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An <i>in vitro</i> intestinal platform with a self-sustaining oxygen gradient to study the human gut/microbiome interface.

Kim R, Attayek P, Wang Y, Furtado K, Tamayo R, Sims CE, Allbritton N.

Biofabrication. 2019 Sep 13. doi: 10.1088/1758-5090/ab446e. [Epub ahead of print]


Automated sensing and splitting of stem cell colonies on microraft arrays.

DiSalvo M, Smiddy NM, Allbritton NL.

APL Bioeng. 2019 Aug 29;3(3):036106. doi: 10.1063/1.5113719. eCollection 2019 Sep.


Building a Thick Mucus Hydrogel Layer to Improve the Physiological Relevance of In Vitro Primary Colonic Epithelial Models.

Wang Y, Kim R, Sims CE, Allbritton NL.

Cell Mol Gastroenterol Hepatol. 2019 Jul 26. pii: S2352-345X(19)30097-9. doi: 10.1016/j.jcmgh.2019.07.009. [Epub ahead of print] No abstract available.


Selection and optimization of enzyme reporters for chemical cytometry.

Proctor A, Wang Q, Lawrence DS, Allbritton NL.

Methods Enzymol. 2019;622:221-248. doi: 10.1016/bs.mie.2019.02.023. Epub 2019 Mar 23.


Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking.

Speer JE, Gunasekara DB, Wang Y, Fallon JK, Attayek PJ, Smith PC, Sims CE, Allbritton NL.

J Biol Eng. 2019 Apr 27;13:36. doi: 10.1186/s13036-019-0165-4. eCollection 2019.


Primary Cell-Derived Intestinal Models: Recapitulating Physiology.

Dutton JS, Hinman SS, Kim R, Wang Y, Allbritton NL.

Trends Biotechnol. 2019 Jul;37(7):744-760. doi: 10.1016/j.tibtech.2018.12.001. Epub 2018 Dec 24. Review.


A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies.

Gunasekara DB, Speer J, Wang Y, Nguyen DL, Reed MI, Smiddy NM, Parker JS, Fallon JK, Smith PC, Sims CE, Magness ST, Allbritton NL.

Anal Chem. 2018 Nov 20;90(22):13331-13340. doi: 10.1021/acs.analchem.8b02845. Epub 2018 Oct 30.


Colonic epithelial miR-31 associates with the development of Crohn's phenotypes.

Keith BP, Barrow JB, Toyonaga T, Kazgan N, O'Connor MH, Shah ND, Schaner MS, Wolber EA, Trad OK, Gipson GR, Pitman WA, Kanke M, Saxena SJ, Chaumont N, Sadiq TS, Koruda MJ, Cotney PA, Allbritton N, Trembath DG, Sylvester F, Furey TS, Sethupathy P, Sheikh SZ.

JCI Insight. 2018 Oct 4;3(19). pii: 122788. doi: 10.1172/jci.insight.122788.


"Fix and assay": separating in-cellulo sphingolipid reactions from analytical assay in time and space using an aldehyde-based fixative.

Proctor A, Allbritton NL.

Analyst. 2019 Jan 28;144(3):961-971. doi: 10.1039/c8an01353e.


Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human-Intestinal-Epithelial-Monolayer Platform.

Wang Y, Kim R, Hwang SJ, Dutton J, Sims CE, Allbritton NL.

Anal Chem. 2018 Oct 2;90(19):11523-11530. doi: 10.1021/acs.analchem.8b02835. Epub 2018 Sep 21.


A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology.

Williamson IA, Arnold JW, Samsa LA, Gaynor L, DiSalvo M, Cocchiaro JL, Carroll I, Azcarate-Peril MA, Rawls JF, Allbritton NL, Magness ST.

Cell Mol Gastroenterol Hepatol. 2018 May 22;6(3):301-319. doi: 10.1016/j.jcmgh.2018.05.004. eCollection 2018.


Formation of arrays of planar, murine, intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone.

Kim R, Wang Y, Hwang SJ, Attayek PJ, Smiddy NM, Reed MI, Sims CE, Allbritton NL.

