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Items: 1 to 50 of 117

1.

Chronic E-Cigarette Use Increases Neutrophil Elastase and Matrix Metalloprotease Levels in the Lung.

Ghosh A, Coakley RD, Ghio AJ, Muhlebach MS, Esther CR Jr, Alexis NE, Tarran R.

Am J Respir Crit Care Med. 2019 Aug 7. doi: 10.1164/rccm.201903-0615OC. [Epub ahead of print]

PMID:
31390877
2.

Endotracheal Tube Mucus as a Source of Airway Mucus for Rheological Study.

Markovetz MR, Subramani DB, Kissner WJ, Morrison CB, Garbarine IC, Ghio A, Ramsey KA, Arora H, Kumar PA, Nix DB, Kumagai T, Krunkosky TM, Krause DC, Radicioni G, Alexis NE, Kesimer M, Tiemeyer M, Boucher RC, Ehre C, Hill DB.

Am J Physiol Lung Cell Mol Physiol. 2019 Aug 7. doi: 10.1152/ajplung.00238.2019. [Epub ahead of print]

PMID:
31389736
3.

Tobacco exposure inhibits SPLUNC1-dependent antimicrobial activity.

Moore PJ, Sesma J, Alexis NE, Tarran R.

Respir Res. 2019 May 21;20(1):94. doi: 10.1186/s12931-019-1066-2.

4.

SPLUNC1 Loses its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions.

Ahmad S, Gilmore RC, Alexis NE, Tarran R.

Am J Respir Crit Care Med. 2019 Apr 23. doi: 10.1164/rccm.201812-2303LE. [Epub ahead of print] No abstract available.

PMID:
31013116
5.

The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation.

Burbank AJ, Vadlamudi A, Mills KH, Alt EM, Wells H, Zhou H, Alexis N, Hernandez ML, Peden DB.

J Allergy Clin Immunol. 2019 Jun;143(6):2299-2302.e3. doi: 10.1016/j.jaci.2019.02.006. Epub 2019 Feb 18. No abstract available.

PMID:
30790595
6.

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.

Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC.

COPD. 2018 Dec;15(6):572-580. doi: 10.1080/15412555.2019.1566892. Epub 2019 Feb 4.

PMID:
30712400
7.

Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS.

Garudadri S, Woodruff PG, Han MK, Curtis JL, Barr RG, Bleecker ER, Bowler RP, Comellas A, Cooper CB, Criner G, Dransfield MT, Hansel NN, Paine R 3rd, Krishnan JA, Peters SP, Hastie AT, Martinez FJ, O'Neal WK, Couper DJ, Alexis NE, Christenson SA.

Chest. 2019 May;155(5):908-917. doi: 10.1016/j.chest.2018.12.022. Epub 2019 Jan 23.

PMID:
30684474
8.

Isolating and culturing of sputum macrophages: A potential ex vivo/in vitro model.

Bølling AK, Steensen TB, Alexis NE, Sikkeland LIB.

Exp Lung Res. 2018 Aug;44(6):312-322. doi: 10.1080/01902148.2018.1539788. Epub 2018 Nov 22.

PMID:
30465455
9.

SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration.

Webster MJ, Reidel B, Tan CD, Ghosh A, Alexis NE, Donaldson SH, Kesimer M, Ribeiro CMP, Tarran R.

Eur Respir J. 2018 Oct 4;52(4). pii: 1800668. doi: 10.1183/13993003.00668-2018. Print 2018 Oct.

10.

Reply to Shields et al.: Electronic Cigarettes and the Lung Proteome.

Tarran R, Ghosh A, Alexis N.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1351-1352. doi: 10.1164/rccm.201807-1336LE. No abstract available.

PMID:
30153039
11.

Macrophages from the upper and lower human respiratory tract are metabolically distinct.

Lavrich KS, Speen AM, Ghio AJ, Bromberg PA, Samet JM, Alexis NE.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L752-L764. doi: 10.1152/ajplung.00208.2018. Epub 2018 Aug 9.

PMID:
30091382
12.

Neuropilin-2 regulates airway inflammatory responses to inhaled lipopolysaccharide.

