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Items: 1 to 50 of 647

1.

Vascular endothelial growth factor signaling in development and disease.

Karaman S, Leppänen VM, Alitalo K.

Development. 2018 Jul 20;145(14). pii: dev151019. doi: 10.1242/dev.151019. Review.

PMID:
30030240
2.

Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits.

Hytönen JP, Taavitsainen J, Laitinen JTT, Partanen A, Alitalo K, Leppänen O, Ylä-Herttuala S.

J Mol Cell Cardiol. 2018 Jul 9;121:145-154. doi: 10.1016/j.yjmcc.2018.07.007. [Epub ahead of print]

PMID:
30003882
3.

PROX1 is a transcriptional regulator of MMP14.

Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM.

Sci Rep. 2018 Jun 22;8(1):9531. doi: 10.1038/s41598-018-27739-w.

4.

Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW.

Angiogenesis. 2018 May 15. doi: 10.1007/s10456-018-9613-x. [Epub ahead of print] Review.

5.

VEGF-C promotes the development of lymphatics in bone and bone loss.

Hominick D, Silva A, Khurana N, Liu Y, Dechow PC, Feng JQ, Pytowski B, Rutkowski JM, Alitalo K, Dellinger MT.

Elife. 2018 Apr 5;7. pii: e34323. doi: 10.7554/eLife.34323.

6.

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms.

Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo K, Mäkinen T.

Nat Commun. 2018 Apr 3;9(1):1296. doi: 10.1038/s41467-018-03692-0.

7.

Development and plasticity of meningeal lymphatic vessels.

Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, Alitalo K.

J Exp Med. 2017 Dec 4;214(12):3645-3667. doi: 10.1084/jem.20170391. Epub 2017 Nov 15.

8.

Fighting vessel dysmorphia to improve glioma chemotherapy.

Lohela M, Alitalo K.

EMBO Mol Med. 2017 Dec;9(12):1626-1628. doi: 10.15252/emmm.201708431. No abstract available.

9.

White adipose tissue coloring by intermittent fasting.

Kivelä R, Alitalo K.

Cell Res. 2017 Nov;27(11):1300-1301. doi: 10.1038/cr.2017.130. Epub 2017 Oct 24.

PMID:
29097740
10.

SnapShot: Angiopoietins and Their Functions.

Saharinen P, Leppänen VM, Alitalo K.

Cell. 2017 Oct 19;171(3):724-724.e1. doi: 10.1016/j.cell.2017.10.009.

PMID:
29053972
11.

Lymphangiogenesis guidance by paracrine and pericellular factors.

Vaahtomeri K, Karaman S, Mäkinen T, Alitalo K.

Genes Dev. 2017 Aug 15;31(16):1615-1634. doi: 10.1101/gad.303776.117. Review.

12.

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Adams RH, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B.

Nat Commun. 2017 Sep 18;8(1):578. doi: 10.1038/s41467-017-00654-w.

13.

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J.

J Clin Invest. 2017 Sep 1;127(9):3210-3219. doi: 10.1172/JCI90603. Epub 2017 Sep 1. Review.

14.

Midkine and Melanoma Metastasis: A Malevolent Mix.

Karaman S, Alitalo K.

Dev Cell. 2017 Aug 7;42(3):205-207. doi: 10.1016/j.devcel.2017.07.015.

15.

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.

Jha SK, Rauniyar K, Karpanen T, Leppänen VM, Brouillard P, Vikkula M, Alitalo K, Jeltsch M.

Sci Rep. 2017 Jul 7;7(1):4916. doi: 10.1038/s41598-017-04982-1.

16.

Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.

Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM.

Am J Pathol. 2017 Sep;187(9):1984-1997. doi: 10.1016/j.ajpath.2017.05.009. Epub 2017 Jul 3.

PMID:
28683257
17.

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart.

Naumenko N, Huusko J, Tuomainen T, Koivumäki JT, Merentie M, Gurzeler E, Alitalo K, Kivelä R, Ylä-Herttuala S, Tavi P.

Front Physiol. 2017 May 31;8:373. doi: 10.3389/fphys.2017.00373. eCollection 2017.

18.

Therapeutic targeting of the angiopoietin-TIE pathway.

Saharinen P, Eklund L, Alitalo K.

Nat Rev Drug Discov. 2017 Sep;16(9):635-661. doi: 10.1038/nrd.2016.278. Epub 2017 May 19. Review.