Lab Chip. 2018 Jul 24;18(15):2202-2213. doi: 10.1039/c8lc00332g.


Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer.

Wang Y, Kim R, Gunasekara DB, Reed MI, DiSalvo M, Nguyen DL, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

Cell Mol Gastroenterol Hepatol. 2017 Nov 3;5(2):113-130. doi: 10.1016/j.jcmgh.2017.10.007. eCollection 2018.


Bioengineered Systems and Designer Matrices That Recapitulate the Intestinal Stem Cell Niche.

Wang Y, Kim R, Hinman SS, Zwarycz B, Magness ST, Allbritton NL.

Cell Mol Gastroenterol Hepatol. 2018 Jan 17;5(3):440-453.e1. doi: 10.1016/j.jcmgh.2018.01.008. eCollection 2018 Mar. Review.


Characterization of Tensioned PDMS Membranes for Imaging Cytometry on Microraft Arrays.

DiSalvo M, Harris DM, Kantesaria S, Peña AN, Allbritton-King JD, Cole JH, Allbritton NL.

Anal Chem. 2018 Apr 3;90(7):4792-4800. doi: 10.1021/acs.analchem.8b00176. Epub 2018 Mar 13.


LITE microscopy: Tilted light-sheet excitation of model organisms offers high resolution and low photobleaching.

Fadero TC, Gerbich TM, Rana K, Suzuki A, DiSalvo M, Schaefer KN, Heppert JK, Boothby TC, Goldstein B, Peifer M, Allbritton NL, Gladfelter AS, Maddox AS, Maddox PS.

J Cell Biol. 2018 May 7;217(5):1869-1882. doi: 10.1083/jcb.201710087. Epub 2018 Feb 28.


Design and Application of Sensors for Chemical Cytometry.

Vickerman BM, Anttila MM, Petersen BV, Allbritton NL, Lawrence DS.

ACS Chem Biol. 2018 Jul 20;13(7):1741-1751. doi: 10.1021/acschembio.7b01009. Epub 2018 Feb 8. Review.


Development of Arrayed Colonic Organoids for Screening of Secretagogues Associated with Enterotoxins.

Gunasekara DB, DiSalvo M, Wang Y, Nguyen DL, Reed MI, Speer J, Sims CE, Magness ST, Allbritton NL.

Anal Chem. 2018 Feb 6;90(3):1941-1950. doi: 10.1021/acs.analchem.7b04032. Epub 2018 Jan 12.


N-Gemini peptides: cytosolic protease resistance via N-terminal dimerization of unstructured peptides.

Fayer EL, Gilliland WM, Ramsey JM, Allbritton NL, Waters ML.

Chem Commun (Camb). 2017 Dec 21;54(2):204-207. doi: 10.1039/c7cc06819k.


Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells.

Wang Y, DiSalvo M, Gunasekara DB, Dutton J, Proctor A, Lebhar MS, Williamson IA, Speer J, Howard RL, Smiddy NM, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

Cell Mol Gastroenterol Hepatol. 2017 Mar 6;4(1):165-182.e7. doi: 10.1016/j.jcmgh.2017.02.011. eCollection 2017 Jul.


Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells.

Bhatt AP, Gunasekara DB, Speer J, Reed MI, Peña AN, Midkiff BR, Magness ST, Bultman SJ, Allbritton NL, Redinbo MR.

ACS Infect Dis. 2018 Jan 12;4(1):46-52. doi: 10.1021/acsinfecdis.7b00139. Epub 2017 Nov 10.


In Vitro Generation of Mouse Colon Crypts.

Wang Y, Gunasekara DB, Attayek PJ, Reed MI, DiSalvo M, Nguyen DL, Dutton JS, Lebhar MS, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

ACS Biomater Sci Eng. 2017 Oct 9;3(10):2502-2513. doi: 10.1021/acsbiomaterials.7b00368. Epub 2017 Aug 29.


Required hydrophobicity of fluorescent reporters for phosphatidylinositol family of lipid enzymes.

Waybright J, Huang W, Proctor A, Wang X, Allbritton NL, Zhang Q.

