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Items: 1 to 20 of 126

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1.

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Wauters L, Terheyden S, Gilsbach BK, Leemans M, Athanasopoulos PS, Guaitoli G, Wittinghofer A, Gloeckner CJ, Versées W, Kortholt A.

Biol Chem. 2018 Sep 4. pii: /j/bchm.ahead-of-print/hsz-2018-0227/hsz-2018-0227.xml. doi: 10.1515/hsz-2018-0227. [Epub ahead of print] No abstract available.

PMID:
30067506
2.

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodelling.

Lyraki R, Lokaj M, Soares DC, Little A, Vermeren M, Marsh JA, Wittinghofer A, Hurd T.

J Cell Sci. 2018 Feb 20;131(4). pii: jcs211748. doi: 10.1242/jcs.211748.

3.

A recombinant BBSome core complex and how it interacts with ciliary cargo.

Klink BU, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A.

Elife. 2017 Nov 15;6. pii: e27434. doi: 10.7554/eLife.27434.

4.

Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment.

Kösling SK, Fansa EK, Maffini S, Wittinghofer A.

Biol Chem. 2018 Feb 23;399(3):277-292. doi: 10.1515/hsz-2017-0226.

PMID:
29140789
5.

Domain topology of human Rasal.

Cuellar J, Valpuesta JM, Wittinghofer A, Sot B.

Biol Chem. 2017 Dec 20;399(1):63-72. doi: 10.1515/hsz-2017-0159.

PMID:
28885980
6.

Small-Molecule Inhibition of the UNC119-Cargo Interaction.

Mejuch T, Garivet G, Hofer W, Kaiser N, Fansa EK, Ehrt C, Koch O, Baumann M, Ziegler S, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186. doi: 10.1002/anie.201701905. Epub 2017 May 4.

PMID:
28471079
7.

Covalent Protein Labeling at Glutamic Acids.

Martín-Gago P, Fansa EK, Winzker M, Murarka S, Janning P, Schultz-Fademrecht C, Baumann M, Wittinghofer A, Waldmann H.

Cell Chem Biol. 2017 May 18;24(5):589-597.e5. doi: 10.1016/j.chembiol.2017.03.015. Epub 2017 Apr 20.

8.

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. doi: 10.1002/anie.201610957. Epub 2017 Jan 20.

PMID:
28106325
9.

Structure-based development of PDEδ inhibitors.

Martín-Gago P, Fansa EK, Wittinghofer A, Waldmann H.

Biol Chem. 2017 May 1;398(5-6):535-545. doi: 10.1515/hsz-2016-0272. Review.

PMID:
27935847
10.

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.

Murarka S, Martín-Gago P, Schultz-Fademrecht C, Al Saabi A, Baumann M, Fansa EK, Ismail S, Nussbaumer P, Wittinghofer A, Waldmann H.

Chemistry. 2017 May 2;23(25):6083-6093. doi: 10.1002/chem.201603222. Epub 2016 Nov 3.

PMID:
27809361
11.

Sorting of lipidated cargo by the Arl2/Arl3 system.

Fansa EK, Wittinghofer A.

Small GTPases. 2016 Oct;7(4):222-230. Epub 2016 Nov 2. Review.

12.

Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.

Jaiswal M, Fansa EK, Kösling SK, Mejuch T, Waldmann H, Wittinghofer A.

J Biol Chem. 2016 Sep 23;291(39):20766-78. doi: 10.1074/jbc.M116.741827. Epub 2016 Aug 1.

13.

GTP and ATP hydrolysis in biology.

Wittinghofer A.

Biopolymers. 2016 Aug;105(8):419-21. doi: 10.1002/bip.22867. No abstract available.

PMID:
27135900
14.

Identification of pyrazolopyridazinones as PDEδ inhibitors.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI.

Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360.

15.

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.

Blaževitš O, Mideksa YG, Šolman M, Ligabue A, Ariotti N, Nakhaeizadeh H, Fansa EK, Papageorgiou AC, Wittinghofer A, Ahmadian MR, Abankwa D.

Sci Rep. 2016 Apr 18;6:24165. doi: 10.1038/srep24165.

16.

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.

Fansa EK, Kösling SK, Zent E, Wittinghofer A, Ismail S.

Nat Commun. 2016 Apr 11;7:11366. doi: 10.1038/ncomms11366.

17.

Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down.

Hobbs GA, Wittinghofer A, Der CJ.

Cancer Cell. 2016 Mar 14;29(3):251-253. doi: 10.1016/j.ccell.2016.02.015. Review.

18.

The N- and C-terminal ends of RPGR can bind to PDE6δ.

Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A.

EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9. No abstract available.

19.

A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins.

Gotthardt K, Lokaj M, Koerner C, Falk N, Gießl A, Wittinghofer A.

Elife. 2015 Nov 9;4. pii: e11859. doi: 10.7554/eLife.11859.

20.

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

Kapoor S, Fansa EK, Möbitz S, Ismail SA, Winter R, Wittinghofer A, Weise K.

Biophys J. 2015 Oct 20;109(8):1619-29. doi: 10.1016/j.bpj.2015.08.033.

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