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Items: 1 to 50 of 312

1.

Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus.

Sen A, Nelson TJ, Alkon DL, Hongpaisan J.

J Alzheimers Dis. 2018;63(3):1173-1189. doi: 10.3233/JAD-171008.

PMID:
29710707
2.

Bryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents.

Khan TK, Wender PA, Alkon DL.

J Cell Physiol. 2018 Feb;233(2):1523-1534. doi: 10.1002/jcp.26043. Epub 2017 Jul 11.

PMID:
28590053
3.

ApoE isoforms differentially regulates cleavage and secretion of BDNF.

Sen A, Nelson TJ, Alkon DL.

Mol Brain. 2017 Jun 1;10(1):19. doi: 10.1186/s13041-017-0301-3.

4.

Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer's Disease Phase IIa and Expanded Access Trials.

Nelson TJ, Sun MK, Lim C, Sen A, Khan T, Chirila FV, Alkon DL.

J Alzheimers Dis. 2017;58(2):521-535. doi: 10.3233/JAD-170161.

5.

Effects of chronic bryostatin-1 on treatment-resistant depression in rats.

Alkon DL, Hongpaisan J, Sun MK.

Eur J Pharmacol. 2017 Jul 15;807:71-74. doi: 10.1016/j.ejphar.2017.05.001. Epub 2017 May 2.

PMID:
28472666
6.

Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons.

Lim CS, Alkon DL.

J Biol Chem. 2017 Apr 14;292(15):6402-6413. doi: 10.1074/jbc.M117.775619. Epub 2017 Mar 6.

7.

Protein Kinase Cϵ (PKCϵ) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95.

Sen A, Hongpaisan J, Wang D, Nelson TJ, Alkon DL.

J Biol Chem. 2016 Aug 5;291(32):16462-76. doi: 10.1074/jbc.M116.730440. Epub 2016 Jun 21.

8.

Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice.

Sun MK, Hongpaisan J, Alkon DL.

J Pharmacol Exp Ther. 2016 May;357(2):300-10. doi: 10.1124/jpet.115.231100. Epub 2016 Mar 3.

9.

Alzheimer's Disease Cerebrospinal Fluid and Neuroimaging Biomarkers: Diagnostic Accuracy and Relationship to Drug Efficacy.

Khan TK, Alkon DL.

J Alzheimers Dis. 2015;46(4):817-36. doi: 10.3233/JAD-150238. Review.

PMID:
26402622
10.

Bryostatin extends tPA time window to 6 h following middle cerebral artery occlusion in aged female rats.

Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J, Alkon DL, Simpkins JW, Rosen CL, Huber JD.

Eur J Pharmacol. 2015 Oct 5;764:404-12. doi: 10.1016/j.ejphar.2015.07.035. Epub 2015 Jul 17.

11.

ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation.

Sen A, Nelson TJ, Alkon DL.

J Neurosci. 2015 May 13;35(19):7538-51. doi: 10.1523/JNEUROSCI.0260-15.2015.

12.

Towards universal therapeutics for memory disorders.

Sun MK, Nelson TJ, Alkon DL.

Trends Pharmacol Sci. 2015 Jun;36(6):384-94. doi: 10.1016/j.tips.2015.04.004. Epub 2015 May 7. Review.

PMID:
25959522
13.

Identification of the PS1 Thr147Ile Variant in a Family with Very Early Onset Dementia and Expressive Aphasia.

Denvir J, Neitch S, Fan J, Niles RM, Boskovic G, Schreurs BG, Primerano DA, Alkon DL.

J Alzheimers Dis. 2015;46(2):483-90. doi: 10.3233/JAD-150051.

14.

Molecular regulation of synaptogenesis during associative learning and memory.

Nelson TJ, Alkon DL.

Brain Res. 2015 Sep 24;1621:239-51. doi: 10.1016/j.brainres.2014.11.054. Epub 2014 Dec 5.

PMID:
25485772
15.

Peripheral biomarkers of Alzheimer's disease.

Khan TK, Alkon DL.

J Alzheimers Dis. 2015;44(3):729-44. doi: 10.3233/JAD-142262. Review.

PMID:
25374110
16.

Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury.

Lucke-Wold BP, Logsdon AF, Smith KE, Turner RC, Alkon DL, Tan Z, Naser ZJ, Knotts CM, Huber JD, Rosen CL.

Mol Neurobiol. 2015 Dec;52(3):1119-1134. doi: 10.1007/s12035-014-8902-7. Epub 2014 Oct 10.

17.

PKCε deficits in Alzheimer's disease brains and skin fibroblasts.