Anal Bioanal Chem. 2017 Nov;409(29):6781-6789. doi: 10.1007/s00216-017-0633-y. Epub 2017 Sep 20.


Chemical fixation to arrest phospholipid signaling for chemical cytometry.

Proctor A, Sims CE, Allbritton NL.

J Chromatogr A. 2017 Nov 10;1523:97-106. doi: 10.1016/j.chroma.2017.05.022. Epub 2017 May 10.


Development of β-Hairpin Peptides for the Measurement of SCF-Family E3 Ligase Activity in Vitro via Ornithine Ubiquitination.

Houston KM, Melvin AT, Woss GS, Fayer EL, Waters ML, Allbritton NL.

ACS Omega. 2017 Mar 31;2(3):1198-1206. doi: 10.1021/acsomega.7b00109. Epub 2017 Mar 29.


A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium.

Wang Y, Gunasekara DB, Reed MI, DiSalvo M, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

Biomaterials. 2017 Jun;128:44-55. doi: 10.1016/j.biomaterials.2017.03.005. Epub 2017 Mar 6.


Automated microraft platform to identify and collect non-adherent cells successfully gene-edited with CRISPR-Cas9.

Attayek PJ, Waugh JP, Hunsucker SA, Grayeski PJ, Sims CE, Armistead PM, Allbritton NL.

Biosens Bioelectron. 2017 May 15;91:175-182. doi: 10.1016/j.bios.2016.12.019. Epub 2016 Dec 10.


Identification and isolation of antigen-specific cytotoxic T lymphocytes with an automated microraft sorting system.

Attayek PJ, Hunsucker SA, Sims CE, Allbritton NL, Armistead PM.

Integr Biol (Camb). 2016 Dec 5;8(12):1208-1220.


Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells.

Proctor A, Zigoneanu IG, Wang Q, Sims CE, Lawrence DS, Allbritton NL.

Analyst. 2016 Oct 17;141(21):6008-6017. doi: 10.1039/c6an01378c.


An Integrated Chemical Cytometry Method: Shining a Light on Akt Activity in Single Cells.

Mainz ER, Wang Q, Lawrence DS, Allbritton NL.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13095-13098. doi: 10.1002/anie.201606914.


Selective single cell isolation for genomics using microraft arrays.

Welch JD, Williams LA, DiSalvo M, Brandt AT, Marayati R, Sims CE, Allbritton NL, Prins JF, Yeh JJ, Jones CD.

Nucleic Acids Res. 2016 Sep 30;44(17):8292-301. doi: 10.1093/nar/gkw700. Epub 2016 Aug 16.


Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.

Mainz ER, Serafin DS, Nguyen TT, Tarrant TK, Sims CE, Allbritton NL.

Anal Chem. 2016 Aug 2;88(15):7786-92. doi: 10.1021/acs.analchem.6b01801. Epub 2016 Jul 20.


In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment.

Attayek PJ, Ahmad AA, Wang Y, Williamson I, Sims CE, Magness ST, Allbritton NL.

PLoS One. 2016 Apr 21;11(4):e0153795. doi: 10.1371/journal.pone.0153795. eCollection 2016.


Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism.

Koh J, Hogue JA, Wang Y, DiSalvo M, Allbritton NL, Shi Y, Olson JA Jr, Sosa JA.

J Cell Mol Med. 2016 Feb;20(2):351-9. doi: 10.1111/jcmm.12732. Epub 2015 Dec 5.


Single-cell approaches for molecular classification of endocrine tumors.

Koh J, Allbritton NL, Sosa JA.

Curr Opin Oncol. 2016 Jan;28(1):43-9. doi: 10.1097/CCO.0000000000000246. Review.


Rational Design of a Dephosphorylation-Resistant Reporter Enables Single-Cell Measurement of Tyrosine Kinase Activity.

Turner AH, Lebhar MS, Proctor A, Wang Q, Lawrence DS, Allbritton NL.

ACS Chem Biol. 2016 Feb 19;11(2):355-62. doi: 10.1021/acschembio.5b00667. Epub 2015 Dec 4.


