Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 46

1.

Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities.

Bisi A, Mokhtar Mahmoud A, Allará M, Naldi M, Belluti F, Gobbi S, Ligresti A, Rampa A.

ACS Med Chem Lett. 2019 Feb 26;10(4):596-600. doi: 10.1021/acsmedchemlett.8b00594. eCollection 2019 Apr 11.

PMID:
30996802
2.

Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach.

D'Aniello E, Fellous T, Iannotti FA, Gentile A, Allarà M, Balestrieri F, Gray R, Amodeo P, Vitale RM, Di Marzo V.

Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):586-597. doi: 10.1016/j.bbagen.2019.01.002. Epub 2019 Jan 3.

PMID:
30611848
3.

FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.

Ligresti A, Silvestri C, Vitale RM, Martos JL, Piscitelli F, Wang JW, Allarà M, Carling RW, Luongo L, Guida F, Illiano A, Amoresano A, Maione S, Amodeo P, Woodward DF, Di Marzo V, Marino G.

ACS Chem Neurosci. 2019 Jan 16;10(1):424-437. doi: 10.1021/acschemneuro.8b00315. Epub 2018 Oct 4.

PMID:
30226747
4.

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.

Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, di Marzo V, Butini S, Gemma S.

ChemMedChem. 2018 Oct 8;13(19):2090-2103. doi: 10.1002/cmdc.201800397. Epub 2018 Aug 30.

PMID:
30085402
5.

Endocrine disruptors in the diet of male Sparus aurata: Modulation of the endocannabinoid system at the hepatic and central level by Di-isononyl phthalate and Bisphenol A.

Forner-Piquer I, Mylonas CC, Calduch-Giner J, Maradonna F, Gioacchini G, Allarà M, Piscitelli F, Di Marzo V, Pérez-Sánchez J, Carnevali O.

Environ Int. 2018 Oct;119:54-65. doi: 10.1016/j.envint.2018.06.011. Epub 2018 Jun 19.

PMID:
29933238
6.

Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis.

Petrosino S, Verde R, Vaia M, Allarà M, Iuvone T, Di Marzo V.

J Pharmacol Exp Ther. 2018 Jun;365(3):652-663. doi: 10.1124/jpet.117.244368. Epub 2018 Apr 9.

PMID:
29632236
7.

Endocannabinoid Tone Regulates Human Sebocyte Biology.

Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch J, Di Marzo V, Bíró T, Szabó T.

J Invest Dermatol. 2018 Aug;138(8):1699-1706. doi: 10.1016/j.jid.2018.02.022. Epub 2018 Mar 6.

8.

Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish.

Forner-Piquer I, Maradonna F, Gioacchini G, Santangeli S, Allarà M, Piscitelli F, Habibi HR, Di Marzo V, Carnevali O.

Endocrinology. 2017 Oct 1;158(10):3462-3476. doi: 10.1210/en.2017-00458.

PMID:
28938452
9.

2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation.

Petrosino S, Campolo M, Impellizzeri D, Paterniti I, Allarà M, Gugliandolo E, D'Amico R, Siracusa R, Cordaro M, Esposito E, Di Marzo V, Cuzzocrea S.

Front Pharmacol. 2017 May 30;8:308. doi: 10.3389/fphar.2017.00308. eCollection 2017.

10.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M.

Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497.

11.

Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.

Romero-Parra J, Mella-Raipán J, Palmieri V, Allarà M, Torres MJ, Pessoa-Mahana H, Iturriaga-Vásquez P, Escobar R, Faúndez M, Di Marzo V, Pessoa-Mahana CD.

Eur J Med Chem. 2016 Nov 29;124:17-35. doi: 10.1016/j.ejmech.2016.08.005. Epub 2016 Aug 5.

PMID:
27560280
12.

Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality.

Osman NA, Ligresti A, Klein CD, Allarà M, Rabbito A, Di Marzo V, Abouzid KA, Abadi AH.

