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Items: 1 to 50 of 413

1.

Pharmacokinetic modeling of intravenous sildenafil in newborns with congenital diaphragmatic hernia.

Cochius-den Otter SCM, Kipfmueller F, de Winter BCM, Allegaert K, Tibboel D, Mueller A, Koch BCP.

Eur J Clin Pharmacol. 2019 Nov 18. doi: 10.1007/s00228-019-02767-1. [Epub ahead of print]

PMID:
31740991
2.

Standardizing Safety Assessment and Reporting for Neonatal Clinical Trials.

Davis JM, Baer GR, McCune S, Klein A, Sato J, Fabbri L, Mangili A, Short MA, Tansey S, Mangum B, Hokuto I, Nakamura H, Salaets T, Allegaert K, Yao L, Blum M, Toerner J, Turner M, Portman R; International Neonatal Consortium.

J Pediatr. 2019 Nov 7. pii: S0022-3476(19)31295-8. doi: 10.1016/j.jpeds.2019.09.060. [Epub ahead of print] No abstract available.

PMID:
31708158
3.

The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia.

Cochius-den Otter S, Schaible T, Greenough A, van Heijst A, Patel N, Allegaert K, van Rosmalen J, Tibboel D; CDH EURO Consortium.

BMJ Open. 2019 Nov 5;9(11):e032122. doi: 10.1136/bmjopen-2019-032122.

4.

A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood.

Qi B, Nicolaï J, Smits A, De Vocht T, Deferm N, Van Brantegem P, Allegaert K, Annaert P.

J Clin Pharm Ther. 2019 Oct 3. doi: 10.1111/jcpt.13038. [Epub ahead of print]

PMID:
31583723
5.

Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.

Raffaeli G, Pokorna P, Allegaert K, Mosca F, Cavallaro G, Wildschut ED, Tibboel D.

Front Pediatr. 2019 Sep 3;7:360. doi: 10.3389/fped.2019.00360. eCollection 2019. Review.

6.

Development of a neonatal adverse event severity scale through a Delphi consensus approach.

Salaets T, Turner MA, Short M, Ward RM, Hokuto I, Ariagno RL, Klein A, Beauman S, Wade K, Thomson M, Roberts E, Harrison J, Quinn T, Baer G, Davis J, Allegaert K; International Neonatal Consortium.

Arch Dis Child. 2019 Sep 19. pii: archdischild-2019-317399. doi: 10.1136/archdischild-2019-317399. [Epub ahead of print]

7.

Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis.

Gilarska M, Raaijmakers A, Zhang ZY, Staessen JA, Levtchenko E, Klimek M, Grudzień A, Starzec K, Allegaert K, Kwinta P.

Kidney Blood Press Res. 2019;44(5):897-906. doi: 10.1159/000502715. Epub 2019 Sep 19.

8.

Medical devices that look like medicines: safety and regulatory concerns for children in Europe.

Huijghebaert S, De Bruyne P, Allegaert K, Vande Velde S, DeBruyne R, Van Biervliet S, Van Winckel M.

Arch Dis Child. 2019 Sep 18. pii: archdischild-2018-316391. doi: 10.1136/archdischild-2018-316391. [Epub ahead of print] No abstract available.

PMID:
31533915
9.

Ontogeny of Phase I Metabolism of Drugs.

Allegaert K, van den Anker J.

J Clin Pharmacol. 2019 Sep;59 Suppl 1:S33-S41. doi: 10.1002/jcph.1483.

PMID:
31502685
10.

Rapidly maturing fentanyl clearance in preterm neonates.

Völler S, Flint RB, Andriessen P, Allegaert K, Zimmermann LJI, Liem KD, Koch BCP, Simons SHP, Knibbe CAJ; DINO study group.

Arch Dis Child Fetal Neonatal Ed. 2019 Nov;104(6):F598-F603. doi: 10.1136/archdischild-2018-315920. Epub 2019 Feb 1.

PMID:
31498775
11.

Propofol Formulation Affects Myocardial Function in Newborn Infants.

Massolo AC, Sgrò S, Piersigilli F, Allegaert K, Capolupo I, Rechichi J, Landolfo F, Calzolari F, Toscano A, Picardo S, Patel N.

Pediatr Cardiol. 2019 Oct;40(7):1536-1542. doi: 10.1007/s00246-019-02182-4. Epub 2019 Aug 14.

PMID:
31414158
12.

Pharmacokinetic modelling and Bayesian estimation-assisted decision tools to optimize vancomycin dosage in neonates: only one piece of the puzzle.