Immormino RM, Lauzier DC, Nakano H, Hernandez ML, Alexis NE, Ghio AJ, Tilley SL, Doerschuk CM, Peden DB, Cook DN, Moran TP.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L202-L211. doi: 10.1152/ajplung.00067.2018. Epub 2018 Apr 19.

13.

Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.

Ghosh A, Coakley RC, Mascenik T, Rowell TR, Davis ES, Rogers K, Webster MJ, Dang H, Herring LE, Sassano MF, Livraghi-Butrico A, Van Buren SK, Graves LM, Herman MA, Randell SH, Alexis NE, Tarran R.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):67-76. doi: 10.1164/rccm.201710-2033OC.

14.

Respiratory Responses to Ozone Exposure. MOSES (The Multicenter Ozone Study in Older Subjects).

Arjomandi M, Balmes JR, Frampton MW, Bromberg P, Rich DQ, Stark P, Alexis NE, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha MJ.

Am J Respir Crit Care Med. 2018 May 15;197(10):1319-1327. doi: 10.1164/rccm.201708-1613OC.

PMID:
29232153
15.

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.

Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R 3rd, Peters SP, Alexis NE, Woodruff PG, Han MK, Meyers DA, Bleecker ER; SPIROMICS investigators.

Lancet Respir Med. 2017 Dec;5(12):956-967. doi: 10.1016/S2213-2600(17)30432-0. Epub 2017 Nov 13.

16.

Systemic and Airway Inflammation after Exposure to Fumes from Military Small Arms.

Sikkeland LIB, Borander AK, Voie ØA, Aass HCD, Øvstebø R, Aukrust P, Longva K, Alexis NE, Kongerud J, Ueland T.

Am J Respir Crit Care Med. 2018 May 15;197(10):1349-1353. doi: 10.1164/rccm.201709-1857LE. No abstract available.

PMID:
29144885
17.

E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion.

Reidel B, Radicioni G, Clapp PW, Ford AA, Abdelwahab S, Rebuli ME, Haridass P, Alexis NE, Jaspers I, Kesimer M.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):492-501. doi: 10.1164/rccm.201708-1590OC.

18.

Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study.

Hansel NN, Paulin LM, Gassett AJ, Peng RD, Alexis N, Fan VS, Bleecker E, Bowler R, Comellas AP, Dransfield M, Han MK, Kim V, Krishnan JA, Pirozzi C, Cooper CB, Martinez F, Woodruff PG, Breysse PJ, Barr RG, Kaufman JD.

BMJ Open Respir Res. 2017 May 18;4(1):e000186. doi: 10.1136/bmjresp-2017-000186. eCollection 2017.

19.

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R 3rd, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM; SPIROMICS Investigators.

J Allergy Clin Immunol. 2018 Jan;141(1):429-432. doi: 10.1016/j.jaci.2017.07.039. Epub 2017 Sep 12. No abstract available.

20.

Airway Mucin Concentration as a Marker of Chronic Bronchitis.

Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC.

N Engl J Med. 2017 Sep 7;377(10):911-922. doi: 10.1056/NEJMoa1701632.

21.

Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.

Burbank AJ, Duran CG, Pan Y, Burns P, Jones S, Jiang Q, Yang C, Jenkins S, Wells H, Alexis N, Kesimer M, Bennett WD, Zhou H, Peden DB, Hernandez ML.

J Allergy Clin Immunol. 2018 Apr;141(4):1231-1238.e1. doi: 10.1016/j.jaci.2017.06.029. Epub 2017 Jul 20.

22.

Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.

Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R.

Nat Commun. 2017 Feb 6;8:14118. doi: 10.1038/ncomms14118.

23.

Novel flow cytometry approach to identify bronchial epithelial cells from healthy human airways.

Maestre-Batlle D, Pena OM, Hirota JA, Gunawan E, Rider CF, Sutherland D, Alexis NE, Carlsten C.

Sci Rep. 2017 Feb 6;7:42214. doi: 10.1038/srep42214.

24.

Safety and benefits of inhaled hypertonic saline following airway challenges with endotoxin and allergen in asthmatics.

Alexis NE, Bennett W, Peden DB.

J Asthma. 2017 Nov;54(9):957-960. doi: 10.1080/02770903.2016.1278019. Epub 2017 Jan 17.