Eur J Med Chem. 2016 Oct 21;122:619-634. doi: 10.1016/j.ejmech.2016.07.012. Epub 2016 Jul 9.

PMID:
27448919
13.

Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop.

Martella A, Silvestri C, Maradonna F, Gioacchini G, Allarà M, Radaelli G, Overby DR, Di Marzo V, Carnevali O.

Endocrinology. 2016 May;157(5):1751-63. doi: 10.1210/en.2015-1384. Epub 2016 Mar 25.

14.

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress.

Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano Moriello A, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A.

ACS Chem Neurosci. 2016 Jun 15;7(6):737-48. doi: 10.1021/acschemneuro.5b00333. Epub 2016 Mar 22.

PMID:
26942555
15.

Arylboronic acids as dual-action FAAH and TRPV1 ligands.

Morera E, Di Marzo V, Monti L, Allarà M, Schiano Moriello A, Nalli M, Ortar G, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1401-5. doi: 10.1016/j.bmcl.2016.01.071. Epub 2016 Jan 25.

PMID:
26850005
16.

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility.

Mugnaini C, Brizzi A, Ligresti A, Allarà M, Lamponi S, Vacondio F, Silva C, Mor M, Di Marzo V, Corelli F.

J Med Chem. 2016 Feb 11;59(3):1052-67. doi: 10.1021/acs.jmedchem.5b01559. Epub 2016 Jan 26.

PMID:
26756097
17.

Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis.

Petrosino S, Puigdemont A, Della Valle MF, Fusco M, Verde R, Allarà M, Aveta T, Orlando P, Di Marzo V.

Vet J. 2016 Jan;207:85-91. doi: 10.1016/j.tvjl.2015.10.060. Epub 2015 Nov 10.

PMID:
26639824
18.

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.

Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H, Allarà M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, Overkleeft HS, Hankemeier T, Werkman TR, Cravatt BF, van der Stelt M.

J Am Chem Soc. 2015 Jul 15;137(27):8851-7. doi: 10.1021/jacs.5b04883. Epub 2015 Jul 1.

19.

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.

Bertini S, Parkkari T, Savinainen JR, Arena C, Saccomanni G, Saguto S, Ligresti A, Allarà M, Bruno A, Marinelli L, Di Marzo V, Novellino E, Manera C, Macchia M.

Eur J Med Chem. 2015 Jan 27;90:526-36. doi: 10.1016/j.ejmech.2014.11.066. Epub 2014 Dec 2.

PMID:
25486424
20.

Diacerein is a potent and selective inhibitor of palmitoylethanolamide inactivation with analgesic activity in a rat model of acute inflammatory pain.

Petrosino S, Ahmad A, Marcolongo G, Esposito E, Allarà M, Verde R, Cuzzocrea S, Di Marzo V.

Pharmacol Res. 2015 Jan;91:9-14. doi: 10.1016/j.phrs.2014.10.008. Epub 2014 Nov 1.

PMID:
25447594
21.

CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.

Lucchesi V, Hurst DP, Shore DM, Bertini S, Ehrmann BM, Allarà M, Lawrence L, Ligresti A, Minutolo F, Saccomanni G, Sharir H, Macchia M, Di Marzo V, Abood ME, Reggio PH, Manera C.

J Med Chem. 2014 Nov 13;57(21):8777-91. doi: 10.1021/jm500807e. Epub 2014 Oct 15.

22.

Mooreamide A: a cannabinomimetic lipid from the marine cyanobacterium Moorea bouillonii.

Mevers E, Matainaho T, Allara' M, Di Marzo V, Gerwick WH.

Lipids. 2014 Nov;49(11):1127-32. doi: 10.1007/s11745-014-3949-9. Epub 2014 Sep 10.

PMID:
25204580
23.

Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6.

Janssen FJ, Deng H, Baggelaar MP, Allarà M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R, Di Marzo V, Overkleeft HS, van der Stelt M.

