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Items: 1 to 50 of 143

1.

Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence.

McCulloch L, Allan SM, Emsley HC, Smith CJ, McColl BW.

Version 2. F1000Res. 2019 Jul 10 [revised 2019 Jan 1];8:1039. doi: 10.12688/f1000research.19308.2. eCollection 2019.

2.

Selective Liposomal Transport through Blood Brain Barrier Disruption in Ischemic Stroke Reveals Two Distinct Therapeutic Opportunities.

Al-Ahmady ZS, Jasim D, Ahmad SS, Wong R, Haley M, Coutts G, Schiessl I, Allan SM, Kostarelos K.

ACS Nano. 2019 Nov 6. doi: 10.1021/acsnano.9b01808. [Epub ahead of print]

PMID:
31693858
3.

Pentraxin 3 regulates neutrophil infiltration to the brain during neuroinflammation.

Rajkovic I, Wong R, Lemarchand E, Tinker R, Allan SM, Pinteaux E.

AMRC Open Res. 2019 May 15;1:10. doi: 10.12688/amrcopenres.12875.1.

4.

Early Intervention in Psychosis Treatment Components Utilization in Patients Aged Over 35.

Jagger G, de la Fuente-Tomas L, Stochl J, Allan SM, Clay F, Kenedler L, Treise C, Perez J.

Community Ment Health J. 2019 Sep 28. doi: 10.1007/s10597-019-00479-5. [Epub ahead of print]

PMID:
31564011
5.

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke.

Crilly S, Njegic A, Parry-Jones AR, Allan SM, Kasher PR.

J Vis Exp. 2019 Jun 5;(148). doi: 10.3791/59716.

PMID:
31233021
6.

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Lemarchand E, Barrington J, Chenery A, Haley M, Coutts G, Allen JE, Allan SM, Brough D.

Stroke. 2019 May;50(5):1232-1239. doi: 10.1161/STROKEAHA.118.023620.

7.

Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.

O'Boyle C, Haley MJ, Lemarchand E, Smith CJ, Allan SM, Konkel JE, Lawrence CB.

Int J Stroke. 2019 Feb 22:1747493019834191. doi: 10.1177/1747493019834191. [Epub ahead of print]

PMID:
30794103
8.

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.

Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222.

9.

Stroke: The past, present and future.

Macrae IM, Allan SM.

Brain Neurosci Adv. 2018;2:2398212818810689. doi: 10.1177/2398212818810689.

10.

Using zebrafish larval models to study brain injury, locomotor and neuroinflammatory outcomes following intracerebral haemorrhage.

Crilly S, Njegic A, Laurie SE, Fotiou E, Hudson G, Barrington J, Webb K, Young HL, Badrock AP, Hurlstone A, Rivers-Auty J, Parry-Jones AR, Allan SM, Kasher PR.

Version 2. F1000Res. 2018 Oct 8 [revised 2018 Jan 1];7:1617. doi: 10.12688/f1000research.16473.2. eCollection 2018.

11.

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons.

Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, Császár E, Nyiri G, Papaemmanouil A, Waisman A, Müller W, Schwaninger M, Rothwell N, Francis S, Pinteaux E, Denés A, Allan SM.

Brain Behav Immun. 2019 Feb;76:126-138. doi: 10.1016/j.bbi.2018.11.012. Epub 2018 Nov 16.

12.

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming.

Hoyle C, Rivers-Auty J, Lemarchand E, Vranic S, Wang E, Buggio M, Rothwell NJ, Allan SM, Kostarelos K, Brough D.

ACS Nano. 2018 Dec 26;12(12):11949-11962. doi: 10.1021/acsnano.8b03642. Epub 2018 Nov 20.

PMID:
30444603
13.

Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke.

Rajkovic I, Wong R, Lemarchand E, Rivers-Auty J, Rajkovic O, Garlanda C, Allan SM, Pinteaux E.

J Mol Med (Berl). 2018 Dec;96(12):1319-1332. doi: 10.1007/s00109-018-1698-6. Epub 2018 Oct 13.

14.

