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Items: 1 to 50 of 175

1.

Activation of Polyamine Catabolism by N¹,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype.

Ivanova ON, Snezhkina AV, Krasnov GS, Valuev-Elliston VT, Khomich OA, Khomutov AR, Keinanen TA, Alhonen L, Bartosch B, Kudryavtseva AV, Kochetkov SN, Ivanov AV.

Cells. 2018 Dec 18;7(12). pii: E275. doi: 10.3390/cells7120275.

2.

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators.

Keinänen TA, Grigorenko N, Khomutov AR, Huang Q, Uimari A, Alhonen L, Hyvönen MT, Vepsäläinen J.

Biosci Rep. 2018 Aug 29;38(4). pii: BSR20180527. doi: 10.1042/BSR20180527. Print 2018 Aug 31.

3.

Controlling of N-alkylpolyamine analogue metabolism by selective deuteration.

Ucal S, Häkkinen MR, Alanne AL, Alhonen L, Vepsäläinen J, Keinänen TA, Hyvönen MT.

Biochem J. 2018 Feb 14;475(3):663-676. doi: 10.1042/BCJ20170887.

PMID:
29301981
4.

Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.

Hyvönen MT, Ucal S, Pasanen M, Peräniemi S, Weisell J, Khomutov M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2016 May 15;473(10):1433-41. doi: 10.1042/BCJ20160134. Epub 2016 Mar 21.

PMID:
27001865
5.

[Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines].

Khomutov MA, Keinanen TA, Hyvonen MT, Weisell J, Vepsalainen J, Alhonen L, Kochetkov SN, Khomutov AR.

Bioorg Khim. 2015 Sep-Oct;41(5):612-8. Russian.

PMID:
26762100
6.

[Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. synthesis, interaction with the enzyme].

Keĭnanen TA, Khivonen T, Vepsalajnen Ĭ, Alhonen L, Homutov AR, Ianne Iu.

Bioorg Khim. 2014 Mar-Apr;40(2):170-7. Russian.

PMID:
25895336
7.

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Hyvönen MT, Khomutov M, Petit M, Weisell J, Kochetkov SN, Alhonen L, Vepsäläinen J, Khomutov AR, Keinänen TA.

ACS Chem Biol. 2015 Jun 19;10(6):1417-24. doi: 10.1021/cb500938e. Epub 2015 Feb 27.

PMID:
25689365
8.

Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype.

Pirnes-Karhu S, Määttä J, Finnilä M, Alhonen L, Uimari A.

Transgenic Res. 2015 Apr;24(2):253-65. doi: 10.1007/s11248-014-9836-6. Epub 2014 Sep 18.

PMID:
25231394
9.

Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice.

Vapola MH, Rokka A, Sormunen RT, Alhonen L, Schmitz W, Conzelmann E, Wärri A, Grunau S, Antonenkov VD, Hiltunen JK.

Dev Biol. 2014 Jul 1;391(1):66-80. doi: 10.1016/j.ydbio.2014.03.022. Epub 2014 Apr 12.

10.

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.

Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198.

11.

Spermidine/spermine N(1)-acetyltransferase activity associates with white blood cell count in myeloid leukemias.

Pirnes-Karhu S, Jantunen E, Mäntymaa P, Mustjoki S, Alhonen L, Uimari A.

Exp Hematol. 2014 Jul;42(7):574-80. doi: 10.1016/j.exphem.2014.02.008. Epub 2014 Mar 4.

PMID:
24607957
12.

Ethanol-induced impairment of polyamine homeostasis--a potential cause of neural tube defect and intrauterine growth restriction in fetal alcohol syndrome.

Haghighi Poodeh S, Alhonen L, Salonurmi T, Savolainen MJ.

Biochem Biophys Res Commun. 2014 Mar 28;446(1):173-8. doi: 10.1016/j.bbrc.2014.02.079. Epub 2014 Feb 25.