Allegaert K, Flint R, Smits A.

Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):735-749. doi: 10.1080/17425255.2019.1655540. Epub 2019 Aug 19. Review.

PMID:
31402708
13.

Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women.

Mian P, van den Anker JN, van Calsteren K, Annaert P, Tibboel D, Pfister M, Allegaert K, Dallmann A.

Clin Pharmacokinet. 2019 Jul 25. doi: 10.1007/s40262-019-00799-5. [Epub ahead of print]

PMID:
31347013
14.

Health products' and substance use among pregnant women visiting a tertiary hospital in Belgium: A cross-sectional study.

Ceulemans M, Van Calsteren K, Allegaert K, Foulon V.

Pharmacoepidemiol Drug Saf. 2019 Sep;28(9):1231-1238. doi: 10.1002/pds.4862. Epub 2019 Jul 25.

PMID:
31342605
15.

A manual propofol infusion regimen for neonates and infants.

Morse J, Hannam JA, Cortinez LI, Allegaert K, Anderson BJ.

Paediatr Anaesth. 2019 Sep;29(9):907-914. doi: 10.1111/pan.13706. Epub 2019 Aug 12.

PMID:
31325395
16.

Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns: impact of design optimisation.

van Dijkman SC, De Cock PAJG, Smets K, Decaluwe W, Smits A, Allegaert K, Vande Walle J, De Paepe P, Della Pasqua O.

Eur J Clin Pharmacol. 2019 Oct;75(10):1393-1404. doi: 10.1007/s00228-019-02708-y. Epub 2019 Jul 16.

PMID:
31312867
17.

Prevalence and characteristics of pregnancy- and lactation-related calls to the National Poison Centre in Belgium: A retrospective analysis of calls from 2012 to 2017.

Ceulemans M, Fortuin M, Van Calsteren K, Allegaert K, Foulon V.

J Eval Clin Pract. 2019 Jul 12. doi: 10.1111/jep.13228. [Epub ahead of print]

PMID:
31298801
18.

RAIN study: a protocol for a randomised controlled trial evaluating efficacy, safety and cost-effectiveness of intravenous-to-oral antibiotic switch therapy in neonates with a probable bacterial infection.

Keij FM, Kornelisse RF, Hartwig NG, Mauff K, Poley MJ, Allegaert K, Reiss IKM, Tramper-Stranders GA.

BMJ Open. 2019 Jul 9;9(7):e026688. doi: 10.1136/bmjopen-2018-026688.

19.

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III).

Maiwald CA, Annink KV, Rüdiger M, Benders MJNL, van Bel F, Allegaert K, Naulaers G, Bassler D, Klebermaß-Schrehof K, Vento M, Guimarães H, Stiris T, Cattarossi L, Metsäranta M, Vanhatalo S, Mazela J, Metsvaht T, Jacobs Y, Franz AR; ALBINO Study Group.

BMC Pediatr. 2019 Jun 27;19(1):210. doi: 10.1186/s12887-019-1566-8.

20.

Oral antibiotics for neonatal infections: a systematic review and meta-analysis.

Keij FM, Kornelisse RF, Hartwig NG, Reiss IKM, Allegaert K, Tramper-Stranders GA.

J Antimicrob Chemother. 2019 Nov 1;74(11):3150-3161. doi: 10.1093/jac/dkz252.

21.

Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333-3335.

Myngheer N, Allegaert K, Hattersley A, McDonald T, Kramer H, Ashcroft FM, Verhaeghe J, Mathieu C, Casteels K.

Diabetes Care. 2019 Jul;42(7):1352. doi: 10.2337/dc19-er07. Epub 2019 May 21. No abstract available.

PMID:
31221702
22.

Arabic-speaking pregnant women with a migration background: A vulnerable target group for prenatal counseling on medicines.

Ceulemans M, Chaar R, Van Calsteren K, Allegaert K, Foulon V.

Res Social Adm Pharm. 2019 Jun 13. pii: S1551-7411(19)30183-4. doi: 10.1016/j.sapharm.2019.06.004. [Epub ahead of print]

PMID:
31221568
23.

Developmental neurobiology as a guide for pharmacological management of pain in neonates.

van den Hoogen NJ, de Kort AR, Allegaert KM, Joosten EA, Simons SHP, Tibboel D, van den Bosch GE.

Semin Fetal Neonatal Med. 2019 Aug;24(4):101012. doi: 10.1016/j.siny.2019.05.004. Epub 2019 May 10. Review.

