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Items: 42


Revival of Krebs-Ringer balanced salt solution for the investigation of polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilm interaction.

Bjarnsholt T, Jensen PØ, Alhede M.

Pathog Dis. 2019 Jul 1;77(5). pii: ftz052. doi: 10.1093/femspd/ftz052.


Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis.

Ø Gadsbøll AS, Jee MH, Funch AB, Alhede M, Mraz V, Weber JF, Callender LA, Carroll EC, Bjarnsholt T, Woetmann A, Ødum N, Thomsen AR, Johansen JD, Henson SM, Geisler C, Bonefeld CM.

J Invest Dermatol. 2019 Sep 10. pii: S0022-202X(19)33218-X. doi: 10.1016/j.jid.2019.07.722. [Epub ahead of print]


The use of fluorescent staining techniques for microscopic investigation of polymorphonuclear leukocytes and bacteria.

Alhede M, Stavnsbjerg C, Bjarnsholt T.

APMIS. 2018 Oct;126(10):779-794. doi: 10.1111/apm.12888. Epub 2018 Sep 6. Review.


Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin.

Woetmann A, Alhede M, Dabelsteen S, Bjarnsholt T, Rybtke M, Nastasi C, Krejsgaard T, Andersen MH, Bonefeld CM, Geisler C, Givskov M, Odum N.

Oncotarget. 2018 Apr 13;9(28):19481-19489. doi: 10.18632/oncotarget.24603. eCollection 2018 Apr 13.


The Inoculation Method Could Impact the Outcome of Microbiological Experiments.

Kragh KN, Alhede M, Rybtke M, Stavnsberg C, Jensen PØ, Tolker-Nielsen T, Whiteley M, Bjarnsholt T.

Appl Environ Microbiol. 2018 Feb 14;84(5). pii: e02264-17. doi: 10.1128/AEM.02264-17. Print 2018 Mar 1.


The Consequences of Being in an Infectious Biofilm: Microenvironmental Conditions Governing Antibiotic Tolerance.

Sønderholm M, Bjarnsholt T, Alhede M, Kolpen M, Jensen PØ, Kühl M, Kragh KN.

Int J Mol Sci. 2017 Dec 12;18(12). pii: E2688. doi: 10.3390/ijms18122688. Review.


Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro.

Jakobsen TH, Alhede M, Hultqvist LD, Bjarnsholt T, Givskov M.

Methods Mol Biol. 2018;1673:275-285. doi: 10.1007/978-1-4939-7309-5_21.


Imaging N-Acyl Homoserine Lactone Quorum Sensing In Vivo.

Hultqvist LD, Alhede M, Jakobsen TH, Givskov M, Bjarnsholt T.

Methods Mol Biol. 2018;1673:203-212. doi: 10.1007/978-1-4939-7309-5_16.


Pseudomonas aeruginosa Aggregate Formation in an Alginate Bead Model System Exhibits In Vivo-Like Characteristics.

Sønderholm M, Kragh KN, Koren K, Jakobsen TH, Darch SE, Alhede M, Jensen PØ, Whiteley M, Kühl M, Bjarnsholt T.

Appl Environ Microbiol. 2017 Apr 17;83(9). pii: e00113-17. doi: 10.1128/AEM.00113-17. Print 2017 May 1.


Activation of pulmonary and lymph node dendritic cells during chronic Pseudomonas aeruginosa lung infection in mice.

Damlund DS, Christophersen L, Jensen PØ, Alhede M, Høiby N, Moser C.

APMIS. 2016 Jun;124(6):500-7. doi: 10.1111/apm.12530. Epub 2016 Mar 24.


In silico analyses of metagenomes from human atherosclerotic plaque samples.

Mitra S, Drautz-Moses DI, Alhede M, Maw MT, Liu Y, Purbojati RW, Yap ZH, Kushwaha KK, Gheorghe AG, Bjarnsholt T, Hansen GM, Sillesen HH, Hougen HP, Hansen PR, Yang L, Tolker-Nielsen T, Schuster SC, Givskov M.

Microbiome. 2015 Sep 3;3:38. doi: 10.1186/s40168-015-0100-y.


Antibiofilm Properties of Acetic Acid.

Bjarnsholt T, Alhede M, Jensen PØ, Nielsen AK, Johansen HK, Homøe P, Høiby N, Givskov M, Kirketerp-Møller K.

Adv Wound Care (New Rochelle). 2015 Jul 1;4(7):363-372.


Autofluorescence in samples obtained from chronic biofilm infections--"all that glitters is not gold".

Eickhardt S, Kragh KN, Schrøder S, Poulsen SS, Sillesen H, Givskov M, Høiby N, Bjarnsholt T, Alhede M.

Pathog Dis. 2015 Jun;73(4). pii: ftv012. doi: 10.1093/femspd/ftv012. Epub 2015 Feb 5.


