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Items: 1 to 50 of 135

1.

'Dark' Singlet Oxygen Made Easy.

Elsherbini M, Allemann RK, Wirth T.

Chemistry. 2019 Aug 2. doi: 10.1002/chem.201903505. [Epub ahead of print]

PMID:
31373412
2.

Why are some Enzymes Dimers? Flexibility and Catalysis in Thermotoga Maritima Dihydrofolate Reductase.

Ruiz-Pernía JJ, Tuñón I, Moliner V, Allemann RK.

ACS Catal. 2019 Jul 5;9(7):5902-5911. doi: 10.1021/acscatal.9b01250. Epub 2019 May 13.

3.

Crystal Structure and Biophysical Analysis of Furfural-Detoxifying Aldehyde Reductase from Clostridium beijerinckii.

Scott AF, Cresser-Brown J, Williams TL, Rizkallah PJ, Jin Y, Luk LY, Allemann RK.

Appl Environ Microbiol. 2019 Jul 18;85(15). pii: e00978-19. doi: 10.1128/AEM.00978-19. Print 2019 Aug 1.

PMID:
31101612
4.

A Noncanonical Chromophore Reveals Structural Rearrangements of the Light-Oxygen-Voltage Domain upon Photoactivation.

Kalvaitis ME, Johnson LA, Mart RJ, Rizkallah P, Allemann RK.

Biochemistry. 2019 Jun 4;58(22):2608-2616. doi: 10.1021/acs.biochem.9b00255. Epub 2019 May 17.

PMID:
31082213
5.

Heavy Enzymes and the Rational Redesign of Protein Catalysts.

Scott AF, Luk LY, Tuñón I, Moliner V, Allemann RK.

Chembiochem. 2019 Apr 24. doi: 10.1002/cbic.201900134. [Epub ahead of print]

PMID:
31016852
6.

Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines.

Patel SG, Sayers EJ, He L, Narayan R, Williams TL, Mills EM, Allemann RK, Luk LYP, Jones AT, Tsai YH.

Sci Rep. 2019 Apr 18;9(1):6298. doi: 10.1038/s41598-019-42456-8.

7.

Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase.

Loizzi M, Miller DJ, Allemann RK.

Org Biomol Chem. 2019 Jan 31;17(5):1206-1214. doi: 10.1039/c8ob02821d.

8.

Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space.

Kalash L, Cresser-Brown J, Habchi J, Morgan C, Miller DJ, Glen RC, Allemann RK, Bender A.

Eur J Med Chem. 2018 Sep 5;157:1264-1275. doi: 10.1016/j.ejmech.2018.08.049. Epub 2018 Aug 23.

9.

Sesquiterpene Synthase-Catalyzed Conversion of a Farnesyl Diphosphate Analogue to a Nonnatural Terpenoid Ether.

Huynh F, Miller DJ, Allemann RK.

Methods Enzymol. 2018;608:83-95. doi: 10.1016/bs.mie.2018.05.004. Epub 2018 Jul 6.

PMID:
30173774
10.

Sesquiterpene Synthase-Catalysed Formation of a New Medium-Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues.

Huynh F, Grundy DJ, Jenkins RL, Miller DJ, Allemann RK.

Chembiochem. 2018 Sep 4;19(17):1834-1838. doi: 10.1002/cbic.201800218. Epub 2018 Jul 16.

11.

Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity.

Hallett AJ, Placet E, Prieux R, McCafferty D, Platts JA, Lloyd D, Isaacs M, Hayes AJ, Coles SJ, Pitak MB, Marchant S, Marriott SN, Allemann RK, Dervisi A, Fallis IA.

Dalton Trans. 2018 Oct 16;47(40):14241-14253. doi: 10.1039/c8dt00669e.

PMID:
29789819
12.

Isotope Substitution of Promiscuous Alcohol Dehydrogenase Reveals the Origin of Substrate Preference in the Transition State.

Behiry EM, Ruiz-Pernia JJ, Luk L, Tuñón I, Moliner V, Allemann RK.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3128-3131. doi: 10.1002/anie.201712826. Epub 2018 Feb 19.

13.

Nucleophilic Water Capture or Proton Loss: Single Amino Acid Switch Converts δ-Cadinene Synthase into Germacradien-4-ol Synthase.

Loizzi M, González V, Miller DJ, Allemann RK.

Chembiochem. 2018 Jan 4;19(1):100-105. doi: 10.1002/cbic.201700531. Epub 2017 Nov 23.

14.

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects.

Scott AF, Luk LYP, Allemann RK.

Methods Enzymol. 2017;596:23-41. doi: 10.1016/bs.mie.2017.06.040. Epub 2017 Aug 7.

PMID:
28911773
15.

Chemoenzymatic Assembly of Isotopically Labeled Folates.

Angelastro A, Dawson WM, Luk LYP, Loveridge EJ, Allemann RK.

J Am Chem Soc. 2017 Sep 20;139(37):13047-13054. doi: 10.1021/jacs.7b06358. Epub 2017 Sep 6.

PMID:
28820585
16.

Concise synthesis of artemisinin from a farnesyl diphosphate analogue.