Khan TK, Sen A, Hongpaisan J, Lim CS, Nelson TJ, Alkon DL.

J Alzheimers Dis. 2015;43(2):491-509. doi: 10.3233/JAD-141221.

PMID:
25125477
18.

Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration.

Lucke-Wold BP, Turner RC, Logsdon AF, Simpkins JW, Alkon DL, Smith KE, Chen YW, Tan Z, Huber JD, Rosen CL.

J Alzheimers Dis. 2015;43(3):711-24. doi: 10.3233/JAD-141422. Review.

19.

Stress: perspectives on its impact on cognition and pharmacological treatment.

Sun MK, Alkon DL.

Behav Pharmacol. 2014 Sep;25(5-6):410-24. doi: 10.1097/FBP.0000000000000045. Review.

PMID:
25028862
20.

Fibroblast aggregation rate converges with validated peripheral biomarkers for Alzheimer's disease.

Chirila FV, Khan TK, Alkon DL.

J Alzheimers Dis. 2014;42(4):1279-94. doi: 10.3233/JAD-140672.

PMID:
25024330
21.

PKCε promotes HuD-mediated neprilysin mRNA stability and enhances neprilysin-induced Aβ degradation in brain neurons.

Lim CS, Alkon DL.

PLoS One. 2014 May 21;9(5):e97756. doi: 10.1371/journal.pone.0097756. eCollection 2014.

22.

Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile x mice.

Sun MK, Hongpaisan J, Lim CS, Alkon DL.

J Pharmacol Exp Ther. 2014 Jun;349(3):393-401. doi: 10.1124/jpet.114.214098. Epub 2014 Mar 21.

23.

PKC activators enhance GABAergic neurotransmission and paired-pulse facilitation in hippocampal CA1 pyramidal neurons.

Xu C, Liu QY, Alkon DL.

Neuroscience. 2014 May 30;268:75-86. doi: 10.1016/j.neuroscience.2014.03.008. Epub 2014 Mar 15.

PMID:
24637095
24.

Protein kinase C mediates memory consolidation of taste avoidance conditioning in Lymnaea stagnalis.

Takigami S, Sunada H, Lukowiak K, Kuzirian AM, Alkon DL, Sakakibara M.

Neurobiol Learn Mem. 2014 May;111:9-18. doi: 10.1016/j.nlm.2014.02.011. Epub 2014 Mar 6.

PMID:
24613854
25.

The "memory kinases": roles of PKC isoforms in signal processing and memory formation.

Sun MK, Alkon DL.

Prog Mol Biol Transl Sci. 2014;122:31-59. doi: 10.1016/B978-0-12-420170-5.00002-7. Review.

PMID:
24484697
26.

Adduct formation in liquid chromatography-triple quadrupole mass spectrometric measurement of bryostatin 1.

Nelson TJ, Sen A, Alkon DL, Sun MK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 1;944:55-62. doi: 10.1016/j.jchromb.2013.11.020. Epub 2013 Nov 16.

PMID:
24291721
27.

Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke.

Tan Z, Turner RC, Leon RL, Li X, Hongpaisan J, Zheng W, Logsdon AF, Naser ZJ, Alkon DL, Rosen CL, Huber JD.

Stroke. 2013 Dec;44(12):3490-7. doi: 10.1161/STROKEAHA.113.002411. Epub 2013 Oct 30.

28.

Cerebral ischemia-induced difference in sensitivity to depression and potential therapeutics in rats.

Sun MK, Alkon DL.

Behav Pharmacol. 2013 Jun;24(3):222-8. doi: 10.1097/FBP.0b013e3283618afe.

PMID:
23591125
29.

PKC activation during training restores mushroom spine synapses and memory in the aged rat.

Hongpaisan J, Xu C, Sen A, Nelson TJ, Alkon DL.

Neurobiol Dis. 2013 Jul;55:44-62. doi: 10.1016/j.nbd.2013.03.012. Epub 2013 Mar 29.

PMID:
23545166
30.

Spatiotemporal complexity of fibroblast networks screens for Alzheimer's disease.

Chirila FV, Khan TK, Alkon DL.

J Alzheimers Dis. 2013;33(1):165-76. doi: 10.3233/JAD-2012-120745.

PMID:
22886026
31.

Activation of protein kinase C isozymes for the treatment of dementias.

Sun MK, Alkon DL.

Adv Pharmacol. 2012;64:273-302. doi: 10.1016/B978-0-12-394816-8.00008-8. Review.

PMID:
22840750
32.
33.

Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon.

Sen A, Alkon DL, Nelson TJ.