Generation of Human Mesenchymal Stem Cell 3D Spheroids Using Low-binding Plates.

Redondo-Castro E, Cunningham CJ, Miller J, Cain SA, Allan SM, Pinteaux E.

Bio Protoc. 2018 Aug 20;8(16). pii: e2968. doi: 10.21769/BioProtoc.2968.

15.

Assessing Cochlear Length Using Cone Beam Computed Tomography in Adults With Cochlear Implants.

Alnafjan FF, Allan SM, McMahon CM, da Cruz MJ.

Otol Neurotol. 2018 Oct;39(9):e757-e764. doi: 10.1097/MAO.0000000000001934.

PMID:
30080765
16.

Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.

Strangward P, Haley MJ, Albornoz MG, Barrington J, Shaw T, Dookie R, Zeef L, Baker SM, Winter E, Tzeng TC, Golenbock DT, Cruickshank SM, Allan SM, Craig A, Liew FY, Brough D, Couper KN.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7404-7409. doi: 10.1073/pnas.1801737115. Epub 2018 Jun 28.

17.

The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke.

Cunningham CJ, Redondo-Castro E, Allan SM.

J Cereb Blood Flow Metab. 2018 Aug;38(8):1276-1292. doi: 10.1177/0271678X18776802. Epub 2018 May 17. Review.

18.

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30.

19.

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Redondo-Castro E, Faust D, Fox S, Baldwin AG, Osborne S, Haley MJ, Karran E, Nuthall H, Atkinson PJ, Dawson LA, Routledge C, Allan SM, Freeman S, Brownlees J, Brough D.

Sci Rep. 2018 Apr 4;8(1):5667. doi: 10.1038/s41598-018-24029-3.

20.

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial.

Smith CJ, Hulme S, Vail A, Heal C, Parry-Jones AR, Scarth S, Hopkins K, Hoadley M, Allan SM, Rothwell NJ, Hopkins SJ, Tyrrell PJ.

Stroke. 2018 May;49(5):1210-1216. doi: 10.1161/STROKEAHA.118.020750. Epub 2018 Mar 22.

PMID:
29567761
21.

Changes in the secretome of tri-dimensional spheroid-cultured human mesenchymal stem cells in vitro by interleukin-1 priming.

Redondo-Castro E, Cunningham CJ, Miller J, Brown H, Allan SM, Pinteaux E.

Stem Cell Res Ther. 2018 Jan 17;9(1):11. doi: 10.1186/s13287-017-0753-5.

22.

Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbα.

Giles JA, Greenhalgh AD, Denes A, Nieswandt B, Coutts G, McColl BW, Allan SM.

Immunology. 2018 Jun;154(2):322-328. doi: 10.1111/imm.12892. Epub 2018 Feb 8.

23.

Microglial Priming as Trained Immunity in the Brain.

Haley MJ, Brough D, Quintin J, Allan SM.

Neuroscience. 2019 May 1;405:47-54. doi: 10.1016/j.neuroscience.2017.12.039. Epub 2017 Dec 29. Review.

PMID:
29292078
24.

Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome.

Haley MJ, Krishnan S, Burrows D, de Hoog L, Thakrar J, Schiessl I, Allan SM, Lawrence CB.

J Cereb Blood Flow Metab. 2019 Jun;39(6):1026-1037. doi: 10.1177/0271678X17744718. Epub 2017 Nov 24.

25.

Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI.

Abid KA, Sobowale OA, Parkes LM, Naish J, Parker GJM, du Plessis D, Brough D, Barrington J, Allan SM, Hinz R, Parry-Jones AR.

J Neuroimaging. 2018 Mar;28(2):158-161. doi: 10.1111/jon.12477. Epub 2017 Oct 24.

PMID:
29064155
26.

Boron-Based Inhibitors of the NLRP3 Inflammasome.

Baldwin AG, Rivers-Auty J, Daniels MJD, White CS, Schwalbe CH, Schilling T, Hammadi H, Jaiyong P, Spencer NG, England H, Luheshi NM, Kadirvel M, Lawrence CB, Rothwell NJ, Harte MK, Bryce RA, Allan SM, Eder C, Freeman S, Brough D.

Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5. doi: 10.1016/j.chembiol.2017.08.011. Epub 2017 Sep 21.

27.

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).

Percie du Sert N, Alfieri A, Allan SM, Carswell HV, Deuchar GA, Farr TD, Flecknell P, Gallagher L, Gibson CL, Haley MJ, Macleod MR, McColl BW, McCabe C, Morancho A, Moon LD, O'Neill MJ, Pérez de Puig I, Planas A, Ragan CI, Rosell A, Roy LA, Ryder KO, Simats A, Sena ES, Sutherland BA, Tricklebank MD, Trueman RC, Whitfield L, Wong R, Macrae IM.

J Cereb Blood Flow Metab. 2017 Nov;37(11):3488-3517. doi: 10.1177/0271678X17709185. Epub 2017 Aug 11. Review.

28.

Isolation and Cultivation of Primary Brain Endothelial Cells from Adult Mice.

Assmann JC, Müller K, Wenzel J, Walther T, Brands J, Thornton P, Allan SM, Schwaninger M.

Bio Protoc. 2017 May 20;7(10). pii: e2294. doi: 10.21769/BioProtoc.2294.

29.

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro.

Redondo-Castro E, Cunningham C, Miller J, Martuscelli L, Aoulad-Ali S, Rothwell NJ, Kielty CM, Allan SM, Pinteaux E.

Stem Cell Res Ther. 2017 Apr 17;8(1):79. doi: 10.1186/s13287-017-0531-4.

30.

Enhanced susceptibility of triple transgenic Alzheimer's disease (3xTg-AD) mice to acute infection.

Montacute R, Foley K, Forman R, Else KJ, Cruickshank SM, Allan SM.

J Neuroinflammation. 2017 Mar 11;14(1):50. doi: 10.1186/s12974-017-0826-5.

31.

A quantitative brain map of experimental cerebral malaria pathology.

Strangward P, Haley MJ, Shaw TN, Schwartz JM, Greig R, Mironov A, de Souza JB, Cruickshank SM, Craig AG, Milner DA Jr, Allan SM, Couper KN.

PLoS Pathog. 2017 Mar 8;13(3):e1006267. doi: 10.1371/journal.ppat.1006267. eCollection 2017 Mar.

32.

Translational models for vascular cognitive impairment: a review including larger species.

Hainsworth AH, Allan SM, Boltze J, Cunningham C, Farris C, Head E, Ihara M, Isaacs JD, Kalaria RN, Lesnik Oberstein SA, Moss MB, Nitzsche B, Rosenberg GA, Rutten JW, Salkovic-Petrisic M, Troen AM.

BMC Med. 2017 Jan 25;15(1):16. doi: 10.1186/s12916-017-0793-9. Review.

33.

A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?

Barrington J, Lemarchand E, Allan SM.

Brain Pathol. 2017 Mar;27(2):205-212. doi: 10.1111/bpa.12476. Review.

PMID:
27997059
34.

Exome array analysis suggests an increased variant burden in families with schizophrenia.

McCarthy NS, Melton PE, Ward SV, Allan SM, Dragovic M, Clark ML, Morar B, Rubio JP, Blangero J, Badcock JC, Morgan VA, Moses EK, Jablensky A.

Schizophr Res. 2017 Jul;185:9-16. doi: 10.1016/j.schres.2016.12.007. Epub 2016 Dec 9.

PMID:
27939555
35.

Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia.

Pradillo JM, Murray KN, Coutts GA, Moraga A, Oroz-Gonjar F, Boutin H, Moro MA, Lizasoain I, Rothwell NJ, Allan SM.

Brain Behav Immun. 2017 Mar;61:117-126. doi: 10.1016/j.bbi.2016.11.013. Epub 2016 Nov 14.

36.
37.

Mechanisms of Comorbidities Associated With the Metabolic Syndrome: Insights from the JCR:LA-cp Corpulent Rat Strain.

