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Biological activity of weekly ONC201 in adult recurrent glioblastoma patients.

Arrillaga-Romany I, Odia Y, Prabhu VV, Tarapore RS, Merdinger K, Stogniew M, Oster W, Allen JE, Mehta M, Batchelor TT, Wen PY.

Neuro Oncol. 2019 Nov 8. pii: noz164. doi: 10.1093/neuonc/noz164. [Epub ahead of print]


Editorial: Going with the flow.

Allen JE.

Curr Opin Otolaryngol Head Neck Surg. 2019 Dec;27(6):431-432. doi: 10.1097/MOO.0000000000000592. No abstract available.


Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung.

Chenery AL, Alhallaf R, Agha Z, Ajendra J, Parkinson JE, Cooper MM, Chan BHK, Eichenberger RM, Dent LA, Robertson AAB, Kupz A, Brough D, Loukas A, Sutherland TE, Allen JE, Giacomin PR.

J Immunol. 2019 Nov 15;203(10):2724-2734. doi: 10.4049/jimmunol.1900640. Epub 2019 Oct 4.


Particles from the Echinococcus granulosus laminated layer inhibit CD40 upregulation in dendritic cells by interfering with Akt activation.

Pittini Á, Martínez-Acosta YE, Casaravilla C, Seoane PI, Rückerl D, Quijano C, Allen JE, Díaz A.

Infect Immun. 2019 Sep 30. pii: IAI.00641-19. doi: 10.1128/IAI.00641-19. [Epub ahead of print]


Safety of in-office laryngology procedures.

Marinone Lares SG, Allen JE.

Curr Opin Otolaryngol Head Neck Surg. 2019 Dec;27(6):433-438. doi: 10.1097/MOO.0000000000000585.


Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.

Attardo GM, Abd-Alla AMM, Acosta-Serrano A, Allen JE, Bateta R, Benoit JB, Bourtzis K, Caers J, Caljon G, Christensen MB, Farrow DW, Friedrich M, Hua-Van A, Jennings EC, Larkin DM, Lawson D, Lehane MJ, Lenis VP, Lowy-Gallego E, Macharia RW, Malacrida AR, Marco HG, Masiga D, Maslen GL, Matetovici I, Meisel RP, Meki I, Michalkova V, Miller WJ, Minx P, Mireji PO, Ometto L, Parker AG, Rio R, Rose C, Rosendale AJ, Rota-Stabelli O, Savini G, Schoofs L, Scolari F, Swain MT, Takáč P, Tomlinson C, Tsiamis G, Van Den Abbeele J, Vigneron A, Wang J, Warren WC, Waterhouse RM, Weirauch MT, Weiss BL, Wilson RK, Zhao X, Aksoy S.

Genome Biol. 2019 Sep 2;20(1):187. doi: 10.1186/s13059-019-1768-2.


Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201.

Chi AS, Tarapore RS, Hall MD, Shonka N, Gardner S, Umemura Y, Sumrall A, Khatib Z, Mueller S, Kline C, Zaky W, Khatua S, Weathers SP, Odia Y, Niazi TN, Daghistani D, Cherrick I, Korones D, Karajannis MA, Kong XT, Minturn J, Waanders A, Arillaga-Romany I, Batchelor T, Wen PY, Merdinger K, Schalop L, Stogniew M, Allen JE, Oster W, Mehta MP.

J Neurooncol. 2019 Oct;145(1):97-105. doi: 10.1007/s11060-019-03271-3. Epub 2019 Aug 27.


Considerations for chest clearance and cough augmentation in severe bulbar dysfunction: a case study.

Allen JE, O'Leary EL.

Can J Respir Ther. 2018 Fall;54(3):66-70. doi: 10.29390/cjrt-2018-014. Epub 2018 Nov 1.


Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.

Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Nishida Y, Kojima K, Garnett MJ, McDermott U, Benes CH, Charter N, Deacon S, Elemento O, Allen JE, Oster W, Stogniew M, Ishizawa J, Andreeff M.

Leukemia. 2019 May 24. doi: 10.1038/s41375-019-0491-z. [Epub ahead of print]


Crystal-clear treatment for allergic disease.

Allen JE, Sutherland TE.

Science. 2019 May 24;364(6442):738-739. doi: 10.1126/science.aax6175. No abstract available.


Enhanced monocyte recruitment and delayed alternative macrophage polarization accompanies impaired repair following myocardial infarction in C57BL/6 compared to BALB/c mice.

Toor IS, Rückerl D, Mair I, Thomson A, Rossi AG, Newby DE, Allen JE, Gray GA.

