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Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019.

Donaldson K, Buchanich JM, Grigson PS, Deneke E, Donaldson K, Vrana KE, Sacks DB, Kuehn GJ, Cardamone D, Pesce A, Smiley S, Nickley J, Krock K, Thomas R, Wilkerson ML, Farag HA, Challa SR, Tice AM, Wolk DM, Prichard J, Grant ML, Regmi S, Kerbacher B, Quinton LE, Farag HA, Tice AM, Wolk DM, Olson J, Haynes A, Yu E, McCully KS, Assi J, Wong M, Zarrin-Khameh N, Nifong TP, Hawker CD, Carlton GT, Rivera JM, Foulis PR, Zuraw A, Morlote D, Peker D, Reddy V, Harada S, Crutchfield C, Zander D, Barbhuiya MA, Pederson EC, Straub ML, Scott SC, Neibauer TL, Salter WF, Creer MH, Zhu Y, Bornhorst JA, Theobald JP, Algeciras-Schimnich A, Cao L, Knox J, Hardy R, Texas HJ, McGuire MF, Hunter RL, Brown RE, Hicks J, Hicks J, Cai Z, Brown RE, Ali Y, Cheng KC, Katz SR, Ding Y, Vanselow DJ, Yakovlev MA, Lin AY, Clark DP, Vargas P, Xin X, Copper JE, Canfield VA, Ang KC, Wang Y, Xiao X, De Carlo F, van Rossum DB, La Rivière PJ, Newell J, Hossler C, Roche M, Warrick J, Phaeton R, Kesterson J, Donaldson K, Myers C, Barrios R, Mintz P, Robyak K, Hamilton C, McGhee P, Pederson C, Straub M, Scott S, Neibauer T, Salter W, Creer M, Zhu Y, Hamilton C, Robyak K, McGhee P, Pederson C, Straub M, Scott S, Neibauer T, Salter W, Creer M, Zhu Y, Singh N, Morlote D, Vnencak-Jones C, Yemelyanova A, Harada S, Shah M, Moghadamtousi SZ, Lan C, Duose D, Hu P, Esquenazi Y, Luthra R, Ballester LY, Koenig AN, Liu CG, Zhang J, Kalia A, Al-Habib A, Van Arsdall M, Dhingra S, Patel K, Tatevian N.

Ann Clin Lab Sci. 2019 May;49(3):403-416. No abstract available.


Human chorionic gonadotropin suspected heterophile interference investigations in immunoassays: a recommended approach.

Jara-Aguirre JC, Baumann NA, Block DR, Algeciras-Schimnich A.

Clin Chem Lab Med. 2019 Jul 26;57(8):1192-1196. doi: 10.1515/cclm-2018-1142.


GALAD Score for Hepatocellular Carcinoma Detection in Comparison with Liver Ultrasound and Proposal of GALADUS Score.

Yang JD, Addissie BD, Mara KC, Harmsen WS, Dai J, Zhang N, Wongjarupong N, Ali HM, Ali HA, Hassan FA, Lavu S, Cvinar JL, Giama NH, Moser CD, Miyabe K, Allotey LK, Algeciras-Schimnich A, Theobald JP, Ward MM, Nguyen MH, Befeler AS, Reddy KR, Schwartz M, Harnois DM, Yamada H, Srivastava S, Rinaudo JA, Gores GJ, Feng Z, Marrero JA, Roberts LR.

Cancer Epidemiol Biomarkers Prev. 2019 Mar;28(3):531-538. doi: 10.1158/1055-9965.EPI-18-0281. Epub 2018 Nov 21.


Corticotropin hormone assay interference: A case series.

Donegan DM, Algeciras-Schimnich A, Hamidi O, Young WF, Nippoldt T, Bancos I, Erickson D.

Clin Biochem. 2019 Jan;63:143-147. doi: 10.1016/j.clinbiochem.2018.11.006. Epub 2018 Nov 10.


Comparing the performance of CA 15-3 CSF to cytology in a cohort of patients with breast cancer leptomeningeal metastasis.

