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Items: 10

1.

Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity.

Al-Abed Y, Metz CN, Cheng KF, Aljabari B, VanPatten S, Blau S, Lee H, Ochani M, Pavlov VA, Coleman T, Meurice N, Tracey KJ, Miller EJ.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8224-7. doi: 10.1073/pnas.1017624108. Epub 2011 May 2.

2.

The role of macrophage migration inhibitory factor in Alzheimer's disease.

Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese JP, Al-Abed Y, Dodel R.

Mol Med. 2010 Mar;16(3-4):116-21. doi: 10.2119/molmed.2009.00123. Epub 2010 Feb 28.

3.

CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease.

Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Hoppmann A, Sachser N, Klotsche J, Schnell S, Lewejohann L, Al-Abed Y.

J Exp Med. 2008 Jul 7;205(7):1593-9. doi: 10.1084/jem.20060467. Epub 2008 Jun 23.

4.

Imbalance in seminal fluid MIF indicates male infertility.

Aljabari B, Calogero AE, Perdichizzi A, Vicari E, Karaki R, Lahloub T, Zatari R, El-Abed K, Nicoletti F, Miller EJ, Pavlov VA, Al-Abed Y.

Mol Med. 2007 Mar-Apr;13(3-4):199-202.

5.

Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y.

J Biol Chem. 2007 Aug 10;282(32):23089-95. Epub 2007 May 25.

6.

Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agents in sepsis.

Dabideen DR, Cheng KF, Aljabari B, Miller EJ, Pavlov VA, Al-Abed Y.

J Med Chem. 2007 Apr 19;50(8):1993-7. Epub 2007 Mar 27.

7.

Amyloid fibril formation by macrophage migration inhibitory factor.

Lashuel HA, Aljabari B, Sigurdsson EM, Metz CN, Leng L, Callaway DJ, Bucala R.

Biochem Biophys Res Commun. 2005 Dec 16;338(2):973-80. Epub 2005 Oct 21.

PMID:
16286092
8.

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.

Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ.

J Biol Chem. 2005 Nov 4;280(44):36541-4. Epub 2005 Aug 22.

9.

Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity.

Dios A, Mitchell RA, Aljabari B, Lubetsky J, O'Connor K, Liao H, Senter PD, Manogue KR, Lolis E, Metz C, Bucala R, Callaway DJ, Al-Abed Y.

J Med Chem. 2002 Jun 6;45(12):2410-6.

PMID:
12036350
10.

The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents.

Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y.

J Biol Chem. 2002 Jul 12;277(28):24976-82. Epub 2002 May 7.

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