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Items: 8

1.

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.

Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A.

J Med Chem. 2019 Aug 22;62(16):7400-7416. doi: 10.1021/acs.jmedchem.9b00186. Epub 2019 Aug 5.

PMID:
31246024
2.

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.

Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294. doi: 10.1126/scitranslmed.aaf5294.

PMID:
28053157
3.

Prediction of the therapeutic index of marketed anti-coagulants and anti-platelet agents by guinea pig models of thrombosis and hemostasis.

Bird JE, Giancarli MR, Allegretto N, Barbera F, Wong P, Schumacher WA, Ogletree ML, Seiffert D.

Thromb Res. 2008;123(1):146-58. doi: 10.1016/j.thromres.2008.03.010. Epub 2008 May 14.

PMID:
18479740
4.

Development of potent thrombin receptor antagonist peptides.

Bernatowicz MS, Klimas CE, Hartl KS, Peluso M, Allegretto NJ, Seiler SM.

J Med Chem. 1996 Dec 6;39(25):4879-87.

PMID:
8960546
5.

Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.

Sower LE, Froelich CJ, Allegretto N, Rose PM, Hanna WD, Klimpel GR.

J Immunol. 1996 Apr 1;156(7):2585-90.

PMID:
8786323
6.

Macrophage-derived factors increase low density lipoprotein uptake and receptor number in cultured human liver cells.

Grove RI, Mazzucco C, Allegretto N, Kiener PA, Spitalny G, Radka SF, Shoyab M, Antonaccio M, Warr GA.

J Lipid Res. 1991 Dec;32(12):1889-97.

7.

Lipopolysaccharide (LPS) alters phosphatidylcholine metabolism in elicited peritoneal macrophages.

Grove RI, Allegretto NJ, Kiener PA, Warr GA.

J Leukoc Biol. 1990 Jul;48(1):38-42.

PMID:
2358751
8.

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