Kenyon SM, Flieth TL, Algeciras-Schimnich A.

Clin Biochem. 2018 Aug;58:122-124. doi: 10.1016/j.clinbiochem.2018.06.004. Epub 2018 Jun 12.


Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models.

Wongjarupong N, Negron-Ocasio GM, Chaiteerakij R, Addissie BD, Mohamed EA, Mara KC, Harmsen WS, Theobald JP, Peters BE, Balsanek JG, Ward MM, Giama NH, Venkatesh SK, Harnois DM, Charlton MR, Yamada H, Algeciras-Schimnich A, Snyder MR, Therneau TM, Roberts LR.

World J Gastroenterol. 2018 Mar 28;24(12):1321-1331. doi: 10.3748/wjg.v24.i12.1321.


Thyroglobulin measurement in the management of patients with differentiated thyroid cancer.

Algeciras-Schimnich A.

Crit Rev Clin Lab Sci. 2018 May;55(3):205-218. doi: 10.1080/10408363.2018.1450830. Epub 2018 Mar 16. Review.


Validation of the Cut-points Recommended for ROMA Using the Roche Elecsys CA125 and HE4 Assays.

Cradic KW, Lasho MA, Algeciras-Schimnich A.

Ann Clin Lab Sci. 2018 Jan;48(1):90-93.


Current and Emerging Multianalyte Assays with Algorithmic Analyses-Are Laboratories Ready for Clinical Adoption?

Colón-Franco JM, Bossuyt PMM, Algeciras-Schimnich A, Bird C, Engstrom-Melnyk J, Fleisher M, Kattan M, Lambert-Messerlian G.

Clin Chem. 2018 Jun;64(6):885-891. doi: 10.1373/clinchem.2017.275677. Epub 2018 Jan 17. No abstract available.


United States and European Multicenter Prospective Study for the Analytical Performance and Clinical Validation of a Novel Sensitive Fully Automated Immunoassay for Calcitonin.

Kahaly GJ, Algeciras-Schimnich A, Davis TE, Diana T, Feldkamp J, Karger S, König J, Lupo MA, Raue F, Ringel MD, Sipos JA, Kratzsch J.

Clin Chem. 2017 Sep;63(9):1489-1496. doi: 10.1373/clinchem.2016.270009. Epub 2017 Jul 7.


Analytical and clinical performance of thyroglobulin autoantibody assays in thyroid cancer follow-up.

Katrangi W, Grebe SKG, Algeciras-Schimnich A.

Clin Chem Lab Med. 2017 Oct 26;55(12):1987-1994. doi: 10.1515/cclm-2017-0034.


Evaluation of the CLSI EP26-A protocol for detection of reagent lot-to-lot differences.

Katzman BM, Ness KM, Algeciras-Schimnich A.

Clin Biochem. 2017 Sep;50(13-14):768-771. doi: 10.1016/j.clinbiochem.2017.03.012. Epub 2017 Mar 18.


Perspective and priorities for improvement of parathyroid hormone (PTH) measurement - A view from the IFCC Working Group for PTH.

Sturgeon CM, Sprague S, Almond A, Cavalier E, Fraser WD, Algeciras-Schimnich A, Singh R, Souberbielle JC, Vesper HW; IFCC Working Group for PTH.

Clin Chim Acta. 2017 Apr;467:42-47. doi: 10.1016/j.cca.2016.10.016. Epub 2016 Oct 13. Review.


Thyroglobulin Measurement in Fine-Needle Aspiration Improves the Diagnosis of Cervical Lymph Node Metastases in Papillary Thyroid Carcinoma.

Al-Hilli Z, Strajina V, McKenzie TJ, Thompson GB, Farley DR, Regina Castro M, Algeciras-Schimnich A, Richards ML.

Ann Surg Oncol. 2017 Mar;24(3):739-744. doi: 10.1245/s10434-016-5625-1. Epub 2016 Oct 13.