Diane A, Pierce WD, Kelly SE, Sokolik S, Borthwick F, Jacome-Sosa M, Mangat R, Pradillo JM, Allan SM, Ruth MR, Field CJ, Hutcheson R, Rocic P, Russell JC, Vine DF, Proctor SD.

Front Nutr. 2016 Oct 10;3:44. eCollection 2016. Review.

38.

Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection.

Bray N, Burrows FE, Jones M, Berwick J, Allan SM, Schiessl I.

J Neuroinflammation. 2016 Aug 24;13(1):195. doi: 10.1186/s12974-016-0664-x.

39.

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.

Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D.

Nat Commun. 2016 Aug 11;7:12504. doi: 10.1038/ncomms12504.

40.

Integrity of genome-wide genotype data from low passage lymphoblastoid cell lines.

McCarthy NS, Allan SM, Chandler D, Jablensky A, Morar B.

Genom Data. 2016 May 12;9:18-21. doi: 10.1016/j.gdata.2016.05.006. eCollection 2016 Sep.

41.

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis.

Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, El Amki M, Fatar M, Garcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D.

Stroke. 2016 May;47(5):1312-1318. doi: 10.1161/STROKEAHA.116.012238. Epub 2016 Mar 31.

42.

Emerging roles of the acute phase protein pentraxin-3 during central nervous system disorders.

Rajkovic I, Denes A, Allan SM, Pinteaux E.

J Neuroimmunol. 2016 Mar 15;292:27-33. doi: 10.1016/j.jneuroim.2015.12.007. Epub 2016 Jan 14. Review.

PMID:
26943955
43.

Interleukin-1 in Stroke: From Bench to Bedside.

Sobowale OA, Parry-Jones AR, Smith CJ, Tyrrell PJ, Rothwell NJ, Allan SM.

Stroke. 2016 Aug;47(8):2160-7. doi: 10.1161/STROKEAHA.115.010001. Epub 2016 Mar 1. Review. No abstract available.

PMID:
26931154
44.

Systemic inflammation affects reperfusion following transient cerebral ischaemia.

Burrows F, Haley MJ, Scott E, Coutts G, Lawrence CB, Allan SM, Schiessl I.

Exp Neurol. 2016 Mar;277:252-260. doi: 10.1016/j.expneurol.2016.01.013. Epub 2016 Jan 18.

45.

Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system.

Abdulaal WH, Walker CR, Costello R, Redondo-Castro E, Mufazalov IA, Papaemmanouil A, Rothwell NJ, Allan SM, Waisman A, Pinteaux E, Müller W.

Eur J Immunol. 2016 Apr;46(4):912-8. doi: 10.1002/eji.201546075. Epub 2016 Jan 18.

46.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Maysami S, Wong R, Pradillo JM, Denes A, Dhungana H, Malm T, Koistinaho J, Orset C, Rahman M, Rubio M, Schwaninger M, Vivien D, Bath PM, Rothwell NJ, Allan SM.

J Cereb Blood Flow Metab. 2016 Mar;36(3):596-605. doi: 10.1177/0271678X15606714. Epub 2015 Sep 30.

47.

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination.

Oleszycka E, Moran HB, Tynan GA, Hearnden CH, Coutts G, Campbell M, Allan SM, Scott CJ, Lavelle EC.

FEBS J. 2016 Jan;283(1):9-24. doi: 10.1111/febs.13546. Epub 2015 Nov 4.

48.

Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage.

Edye ME, Brough D, Allan SM.

J Biol Chem. 2015 Oct 16;290(42):25374-81. doi: 10.1074/jbc.M115.667162. Epub 2015 Aug 31.

49.

Interleukin-1 as a pharmacological target in acute brain injury.

Brough D, Rothwell NJ, Allan SM.

Exp Physiol. 2015 Dec;100(12):1488-94. doi: 10.1113/EP085135. Epub 2015 Jul 14. Review.

50.

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

Denes A, Coutts G, Lénárt N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM, Brough D.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4050-5. doi: 10.1073/pnas.1419090112. Epub 2015 Mar 16.

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