PMID:
28529319
19.

ORAI1 Controls the Unique Adjustment of Lymphatics to Fluid Flow.

Karaman S, Alitalo K.

Circ Res. 2017 Apr 28;120(9):1373-1375. doi: 10.1161/CIRCRESAHA.117.310917. No abstract available.

PMID:
28450355
20.

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.

Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY.

EMBO Mol Med. 2017 Jun;9(6):750-769. doi: 10.15252/emmm.201607341.

21.

Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.

Leppänen VM, Saharinen P, Alitalo K.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4376-4381. doi: 10.1073/pnas.1616166114. Epub 2017 Apr 10.

22.

Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis.

Rademakers T, van der Vorst EP, Daissormont IT, Otten JJ, Theodorou K, Theelen TL, Gijbels M, Anisimov A, Nurmi H, Lindeman JH, Schober A, Heeneman S, Alitalo K, Biessen EA.

Sci Rep. 2017 Mar 28;7:45263. doi: 10.1038/srep45263.

23.

VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.

Heinolainen K, Karaman S, D'Amico G, Tammela T, Sormunen R, Eklund L, Alitalo K, Zarkada G.

Circ Res. 2017 Apr 28;120(9):1414-1425. doi: 10.1161/CIRCRESAHA.116.310477. Epub 2017 Mar 15.

PMID:
28298294
24.

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.

Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Adams RH, He Y.

Elife. 2016 Dec 22;5. pii: e21032. doi: 10.7554/eLife.21032.

25.

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.

Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13144-13149. Epub 2016 Oct 31.

26.

The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation.

Kivelä R, Salmela I, Nguyen YH, Petrova TV, Koistinen HA, Wiener Z, Alitalo K.

Nat Commun. 2016 Oct 12;7:13124. doi: 10.1038/ncomms13124.

27.

Tie1 controls angiopoietin function in vascular remodeling and inflammation.

Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P.

J Clin Invest. 2016 Sep 1;126(9):3495-510. doi: 10.1172/JCI84923. Epub 2016 Aug 22.

28.

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.

Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald DM.

J Clin Invest. 2016 Sep 1;126(9):3511-25. doi: 10.1172/JCI84871. Epub 2016 Aug 22.

29.

Lymphatic vessels regulate immune microenvironments in human and murine melanoma.

Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA.

J Clin Invest. 2016 Sep 1;126(9):3389-402. doi: 10.1172/JCI79434. Epub 2016 Aug 15.

30.

Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice.

Karaman S, Hollmén M, Yoon SY, Alkan HF, Alitalo K, Wolfrum C, Detmar M.

Sci Rep. 2016 Aug 11;6:31566. doi: 10.1038/srep31566.

31.

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.

Honkanen HK, Izzi V, Petäistö T, Holopainen T, Harjunen V, Pihlajaniemi T, Alitalo K, Heljasvaara R.

Neoplasia. 2016 Jul;18(7):436-46. doi: 10.1016/j.neo.2016.05.002.

32.

PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma.

Saukkonen K, Hagström J, Mustonen H, Juuti A, Nordling S, Kallio P, Alitalo K, Seppänen H, Haglund C.

BMC Cancer. 2016 Jul 13;16:472. doi: 10.1186/s12885-016-2497-5.

33.

Critical requirement of VEGF-C in transition to fetal erythropoiesis.

Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K.

Blood. 2016 Aug 4;128(5):710-20. doi: 10.1182/blood-2015-12-687970. Epub 2016 Jun 24.

34.

Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.

Johns SC, Yin X, Jeltsch M, Bishop JR, Schuksz M, El Ghazal R, Wilcox-Adelman SA, Alitalo K, Fuster MM.

Circ Res. 2016 Jul 8;119(2):210-21. doi: 10.1161/CIRCRESAHA.116.308504. Epub 2016 May 25.

35.

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD.

Bui HM, Enis D, Robciuc MR, Nurmi HJ, Cohen J, Chen M, Yang Y, Dhillon V, Johnson K, Zhang H, Kirkpatrick R, Traxler E, Anisimov A, Alitalo K, Kahn ML.

J Clin Invest. 2016 Jun 1;126(6):2167-80. doi: 10.1172/JCI83967. Epub 2016 May 9.

36.

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications.

Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K.

Cell Metab. 2016 Apr 12;23(4):712-24. doi: 10.1016/j.cmet.2016.03.004.