J Med Chem. 2014 Aug 14;57(15):6610-22. doi: 10.1021/jm500681z. Epub 2014 Jul 23.

PMID:
24988361
24.

1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.

Lucchesi V, Parkkari T, Savinainen JR, Malfitano AM, Allarà M, Bertini S, Castelli F, Del Carlo S, Laezza C, Ligresti A, Saccomanni G, Bifulco M, Di Marzo V, Macchia M, Manera C.

Eur J Med Chem. 2014 Mar 3;74:524-32. doi: 10.1016/j.ejmech.2013.10.070. Epub 2014 Jan 21.

PMID:
24518874
25.

Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain.

Baggelaar MP, Janssen FJ, van Esbroeck AC, den Dulk H, Allarà M, Hoogendoorn S, McGuire R, Florea BI, Meeuwenoord N, van den Elst H, van der Marel GA, Brouwer J, Di Marzo V, Overkleeft HS, van der Stelt M.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12081-5. doi: 10.1002/anie.201306295. Epub 2013 Oct 31. No abstract available.

PMID:
24173880
26.

The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.

Valdeolivas S, Pazos MR, Bisogno T, Piscitelli F, Iannotti FA, Allarà M, Sagredo O, Di Marzo V, Fernández-Ruiz J.

Cell Death Dis. 2013 Oct 17;4:e862. doi: 10.1038/cddis.2013.387.

27.

Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition.

Ligresti A, Martos J, Wang J, Guida F, Allarà M, Palmieri V, Luongo L, Woodward D, Di Marzo V.

Br J Pharmacol. 2014 Mar;171(6):1408-19. doi: 10.1111/bph.12410.

28.

Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats.

Iannotti FA, Piscitelli F, Martella A, Mazzarella E, Allarà M, Palmieri V, Parrella C, Capasso R, Di Marzo V.

Prostaglandins Leukot Essent Fatty Acids. 2013 Aug;89(2-3):127-35. doi: 10.1016/j.plefa.2013.06.002. Epub 2013 Jul 2.

PMID:
23830028
29.

Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.

Ortar G, De Petrocellis L, Moriello AS, Allarà M, Morera E, Nalli M, Di Marzo V.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):138-42. doi: 10.1016/j.bmcl.2012.10.137. Epub 2012 Nov 12.

PMID:
23206861
30.

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.

Rizzo S, Tarozzi A, Bartolini M, Da Costa G, Bisi A, Gobbi S, Belluti F, Ligresti A, Allarà M, Monti JP, Andrisano V, Di Marzo V, Hrelia P, Rampa A.

Eur J Med Chem. 2012 Dec;58:519-32. doi: 10.1016/j.ejmech.2012.10.045. Epub 2012 Nov 2.

PMID:
23164658
31.

A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects.

Bisogno T, Mahadevan A, Coccurello R, Chang JW, Allarà M, Chen Y, Giacovazzo G, Lichtman A, Cravatt B, Moles A, Di Marzo V.

Br J Pharmacol. 2013 Jun;169(4):784-93. doi: 10.1111/bph.12013.

32.

Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.

Piscitelli F, Ligresti A, La Regina G, Coluccia A, Morera L, Allarà M, Novellino E, Di Marzo V, Silvestri R.

J Med Chem. 2012 Jun 14;55(11):5627-31. doi: 10.1021/jm201485c. Epub 2012 May 17.

PMID:
22571451
33.

Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand.

Ligresti A, Villano R, Allarà M, Ujváry I, Di Marzo V.

Pharmacol Res. 2012 Aug;66(2):163-9. doi: 10.1016/j.phrs.2012.04.003. Epub 2012 Apr 14.

PMID:
22525682
34.

Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes.

Taher AT, Kadry HH, Allarà M, Di Marzo V, Abadi AH, Abouzid KA.

J Enzyme Inhib Med Chem. 2013 Jun;28(3):436-9. doi: 10.3109/14756366.2011.645241. Epub 2012 Jan 3.