PMID:
31221544
24.

Perinatal Clinical Pharmacology: Optimizing Pharmacotherapy for Pregnant Women, Their Fetuses and Infants.

Allegaert K, van den Anker JN.

Curr Pharm Des. 2019;25(5):467-468. doi: 10.2174/138161282504190516090723.

PMID:
31215371
25.

Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief.

Mian P, Dallmann A, van den Anker JN, Tibboel D, Allegaert K.

Pain Med. 2019 Jun 18. pii: pnz136. doi: 10.1093/pm/pnz136. [Epub ahead of print] No abstract available.

PMID:
31211382
26.

Development of CliniPup, a Serious Game Aimed at Reducing Perioperative Anxiety and Pain in Children: Mixed Methods Study.

Verschueren S, van Aalst J, Bangels AM, Toelen J, Allegaert K, Buffel C, Vander Stichele G.

JMIR Serious Games. 2019 Jun 1;7(2):e12429. doi: 10.2196/12429.

27.

A Web-Based Serious Game for Health to Reduce Perioperative Anxiety and Pain in Children (CliniPup): Pilot Randomized Controlled Trial.

Buffel C, van Aalst J, Bangels AM, Toelen J, Allegaert K, Verschueren S, Vander Stichele G.

JMIR Serious Games. 2019 Jun 1;7(2):e12431. doi: 10.2196/12431.

28.

Phenobarbital Increases Midazolam Clearance in Neonates Treated with Hypothermia: Do We Really Need to Know?

Allegaert K, Smits A, van den Anker JN.

Neonatology. 2019;116(2):188-190. doi: 10.1159/000499742. Epub 2019 Jun 11. No abstract available.

PMID:
31185480
29.

Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen.

Cristea S, Allegaert K, Falcao AC, Falcao F, Silva R, Smits A, Knibbe CAJ, Krekels EHJ.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00853-19. doi: 10.1128/AAC.00853-19. Print 2019 Aug.

PMID:
31182538
30.

Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates.

Krzyzanski W, Cook SF, Wilbaux M, Sherwin CMT, Allegaert K, Vermeulen A, van den Anker JN.

AAPS J. 2019 May 28;21(4):68. doi: 10.1208/s12248-019-0331-0.

31.

Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants.

Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W.

J Antimicrob Chemother. 2019 Aug 1;74(8):2128-2138. doi: 10.1093/jac/dkz158.

PMID:
31049551
32.

Actual body weight-based vancomycin dosing in neonates.

Pokorná P, Šíma M, Černá O, Allegaert K, Tibboel D, Slanař O.

J Chemother. 2019 Oct;31(6):307-312. doi: 10.1080/1120009X.2019.1599574. Epub 2019 Apr 14.

PMID:
30983533
33.

Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools.

Dallmann A, Mian P, Van den Anker J, Allegaert K.

Curr Pharm Des. 2019;25(5):483-495. doi: 10.2174/1381612825666190320135137.

PMID:
30894099
34.

Characterization of Esophageal Motility in Infants With Congenital Diaphragmatic Hernia Using High-resolution Manometry.

Rayyan M, Omari T, Debeer A, Decaluwe H, Deprest J, Allegaert K, Rommel N.

J Pediatr Gastroenterol Nutr. 2019 Jul;69(1):32-38. doi: 10.1097/MPG.0000000000002325.

PMID:
30889138
35.

Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care.

Allegaert K, Tibboel D, van den Anker J.

Handb Exp Pharmacol. 2019 Mar 17. doi: 10.1007/164_2019_207. [Epub ahead of print]

PMID:
30879201
36.

Maturational changes in vancomycin protein binding affect vancomycin dosing in neonates.

Leroux S, van den Anker JN, Smits A, Pfister M, Allegaert K.

Br J Clin Pharmacol. 2019 May;85(5):865-867. doi: 10.1111/bcp.13899. Epub 2019 Mar 4. No abstract available.

PMID:
30834552
37.

Beliefs about medicines and information needs among pregnant women visiting a tertiary hospital in Belgium.

Ceulemans M, Van Calsteren K, Allegaert K, Foulon V.

Eur J Clin Pharmacol. 2019 Jul;75(7):995-1003. doi: 10.1007/s00228-019-02653-w. Epub 2019 Mar 4.

PMID:
30834472
38.

Rational Use of Antibiotics in Neonates: Still in Search of Tailored Tools.

van den Anker J, Allegaert K.

Healthcare (Basel). 2019 Feb 16;7(1). pii: E28. doi: 10.3390/healthcare7010028. Review.