PMID:
28095128
25.

Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females.

Bennett WD, Ivins S, Alexis NE, Wu J, Bromberg PA, Brar SS, Travlos G, London SJ.

PLoS One. 2016 Aug 11;11(8):e0160030. doi: 10.1371/journal.pone.0160030. eCollection 2016.

26.

UDP-glucose promotes neutrophil recruitment in the lung.

Sesma JI, Weitzer CD, Livraghi-Butrico A, Dang H, Donaldson S, Alexis NE, Jacobson KA, Harden TK, Lazarowski ER.

Purinergic Signal. 2016 Dec;12(4):627-635. Epub 2016 Jul 15.

27.

Reproducibility of the inflammatory response to inhaled endotoxin in healthy volunteers.

Kobernick AK, Peden DB, Zhou H, Zhou Q, Dillon MA, Alexis NE.

J Allergy Clin Immunol. 2016 Oct;138(4):1205-1207. doi: 10.1016/j.jaci.2016.04.017. Epub 2016 May 10. No abstract available.

28.

A work group report on ultrafine particles (American Academy of Allergy, Asthma & Immunology): Why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in human subjects.

Li N, Georas S, Alexis N, Fritz P, Xia T, Williams MA, Horner E, Nel A.

J Allergy Clin Immunol. 2016 Aug;138(2):386-96. doi: 10.1016/j.jaci.2016.02.023. Epub 2016 Apr 6. Review.

29.

Sputum neutrophils are elevated in smelter workers, and systemic neutrophils are associated with rapid decline in FEV1.

Sikkeland LI, Johnsen HL, Riste TB, Alexis NE, Halvorsen B, Søyseth V, Kongerud J.

Occup Environ Med. 2016 Jul;73(7):459-66. doi: 10.1136/oemed-2015-103083. Epub 2016 Apr 6.

PMID:
27052769
30.

Inflammation in induced sputum after aluminium oxide exposure: an experimental chamber study.

Sikkeland L, Alexis NE, Fry RC, Martin E, Danielsen TE, Søstrand P, Kongerud J.

Occup Environ Med. 2016 Mar;73(3):199-205. doi: 10.1136/oemed-2015-103254. Epub 2016 Jan 19.

PMID:
26786756
31.

Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study.

Carlsten C, Blomberg A, Pui M, Sandstrom T, Wong SW, Alexis N, Hirota J.

Thorax. 2016 Jan;71(1):35-44. doi: 10.1136/thoraxjnl-2015-207399. Epub 2015 Nov 16. Erratum in: Thorax. 2016 Apr;71(4):385.

PMID:
26574583
32.

The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.

Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC.

33.

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).

Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O'Neal WK, Paine R 3rd, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL.

J Transl Med. 2015 Jan 27;13:19. doi: 10.1186/s12967-014-0374-z.

34.

Air pollution and asthma: how can a public health concern inform the care of individual patients?

North ML, Alexis NE, Ellis AK, Carlsten C.

Ann Allergy Asthma Immunol. 2014 Oct;113(4):343-6. doi: 10.1016/j.anai.2014.07.019. Review. No abstract available.

PMID:
25256028
35.

Interplay of air pollution and asthma immunopathogenesis: a focused review of diesel exhaust and ozone.

Alexis NE, Carlsten C.

Int Immunopharmacol. 2014 Nov;23(1):347-55. doi: 10.1016/j.intimp.2014.08.009. Epub 2014 Sep 3. Review.

PMID:
25194677
36.

Sputum adiponectin as a marker for western red cedar asthma.

Biagioni BJ, Pui MM, Fung E, Wong S, Hosseini A, Dybuncio A, Alexis NE, Carlsten C.

J Allergy Clin Immunol. 2014 Dec;134(6):1446-1448.e5. doi: 10.1016/j.jaci.2014.06.037. Epub 2014 Aug 13. No abstract available.

PMID:
25129682
37.

Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter.

Alexis NE, Huang YC, Rappold AG, Kehrl H, Devlin R, Peden DB.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):235-7. doi: 10.1164/rccm.201401-0126LE. No abstract available.

38.

Keel petal incision: a simple and efficient method for genetic crossing in Medicago truncatula.