PMID:
22214210
35.

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands.

Piscitelli F, Ligresti A, La Regina G, Gatti V, Brizzi A, Pasquini S, Allarà M, Carai MA, Novellino E, Colombo G, Di Marzo V, Corelli F, Silvestri R.

Eur J Med Chem. 2011 Nov;46(11):5641-53. doi: 10.1016/j.ejmech.2011.09.037. Epub 2011 Sep 29.

PMID:
21996466
36.

Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).

Pollastro F, Taglialatela-Scafati O, Allarà M, Muñoz E, Di Marzo V, De Petrocellis L, Appendino G.

J Nat Prod. 2011 Sep 23;74(9):2019-22. doi: 10.1021/np200500p. Epub 2011 Sep 8.

PMID:
21902175
37.

Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor.

Cichero E, Ligresti A, Allarà M, di Marzo V, Lazzati Z, D'Ursi P, Marabotti A, Milanesi L, Spallarossa A, Ranise A, Fossa P.

Eur J Med Chem. 2011 Sep;46(9):4489-505. doi: 10.1016/j.ejmech.2011.07.023. Epub 2011 Jul 23.

PMID:
21835510
38.

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.

De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, Stott CG, Di Marzo V.

Br J Pharmacol. 2011 Aug;163(7):1479-94. doi: 10.1111/j.1476-5381.2010.01166.x.

39.

Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands.

Osman NA, Mahmoud AH, Allarà M, Niess R, Abouzid KA, Di Marzo V, Abadi AH.

Bioorg Med Chem. 2010 Dec 15;18(24):8463-77. doi: 10.1016/j.bmc.2010.10.050. Epub 2010 Oct 27.

PMID:
21074998
40.

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.

Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Lavecchia A, Brizzi A, Pasquini S, Allarà M, Fantini N, Carai MA, Bigogno C, Rozio MG, Sinisi R, Novellino E, Colombo G, Di Marzo V, Dondio G, Corelli F.

Eur J Med Chem. 2010 Dec;45(12):5878-86. doi: 10.1016/j.ejmech.2010.09.053. Epub 2010 Oct 1.

PMID:
20943290
41.

Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.

Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Brizzi A, Pasquini S, Lavecchia A, Allarà M, Fantini N, Carai MA, Novellino E, Colombo G, Di Marzo V, Corelli F.

Bioorg Med Chem. 2009 Aug 1;17(15):5549-64. doi: 10.1016/j.bmc.2009.06.027. Epub 2009 Jun 21.

PMID:
19595596
42.

Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.

Appendino G, Ligresti A, Minassi A, Cascio MG, Allarà M, Taglialatela-Scafati O, Pertwee RG, De Petrocellis L, Di Marzo V.

J Med Chem. 2009 May 14;52(9):3001-9. doi: 10.1021/jm900130m.

PMID:
19361197
43.

Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.

Bisogno T, Burston JJ, Rai R, Allarà M, Saha B, Mahadevan A, Razdan RK, Wiley JL, Di Marzo V.

ChemMedChem. 2009 Jun;4(6):946-50. doi: 10.1002/cmdc.200800442.

PMID:
19266526
44.

New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.

Manera C, Cascio MG, Benetti V, Allarà M, Tuccinardi T, Martinelli A, Saccomanni G, Vivoli E, Ghelardini C, Di Marzo V, Ferrarini PL.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. Epub 2007 Oct 1.

PMID:
17942307
45.

[Method of calculation of doses of drugs in childhood].

Nasso S, Allara M.

Minerva Pediatr. 1971 Sep 15;23(37):1505-6. Italian. No abstract available.

PMID:
5131912
46.

[Use of local corticosteroid therapy in peripheral tuberculous lymphadenitis].

Nasso S, Pedretti G, Allara M.

Minerva Pediatr. 1969 Nov 3;21(44):2087. Italian. No abstract available.

PMID:
5405648

Supplemental Content

Loading ...
Support Center