Tang X, Demiray M, Wirth T, Allemann RK.

Bioorg Med Chem. 2018 Apr 1;26(7):1314-1319. doi: 10.1016/j.bmc.2017.03.068. Epub 2017 Apr 4.

17.

A Rapid Analysis of Variations in Conformational Behavior during Dihydrofolate Reductase Catalysis.

Hughes RL, Johnson LA, Behiry EM, Loveridge EJ, Allemann RK.

Biochemistry. 2017 Apr 18;56(15):2126-2133. doi: 10.1021/acs.biochem.7b00045. Epub 2017 Apr 7.

PMID:
28368101
18.

Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima.

Loveridge EJ, Hroch L, Hughes RL, Williams T, Davies RL, Angelastro A, Luk LY, Maglia G, Allemann RK.

Biochemistry. 2017 Apr 4;56(13):1879-1886. doi: 10.1021/acs.biochem.6b01268. Epub 2017 Mar 24.

19.

An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde.

Demiray M, Tang X, Wirth T, Faraldos JA, Allemann RK.

Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4347-4350. doi: 10.1002/anie.201609557. Epub 2017 Mar 13.

20.

Optimising Terpene Synthesis with Flow Biocatalysis.

Tang X, Allemann RK, Wirth T.

European J Org Chem. 2017 Jan 10;2017(2):414-418. doi: 10.1002/ejoc.201601388. Epub 2017 Jan 13.

21.

Pinpointing dynamic coupling in enzymes for efficient drug design.

Loveridge EJ, Allemann RK.

Future Sci OA. 2016 Jan 25;2(1):FSO95. doi: 10.4155/fsoa.2015.0017. eCollection 2016 Mar. No abstract available.

22.

Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate.

Faraldos JA, Grundy DJ, Cascon O, Leoni S, van der Kamp MW, Allemann RK.

Chem Commun (Camb). 2016 Nov 29;52(97):14027-14030.

PMID:
27853760
23.

Azobenzene photocontrol of peptides and proteins.

Mart RJ, Allemann RK.

Chem Commun (Camb). 2016 Oct 11;52(83):12262-12277.

PMID:
27541361
24.

The amino-terminal segment in the β-domain of δ-cadinene synthase is essential for catalysis.

González V, Grundy DJ, Faraldos JA, Allemann RK.

Org Biomol Chem. 2016 Aug 21;14(31):7451-4. doi: 10.1039/c6ob01398h. Epub 2016 Jul 19.

PMID:
27431578
25.

Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase.

Chen M, Chou WK, Al-Lami N, Faraldos JA, Allemann RK, Cane DE, Christianson DW.

Biochemistry. 2016 May 24;55(20):2864-74. doi: 10.1021/acs.biochem.6b00343. Epub 2016 May 12.

26.

Minimization of dynamic effects in the evolution of dihydrofolate reductase.

Ruiz-Pernía JJ, Behiry E, Luk LYP, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

Chem Sci. 2016 May 1;7(5):3248-3255. doi: 10.1039/c5sc04209g. Epub 2016 Feb 3.

27.

Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture.

Grundy DJ, Chen M, González V, Leoni S, Miller DJ, Christianson DW, Allemann RK.

Biochemistry. 2016 Apr 12;55(14):2112-21. doi: 10.1021/acs.biochem.6b00115. Epub 2016 Mar 30.

28.

Conformationally restricted calpain inhibitors.

Adams SE, Robinson EJ, Miller DJ, Rizkallah PJ, Hallett MB, Allemann RK.

Chem Sci. 2015 Dec 1;6(12):6865-6871. doi: 10.1039/c5sc01158b. Epub 2015 Aug 24.

29.

Photocontrolled Exposure of Pro-apoptotic Peptide Sequences in LOV Proteins Modulates Bcl-2 Family Interactions.

Mart RJ, Meah D, Allemann RK.

Chembiochem. 2016 Apr 15;17(8):698-701. doi: 10.1002/cbic.201500469. Epub 2015 Nov 20.

30.

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

Luk LY, Ruiz-Pernía JJ, Adesina AS, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

Angew Chem Int Ed Engl. 2015 Jul 27;54(31):9016-20. doi: 10.1002/anie.201503968. Epub 2015 Jun 16.

31.

Protein motions and dynamic effects in enzyme catalysis.

Luk LY, Loveridge EJ, Allemann RK.

Phys Chem Chem Phys. 2015 Dec 14;17(46):30817-27. doi: 10.1039/c5cp00794a.

PMID:
25854702
32.

Novel olfactory ligands via terpene synthases.

Touchet S, Chamberlain K, Woodcock CM, Miller DJ, Birkett MA, Pickett JA, Allemann RK.

Chem Commun (Camb). 2015 May 1;51(35):7550-3. doi: 10.1039/c5cc01814e.

PMID:
25847629
33.

Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant.

Luk LY, Ruiz-Pernía JJ, Dawson WM, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2014 Dec 10;136(49):17317-23. doi: 10.1021/ja5102536. Epub 2014 Nov 26.

PMID:
25396728
34.

Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase.

Gonzalez V, Touchet S, Grundy DJ, Faraldos JA, Allemann RK.

J Am Chem Soc. 2014 Oct 15;136(41):14505-12. doi: 10.1021/ja5066366. Epub 2014 Oct 2.

35.

The structural basis of differential inhibition of human calpain by indole and phenyl α-mercaptoacrylic acids.

Adams SE, Rizkallah PJ, Miller DJ, Robinson EJ, Hallett MB, Allemann RK.

J Struct Biol. 2014 Sep;187(3):236-241. doi: 10.1016/j.jsb.2014.07.004. Epub 2014 Jul 30.

PMID:
25086406
36.

Role of the occluded conformation in bacterial dihydrofolate reductases.

Behiry EM, Luk LY, Matthews SM, Loveridge EJ, Allemann RK.

Biochemistry. 2014 Jul 29;53(29):4761-8. doi: 10.1021/bi500507v. Epub 2014 Jul 18.

37.

Loop interactions during catalysis by dihydrofolate reductase from Moritella profunda.

Behiry EM, Evans RM, Guo J, Loveridge EJ, Allemann RK.

Biochemistry. 2014 Jul 29;53(29):4769-74. doi: 10.1021/bi500508z. Epub 2014 Jul 18.

38.

Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases.

Luk LY, Loveridge EJ, Allemann RK.

J Am Chem Soc. 2014 May 14;136(19):6862-5. doi: 10.1021/ja502673h. Epub 2014 May 5.

39.

Thermal adaptation of dihydrofolate reductase from the moderate thermophile Geobacillus stearothermophilus.

Guo J, Luk LY, Loveridge EJ, Allemann RK.

Biochemistry. 2014 May 6;53(17):2855-63. doi: 10.1021/bi500238q. Epub 2014 Apr 22.

40.

Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.

Ruiz-Pernia JJ, Luk LY, García-Meseguer R, Martí S, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2013 Dec 11;135(49):18689-96. doi: 10.1021/ja410519h. Epub 2013 Nov 26.

41.

Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?

Miller DJ, Adams SE, Hallett MB, Allemann RK.

Future Med Chem. 2013 Nov;5(17):2057-74. doi: 10.4155/fmc.13.172. Review.

PMID:
24215346
42.

Conformational change and ligand binding in the aristolochene synthase catalytic cycle.

van der Kamp MW, Sirirak J, Żurek J, Allemann RK, Mulholland AJ.

Biochemistry. 2013 Nov 12;52(45):8094-105. doi: 10.1021/bi400898k. Epub 2013 Oct 29.

PMID:
24106830
43.

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis.

Luk LY, Javier Ruiz-Pernía J, Dawson WM, Roca M, Loveridge EJ, Glowacki DR, Harvey JN, Mulholland AJ, Tuñón I, Moliner V, Allemann RK.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16344-9. doi: 10.1073/pnas.1312437110. Epub 2013 Sep 24.

44.

BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells.

Mart RJ, Errington RJ, Watkins CL, Chappell SC, Wiltshire M, Jones AT, Smith PJ, Allemann RK.

Mol Biosyst. 2013 Nov;9(11):2597-603. doi: 10.1039/c3mb70246d.

PMID:
23942570
45.

Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.

Chen M, Al-lami N, Janvier M, D'Antonio EL, Faraldos JA, Cane DE, Allemann RK, Christianson DW.

Biochemistry. 2013 Aug 13;52(32):5441-53. doi: 10.1021/bi400691v. Epub 2013 Aug 1.

46.

Effect of dimerization on dihydrofolate reductase catalysis.

Guo J, Loveridge EJ, Luk LY, Allemann RK.

Biochemistry. 2013 Jun 4;52(22):3881-7. doi: 10.1021/bi4005073. Epub 2013 May 22.

PMID:
23672258
47.

Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency.

Li JX, Fang X, Zhao Q, Ruan JX, Yang CQ, Wang LJ, Miller DJ, Faraldos JA, Allemann RK, Chen XY, Zhang P.

Biochem J. 2013 May 1;451(3):417-26. doi: 10.1042/BJ20130041.

PMID:
23438177
48.

Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.

Faraldos JA, Gonzalez V, Li A, Yu F, Köksal M, Christianson DW, Allemann RK.

J Am Chem Soc. 2012 Dec 26;134(51):20844-8. doi: 10.1021/ja311022s. Epub 2012 Dec 11.

49.

Chemoenzymatic preparation of germacrene analogues.

Cascón O, Touchet S, Miller DJ, Gonzalez V, Faraldos JA, Allemann RK.

Chem Commun (Camb). 2012 Oct 9;48(78):9702-4. doi: 10.1039/c2cc35542f.

PMID:
22914774
50.

¹H, ¹³C and ¹⁵N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide.

Wysoczanski P, Mart RJ, Loveridge EJ, Williams C, Whittaker SB, Crump MP, Allemann RK.

Biomol NMR Assign. 2013 Oct;7(2):187-91. doi: 10.1007/s12104-012-9407-9. Epub 2012 Jun 30.

PMID:
22744789

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