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Items: 9

1.

Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds.

Alkhaldi AA, de Koning HP, Bukhari SNA.

Drug Des Devel Ther. 2019 Apr 24;13:1179-1185. doi: 10.2147/DDDT.S204733. eCollection 2019.

2.

Prevalence of hypertension, obesity, hematuria and proteinuria amongst healthy adolescents living in Western Saudi Arabia.

Hothan KA, Alasmari BA, Alkhelaiwi OK, Althagafi KM, Alkhaldi AA, Alfityani AK, Aladawi MM, Sharief SN, El Desoky S, Kari JA.

Saudi Med J. 2016 Oct;37(10):1120-6. doi: 10.15537/smj.2016.10.14784.

3.

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei.

Alkhaldi AAM, Martinek J, Panicucci B, Dardonville C, Zíková A, de Koning HP.

Int J Parasitol Drugs Drug Resist. 2015 Dec 11;6(1):23-34. doi: 10.1016/j.ijpddr.2015.12.002. eCollection 2016 Apr.

4.

Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.

Rodenko B, Wanner MJ, Alkhaldi AA, Ebiloma GU, Barnes RL, Kaiser M, Brun R, McCulloch R, Koomen GJ, de Koning HP.

Antimicrob Agents Chemother. 2015 Nov;59(11):6708-16. doi: 10.1128/AAC.00596-15. Epub 2015 Aug 17.

5.

Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.

Munday JC, Tagoe DN, Eze AA, Krezdorn JA, Rojas López KE, Alkhaldi AA, McDonald F, Still J, Alzahrani KJ, Settimo L, De Koning HP.

Mol Microbiol. 2015 May;96(4):887-900. doi: 10.1111/mmi.12979. Epub 2015 Mar 21.

6.

SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts.

Dardonville C, Alkhaldi AA, De Koning HP.

ACS Med Chem Lett. 2014 Dec 10;6(2):151-5. doi: 10.1021/ml500408d. eCollection 2015 Feb 12.

7.

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.

Alkhaldi AA, Creek DJ, Ibrahim H, Kim DH, Quashie NB, Burgess KE, Changtam C, Barrett MP, Suksamrarn A, de Koning HP.

Mol Pharmacol. 2015;87(3):451-64. doi: 10.1124/mol.114.096016. Epub 2014 Dec 19.

PMID:
25527638
8.

Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.

Taladriz A, Healy A, Flores Pérez EJ, Herrero García V, Ríos Martínez C, Alkhaldi AA, Eze AA, Kaiser M, de Koning HP, Chana A, Dardonville C.

J Med Chem. 2012 Mar 22;55(6):2606-22. doi: 10.1021/jm2014259. Epub 2012 Mar 6.

PMID:
22390399
9.

Symmetrical choline-derived dications display strong anti-kinetoplastid activity.

Ibrahim HM, Al-Salabi MI, El Sabbagh N, Quashie NB, Alkhaldi AA, Escale R, Smith TK, Vial HJ, de Koning HP.

J Antimicrob Chemother. 2011 Jan;66(1):111-25. doi: 10.1093/jac/dkq401. Epub 2010 Nov 14.

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