A novel in vitro wound biofilm model used to evaluate low-frequency ultrasonic-assisted wound debridement.

Crone S, Garde C, Bjarnsholt T, Alhede M.

J Wound Care. 2015 Feb;24(2):64, 66-9, 72. doi: 10.12968/jowc.2015.24.2.64.


Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum.

Line L, Alhede M, Kolpen M, Kühl M, Ciofu O, Bjarnsholt T, Moser C, Toyofuku M, Nomura N, Høiby N, Jensen PØ.

Front Microbiol. 2014 Oct 24;5:554. doi: 10.3389/fmicb.2014.00554. eCollection 2014.


Microbial biofilms and adverse reactions to gel fillers used in cosmetic surgery.

Alhede M, Christensen LH, Bjarnsholt T.

Adv Exp Med Biol. 2015;831:45-52. doi: 10.1007/978-3-319-09782-4_4. Review. No abstract available.


Biofilms in wounds: a review of present knowledge.

Cooper RA, Bjarnsholt T, Alhede M.

J Wound Care. 2014 Nov;23(11):570, 572-4, 576-80 passim. doi: 10.12968/jowc.2014.23.11.570. Review.


Are biofilms responsible for the adverse effects experienced following soft-tissue fillers?

Alhede M, Bjarnsholt T.

Future Microbiol. 2014;9(8):931-3. doi: 10.2217/fmb.14.57. No abstract available.


Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.

Kragh KN, Alhede M, Jensen PØ, Moser C, Scheike T, Jacobsen CS, Seier Poulsen S, Eickhardt-Sørensen SR, Trøstrup H, Christoffersen L, Hougen HP, Rickelt LF, Kühl M, Høiby N, Bjarnsholt T.

Infect Immun. 2014 Nov;82(11):4477-86. doi: 10.1128/IAI.01969-14. Epub 2014 Aug 11.


Bacterial biofilm formation and treatment in soft tissue fillers.

Alhede M, Er Ö, Eickhardt S, Kragh K, Alhede M, Christensen LD, Poulsen SS, Givskov M, Christensen LH, Høiby N, Tvede M, Bjarnsholt T.

Pathog Dis. 2014 Apr;70(3):339-46. doi: 10.1111/2049-632X.12139. Epub 2014 Feb 18.


Pseudomonas aeruginosa biofilms: mechanisms of immune evasion.

Alhede M, Bjarnsholt T, Givskov M, Alhede M.

Adv Appl Microbiol. 2014;86:1-40. doi: 10.1016/B978-0-12-800262-9.00001-9. Review.


Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes.

Jakobsen TH, Hansen MA, Jensen PØ, Hansen L, Riber L, Cockburn A, Kolpen M, Rønne Hansen C, Ridderberg W, Eickhardt S, Hansen M, Kerpedjiev P, Alhede M, Qvortrup K, Burmølle M, Moser C, Kühl M, Ciofu O, Givskov M, Sørensen SJ, Høiby N, Bjarnsholt T.

PLoS One. 2013 Jul 22;8(7):e68484. doi: 10.1371/journal.pone.0068484. Print 2013.


The in vivo biofilm.

Bjarnsholt T, Alhede M, Alhede M, Eickhardt-Sørensen SR, Moser C, Kühl M, Jensen PØ, Høiby N.

Trends Microbiol. 2013 Sep;21(9):466-74. doi: 10.1016/j.tim.2013.06.002. Epub 2013 Jul 2. Review.


Clearance of Pseudomonas aeruginosa foreign-body biofilm infections through reduction of the cyclic Di-GMP level in the bacteria.

Christensen LD, van Gennip M, Rybtke MT, Wu H, Chiang WC, Alhede M, Høiby N, Nielsen TE, Givskov M, Tolker-Nielsen T.

Infect Immun. 2013 Aug;81(8):2705-13. doi: 10.1128/IAI.00332-13. Epub 2013 May 20.


P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs.

Ciofu O, Johansen HK, Aanaes K, Wassermann T, Alhede M, von Buchwald C, Høiby N.

J Cyst Fibros. 2013 Dec;12(6):729-36. doi: 10.1016/j.jcf.2013.02.004. Epub 2013 Mar 9.


A non-fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient.

Eickhardt S, Braendstrup P, Clasen-Linde E, Jensen KE, Alhede M, Bjarnsholt T, Høiby N, Vindeløv L, Moser C.

APMIS. 2013 May;121(5):456-9. doi: 10.1111/apm.12008. Epub 2012 Nov 23.


Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo.

van Gennip M, Christensen LD, Alhede M, Qvortrup K, Jensen PØ, Høiby N, Givskov M, Bjarnsholt T.

Infect Immun. 2012 Aug;80(8):2601-7. doi: 10.1128/IAI.06215-11. Epub 2012 May 14.


Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition.

Alhede M, Qvortrup K, Liebrechts R, Høiby N, Givskov M, Bjarnsholt T.

FEMS Immunol Med Microbiol. 2012 Jul;65(2):335-42. doi: 10.1111/j.1574-695X.2012.00956.x. Epub 2012 Apr 23.


Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.

Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PØ, Moser C, Nielsen KF, Eberl L, Larsen TO, Tanner D, Høiby N, Bjarnsholt T, Givskov M.

Antimicrob Agents Chemother. 2012 May;56(5):2314-25. doi: 10.1128/AAC.05919-11. Epub 2012 Feb 6.


Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.

Christensen LD, van Gennip M, Jakobsen TH, Alhede M, Hougen HP, Høiby N, Bjarnsholt T, Givskov M.

J Antimicrob Chemother. 2012 May;67(5):1198-206. doi: 10.1093/jac/dks002. Epub 2012 Feb 1.


Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa.

Jakobsen TH, Bragason SK, Phipps RK, Christensen LD, van Gennip M, Alhede M, Skindersoe M, Larsen TO, Høiby N, Bjarnsholt T, Givskov M.

Appl Environ Microbiol. 2012 Apr;78(7):2410-21. doi: 10.1128/AEM.05992-11. Epub 2012 Jan 27.


The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients.

Rudkjøbing VB, Thomsen TR, Alhede M, Kragh KN, Nielsen PH, Johansen UR, Givskov M, Høiby N, Bjarnsholt T.

FEMS Immunol Med Microbiol. 2012 Jul;65(2):236-44. doi: 10.1111/j.1574-695X.2011.00925.x. Epub 2012 Jan 23.


Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm.

Alhede M, Kragh KN, Qvortrup K, Allesen-Holm M, van Gennip M, Christensen LD, Jensen PØ, Nielsen AK, Parsek M, Wozniak D, Molin S, Tolker-Nielsen T, Høiby N, Givskov M, Bjarnsholt T.

PLoS One. 2011;6(11):e27943. doi: 10.1371/journal.pone.0027943. Epub 2011 Nov 21.


Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM).

Mandsberg LF, Maciá MD, Bergmann KR, Christiansen LE, Alhede M, Kirkby N, Høiby N, Oliver A, Ciofu O.

FEMS Microbiol Lett. 2011 Nov;324(1):28-37. doi: 10.1111/j.1574-6968.2011.02383.x. Epub 2011 Sep 13.


True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis.

Rudkjøbing VB, Thomsen TR, Alhede M, Kragh KN, Nielsen PH, Johansen UR, Givskov M, Høiby N, Bjarnsholt T.

J Clin Microbiol. 2011 Dec;49(12):4352-5. doi: 10.1128/JCM.06092-11. Epub 2011 Oct 19.


Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells.

Parker D, Cohen TS, Alhede M, Harfenist BS, Martin FJ, Prince A.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):6-13. doi: 10.1165/rcmb.2011-0080OC.


Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes.

Alhede M, Bjarnsholt T, Jensen PØ, Phipps RK, Moser C, Christophersen L, Christensen LD, van Gennip M, Parsek M, Høiby N, Rasmussen TB, Givskov M.

Microbiology. 2009 Nov;155(Pt 11):3500-8. doi: 10.1099/mic.0.031443-0. Epub 2009 Jul 30.


Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes.

Van Gennip M, Christensen LD, Alhede M, Phipps R, Jensen PØ, Christophersen L, Pamp SJ, Moser C, Mikkelsen PJ, Koh AY, Tolker-Nielsen T, Pier GB, Høiby N, Givskov M, Bjarnsholt T.

APMIS. 2009 Jul;117(7):537-46. doi: 10.1111/j.1600-0463.2009.02466.x.


Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa.

Skindersoe ME, Alhede M, Phipps R, Yang L, Jensen PO, Rasmussen TB, Bjarnsholt T, Tolker-Nielsen T, Høiby N, Givskov M.

Antimicrob Agents Chemother. 2008 Oct;52(10):3648-63. doi: 10.1128/AAC.01230-07. Epub 2008 Jul 21.


Pseudomonas aeruginosa uses type III secretion system to kill biofilm-associated amoebae.

Matz C, Moreno AM, Alhede M, Manefield M, Hauser AR, Givskov M, Kjelleberg S.

ISME J. 2008 Aug;2(8):843-52. doi: 10.1038/ismej.2008.47. Epub 2008 May 15.


Phenotypic diversification and adaptation of Serratia marcescens MG1 biofilm-derived morphotypes.

Koh KS, Lam KW, Alhede M, Queck SY, Labbate M, Kjelleberg S, Rice SA.

J Bacteriol. 2007 Jan;189(1):119-30. Epub 2006 Oct 27.

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