Clin Exp Immunol. 2019 Oct;198(1):83-93. doi: 10.1111/cei.13330. Epub 2019 Jun 17.


Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration.

Stein MN, Malhotra J, Tarapore RS, Malhotra U, Silk AW, Chan N, Rodriguez L, Aisner J, Aiken RD, Mayer T, Haffty BG, Newman JH, Aspromonte SM, Bommareddy PK, Estupinian R, Chesson CB, Sadimin ET, Li S, Medina DJ, Saunders T, Frankel M, Kareddula A, Damare S, Wesolowsky E, Gabel C, El-Deiry WS, Prabhu VV, Allen JE, Stogniew M, Oster W, Bertino JR, Libutti SK, Mehnert JM, Zloza A.

J Immunother Cancer. 2019 May 22;7(1):136. doi: 10.1186/s40425-019-0599-8.


Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Lemarchand E, Barrington J, Chenery A, Haley M, Coutts G, Allen JE, Allan SM, Brough D.

Stroke. 2019 May;50(5):1232-1239. doi: 10.1161/STROKEAHA.118.023620.


First clinical experience with DRD2/3 antagonist ONC201 in H3 K27M-mutant pediatric diffuse intrinsic pontine glioma: a case report.

Hall MD, Odia Y, Allen JE, Tarapore R, Khatib Z, Niazi TN, Daghistani D, Schalop L, Chi AS, Oster W, Mehta MP.

J Neurosurg Pediatr. 2019 Apr 5:1-7. doi: 10.3171/2019.2.PEDS18480. [Epub ahead of print]


Depressive Symptoms and Care Demands Among Primary Caregivers of Young Children with Evidence of Congenital Zika Virus Infection in Brazil.

Kotzky K, Allen JE, Robinson LR, Satterfield-Nash A, Bertolli J, Smith C, Ornelas Pereira I, Faria E Silva Santelli AC, Peacock G.

J Dev Behav Pediatr. 2019 Jun;40(5):344-353. doi: 10.1097/DBP.0000000000000666.


A novel variant of torque teno virus 7 identified in patients with Kawasaki disease.

Thissen JB, Isshiki M, Jaing C, Nagao Y, Lebron Aldea D, Allen JE, Izui M, Slezak TR, Ishida T, Sano T.

PLoS One. 2018 Dec 28;13(12):e0209683. doi: 10.1371/journal.pone.0209683. eCollection 2018.


Predicting tumor cell line response to drug pairs with deep learning.

Xia F, Shukla M, Brettin T, Garcia-Cardona C, Cohn J, Allen JE, Maslov S, Holbeck SL, Doroshow JH, Evrard YA, Stahlberg EA, Stevens RL.

BMC Bioinformatics. 2018 Dec 21;19(Suppl 18):486. doi: 10.1186/s12859-018-2509-3.


Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.

Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE.

Clin Cancer Res. 2019 Apr 1;25(7):2305-2313. doi: 10.1158/1078-0432.CCR-18-2572. Epub 2018 Dec 17.


Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.

Sutherland TE, Rückerl D, Logan N, Duncan S, Wynn TA, Allen JE.

PLoS Pathog. 2018 Nov 30;14(11):e1007423. doi: 10.1371/journal.ppat.1007423. eCollection 2018 Nov.


Current approaches to instrumental assessment of swallowing in children.

Dharmarathna I, Miles A, Allen JE.

Curr Opin Otolaryngol Head Neck Surg. 2018 Dec;26(6):349-355. doi: 10.1097/MOO.0000000000000492. Review.


The long and winding road.

Allen JE.

Curr Opin Otolaryngol Head Neck Surg. 2018 Dec;26(6):347-348. doi: 10.1097/MOO.0000000000000500. No abstract available.


IgG4-related disease in the head and neck.

Johnston J, Allen JE.

Curr Opin Otolaryngol Head Neck Surg. 2018 Dec;26(6):403-408. doi: 10.1097/MOO.0000000000000487. Review.


Swallowing function in advanced age.

Jardine M, Miles A, Allen JE.

Curr Opin Otolaryngol Head Neck Surg. 2018 Dec;26(6):367-374. doi: 10.1097/MOO.0000000000000485. Review.


Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.

Ishida CT, Zhang Y, Bianchetti E, Shu C, Nguyen TTT, Kleiner G, Sanchez-Quintero MJ, Quinzii CM, Westhoff MA, Karpel-Massler G, Prabhu VV, Allen JE, Siegelin MD.

Clin Cancer Res. 2018 Nov 1;24(21):5392-5406. doi: 10.1158/1078-0432.CCR-18-1040. Epub 2018 Jul 23.


Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression.

Shaw TN, Houston SA, Wemyss K, Bridgeman HM, Barbera TA, Zangerle-Murray T, Strangward P, Ridley AJL, Wang P, Tamoutounour S, Allen JE, Konkel JE, Grainger JR.

J Exp Med. 2018 Jun 4;215(6):1507-1518. doi: 10.1084/jem.20180019. Epub 2018 May 22.


Improving quality of care in patients with Barrett's esophagus by measuring and improving neoplasia detection rates.

Sharma P, Allen JE, Gorrepati VS, Gupta N.

Gastrointest Endosc. 2018 May;87(5):1195-1197. doi: 10.1016/j.gie.2018.01.033. No abstract available.


Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.

Turner JD, Pionnier N, Furlong-Silva J, Sjoberg H, Cross S, Halliday A, Guimaraes AF, Cook DAN, Steven A, Van Rooijen N, Allen JE, Jenkins SJ, Taylor MJ.

PLoS Pathog. 2018 Mar 16;14(3):e1006949. doi: 10.1371/journal.ppat.1006949. eCollection 2018 Mar.


Management of Barrett's esophagus with low-grade dysplasia.

Harrison M, Allen JE, Gorrepati VS, López-Jamar JME, Sharma P.

Dis Esophagus. 2018 Apr 1;31(4). doi: 10.1093/dote/doy004. Review.


The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.

Czimmerer Z, Daniel B, Horvath A, Rückerl D, Nagy G, Kiss M, Peloquin M, Budai MM, Cuaranta-Monroy I, Simandi Z, Steiner L, Nagy B Jr, Poliska S, Banko C, Bacso Z, Schulman IG, Sauer S, Deleuze JF, Allen JE, Benko S, Nagy L.

Immunity. 2018 Jan 16;48(1):75-90.e6. doi: 10.1016/j.immuni.2017.12.010.


Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces.

Urbaniak C, Sielaff AC, Frey KG, Allen JE, Singh N, Jaing C, Wheeler K, Venkateswaran K.

Sci Rep. 2018 Jan 16;8(1):814. doi: 10.1038/s41598-017-18506-4.


Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection.

Campbell SM, Knipper JA, Ruckerl D, Finlay CM, Logan N, Minutti CM, Mack M, Jenkins SJ, Taylor MD, Allen JE.

Elife. 2018 Jan 4;7. pii: e30947. doi: 10.7554/eLife.30947.


Role of Dopamine Receptors in the Anticancer Activity of ONC201.

Kline CLB, Ralff MD, Lulla AR, Wagner JM, Abbosh PH, Dicker DT, Allen JE, El-Deiry WS.

Neoplasia. 2018 Jan;20(1):80-91. doi: 10.1016/j.neo.2017.10.002. Epub 2017 Dec 5.


The Silent Undertakers: Macrophages Programmed for Efferocytosis.

Allen JE, Rückerl D.

Immunity. 2017 Nov 21;47(5):810-812. doi: 10.1016/j.immuni.2017.10.010.


Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies.

Prabhu VV, Talekar MK, Lulla AR, Kline CLB, Zhou L, Hall J, Van den Heuvel APJ, Dicker DT, Babar J, Grupp SA, Garnett MJ, McDermott U, Benes CH, Pu JJ, Claxton DF, Khan N, Oster W, Allen JE, El-Deiry WS.

Cell Cycle. 2018;17(4):468-478. doi: 10.1080/15384101.2017.1403689. Epub 2018 Feb 19.


A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma.

Arrillaga-Romany I, Chi AS, Allen JE, Oster W, Wen PY, Batchelor TT.

Oncotarget. 2017 May 12;8(45):79298-79304. doi: 10.18632/oncotarget.17837. eCollection 2017 Oct 3.


Ensembl Genomes 2018: an integrated omics infrastructure for non-vertebrate species.

Kersey PJ, Allen JE, Allot A, Barba M, Boddu S, Bolt BJ, Carvalho-Silva D, Christensen M, Davis P, Grabmueller C, Kumar N, Liu Z, Maurel T, Moore B, McDowall MD, Maheswari U, Naamati G, Newman V, Ong CK, Paulini M, Pedro H, Perry E, Russell M, Sparrow H, Tapanari E, Taylor K, Vullo A, Williams G, Zadissia A, Olson A, Stein J, Wei S, Tello-Ruiz M, Ware D, Luciani A, Potter S, Finn RD, Urban M, Hammond-Kosack KE, Bolser DM, De Silva N, Howe KL, Langridge N, Maslen G, Staines DM, Yates A.