J Biol Chem. 2012 May 4;287(19):15947-58. doi: 10.1074/jbc.M111.312710. Epub 2012 Mar 17.

34.

New developments in the search for a cure.

Alkon DL.

W V Med J. 2011 May-Jun;107(3):10-3. Review. No abstract available.

PMID:
21702408
35.

PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic mice.

Hongpaisan J, Sun MK, Alkon DL.

J Neurosci. 2011 Jan 12;31(2):630-43. doi: 10.1523/JNEUROSCI.5209-10.2011.

36.

PKC activator therapeutic for mild traumatic brain injury in mice.

Zohar O, Lavy R, Zi X, Nelson TJ, Hongpaisan J, Pick CG, Alkon DL.

Neurobiol Dis. 2011 Feb;41(2):329-37. doi: 10.1016/j.nbd.2010.10.001. Epub 2010 Oct 15.

PMID:
20951803
37.

Pharmacology of protein kinase C activators: cognition-enhancing and antidementic therapeutics.

Sun MK, Alkon DL.

Pharmacol Ther. 2010 Jul;127(1):66-77. doi: 10.1016/j.pharmthera.2010.03.001. Epub 2010 Apr 8. Review.

PMID:
20382181
38.

Protein kinase C activators as synaptogenic and memory therapeutics.

Sun MK, Alkon DL.

Arch Pharm (Weinheim). 2009 Dec;342(12):689-98. doi: 10.1002/ardp.200900050. Review.

PMID:
19899099
39.

Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activators.

Nelson TJ, Cui C, Luo Y, Alkon DL.

J Biol Chem. 2009 Dec 11;284(50):34514-21. doi: 10.1074/jbc.M109.016683. Epub 2009 Oct 22.

40.

Postischemic PKC activation rescues retrograde and anterograde long-term memory.

Sun MK, Hongpaisan J, Alkon DL.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14676-80. doi: 10.1073/pnas.0907842106. Epub 2009 Aug 10.

41.

Neuroprotective versus tumorigenic protein kinase C activators.

Nelson TJ, Alkon DL.

Trends Biochem Sci. 2009 Mar;34(3):136-45. doi: 10.1016/j.tibs.2008.11.006. Epub 2009 Feb 23. Review.

PMID:
19233655
42.

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.

Khan TK, Nelson TJ, Verma VA, Wender PA, Alkon DL.

Neurobiol Dis. 2009 May;34(2):332-9. doi: 10.1016/j.nbd.2009.02.003. Epub 2009 Feb 20.

43.

Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors.

Xu C, Cui C, Alkon DL.

Hippocampus. 2009 Aug;19(8):706-17. doi: 10.1002/hipo.20544.

PMID:
19123252
44.

Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains.

Sun MK, Hongpaisan J, Nelson TJ, Alkon DL.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13620-5. doi: 10.1073/pnas.0805952105. Epub 2008 Sep 3.

45.

Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.

Khan TK, Alkon DL.

Neurobiol Aging. 2010 Jun;31(6):889-900. doi: 10.1016/j.neurobiolaging.2008.07.010. Epub 2008 Aug 28.

PMID:
18760507
46.

Effects of age on susceptibility to the induction of depressive behavior and imipramine in rats.

Sun MK, Alkon DL.

Behav Pharmacol. 2008 Jul;19(4):334-8. doi: 10.1097/FBP.0b013e328308f239.

PMID:
18622181
47.

Analysis of long-term cognitive-enhancing effects of bryostatin-1 on the rabbit (Oryctolagus cuniculus) nictitating membrane response.

Wang D, Darwish DS, Schreurs BG, Alkon DL.

Behav Pharmacol. 2008 May;19(3):245-56. doi: 10.1097/FBP.0b013e3282feb0d2.

PMID:
18469542
48.

Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair.

Nelson TJ, Sun MK, Hongpaisan J, Alkon DL.

Eur J Pharmacol. 2008 May 6;585(1):76-87. doi: 10.1016/j.ejphar.2008.01.051. Epub 2008 Mar 4. Review.

PMID:
18402935
49.

Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats.

Sun MK, Alkon DL.

Eur J Pharmacol. 2008 Apr 28;584(2-3):328-37. doi: 10.1016/j.ejphar.2008.02.014. Epub 2008 Feb 14.

PMID:
18313045
50.

Effects of 4-methylcatechol on spatial memory and depression.

Sun MK, Alkon DL.

Neuroreport. 2008 Feb 12;19(3):355-9. doi: 10.1097/WNR.0b013e3282f519c7.

PMID:
18303581

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