PMID:
24582559
13.

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN.

Biochemistry (Mosc). 2013 Dec;78(13):1431-46. doi: 10.1134/S0006297913130051. Review.

14.

Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis.

Pietilä M, Dhungana H, Uimari A, Sironen R, Alhonen L.

Transgenic Res. 2014 Feb;23(1):153-63. doi: 10.1007/s11248-013-9763-y. Epub 2013 Oct 31.

PMID:
24174210
15.

Selective regulation of polyamine metabolism with methylated polyamine analogues.

Keinänen TA, Hyvönen MT, Alhonen L, Vepsäläinen J, Khomutov AR.

Amino Acids. 2014 Mar;46(3):605-20. Epub 2013 Oct 10. Review.

PMID:
24022706
16.

Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N¹-acetyltransferase.

Pirnes-Karhu S, Mäntymaa P, Sironen R, Mäkinen PI, Wojciechowski S, Juutinen S, Koistinaho J, Hörkkö S, Jantunen E, Alhonen L, Uimari A.

Amino Acids. 2014 Mar;46(3):689-700. doi: 10.1007/s00726-013-1546-5. Epub 2013 Jul 9.

PMID:
23836421
17.

Charge deficient analogues of the natural polyamines.

Weisell J, Hyvönen MT, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

Curr Pharm Des. 2014;20(2):262-77. Review.

PMID:
23701551
18.

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A.

Hyvönen MT, Koponen T, Weisell J, Pietilä M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2013 Aug 1;453(3):467-74. doi: 10.1042/BJ20130263.

PMID:
23672317
19.

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.

Hyvönen MT, Weisell J, Khomutov AR, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2013 Jan;41(1):30-2. doi: 10.1124/dmd.112.047274. Epub 2012 Sep 28.

PMID:
23024204
20.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

Smirnova OA, Isaguliants MG, Hyvonen MT, Keinanen TA, Tunitskaya VL, Vepsalainen J, Alhonen L, Kochetkov SN, Ivanov AV.

Biochimie. 2012 Sep;94(9):1876-83. doi: 10.1016/j.biochi.2012.04.023. Epub 2012 May 8.

PMID:
22579641
21.

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes.

Van den Bossche J, Lamers WH, Koehler ES, Geuns JM, Alhonen L, Uimari A, Pirnes-Karhu S, Van Overmeire E, Morias Y, Brys L, Vereecke L, De Baetselier P, Van Ginderachter JA.

J Leukoc Biol. 2012 May;91(5):685-99. doi: 10.1189/jlb.0911453. Epub 2012 Mar 13.

PMID:
22416259
22.

Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism.

Cerrada-Gimenez M, Tusa M, Casellas A, Pirinen E, Moya M, Bosch F, Alhonen L.

Transgenic Res. 2012 Aug;21(4):843-53. doi: 10.1007/s11248-011-9579-6. Epub 2011 Dec 18.

PMID:
22180015
23.

Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.

Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Grigorenko N, Khomutov AR, Nordback I, Räty S, Pörsti I, Alhonen L, Sand J.

Pharmacol Rep. 2011;63(4):999-1008.

24.

Complex N-acetylation of triethylenetetramine.

Cerrada-Gimenez M, Weisell J, Hyvönen MT, Park MH, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2011 Dec;39(12):2242-9. doi: 10.1124/dmd.111.041798. Epub 2011 Aug 30.

25.

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Vepsäläinen J, Park JH, Khomutov AR, Alhonen L, Park MH.

Amino Acids. 2012 Feb;42(2-3):685-95. doi: 10.1007/s00726-011-0984-1. Epub 2011 Aug 23.

26.

A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells.

Nayvelt I, John S, Hsu HC, Yang P, Liu W, Das G, Hyvönen MT, Alhonen L, Keinänen TA, Shirahata A, Patel R, Thomas T, Thomas TJ.