37.

Lymphatic System in Cardiovascular Medicine.

Aspelund A, Robciuc MR, Karaman S, Makinen T, Alitalo K.

Circ Res. 2016 Feb 5;118(3):515-30. doi: 10.1161/CIRCRESAHA.115.306544. Review.

PMID:
26846644
38.

Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts.

Dashkevich A, Raissadati A, Syrjälä SO, Zarkada G, Keränen MA, Tuuminen R, Krebs R, Anisimov A, Jeltsch M, Leppänen VM, Alitalo K, Nykänen AI, Lemström KB.

Am J Transplant. 2016 Apr;16(4):1160-72. doi: 10.1111/ajt.13564. Epub 2015 Dec 21.

39.

Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?

Heindl LM, Kaser-Eichberger A, Schlereth SL, Bock F, Regenfuss B, Reitsamer HA, McMenamin P, Lutty GA, Maruyama K, Chen L, Dana R, Kerjaschki D, Alitalo K, De Stefano ME, Junghans BM, Schroedl F, Cursiefen C.

Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6709-10. doi: 10.1167/iovs.15-17686. No abstract available.

40.

VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption.

Nurmi H, Saharinen P, Zarkada G, Zheng W, Robciuc MR, Alitalo K.

EMBO Mol Med. 2015 Nov;7(11):1418-25. doi: 10.15252/emmm.201505731.

41.

Intravital imaging of intestinal lacteals unveils lipid drainage through contractility.

Choe K, Jang JY, Park I, Kim Y, Ahn S, Park DY, Hong YK, Alitalo K, Koh GY, Kim P.

J Clin Invest. 2015 Nov 2;125(11):4042-52. doi: 10.1172/JCI76509. Epub 2015 Oct 5.

42.

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.

Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13063-8. doi: 10.1073/pnas.1517810112. Epub 2015 Oct 1.

43.

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1.

Tamminen K, Balboa D, Toivonen S, Pakarinen MP, Wiener Z, Alitalo K, Otonkoski T.

PLoS One. 2015 Jul 31;10(7):e0134551. doi: 10.1371/journal.pone.0134551. eCollection 2015.

44.

Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy.

Orleth A, Mamot C, Rochlitz C, Ritschard R, Alitalo K, Christofori G, Wicki A.

J Drug Target. 2016;24(1):80-9. doi: 10.3109/1061186X.2015.1056189. Epub 2015 Jul 23.

PMID:
26204325
45.

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K.

J Exp Med. 2015 Jun 29;212(7):991-9. doi: 10.1084/jem.20142290. Epub 2015 Jun 15.

46.

PROX1 is involved in progression of rectal neuroendocrine tumors, NETs.

Jernman J, Kallio P, Hagström J, Välimäki MJ, Haapasalo H, Alitalo K, Arola J, Haglund C.

Virchows Arch. 2015 Sep;467(3):279-84. doi: 10.1007/s00428-015-1795-7. Epub 2015 Jun 11.

PMID:
26063416
47.

Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice.

Theelen TL, Lappalainen JP, Sluimer JC, Gurzeler E, Cleutjens JP, Gijbels MJ, Biessen EA, Daemen MJ, Alitalo K, Ylä-Herttuala S.

Atherosclerosis. 2015 Aug;241(2):297-304. doi: 10.1016/j.atherosclerosis.2015.05.018. Epub 2015 Jun 3.

48.

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis.

Turkki R, Linder N, Holopainen T, Wang Y, Grote A, Lundin M, Alitalo K, Lundin J.

J Clin Pathol. 2015 Aug;68(8):614-21. doi: 10.1136/jclinpath-2015-202888. Epub 2015 May 28.

49.

VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study.

Visuri MT, Honkonen KM, Hartiala P, Tervala TV, Halonen PJ, Junkkari H, Knuutinen N, Ylä-Herttuala S, Alitalo KK, Saarikko AM.

Angiogenesis. 2015 Jul;18(3):313-26. doi: 10.1007/s10456-015-9469-2. Epub 2015 May 28.

PMID:
26018927
50.

Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts.

Syrjälä SO, Nykänen AI, Tuuminen R, Raissadati A, Keränen MA, Arnaudova R, Krebs R, Koh GY, Alitalo K, Lemström KB.

Am J Transplant. 2015 Aug;15(8):2075-84. doi: 10.1111/ajt.13296. Epub 2015 May 1.

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