Nucleic Acids Res. 2018 Jan 4;46(D1):D802-D808. doi: 10.1093/nar/gkx1011.


ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways.

Ni X, Zhang X, Hu CH, Langridge T, Tarapore RS, Allen JE, Oster W, Duvic M.

Oncotarget. 2017 Jun 27;8(37):61761-61776. doi: 10.18632/oncotarget.18688. eCollection 2017 Sep 22.


Randomized Controlled Trial of Self-directed Versus In-Classroom Education of Narrow Band Imaging in Diagnosing Colorectal Polyps Using the NICE Criteria.

Allen JE, Vennalaganti P, Gupta N, Hornung B, Choudhary A, Titi M, Alsop BR, Lim D, Sharma P.

J Clin Gastroenterol. 2018 May/Jun;52(5):413-417. doi: 10.1097/MCG.0000000000000791.


Predicting ligand-dependent tumors from multi-dimensional signaling features.

Hass H, Masson K, Wohlgemuth S, Paragas V, Allen JE, Sevecka M, Pace E, Timmer J, Stelling J, MacBeath G, Schoeberl B, Raue A.

NPJ Syst Biol Appl. 2017 Sep 20;3:27. doi: 10.1038/s41540-017-0030-3. eCollection 2017.



Allen JE.

Curr Opin Otolaryngol Head Neck Surg. 2017 Dec;25(6):445-446. doi: 10.1097/MOO.0000000000000411. No abstract available.


Erratum to: Whole metagenome profiles of particulates collected from the International Space Station.

Be NA, Avila-Herrera A, Allen JE, Singh N, Sielaff AC, Jaing C, Venkateswaran K.

Microbiome. 2017 Sep 1;5(1):111. doi: 10.1186/s40168-017-0330-2. No abstract available.


The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma.

Tu YS, He J, Liu H, Lee HC, Wang H, Ishizawa J, Allen JE, Andreeff M, Orlowski RZ, Davis RE, Yang J.

Neoplasia. 2017 Oct;19(10):772-780. doi: 10.1016/j.neo.2017.07.009. Epub 2017 Aug 30.


Gene expression analysis of whole blood RNA from pigs infected with low and high pathogenic African swine fever viruses.

Jaing C, Rowland RRR, Allen JE, Certoma A, Thissen JB, Bingham J, Rowe B, White JR, Wynne JW, Johnson D, Gaudreault NN, Williams DT.

Sci Rep. 2017 Aug 31;7(1):10115. doi: 10.1038/s41598-017-10186-4.


Polyp characterization at colonoscopy: Clinical implications.

Allen JE, Sharma P.

Best Pract Res Clin Gastroenterol. 2017 Aug;31(4):435-440. doi: 10.1016/j.bpg.2017.07.001. Epub 2017 Jul 6. Review.


Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.

Prabhu VV, Lulla AR, Madhukar NS, Ralff MD, Zhao D, Kline CLB, Van den Heuvel APJ, Lev A, Garnett MJ, McDermott U, Benes CH, Batchelor TT, Chi AS, Elemento O, Allen JE, El-Deiry WS.

PLoS One. 2017 Aug 2;12(8):e0180541. doi: 10.1371/journal.pone.0180541. eCollection 2017.


Whole metagenome profiles of particulates collected from the International Space Station.

Be NA, Avila-Herrera A, Allen JE, Singh N, Checinska Sielaff A, Jaing C, Venkateswaran K.

Microbiome. 2017 Jul 17;5(1):81. doi: 10.1186/s40168-017-0292-4. Erratum in: Microbiome. 2017 Sep 1;5(1):111.


Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.

Pelly VS, Coomes SM, Kannan Y, Gialitakis M, Entwistle LJ, Perez-Lloret J, Czieso S, Okoye IS, Rückerl D, Allen JE, Brombacher F, Wilson MS.

J Exp Med. 2017 Jun 5;214(6):1809-1826. doi: 10.1084/jem.20161104. Epub 2017 May 15.


Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.

Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Ringqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE.

Science. 2017 Jun 9;356(6342):1076-1080. doi: 10.1126/science.aaj2067. Epub 2017 May 11.


Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.

Wagner J, Kline CL, Ralff MD, Lev A, Lulla A, Zhou L, Olson GL, Nallaganchu BR, Benes CH, Allen JE, Prabhu VV, Stogniew M, Oster W, El-Deiry WS.

Cell Cycle. 2017 Oct 2;16(19):1790-1799. doi: 10.1080/15384101.2017.1325046. Epub 2017 May 10.

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