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Items: 32


Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability.

Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML, Sheetz MP.

Immunol Cell Biol. 2016 Nov;94(10):981-993. doi: 10.1038/icb.2016.61. Epub 2016 Jun 30.


Medullary thymic epithelial cells and CD8α+ dendritic cells coordinately regulate central tolerance but CD8α+ cells are dispensable for thymic regulatory T cell production.

Herbin O, Bonito AJ, Jeong S, Weinstein EG, Rahman AH, Xiong H, Merad M, Alexandropoulos K.

J Autoimmun. 2016 Dec;75:141-149. doi: 10.1016/j.jaut.2016.08.002. Epub 2016 Aug 16.


Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.

Herbin O, Regelmann AG, Ramkhelawon B, Weinstein EG, Moore KJ, Alexandropoulos K.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1791-801. doi: 10.1161/ATVBAHA.116.308014. Epub 2016 Jul 14.


Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses.

Ruane D, Chorny A, Lee H, Faith J, Pandey G, Shan M, Simchoni N, Rahman A, Garg A, Weinstein EG, Oropallo M, Gaylord M, Ungaro R, Cunningham-Rundles C, Alexandropoulos K, Mucida D, Merad M, Cerutti A, Mehandru S.

J Exp Med. 2016 Jan 11;213(1):53-73. doi: 10.1084/jem.20150567. Epub 2015 Dec 28.


Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.

Haines JD, Herbin O, de la Hera B, Vidaurre OG, Moy GA, Sun Q, Fung HY, Albrecht S, Alexandropoulos K, McCauley D, Chook YM, Kuhlmann T, Kidd GJ, Shacham S, Casaccia P.

Nat Neurosci. 2015 Apr;18(4):511-20. doi: 10.1038/nn.3953. Epub 2015 Feb 23.


Medullary thymic epithelial cells and central tolerance in autoimmune hepatitis development: novel perspective from a new mouse model.

Alexandropoulos K, Bonito AJ, Weinstein EG, Herbin O.

Int J Mol Sci. 2015 Jan 16;16(1):1980-2000. doi: 10.3390/ijms16011980. Review.


Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling.

Riccomagno MM, Sun LO, Brady CM, Alexandropoulos K, Seo S, Kurokawa M, Kolodkin AL.

Neuron. 2014 Feb 19;81(4):779-86. doi: 10.1016/j.neuron.2014.01.036.


Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6.

Danzl NM, Jeong S, Choi Y, Alexandropoulos K.

PLoS One. 2014 Jan 21;9(1):e86129. doi: 10.1371/journal.pone.0086129. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110921.


Medullary thymic epithelial cell depletion leads to autoimmune hepatitis.

Bonito AJ, Aloman C, Fiel MI, Danzl NM, Cha S, Weinstein EG, Jeong S, Choi Y, Walsh MC, Alexandropoulos K.

J Clin Invest. 2013 Aug;123(8):3510-24. doi: 10.1172/JCI65414. Epub 2013 Jul 15.


Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.

Alexandropoulos K, Danzl NM.

Immunol Res. 2012 Dec;54(1-3):177-90. doi: 10.1007/s12026-012-8301-y. Review.


Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.

Danzl NM, Donlin LT, Alexandropoulos K.

J Exp Med. 2010 May 10;207(5):999-1013. doi: 10.1084/jem.20092384. Epub 2010 Apr 19.


Regulation of T-lymphocyte physiology by the Chat-H/CasL adapter complex.

Alexandropoulos K, Regelmann AG.

Immunol Rev. 2009 Nov;232(1):160-74. doi: 10.1111/j.1600-065X.2009.00831.x. Review.


Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.

Donlin LT, Danzl NM, Wanjalla C, Alexandropoulos K.

Mol Cell Biol. 2005 Dec;25(24):11035-46.


HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells.

Natarajan M, Stewart JE, Golemis EA, Pugacheva EN, Alexandropoulos K, Cox BD, Wang W, Grammer JR, Gladson CL.

Oncogene. 2006 Mar 16;25(12):1721-32. Erratum in: Oncogene. 2007 Nov 8;26(51):7282.


Sin: good or bad? A T lymphocyte perspective.

Alexandropoulos K, Donlin LT, Xing L, Regelmann AG.

Immunol Rev. 2003 Apr;192:181-95. Review.


Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin.

Donlin LT, Roman CA, Adlam M, Regelmann AG, Alexandropoulos K.

J Immunol. 2002 Dec 15;169(12):6900-9. Erratum in: J Immunol. 2003 Feb 15;170(4):2242..


c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.

Xing L, Ge C, Zeltser R, Maskevitch G, Mayer BJ, Alexandropoulos K.

Mol Cell Biol. 2000 Oct;20(19):7363-77.


A nuclear tyrosine kinase becomes a cytoplasmic oncogene.

Baltimore D, Ren R, Cheng G, Alexandropoulos K, Cicchetti P.

Ann N Y Acad Sci. 1995 Jun 30;758:339-44. Review. No abstract available.


Proline-rich sequences that bind to Src homology 3 domains with individual specificities.

Alexandropoulos K, Cheng G, Baltimore D.

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3110-4.


Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.

Jiang H, Alexandropoulos K, Song J, Foster DA.

Mol Cell Biol. 1994 Jun;14(6):3676-82.


Evidence that Ha-Ras mediates two distinguishable intracellular signals activated by v-Src.

Qureshi SA, Alexandropoulos K, Rim M, Joseph CK, Bruder JT, Rapp UR, Foster DA.

J Biol Chem. 1992 Sep 5;267(25):17635-9.


v-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements.

Alexandropoulos K, Qureshi SA, Rim M, Sukhatme VP, Foster DA.

Nucleic Acids Res. 1992 May 11;20(9):2355-9.


Sustained induction of egr-1 by v-src correlates with a lack of fos-mediated repression of the egr-1 promoter.

Qureshi SA, Rim MH, Alexandropoulos K, Berg K, Sukhatme VP, Foster DA.

Oncogene. 1992 Jan;7(1):121-5.


Evidence that a G-protein transduces signals initiated by the protein-tyrosine kinase v-Fps.

Alexandropoulos K, Joseph CK, Spangler R, Foster DA.

J Biol Chem. 1991 Aug 25;266(24):15583-6.


Cholera toxin induces expression of the immediate-early response gene JE via a cyclic AMP-independent signaling pathway.

Qureshi SA, Alexandropoulos K, Joseph CK, Spangler R, Foster DA.

Mol Cell Biol. 1991 Jan;11(1):102-7.


Reduction in temporal lobe size in siblings with schizophrenia: a magnetic resonance imaging study.

Dauphinais ID, DeLisi LE, Crow TJ, Alexandropoulos K, Colter N, Tuma I, Gershon ES.

Psychiatry Res. 1990 Dec;35(2):137-47.


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