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Items: 43


Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.

Mohammed S, Vineetha NS, James S, Aparna JS, Lankadasari MB, Allegood JC, Li QZ, Spiegel S, Harikumar KB.

FASEB J. 2019 Jun;33(6):7061-7071. doi: 10.1096/fj.201802535R. Epub 2019 Mar 6.


Analysis of sphingolipid composition in human vitreous from control and diabetic individuals.

Wilmott LA, Grambergs RC, Allegood JC, Lyons TJ, Mandal N.

J Diabetes Complications. 2019 Mar;33(3):195-201. doi: 10.1016/j.jdiacomp.2018.12.005. Epub 2018 Dec 14.


Non-alcoholic fatty liver disease: Insights from sphingolipidomics.

Montefusco DJ, Allegood JC, Spiegel S, Cowart LA.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):608-616. doi: 10.1016/j.bbrc.2018.05.078. Epub 2018 May 21. Review.


Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

Nagahashi M, Yamada A, Katsuta E, Aoyagi T, Huang WC, Terracina KP, Hait NC, Allegood JC, Tsuchida J, Yuza K, Nakajima M, Abe M, Sakimura K, Milstien S, Wakai T, Spiegel S, Takabe K.

Cancer Res. 2018 Apr 1;78(7):1713-1725. doi: 10.1158/0008-5472.CAN-17-1423. Epub 2018 Jan 19.


The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans.

Rizzo J, Colombo AC, Zamith-Miranda D, Silva VKA, Allegood JC, Casadevall A, Del Poeta M, Nosanchuk JD, Kronstad JW, Rodrigues ML.

Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):532-541. doi: 10.1016/j.bbamcr.2017.12.007. Epub 2017 Dec 29.


Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.

Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K.

J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):9-17. doi: 10.1007/s10911-016-9354-7. Epub 2016 May 19.


Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2015 Oct;136(4):1035-46.e6. doi: 10.1016/j.jaci.2015.02.031. Epub 2015 Apr 2.


Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression.

Nagahashi M, Takabe K, Liu R, Peng K, Wang X, Wang Y, Hait NC, Wang X, Allegood JC, Yamada A, Aoyagi T, Liang J, Pandak WM, Spiegel S, Hylemon PB, Zhou H.

Hepatology. 2015 Apr;61(4):1216-26. doi: 10.1002/hep.27592. Epub 2015 Mar 9.


Electron flow into cytochrome c coupled with reactive oxygen species from the electron transport chain converts cytochrome c to a cardiolipin peroxidase: role during ischemia-reperfusion.

Aluri HS, Simpson DC, Allegood JC, Hu Y, Szczepanek K, Gronert S, Chen Q, Lesnefsky EJ.

Biochim Biophys Acta. 2014 Nov;1840(11):3199-207. doi: 10.1016/j.bbagen.2014.07.017. Epub 2014 Aug 1.


Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Hait NC, Wise LE, Allegood JC, O'Brien M, Avni D, Reeves TM, Knapp PE, Lu J, Luo C, Miles MF, Milstien S, Lichtman AH, Spiegel S.

Nat Neurosci. 2014 Jul;17(7):971-80. doi: 10.1038/nn.3728. Epub 2014 May 25.


Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development.

Kondo S, Bottos A, Allegood JC, Masson R, Maurer FG, Genoud C, Kaeser P, Huwiler A, Murakami M, Spiegel S, Hynes NE.

PLoS One. 2014 Apr 8;9(4):e94114. doi: 10.1371/journal.pone.0094114. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e101351.


K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.

Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC, Hait NC, Allegood JC, Yamada A, Kong X, Lazear HM, Bhardwaj R, Takabe K, Diamond MS, Luo C, Milstien S, Spiegel S, Kordula T.

Nat Immunol. 2014 Mar;15(3):231-8. doi: 10.1038/ni.2810. Epub 2014 Jan 26.


Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S.

Cancer Cell. 2013 Jan 14;23(1):107-20. doi: 10.1016/j.ccr.2012.11.013. Epub 2012 Dec 27.


Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.

Nagahashi M, Kim EY, Yamada A, Ramachandran S, Allegood JC, Hait NC, Maceyka M, Milstien S, Takabe K, Spiegel S.

FASEB J. 2013 Mar;27(3):1001-11. doi: 10.1096/fj.12-219618. Epub 2012 Nov 24.


A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. doi: 10.1016/j.jaci.2012.07.014. Epub 2012 Aug 30.


Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

Nagahashi M, Ramachandran S, Kim EY, Allegood JC, Rashid OM, Yamada A, Zhao R, Milstien S, Zhou H, Spiegel S, Takabe K.

Cancer Res. 2012 Feb 1;72(3):726-35. doi: 10.1158/0008-5472.CAN-11-2167.


Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans.

Bogaard HJ, Mizuno S, Guignabert C, Al Hussaini AA, Farkas D, Ruiter G, Kraskauskas D, Fadel E, Allegood JC, Humbert M, Vonk Noordegraaf A, Spiegel S, Farkas L, Voelkel NF.

Am J Respir Cell Mol Biol. 2012 May;46(5):582-91. doi: 10.1165/rcmb.2011-0296OC. Epub 2011 Dec 28.


Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.

Lépine S, Allegood JC, Edmonds Y, Milstien S, Spiegel S.

J Biol Chem. 2011 Dec 30;286(52):44380-90. doi: 10.1074/jbc.M111.257519. Epub 2011 Nov 3.


Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry.

Haynes CA, Allegood JC, Wang EW, Kelly SL, Sullards MC, Merrill AH Jr.

J Lipid Res. 2011 Aug;52(8):1583-94. doi: 10.1194/jlr.D015586. Epub 2011 May 17.


Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.

Symolon H, Bushnev A, Peng Q, Ramaraju H, Mays SG, Allegood JC, Pruett ST, Sullards MC, Dillehay DL, Liotta DC, Merrill AH Jr.

Mol Cancer Ther. 2011 Apr;10(4):648-57. doi: 10.1158/1535-7163.MCT-10-0754. Epub 2011 Mar 11.


Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, Maceyka M, Price MM, Chen Q, Simpson DC, Kordula T, Milstien S, Lesnefsky EJ, Spiegel S.

FASEB J. 2011 Feb;25(2):600-12. doi: 10.1096/fj.10-167502. Epub 2010 Oct 19.


Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy.

Sims K, Haynes CA, Kelly S, Allegood JC, Wang E, Momin A, Leipelt M, Reichart D, Glass CK, Sullards MC, Merrill AH Jr.

J Biol Chem. 2010 Dec 3;285(49):38568-79. doi: 10.1074/jbc.M110.170621. Epub 2010 Sep 27.


Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.

Lépine S, Allegood JC, Park M, Dent P, Milstien S, Spiegel S.

Cell Death Differ. 2011 Feb;18(2):350-61. doi: 10.1038/cdd.2010.104. Epub 2010 Aug 27.


Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

Takabe K, Kim RH, Allegood JC, Mitra P, Ramachandran S, Nagahashi M, Harikumar KB, Hait NC, Milstien S, Spiegel S.

J Biol Chem. 2010 Apr 2;285(14):10477-86. doi: 10.1074/jbc.M109.064162. Epub 2010 Jan 28.


Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.

Sauane M, Su ZZ, Dash R, Liu X, Norris JS, Sarkar D, Lee SG, Allegood JC, Dent P, Spiegel S, Fisher PB.

J Cell Physiol. 2010 Mar;222(3):546-55. doi: 10.1002/jcp.21969.


Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.

Kapitonov D, Allegood JC, Mitchell C, Hait NC, Almenara JA, Adams JK, Zipkin RE, Dent P, Kordula T, Milstien S, Spiegel S.

Cancer Res. 2009 Sep 1;69(17):6915-23. doi: 10.1158/0008-5472.CAN-09-0664.


Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels.

