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Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C.

Paschos K, Bazot Q, Lees J, Farrell PJ, Allday MJ.

Nucleic Acids Res. 2019 Apr 8;47(6):2807-2821. doi: 10.1093/nar/gky1323.


Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B.

Gillman ACT, Parker G, Allday MJ, Bazot Q.

J Virol. 2018 Oct 12;92(21). pii: e01362-18. doi: 10.1128/JVI.01362-18. Print 2018 Nov 1.


Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV.

Bazot Q, Paschos K, Allday MJ.

J Virol. 2018 Mar 14;92(7). pii: e01918-17. doi: 10.1128/JVI.01918-17. Print 2018 Apr 1.


EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency.

Styles CT, Bazot Q, Parker GA, White RE, Paschos K, Allday MJ.

PLoS Biol. 2017 Aug 3;15(8):e2001992. doi: 10.1371/journal.pbio.2001992. eCollection 2017 Aug.


Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression.

McHugh D, Caduff N, Barros MHM, Rämer PC, Raykova A, Murer A, Landtwing V, Quast I, Styles CT, Spohn M, Fowotade A, Delecluse HJ, Papoudou-Bai A, Lee YM, Kim JM, Middeldorp J, Schulz TF, Cesarman E, Zbinden A, Capaul R, White RE, Allday MJ, Niedobitek G, Blackbourn DJ, Grundhoff A, Münz C.

Cell Host Microbe. 2017 Jul 12;22(1):61-73.e7. doi: 10.1016/j.chom.2017.06.009.


Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.

Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA.

Elife. 2017 Apr 20;6. pii: e22509. doi: 10.7554/eLife.22509.


Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression.

Paschos K, Bazot Q, Ho G, Parker GA, Lees J, Barton G, Allday MJ.

Nucleic Acids Res. 2017 Mar 17;45(5):2368-2383. doi: 10.1093/nar/gkw1167.


Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells.

Kalchschmidt JS, Bashford-Rogers R, Paschos K, Gillman AC, Styles CT, Kellam P, Allday MJ.

J Exp Med. 2016 May 30;213(6):921-8. doi: 10.1084/jem.20160120. Epub 2016 May 23.


EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells.

Kalchschmidt JS, Gillman AC, Paschos K, Bazot Q, Kempkes B, Allday MJ.

PLoS Pathog. 2016 Jan 11;12(1):e1005383. doi: 10.1371/journal.ppat.1005383. eCollection 2016 Jan.


The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B Cells.

Allday MJ, Bazot Q, White RE.

Curr Top Microbiol Immunol. 2015;391:61-117. doi: 10.1007/978-3-319-22834-1_3. Review.


Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2.

Bazot Q, Paschos K, Skalska L, Kalchschmidt JS, Parker GA, Allday MJ.

PLoS Pathog. 2015 Jul 8;11(7):e1005031. doi: 10.1371/journal.ppat.1005031. eCollection 2015 Jul.


Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.

Palser AL, Grayson NE, White RE, Corton C, Correia S, Ba Abdullah MM, Watson SJ, Cotten M, Arrand JR, Murray PG, Allday MJ, Rickinson AB, Young LS, Farrell PJ, Kellam P.

J Virol. 2015 May;89(10):5222-37. doi: 10.1128/JVI.03614-14. Epub 2015 Mar 18.


Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines.

Skalska L, White RE, Parker GA, Turro E, Sinclair AJ, Paschos K, Allday MJ.

PLoS Pathog. 2013 Feb;9(2):e1003187. doi: 10.1371/journal.ppat.1003187. Epub 2013 Feb 21. Erratum in: PLoS Pathog. 2013 Mar; 9(3): doi:10.1371/annotation/2c4b89c1-6d4a-4bf3-9467-9367227d7e74. Turro, Ernest [added].


BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV.

Paschos K, Parker GA, Watanatanasup E, White RE, Allday MJ.

Nucleic Acids Res. 2012 Aug;40(15):7233-46. doi: 10.1093/nar/gks391. Epub 2012 May 14.


EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.

White RE, Rämer PC, Naresh KN, Meixlsperger S, Pinaud L, Rooney C, Savoldo B, Coutinho R, Bödör C, Gribben J, Ibrahim HA, Bower M, Nourse JP, Gandhi MK, Middeldorp J, Cader FZ, Murray P, Münz C, Allday MJ.

J Clin Invest. 2012 Apr;122(4):1487-502. doi: 10.1172/JCI58092. Epub 2012 Mar 12.


Latent Epstein-Barr virus can inhibit apoptosis in B cells by blocking the induction of NOXA expression.

Yee J, White RE, Anderton E, Allday MJ.

PLoS One. 2011;6(12):e28506. doi: 10.1371/journal.pone.0028506. Epub 2011 Dec 9.


Epigenetic regulation of the latency-associated region of Marek's disease virus in tumor-derived T-cell lines and primary lymphoma.

Brown AC, Nair V, Allday MJ.

J Virol. 2012 Feb;86(3):1683-95. doi: 10.1128/JVI.06113-11. Epub 2011 Nov 16.


An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.

Nikitin PA, Yan CM, Forte E, Bocedi A, Tourigny JP, White RE, Allday MJ, Patel A, Dave SS, Kim W, Hu K, Guo J, Tainter D, Rusyn E, Luftig MA.

Cell Host Microbe. 2010 Dec 16;8(6):510-22. doi: 10.1016/j.chom.2010.11.004.


Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification.

White RE, Groves IJ, Turro E, Yee J, Kremmer E, Allday MJ.

PLoS One. 2010 Nov 15;5(11):e13979. doi: 10.1371/journal.pone.0013979.


Epigenetic reprogramming of host genes in viral and microbial pathogenesis.

Paschos K, Allday MJ.

Trends Microbiol. 2010 Oct;18(10):439-47. doi: 10.1016/j.tim.2010.07.003. Epub 2010 Aug 18. Review.


Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.

Skalska L, White RE, Franz M, Ruhmann M, Allday MJ.

PLoS Pathog. 2010 Jun 10;6(6):e1000951. doi: 10.1371/journal.ppat.1000951.


Homodimerization of the Meq viral oncoprotein is necessary for induction of T-cell lymphoma by Marek's disease virus.

Brown AC, Smith LP, Kgosana L, Baigent SJ, Nair V, Allday MJ.

J Virol. 2009 Nov;83(21):11142-51. doi: 10.1128/JVI.01393-09. Epub 2009 Aug 19.


How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma?

Allday MJ.

Semin Cancer Biol. 2009 Dec;19(6):366-76. doi: 10.1016/j.semcancer.2009.07.007. Epub 2009 Jul 25. Review.


Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim.

Paschos K, Smith P, Anderton E, Middeldorp JM, White RE, Allday MJ.

PLoS Pathog. 2009 Jun;5(6):e1000492. doi: 10.1371/journal.ppat.1000492. Epub 2009 Jun 26.


TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL.

Spender LC, O'Brien DI, Simpson D, Dutt D, Gregory CD, Allday MJ, Clark LJ, Inman GJ.

Cell Death Differ. 2009 Apr;16(4):593-602. doi: 10.1038/cdd.2008.183. Epub 2009 Jan 9.


The curious case of the tumour virus: 50 years of Burkitt's lymphoma.

Thorley-Lawson DA, Allday MJ.

Nat Rev Microbiol. 2008 Dec;6(12):913-24. doi: 10.1038/nrmicro2015. Review. Erratum in: Nat Rev Microbiol. 2009 Feb;7(2):172.


Epstein-Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and co-chaperones.

Young P, Anderton E, Paschos K, White R, Allday MJ.

J Gen Virol. 2008 Apr;89(Pt 4):866-77. doi: 10.1099/vir.0.83414-0.


Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma.

Anderton E, Yee J, Smith P, Crook T, White RE, Allday MJ.

Oncogene. 2008 Jan 17;27(4):421-33. Epub 2007 Jul 23.


Mutagenesis of the herpesvirus saimiri terminal repeat region reveals important elements for virus production.

White RE, Carline L, Allday MJ.

J Virol. 2007 Jun;81(12):6765-70. Epub 2007 Apr 11.


Epstein-barr virus-induced resistance to drugs that activate the mitotic spindle assembly checkpoint in Burkitt's lymphoma cells.

Leao M, Anderton E, Wade M, Meekings K, Allday MJ.

J Virol. 2007 Jan;81(1):248-60. Epub 2006 Oct 11.


The transcriptional co-repressor C-terminal binding protein (CtBP) associates with centrosomes during mitosis.

Spyer M, Allday MJ.

Cell Cycle. 2006 Mar;5(5):530-7. Epub 2006 Mar 1.


Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus.

Brown AC, Baigent SJ, Smith LP, Chattoo JP, Petherbridge LJ, Hawes P, Allday MJ, Nair V.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1687-92. Epub 2006 Jan 30.


MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

Sdek P, Ying H, Chang DL, Qiu W, Zheng H, Touitou R, Allday MJ, Xiao ZX.

Mol Cell. 2005 Dec 9;20(5):699-708.


Deregulation of the cell cycle by the Epstein-Barr virus.

O'Nions J, Allday MJ.

Adv Cancer Res. 2004;92:119-86. Review. No abstract available.


Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2.

O'Nions J, Allday MJ.

Oncogene. 2003 Oct 16;22(46):7181-91. Erratum in: Oncogene. 2004 Aug 19;23(37):6326.


Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP).

Hickabottom M, Parker GA, Freemont P, Crook T, Allday MJ.

J Biol Chem. 2002 Dec 6;277(49):47197-204. Epub 2002 Oct 7.


Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C.

Touitou R, Hickabottom M, Parker G, Crook T, Allday MJ.

J Virol. 2001 Aug;75(16):7749-55.


A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.

Touitou R, Richardson J, Bose S, Nakanishi M, Rivett J, Allday MJ.

EMBO J. 2001 May 15;20(10):2367-75.


High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

Crook T, Nicholls JM, Brooks L, O'Nions J, Allday MJ.

Oncogene. 2000 Jul 13;19(30):3439-44.


A common polymorphism acts as an intragenic modifier of mutant p53 behaviour.

Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, James N, McGregor JM, Harwood CA, Yulug IG, Vousden KH, Allday MJ, Gusterson B, Ikawa S, Hinds PW, Crook T, Kaelin WG Jr.

Nat Genet. 2000 May;25(1):47-54.


Epstein-Barr virus suppresses a G(2)/M checkpoint activated by genotoxins.

Wade M, Allday MJ.

Mol Cell Biol. 2000 Feb;20(4):1344-60.


Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription.

Radkov SA, Touitou R, Brehm A, Rowe M, West M, Kouzarides T, Allday MJ.

J Virol. 1999 Jul;73(7):5688-97.

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