Amino Acids. 2012 Feb;42(2-3):899-911. doi: 10.1007/s00726-011-1005-0. Epub 2011 Aug 10.

PMID:
21830120
27.

Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS.

Cerrada-Gimenez M, Häkkinen MR, Vepsäläinen J, Auriola S, Alhonen L, Keinänen TA.

Amino Acids. 2012 Feb;42(2-3):451-60. doi: 10.1007/s00726-011-1024-x. Epub 2011 Aug 5.

PMID:
21818565
28.

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

Koponen T, Cerrada-Gimenez M, Pirinen E, Hohtola E, Paananen J, Vuohelainen S, Tusa M, Pirnes-Karhu S, Heikkinen S, Virkamäki A, Uimari A, Alhonen L, Laakso M.

Amino Acids. 2012 Feb;42(2-3):427-40. doi: 10.1007/s00726-011-1013-0. Epub 2011 Aug 4.

PMID:
21814795
29.

Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse.

Uimari A, Merentie M, Sironen R, Pirnes-Karhu S, Peräniemi S, Alhonen L.

Amino Acids. 2012 Feb;42(2-3):461-71. doi: 10.1007/s00726-011-1025-9. Epub 2011 Aug 4.

PMID:
21814793
30.

Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N1-acetyltransferase (SSAT) overexpressing mice.

Pirnes-Karhu S, Sironen R, Alhonen L, Uimari A.

Amino Acids. 2012 Feb;42(2-3):473-84. doi: 10.1007/s00726-011-1026-8. Epub 2011 Aug 4.

PMID:
21814792
31.

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase.

Hyvönen MT, Uimari A, Vepsäläinen J, Khomutov AR, Keinänen TA, Alhonen L.

Amino Acids. 2012 Feb;42(2-3):485-93. doi: 10.1007/s00726-011-1027-7. Epub 2011 Aug 2.

PMID:
21809078
32.

Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer.

Pietilä M, Lampinen A, Pellinen R, Alhonen L.

Amino Acids. 2012 Feb;42(2-3):559-64. doi: 10.1007/s00726-011-1033-9. Epub 2011 Jul 29.

PMID:
21800259
33.

The crucial role of early mitochondrial injury in L-lysine-induced acute pancreatitis.

Biczó G, Hegyi P, Dósa S, Shalbuyeva N, Berczi S, Sinervirta R, Hracskó Z, Siska A, Kukor Z, Jármay K, Venglovecz V, Varga IS, Iványi B, Alhonen L, Wittmann T, Gukovskaya A, Takács T, Rakonczay Z Jr.

Antioxid Redox Signal. 2011 Nov 15;15(10):2669-81. doi: 10.1089/ars.2011.4065. Epub 2011 Jul 18.

34.

The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Weisell J, Kochetkov SN, Vepsäläinen J, Alhonen L, Khomutov AR.

J Med Chem. 2011 Jul 14;54(13):4611-8. doi: 10.1021/jm200293r. Epub 2011 Jun 3.

PMID:
21639123
35.

Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis.

Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Räty S, Nordback I, Herzig KH, Alhonen L, Sand J.

Pancreatology. 2011;11(2):83-91. doi: 10.1159/000327260. Epub 2011 Apr 27.

PMID:
21525776
36.

Methylated polyamines as research tools.

Khomutov AR, Weisell J, Khomutov MA, Grigorenko NA, Simonian AR, Häkkinen MR, Keinänen TA, Hyvönen MT, Alhonen L, Kochetkov SN, Vepsäläinen J.

Methods Mol Biol. 2011;720:449-61. doi: 10.1007/978-1-61779-034-8_29.

PMID:
21318892
37.

Transgenic rodents with altered SSAT expression as models of pancreatitis and altered glucose and lipid metabolism.

Uimari A, Hyvönen MT, Pirinen E, Alhonen L.

Methods Mol Biol. 2011;720:143-58. doi: 10.1007/978-1-61779-034-8_8.