Veerappan V, Kadel K, Alexis N, Scott A, Kryvoruchko I, Sinharoy S, Taylor M, Udvardi M, Dickstein R.

Plant Methods. 2014 May 16;10:11. doi: 10.1186/1746-4811-10-11. eCollection 2014.

39.

PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media.

Hirota JA, Alexis NE, Pui M, Wong S, Fung E, Hansbro P, Knight DA, Sin DD, Carlsten C.

Respirology. 2014 Aug;19(6):881-90. doi: 10.1111/resp.12316. Epub 2014 May 15.

40.

Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects.

Fry RC, Rager JE, Bauer R, Sebastian E, Peden DB, Jaspers I, Alexis NE.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1129-37. doi: 10.1152/ajplung.00348.2013. Epub 2014 Apr 25.

41.

Effect of inhaled endotoxin on mucociliary clearance and airway inflammation in mild smokers and nonsmokers.

Bennett WD, Alexis NE, Almond M, Herbst M, Zeman KL, Peden DB.

J Aerosol Med Pulm Drug Deliv. 2014 Dec;27(6):459-65. doi: 10.1089/jamp.2013.1089.

42.

Reply: To PMID 23687635.

Barnes CS, Alexis NE, Bernstein JA, Cohn JR, Demain JG, Levetin E, Phipatanakul W.

J Allergy Clin Immunol Pract. 2013 Sep-Oct;1(5):543-4. doi: 10.1016/j.jaip.2013.05.015. Epub 2013 Jul 24. No abstract available.

43.

A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease.

Hill DB, Vasquez PA, Mellnik J, McKinley SA, Vose A, Mu F, Henderson AG, Donaldson SH, Alexis NE, Boucher RC, Forest MG.

PLoS One. 2014 Feb 18;9(2):e87681. doi: 10.1371/journal.pone.0087681. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e97980.

44.

Biomarker sampling of the airways in asthma.

Alexis NE.

Curr Opin Pulm Med. 2014 Jan;20(1):46-52. doi: 10.1097/MCP.0000000000000010. Review.

PMID:
24285182
45.

Pulmonary responses in current smokers and ex-smokers following a two hour exposure at rest to clean air and fine ambient air particles.

Hazucha MJ, Bromberg PA, Lay JC, Bennett W, Zeman K, Alexis NE, Kehrl H, Rappold AG, Cascio WE, Devlin RB.

Part Fibre Toxicol. 2013 Nov 18;10(1):58. doi: 10.1186/1743-8977-10-58.

46.

Effects of ex vivo γ-tocopherol on airway macrophage function in healthy and mild allergic asthmatics.

Geiser M, Lay JC, Bennett WD, Zhou H, Wang X, Peden DB, Alexis NE.

J Innate Immun. 2013;5(6):613-24. doi: 10.1159/000350234. Epub 2013 May 8.

47.

Climate change and our environment: the effect on respiratory and allergic disease.

Barne C, Alexis NE, Bernstein JA, Cohn JR, Demain JG, Horner E, Levetin E, Nei A, Phipatanakul W.

J Allergy Clin Immunol Pract. 2013 Mar;1(2):137-41.

48.

Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers.

Hernandez ML, Wagner JG, Kala A, Mills K, Wells HB, Alexis NE, Lay JC, Jiang Q, Zhang H, Zhou H, Peden DB.

Free Radic Biol Med. 2013 Jul;60:56-62. doi: 10.1016/j.freeradbiomed.2013.02.001. Epub 2013 Feb 9.

49.

Chronic obstructive pulmonary disease patients have greater systemic responsiveness to ex vivo stimulation with swine dust extract and its components versus healthy volunteers.

Harting JR, Gleason A, Romberger DJ, Von Essen SG, Qiu F, Alexis N, Poole JA.

J Toxicol Environ Health A. 2012;75(24):1456-70. doi: 10.1080/15287394.2012.722186.

50.

Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways.

Fry RC, Rager JE, Zhou H, Zou B, Brickey JW, Ting J, Lay JC, Peden DB, Alexis NE.

Respir Res. 2012 Oct 3;13:89. doi: 10.1186/1465-9921-13-89.

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