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Items: 25


Myc-driven chromatin accessibility regulates Cdc45 assembly into CMG helicases.

Nepon-Sixt BS, Bryant VL, Alexandrow MG.

Commun Biol. 2019 Mar 22;2:110. doi: 10.1038/s42003-019-0353-2. eCollection 2019.


TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions.

Nepon-Sixt BS, Alexandrow MG.

Mol Cancer Res. 2019 Jan;17(1):277-288. doi: 10.1158/1541-7786.MCR-18-0558. Epub 2018 Sep 26.


Data supporting the functional role of Eleven-nineteen Lysine-rich Leukemia 3 (ELL3) in B cell lymphoma cell line cells.

Alexander LMM, Watters J, Reusch JA, Maurin M, Nepon-Sixt BS, Vrzalikova K, Alexandrow MG, Murray PG, Wright KL.

Data Brief. 2017 Sep 22;15:222-227. doi: 10.1016/j.dib.2017.09.042. eCollection 2017 Dec.


Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.

Alexander LMM, Watters J, Reusch JA, Maurin M, Nepon-Sixt BS, Vrzalikova K, Alexandrow MG, Murray PG, Wright KL.

Mol Immunol. 2017 Nov;91:8-16. doi: 10.1016/j.molimm.2017.08.016. Epub 2017 Aug 31.


The N Terminus of the Retinoblastoma Protein Inhibits DNA Replication via a Bipartite Mechanism Disrupted in Partially Penetrant Retinoblastomas.

Borysov SI, Nepon-Sixt BS, Alexandrow MG.

Mol Cell Biol. 2015 Dec 28;36(5):832-45. doi: 10.1128/MCB.00636-15.


Chemoprevention Trial Feasibility Using Botanicals in Exceptionally High Risk Populations for Lung Cancer.

Kumar NB, Quinn GP, Alexandrow MG, Gray J, Schell M, Sutton S, Haura EB.

J Clin Trials. 2014 Sep;4(4). pii: 180.


Suppression of Reserve MCM Complexes Chemosensitizes to Gemcitabine and 5-Fluorouracil.

Bryant VL, Elias RM, McCarthy SM, Yeatman TJ, Alexandrow MG.

Mol Cancer Res. 2015 Sep;13(9):1296-305. doi: 10.1158/1541-7786.MCR-14-0464. Epub 2015 Jun 10.


Analysis of DNA replication associated chromatin decondensation: in vivo assay for understanding chromatin remodeling mechanisms of selected proteins.

Borysov S, Bryant VL, Alexandrow MG.

Methods Mol Biol. 2015;1288:289-303. doi: 10.1007/978-1-4939-2474-5_16.


Phase 2 randomized study of enzastaurin (LY317615) for lung cancer prevention in former smokers.

Gray JE, Altiok S, Alexandrow MG, Walsh FW, Chen J, Schell MJ, Tai DF, Bepler G.

Cancer. 2013 Mar 1;119(5):1023-32. doi: 10.1002/cncr.27836. Epub 2012 Oct 12.


Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer.

Alexandrow MG, Song LJ, Altiok S, Gray J, Haura EB, Kumar NB.

Eur J Cancer Prev. 2012 Sep;21(5):407-12. doi: 10.1097/CEJ.0b013e32834ef194.


Cdc45 limits replicon usage from a low density of preRCs in mammalian cells.

Wong PG, Winter SL, Zaika E, Cao TV, Oguz U, Koomen JM, Hamlin JL, Alexandrow MG.

PLoS One. 2011 Mar 1;6(3):e17533. doi: 10.1371/journal.pone.0017533.


Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction.

Mukherjee P, Winter SL, Alexandrow MG.

Mol Cell Biol. 2010 Feb;30(3):845-56. doi: 10.1128/MCB.01152-09. Epub 2009 Nov 30.


Mammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase.

Mukherjee P, Cao TV, Winter SL, Alexandrow MG.

PLoS One. 2009;4(5):e5462. doi: 10.1371/journal.pone.0005462. Epub 2009 May 7.


In vivo chromatin decondensation assays: molecular genetic analysis of chromatin unfolding characteristics of selected proteins.

Winter SL, Wong P, Alexandrow MG.

Methods Mol Biol. 2009;523:27-40. doi: 10.1007/978-1-59745-190-1_3.


Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis.

Li CG, Gruidl M, Eschrich S, McCarthy S, Wang HG, Alexandrow MG, Yeatman TJ.

Int J Cancer. 2008 Jul 15;123(2):273-282. doi: 10.1002/ijc.23510.


The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.

Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C.

J Biol Chem. 2006 Oct 13;281(41):30631-44. Epub 2006 Aug 15.


Chromatin decondensation in S-phase involves recruitment of Cdk2 by Cdc45 and histone H1 phosphorylation.

Alexandrow MG, Hamlin JL.

J Cell Biol. 2005 Mar 14;168(6):875-86. Epub 2005 Mar 7.


A potential role for mini-chromosome maintenance (MCM) proteins in initiation at the dihydrofolate reductase replication origin.

Alexandrow MG, Ritzi M, Pemov A, Hamlin JL.

J Biol Chem. 2002 Jan 25;277(4):2702-8. Epub 2001 Nov 26.


Kips off to Myc: implications for TGF beta signaling.

Alexandrow MG, Moses HL.

J Cell Biochem. 1997 Sep 15;66(4):427-32. Review.


Transforming growth factor beta and cell cycle regulation.

Alexandrow MG, Moses HL.

Cancer Res. 1995 Apr 1;55(7):1452-7. No abstract available.


TGF beta regulation of cell proliferation.

Moses HL, Arteaga CL, Alexandrow MG, Dagnino L, Kawabata M, Pierce DF Jr, Serra R.

Princess Takamatsu Symp. 1994;24:250-63. Review.


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