Algeciras-Schimnich A.

Clin Chem. 2016 Oct;62(10):1316-7. doi: 10.1373/clinchem.2016.256081. No abstract available.


Association of Ovary-Sparing Hysterectomy With Ovarian Reserve.

Trabuco EC, Moorman PG, Algeciras-Schimnich A, Weaver AL, Cliby WA.

Obstet Gynecol. 2016 May;127(5):819-27. doi: 10.1097/AOG.0000000000001398.


Diagnostic accuracy and clinical relevance of an inflammatory biomarker panel for sepsis in adult critically ill patients.

Bauer PR, Kashyap R, League SC, Park JG, Block DR, Baumann NA, Algeciras-Schimnich A, Jenkins SM, Smith CY, Gajic O, Abraham RS.

Diagn Microbiol Infect Dis. 2016 Feb;84(2):175-80. doi: 10.1016/j.diagmicrobio.2015.10.003. Epub 2015 Oct 9.


Analytical and clinical validation of parathyroid hormone (PTH) measurement in fine-needle aspiration biopsy (FNAB) washings.

Ketha H, Lasho MA, Algeciras-Schimnich A.

Clin Biochem. 2016 Jan;49(1-2):16-21. doi: 10.1016/j.clinbiochem.2015.09.006. Epub 2015 Sep 15.


Thyroglobulin (Tg) Testing Revisited: Tg Assays, TgAb Assays, and Correlation of Results With Clinical Outcomes.

Netzel BC, Grebe SK, Carranza Leon BG, Castro MR, Clark PM, Hoofnagle AN, Spencer CA, Turcu AF, Algeciras-Schimnich A.

J Clin Endocrinol Metab. 2015 Aug;100(8):E1074-83. doi: 10.1210/jc.2015-1967. Epub 2015 Jun 16.


Detection of IGF-1 protein variants by use of LC-MS with high-resolution accurate mass in routine clinical analysis.

Hines J, Milosevic D, Ketha H, Taylor R, Algeciras-Schimnich A, Grebe SK, Singh RJ.

Clin Chem. 2015 Jul;61(7):990-1. doi: 10.1373/clinchem.2014.234799. Epub 2015 Apr 28. No abstract available.


Combinations of biomarkers and Milan criteria for predicting hepatocellular carcinoma recurrence after liver transplantation.

Chaiteerakij R, Zhang X, Addissie BD, Mohamed EA, Harmsen WS, Theobald PJ, Peters BE, Balsanek JG, Ward MM, Giama NH, Moser CD, Oseini AM, Umeda N, Venkatesh S, Harnois DM, Charlton MR, Yamada H, Satomura S, Algeciras-Schimnich A, Snyder MR, Therneau TM, Roberts LR.

Liver Transpl. 2015 May;21(5):599-606. doi: 10.1002/lt.24117.


Evaluation of Beckman Coulter DxI 800 immunoassay system using clinically oriented performance goals.

Akbas N, Schryver PG, Algeciras-Schimnich A, Baumann NA, Block DR, Budd JR, Gaston SJ, Klee GG.

Clin Biochem. 2014 Nov;47(16-17):158-63. doi: 10.1016/j.clinbiochem.2014.08.005. Epub 2014 Aug 15.


Usefulness of a thyroglobulin liquid chromatography-tandem mass spectrometry assay for evaluation of suspected heterophile interference.

Netzel BC, Grebe SK, Algeciras-Schimnich A.

Clin Chem. 2014 Jul;60(7):1016-8. doi: 10.1373/clinchem.2014.224816. Epub 2014 May 8. No abstract available.


Clinical consequences of a change in anti-thyroglobulin antibody assays during the follow-up of patients with differentiated thyroid cancer.

Donegan D, McIver B, Algeciras-Schimnich A.

Endocr Pract. 2014 Oct;20(10):1032-6. doi: 10.4158/EP13499.OR.


Evaluation of Variables Influencing the Measurement of Insulin-like Growth Factor-1.