Wijesinghe DS, Allegood JC, Gentile LB, Fox TE, Kester M, Chalfant CE.

J Lipid Res. 2010 Mar;51(3):641-51. doi: 10.1194/jlr.D000430. Epub 2009 Aug 4.


Characterization of mutant serine palmitoyltransferase 1 in LY-B cells.

Momin AA, Park H, Allegood JC, Leipelt M, Kelly SL, Merrill AH Jr, Hanada K.

Lipids. 2009 Aug;44(8):725-32. doi: 10.1007/s11745-009-3316-4. Epub 2009 Jun 18.


Sphingolipidomics: methods for the comprehensive analysis of sphingolipids.

Haynes CA, Allegood JC, Park H, Sullards MC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2696-708. doi: 10.1016/j.jchromb.2008.12.057. Epub 2008 Dec 31. Review.


Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.

Coward J, Ambrosini G, Musi E, Truman JP, Haimovitz-Friedman A, Allegood JC, Wang E, Merrill AH Jr, Schwartz GK.

Autophagy. 2009 Feb;5(2):184-93. Epub 2009 Feb 6.


Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers.

Shaner RL, Allegood JC, Park H, Wang E, Kelly S, Haynes CA, Sullards MC, Merrill AH Jr.

J Lipid Res. 2009 Aug;50(8):1692-707. doi: 10.1194/jlr.D800051-JLR200. Epub 2008 Nov 25.


N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.

Wang H, Maurer BJ, Liu YY, Wang E, Allegood JC, Kelly S, Symolon H, Liu Y, Merrill AH Jr, Gouazé-Andersson V, Yu JY, Giuliano AE, Cabot MC.

Mol Cancer Ther. 2008 Sep;7(9):2967-76. doi: 10.1158/1535-7163.MCT-08-0549.


Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry.

Haynes CA, Allegood JC, Sims K, Wang EW, Sullards MC, Merrill AH Jr.

J Lipid Res. 2008 May;49(5):1113-25. doi: 10.1194/jlr.D800001-JLR200. Epub 2008 Feb 20.


Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "inside-out" sphingolipidomics.

Sullards MC, Allegood JC, Kelly S, Wang E, Haynes CA, Park H, Chen Y, Merrill AH Jr.

Methods Enzymol. 2007;432:83-115.


Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.

Seiferlein M, Humpf HU, Voss KA, Sullards MC, Allegood JC, Wang E, Merrill AH Jr.

Mol Nutr Food Res. 2007 Sep;51(9):1120-30.


Ceramide transfer protein function is essential for normal oxidative stress response and lifespan.

Rao RP, Yuan C, Allegood JC, Rawat SS, Edwards MB, Wang X, Merrill AH Jr, Acharya U, Acharya JK.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11364-9. Epub 2007 Jun 25.


Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.

Lamour NF, Stahelin RV, Wijesinghe DS, Maceyka M, Wang E, Allegood JC, Merrill AH Jr, Cho W, Chalfant CE.

J Lipid Res. 2007 Jun;48(6):1293-304. Epub 2007 Mar 27.


Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility.

Yildiz Y, Matern H, Thompson B, Allegood JC, Warren RL, Ramirez DM, Hammer RE, Hamra FK, Matern S, Russell DW.

J Clin Invest. 2006 Nov;116(11):2985-94.


Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy.

Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q, Ramaraju H, Sullards MC, Cabot M, Merrill AH Jr.

Biochim Biophys Acta. 2006 Dec;1758(12):1864-84. Epub 2006 Aug 22. Review.


Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans.

Rittershaus PC, Kechichian TB, Allegood JC, Merrill AH Jr, Hennig M, Luberto C, Del Poeta M.

J Clin Invest. 2006 Jun;116(6):1651-9. Erratum in: J Clin Invest. 2007 May;117(5):1450.


Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.

Riebeling C, Allegood JC, Wang E, Merrill AH Jr, Futerman AH.

J Biol Chem. 2003 Oct 31;278(44):43452-9. Epub 2003 Aug 11.


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