell AJ, Porter A, Reichelt A, Zhao X, Treanor JJS, Allen JR.

Bioorg Med Chem. 2014 Dec 1;22(23):6570-6585. doi: 10.1016/j.bmc.2014.10.013.


Effects of sex and gender on adaptation to space: neurosensory systems.

Reschke MF, Cohen HS, Cerisano JM, Clayton JA, Cromwell R, Danielson RW, Hwang EY, Tingen C, Allen JR, Tomko DL.

J Womens Health (Larchmt). 2014 Nov;23(11):959-62. doi: 10.1089/jwh.2014.4908. Review.


A fluorescent indicator for imaging lysosomal zinc(II) with Förster resonance energy transfer (FRET)-enhanced photostability and a narrow band of emission.

Sreenath K, Yuan Z, Allen JR, Davidson MW, Zhu L.

Chemistry. 2015 Jan 7;21(2):867-74. doi: 10.1002/chem.201403479. Epub 2014 Nov 7.


A Fluorescent Indicator for Imaging Lysosomal Zinc(II) with Förster Resonance Energy Transfer (FRET)-Enhanced Photostability and a Narrow Band of Emission.

Sreenath K, Yuan Z, Allen JR, Davidson MW, Zhu L.

Chemistry. 2014 Nov 6. doi: 10.1002/chem.403479. [Epub ahead of print]


A full-length Plasmodium falciparum recombinant circumsporozoite protein expressed by Pseudomonas fluorescens platform as a malaria vaccine candidate.

Noe AR, Espinosa D, Li X, Coelho-Dos-Reis JG, Funakoshi R, Giardina S, Jin H, Retallack DM, Haverstock R, Allen JR, Vedvick TS, Fox CB, Reed SG, Ayala R, Roberts B, Winram SB, Sacci J, Tsuji M, Zavala F, Gutierrez GM.

PLoS One. 2014 Sep 23;9(9):e107764. doi: 10.1371/journal.pone.0107764. eCollection 2014.

Supplemental Content

Loading ...
Support Center