Bancos I, Algeciras-Schimnich A, Grebe SK, Donato LJ, Nippoldt TB, Erickson D.

Endocr Pract. 2014 May;20(5):421-6. doi: 10.4158/EP13359.OR.


Body fluid analysis: clinical utility and applicability of published studies to guide interpretation of today's laboratory testing in serous fluids.

Block DR, Algeciras-Schimnich A.

Crit Rev Clin Lab Sci. 2013 Jul-Oct;50(4-5):107-24. doi: 10.3109/10408363.2013.844679. Review.


Determination of nadir growth hormone concentration cutoff in patients with acromegaly.

Bancos I, Algeciras-Schimnich A, Woodmansee WW, Cullinane AK, Donato LJ, Nippoldt TB, Natt N, Erickson D.

Endocr Pract. 2013 Nov-Dec;19(6):937-45. doi: 10.4158/EP12435.OR.


Individualized correction of neuron-specific enolase (NSE) measurement in hemolyzed serum samples.

Tolan NV, Vidal-Folch N, Algeciras-Schimnich A, Singh RJ, Grebe SK.

Clin Chim Acta. 2013 Sep 23;424:216-21. doi: 10.1016/j.cca.2013.06.009. Epub 2013 Jun 15.


Failure of current laboratory protocols to detect lot-to-lot reagent differences: findings and possible solutions.

Algeciras-Schimnich A, Bruns DE, Boyd JC, Bryant SC, La Fortune KA, Grebe SK.

Clin Chem. 2013 Aug;59(8):1187-94. doi: 10.1373/clinchem.2013.205070. Epub 2013 Apr 16.


CEA, AFP and CA 19-9 analysis in peritoneal fluid to differentiate causes of ascites formation.

Kaleta EJ, Tolan NV, Ness KA, O'Kane D, Algeciras-Schimnich A.

Clin Biochem. 2013 Jun;46(9):814-8. doi: 10.1016/j.clinbiochem.2013.02.010. Epub 2013 Feb 27.


Risks and benefits of parathyroid fine-needle aspiration with parathyroid hormone washout.

Bancos I, Grant CS, Nadeem S, Stan MN, Reading CC, Sebo TJ, Algeciras-Schimnich A, Singh RJ, Dean DS.

Endocr Pract. 2012 Jul-Aug;18(4):441-9. doi: 10.4158/EP11148.OR.


Isolation of a TRAIL antagonist from the serum of HIV-infected patients.

Schnepple DJ, Shepard B, Bren GD, Cummins NW, Natesampillai S, Trushin S, Algeciras-Schimnich A, Meng XW, Sainski AM, Rizza SA, Kaufmann SH, Badley AD.

J Biol Chem. 2011 Oct 14;286(41):35742-54. doi: 10.1074/jbc.M111.274639. Epub 2011 Aug 22.


The Putative PAX8/PPARγ Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPARγ Activity.

Reddi HV, Madde P, Milosevic D, Hackbarth JS, Algeciras-Schimnich A, McIver B, Grebe SK, Eberhardt NL.

Genes Cancer. 2011 Jan;2(1):46-55. doi: 10.1177/1947601911405045.


Analysis of circulating microRNA: preanalytical and analytical challenges.

McDonald JS, Milosevic D, Reddi HV, Grebe SK, Algeciras-Schimnich A.

Clin Chem. 2011 Jun;57(6):833-40. doi: 10.1373/clinchem.2010.157198. Epub 2011 Apr 12.


Performance of CEA and CA19-9 in identifying pleural effusions caused by specific malignancies.

Hackbarth JS, Murata K, Reilly WM, Algeciras-Schimnich A.

Clin Biochem. 2010 Sep;43(13-14):1051-5. doi: 10.1016/j.clinbiochem.2010.05.016. Epub 2010 Jun 8.


Evaluation of the PAX8/PPARG translocation in follicular thyroid cancer with a 4-color reverse-transcription PCR assay and automated high-resolution fragment analysis.