PMID:
21318871
38.

Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.

Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, Mervaala E, Andersson LC, Knuuti J, Alitalo K.

Circulation. 2010 Oct 26;122(17):1725-33. doi: 10.1161/CIRCULATIONAHA.110.957332. Epub 2010 Oct 11.

PMID:
20937974
39.

Synthesis and biological characterization of novel charge-deficient spermine analogues.

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

J Med Chem. 2010 Aug 12;53(15):5738-48. doi: 10.1021/jm100439p.

PMID:
20684609
40.

Polyamines and hair: a couple in search of perfection.

Ramot Y, Pietilä M, Giuliani G, Rinaldi F, Alhonen L, Paus R.

Exp Dermatol. 2010 Sep;19(9):784-90. doi: 10.1111/j.1600-0625.2010.01111.x. Epub 2010 Jul 14. Review.

PMID:
20629736
41.

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.

Cerrada-Gimenez M, Pietilä M, Loimas S, Pirinen E, Hyvönen MT, Keinänen TA, Jänne J, Alhonen L.

Transgenic Res. 2011 Apr;20(2):387-96. doi: 10.1007/s11248-010-9422-5. Epub 2010 Jun 25.

PMID:
20577801
42.

Characterization of polyamine homeostasis in l-ornithine-induced acute pancreatitis in rats.

Biczó G, Hegyi P, Sinervirta R, Berczi S, Dósa S, Siska A, Iványi B, Venglovecz V, Takács T, Alhonen L, Rakonczay Z Jr.

Pancreas. 2010 Oct;39(7):1047-56. doi: 10.1097/MPA.0b013e3181d3cdf0.

PMID:
20531247
43.

Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.

Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L.

Pancreatology. 2010;10(2-3):208-21. doi: 10.1159/000243730. Epub 2010 May 7.

PMID:
20453551
44.

The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury.

Zahedi K, Barone S, Kramer DL, Amlal H, Alhonen L, Jänne J, Porter CW, Soleimani M.

Am J Physiol Cell Physiol. 2010 Jul;299(1):C164-74. doi: 10.1152/ajpcell.00512.2009. Epub 2010 Apr 14.

45.

A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.

Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC.

J Alzheimers Dis. 2010;20(1):113-26. doi: 10.3233/JAD-2010-1349.

PMID:
20164597
46.

Transgenic animals modelling polyamine metabolism-related diseases.

Alhonen L, Uimari A, Pietilä M, Hyvönen MT, Pirinen E, Keinänen TA.

Essays Biochem. 2009 Nov 4;46:125-44. doi: 10.1042/bse0460009. Review.

PMID:
20095974
47.

Proteomic analysis of livers from a transgenic mouse line with activated polyamine catabolism.

Cerrada-Gimenez M, Häyrinen J, Juutinen S, Reponen T, Jänne J, Alhonen L.

Amino Acids. 2010 Feb;38(2):613-22. doi: 10.1007/s00726-009-0420-y. Epub 2009 Dec 10.

PMID:
20012117
48.

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases.

Häkkinen MR, Hyvönen MT, Auriola S, Casero RA Jr, Vepsäläinen J, Khomutov AR, Alhonen L, Keinänen TA.

Amino Acids. 2010 Feb;38(2):369-81. doi: 10.1007/s00726-009-0429-2. Epub 2009 Dec 10.

49.

Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin.

Mäkelä KA, Wigren HK, Zant JC, Sakurai T, Alhonen L, Kostin A, Porkka-Heiskanen T, Herzig KH.

Acta Physiol (Oxf). 2010 Mar;198(3):237-49. doi: 10.1111/j.1748-1716.2009.02068.x. Epub 2009 Dec 10.

PMID:
20003098
50.

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA, Laakso M.

Amino Acids. 2010 Feb;38(2):549-60. doi: 10.1007/s00726-009-0416-7. Epub 2009 Dec 3.

PMID:
19956992

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