39.

Antenatal therapy with sildenafil: don't throw the baby out with the bathwater.

Russo FM, Hooper S, Tibboel D, DeKoninck P, Benachi A, Tréluyer JM, Allegaert K, Kumar S, Deprest J.

Ultrasound Obstet Gynecol. 2019 Feb;53(2):274-275. doi: 10.1002/uog.20201. No abstract available.

PMID:
30741452
40.

Research on medication use in the neonatal intensive care unit.

Allegaert K, Simons S, Van Den Anker J.

Expert Rev Clin Pharmacol. 2019 Apr;12(4):343-353. doi: 10.1080/17512433.2019.1580569. Epub 2019 Feb 20.

PMID:
30741041
41.

Local pulmonary drug delivery in the preterm rabbit: feasibility and efficacy of daily intratracheal injections.

Salaets T, Gie A, Jimenez J, Aertgeerts M, Gheysens O, Vande Velde G, Koole M, Murgia X, Casiraghi C, Ricci F, Salomone F, Villetti G, Allegaert K, Deprest J, Toelen J.

Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L589-L597. doi: 10.1152/ajplung.00255.2018. Epub 2019 Jan 24.

PMID:
30675804
42.

Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations.

Colin PJ, Allegaert K, Thomson AH, Touw DJ, Dolton M, de Hoog M, Roberts JA, Adane ED, Yamamoto M, Santos-Buelga D, Martín-Suarez A, Simon N, Taccone FS, Lo YL, Barcia E, Struys MMRF, Eleveld DJ.

Clin Pharmacokinet. 2019 Jun;58(6):767-780. doi: 10.1007/s40262-018-0727-5.

43.

Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass.

Mian P, Valkenburg AJ, Allegaert K, Koch BCP, Breatnach CV, Knibbe CAJ, Tibboel D, Krekels EHJ.

J Clin Pharmacol. 2019 Jun;59(6):847-855. doi: 10.1002/jcph.1373. Epub 2019 Jan 11.

44.

Physiologically based pharmacokinetic (PBPK) modeling and simulation in neonatal drug development: how clinicians can contribute.

Smits A, De Cock P, Vermeulen A, Allegaert K.

Expert Opin Drug Metab Toxicol. 2019 Jan;15(1):25-34. doi: 10.1080/17425255.2019.1558205. Epub 2018 Dec 17. Review.

PMID:
30554542
45.

Developmental Pharmacology - Special Issues During Childhood and Adolescence.

Allegaert K.

Drug Res (Stuttg). 2018 Nov;68(S 01):S10-S11. doi: 10.1055/a-0731-6913. Epub 2018 Nov 19.

PMID:
30453364
46.

Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability.

Mian P, van Esdonk MJ, Olkkola KT, de Winter BCM, Liukas A, Spriet I, Tibboel D, Petrovic M, Koch BCP, Allegaert K.

Br J Clin Pharmacol. 2019 Jan;85(1):126-135. doi: 10.1111/bcp.13770. Epub 2018 Oct 25.

PMID:
30321459
47.

Inactive matrix Gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans.

Wei FF, Huang QF, Zhang ZY, Van Keer K, Thijs L, Trenson S, Yang WY, Cauwenberghs N, Mujaj B, Kuznetsova T, Allegaert K, Struijker-Boudier HAJ, Verhamme P, Vermeer C, Staessen JA.

Sci Rep. 2018 Oct 10;8(1):15088. doi: 10.1038/s41598-018-33257-6.

48.

Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis.

Allegaert K, Mian P, Lapillonne A, van den Anker JN.

Br J Clin Pharmacol. 2019 Jan;85(1):245-251. doi: 10.1111/bcp.13778. Epub 2018 Oct 25.

49.

Impact of Disease on Amikacin Pharmacokinetics and Dosing in Children.

Liu X, Smits A, Wang Y, Renard M, Wead S, Kagan RJ, Healy DP, De Cock P, Allegaert K, Sherwin CMT.

Ther Drug Monit. 2019 Feb;41(1):44-52. doi: 10.1097/FTD.0000000000000568.

PMID:
30299427
50.

The use of PBPK modeling across the pediatric age range using propofol as a case.

Michelet R, Van Bocxlaer J, Allegaert K, Vermeulen A.

J Pharmacokinet Pharmacodyn. 2018 Dec;45(6):765-785. doi: 10.1007/s10928-018-9607-8. Epub 2018 Oct 8.

PMID:
30298439

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