Algeciras-Schimnich A, Milosevic D, McIver B, Flynn H, Reddi HV, Eberhardt NL, Grebe SK.

Clin Chem. 2010 Mar;56(3):391-8. doi: 10.1373/clinchem.2009.134015. Epub 2010 Jan 7.


Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology.

Snozek CL, O'Kane DJ, Algeciras-Schimnich A.

J Mol Diagn. 2009 Sep;11(5):381-9. doi: 10.2353/jmoldx.2009.090003. Epub 2009 Jul 30. Review.


Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis.

Singh VP, Bren GD, Algeciras-Schimnich A, Schnepple D, Navina S, Rizza SA, Dawra RK, Saluja AK, Chari ST, Vege SS, Badley AD.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1040-6. doi: 10.1152/ajpgi.90642.2008. Epub 2009 Mar 12.


Procalcitonin: a marker for the diagnosis and follow-up of patients with medullary thyroid carcinoma.

Algeciras-Schimnich A, Preissner CM, Theobald JP, Finseth MS, Grebe SK.

J Clin Endocrinol Metab. 2009 Mar;94(3):861-8. doi: 10.1210/jc.2008-1862. Epub 2008 Dec 16.


Pharmacogenomics of tamoxifen and irinotecan therapies.

Algeciras-Schimnich A, O'Kane DJ, Snozek CL.

Clin Lab Med. 2008 Dec;28(4):553-67. doi: 10.1016/j.cll.2008.05.004. Review.


Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria.

Algeciras-Schimnich A, Belzacq-Casagrande AS, Bren GD, Nie Z, Taylor JA, Rizza SA, Brenner C, Badley AD.

Open Virol J. 2007 Dec 27;1:39-46. doi: 10.2174/1874357900701010039.


Chromosomal biomarkers for detection of human papillomavirus associated genomic instability in epithelial cells of cervical cytology specimens.

Sokolova I, Algeciras-Schimnich A, Song M, Sitailo S, Policht F, Kipp BR, Voss JS, Halling KC, Ruth A, King W, Underwood D, Brainard J, Morrison L.

J Mol Diagn. 2007 Nov;9(5):604-11. Erratum in: J Mol Diagn. 2008 Jan;10(1):109.


Plasma chromogranin A or urine fractionated metanephrines follow-up testing improves the diagnostic accuracy of plasma fractionated metanephrines for pheochromocytoma.

Algeciras-Schimnich A, Preissner CM, Young WF Jr, Singh RJ, Grebe SK.

J Clin Endocrinol Metab. 2008 Jan;93(1):91-5. Epub 2007 Oct 16.


Evaluation of hemoglobin interference in capillary heel-stick samples collected for determination of neonatal bilirubin.

Algeciras-Schimnich A, Cook WJ, Milz TC, Saenger AK, Karon BS.

Clin Biochem. 2007 Nov;40(16-17):1311-6. Epub 2007 Aug 11.


Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T cell death that is facilitated by, but does not require cell-associated CD4.

Trushin SA, Algeciras-Schimnich A, Vlahakis SR, Bren GD, Warren S, Schnepple DJ, Badley AD.

J Immunol. 2007 Apr 15;178(8):4846-53.


Flying in the face of resistance: antiviral-independent benefit of HIV protease inhibitors on T-cell survival.

Vlahakis SR, Bren GD, Algeciras-Schimnich A, Trushin SA, Schnepple DJ, Badley AD.

Clin Pharmacol Ther. 2007 Sep;82(3):294-9. Epub 2007 Mar 14.


CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8.

Barnhart BC, Pietras EM, Algeciras-Schimnich A, Salmena L, Sayama K, Hakem R, Peter ME.

Cell Death Differ. 2005 Jan;12(1):25-37.


Two CD95 tumor classes with different sensitivities to antitumor drugs.

Algeciras-Schimnich A, Pietras EM, Barnhart BC, Legembre P, Vijayan S, Holbeck SL, Peter ME.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11445-50. Epub 2003 Sep 22.

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