Array-Based Platform To Select, Release, and Capture Epstein-Barr Virus-Infected Cells Based on Intercellular Adhesion.

Attayek PJ, Hunsucker SA, Wang Y, Sims CE, Armistead PM, Allbritton NL.

Anal Chem. 2015 Dec 15;87(24):12281-9. doi: 10.1021/acs.analchem.5b03579. Epub 2015 Nov 23.


Identification of a p53-based portable degron based on the MDM2-p53 binding region.

Melvin AT, Dumberger LD, Woss GS, Waters ML, Allbritton NL.

Analyst. 2016 Jan 21;141(2):570-8. doi: 10.1039/c5an01429h.


Co-fabrication of chitosan and epoxy photoresist to form microwell arrays with permeable hydrogel bottoms.

Ornoff DM, Wang Y, Proctor A, Shah AS, Allbritton NL.

Biomaterials. 2016 Jan;74:77-88. doi: 10.1016/j.biomaterials.2015.09.032. Epub 2015 Sep 28.


Separation of peptide fragments of a protein kinase C substrate fused to a β-hairpin by capillary electrophoresis.

Zigoneanu IG, Sims CE, Allbritton NL.

Anal Bioanal Chem. 2015 Dec;407(30):8999-9008. doi: 10.1007/s00216-015-9065-8. Epub 2015 Oct 1.


Magnetic Alignment of Microelements Containing Cultured Neuronal Networks for High-Throughput Screening.

Gordon KR, Wang Y, Allbritton NL, Taylor AM.

J Biomol Screen. 2015 Oct;20(9):1091-100. doi: 10.1177/1087057115598609. Epub 2015 Aug 6.


Pronase E-Based Generation of Fluorescent Peptide Fragments: Tracking Intracellular Peptide Fate in Single Cells.

Mainz ER, Dobes NC, Allbritton NL.

Anal Chem. 2015 Aug 4;87(15):7987-95. doi: 10.1021/acs.analchem.5b01929. Epub 2015 Jul 24.


Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.

Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP.

Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24.


Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood.

Dickinson AJ, Meyer M, Pawlak EA, Gomez S, Jaspers I, Allbritton NL.

Integr Biol (Camb). 2015 Apr;7(4):392-401. doi: 10.1039/c5ib00007f.


Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons.

Niedringhaus M, Dumitru R, Mabb AM, Wang Y, Philpot BD, Allbritton NL, Taylor AM.

Sci Rep. 2015 Feb 10;5:8353. doi: 10.1038/srep08353.


A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis.

Gracz AD, Williamson IA, Roche KC, Johnston MJ, Wang F, Wang Y, Attayek PJ, Balowski J, Liu XF, Laurenza RJ, Gaynor LT, Sims CE, Galanko JA, Li L, Allbritton NL, Magness ST.

Nat Cell Biol. 2015 Mar;17(3):340-9. doi: 10.1038/ncb3104. Epub 2015 Feb 9.


Single-cell sphingosine kinase activity measurements in primary leukemia.

Dickinson AJ, Hunsucker SA, Armistead PM, Allbritton NL.

Anal Bioanal Chem. 2014 Nov;406(27):7027-36. doi: 10.1007/s00216-014-7974-6. Epub 2014 Jul 1.


Small sample sorting of primary adherent cells by automated micropallet imaging and release.

Shah PK, Herrera-Loeza SG, Sims CE, Yeh JJ, Allbritton NL.

Cytometry A. 2014 Jul;85(7):642-9. doi: 10.1002/cyto.a.22480. Epub 2014 Jun 17.


Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.

Shah PK, Walker MP, Sims CE, Major MB, Allbritton NL.

Integr Biol (Camb). 2014 Jul 24;6(7):673-84. doi: 10.1039/c4ib00050a. Epub 2014 May 28.


Measurement of protein kinase B activity in single primary human pancreatic cancer cells.

Proctor A, Herrera-Loeza SG, Wang Q, Lawrence DS, Yeh JJ, Allbritton NL.

Anal Chem. 2014 May 6;86(9):4573-80. doi: 10.1021/ac500616q. Epub 2014 Apr 18.

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