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Items: 1 to 50 of 95

1.

Inhibition of Multidrug Resistance Proteins by MK 571 Enhances Bladder, Prostate, and Urethra Relaxation through cAMP or cGMP Accumulation.

Bertollotto GM, de Oliveira MG, Alexandre EC, Calmasini FB, Passos GR, Antunes E, Mónica FZ.

J Pharmacol Exp Ther. 2018 Oct;367(1):138-146. doi: 10.1124/jpet.118.250076. Epub 2018 Aug 14.

PMID:
30108158
2.

Influence of the periprostatic adipose tissue in obesity-associated mouse urethral dysfunction and oxidative stress: Effect of resveratrol treatment.

Alexandre EC, Calmasini FB, Sponton ACDS, de Oliveira MG, André DM, Silva FH, Delbin MA, Mónica FZ, Antunes E.

Eur J Pharmacol. 2018 Oct 5;836:25-33. doi: 10.1016/j.ejphar.2018.08.010. Epub 2018 Aug 11.

PMID:
30102890
3.

Menthol ameliorates voiding dysfunction in types I and II diabetic mouse model.

de Oliveira MG, Nascimento DM, Alexandre EC, Bonilla-Becerra SM, Zapparoli A, Mónica FZ, Antunes E.

Neurourol Urodyn. 2018 Nov;37(8):2510-2518. doi: 10.1002/nau.23785. Epub 2018 Aug 8.

PMID:
30088676
4.

Epigallocatechin-3-gallate protects against the exacerbation of allergic eosinophilic inflammation associated with obesity in mice.

André DM, Horimoto CM, Calixto MC, Alexandre EC, Antunes E.

Int Immunopharmacol. 2018 Sep;62:212-219. doi: 10.1016/j.intimp.2018.06.028. Epub 2018 Jul 20.

PMID:
30015241
5.

Deletion or pharmacological blockade of TLR4 confers protection against cyclophosphamide-induced mouse cystitis.

de Oliveira MG, Mónica FZ, Calmasini FB, Alexandre EC, Tavares EBG, Soares AG, Costa SKP, Antunes E.

Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F460-F468. doi: 10.1152/ajprenal.00100.2018. Epub 2018 May 2.

PMID:
29717937
6.

Mirabegron, a β3-adrenoceptor agonist reduced platelet aggregation through cyclic adenosine monophosphate accumulation.

Mendes-Silvério CB, Alexandre EM, Lescano CH, Antunes E, Mónica FZ.

Eur J Pharmacol. 2018 Jun 15;829:79-84. doi: 10.1016/j.ejphar.2018.04.010. Epub 2018 Apr 11.

PMID:
29654782
7.

Obesity-induced mouse benign prostatic hyperplasia (BPH) is improved by treatment with resveratrol: implication of oxidative stress, insulin sensitivity and neuronal growth factor.

Calmasini FB, de Oliveira MG, Alexandre EC, Silva FH, Tavares EBG, André DM, Zapparoli A, Antunes E.

J Nutr Biochem. 2018 May;55:53-58. doi: 10.1016/j.jnutbio.2017.12.009. Epub 2017 Dec 27. No abstract available.

PMID:
29413489
8.

Sinonasal cancer in a worker exposed to chromium in an unusual industrial sector.

Comiati V, Scapellato ML, Alexandre E, Volo T, Borsetto D, Carrieri M, Emanuelli E, Cazzador D.

Med Lav. 2017 Dec 14;108(6):477-481. doi: 10.23749/mdl.v108i6.6606.

PMID:
29240044
9.

High-fat diet-induced obesity impairs insulin signaling in lungs of allergen-challenged mice: Improvement by resveratrol.

André DM, Calixto MC, Sollon C, Alexandre EC, Tavares EBG, Naime ACA, Anhê GF, Antunes E.

Sci Rep. 2017 Dec 11;7(1):17296. doi: 10.1038/s41598-017-17558-w.

10.

Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose – 2017.

Faludi AA, Izar MCO, Saraiva JFK, Chacra APM, Bianco HT, Afiune A Neto, Bertolami A, Pereira AC, Lottenberg AM, Sposito AC, Chagas ACP, Casella A Filho, Simão AF, Alencar AC Filho, Caramelli B, Magalhães CC, Negrão CE, Ferreira CEDS, Scherr C, Feio CMA, Kovacs C, Araújo DB, Magnoni D, Calderaro D, Gualandro DM, Mello EP Junior, Alexandre ERG, Sato EI, Moriguchi EH, Rached FH, Santos FCD, Cesena FHY, Fonseca FAH, Fonseca HARD, Xavier HT, Mota ICP, Giuliano ICB, Issa JS, Diament J, Pesquero JB, Santos JED, Faria JR Neto, Melo JX Filho, Kato JT, Torres KP, Bertolami MC, Assad MHV, Miname MH, Scartezini M, Forti NA, Coelho OR, Maranhão RC, Santos RDD Filho, Alves RJ, Cassani RL, Betti RTB, Carvalho T, Martinez TLDR, Giraldez VZR, Salgado W Filho.

Arq Bras Cardiol. 2017 Jul;109(2 Supl 1):1-76. doi: 10.5935/abc.20170121. Portuguese. No abstract available. Erratum in: Arq Bras Cardiol. 2017 Nov;109 (5):499.

11.

High-pressure assisted extraction of bioactive compounds from industrial fermented fig by-product.

Alexandre EMC, Araújo P, Duarte MF, de Freitas V, Pintado M, Saraiva JA.

J Food Sci Technol. 2017 Jul;54(8):2519-2531. doi: 10.1007/s13197-017-2697-2. Epub 2017 May 26.

12.

How important is the α1-adrenoceptor in primate and rodent proximal urethra? Sex differences in the contribution of α1-adrenoceptor to urethral contractility.

Alexandre EC, de Oliveira MG, Campos R, Kiguti LR, Calmasini FB, Silva FH, Grant AD, Yoshimura N, Antunes E.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F1026-F1034. doi: 10.1152/ajprenal.00013.2017. Epub 2017 Mar 15.

13.

Sympathetic Hyperactivity, Increased Tyrosine Hydroxylase and Exaggerated Corpus Cavernosum Relaxations Associated with Oxidative Stress Plays a Major Role in the Penis Dysfunction in Townes Sickle Cell Mouse.

Silva FH, Claudino MA, Calmasini FB, Alexandre EC, Franco-Penteado C, Burnett AL, Antunes E, Costa FF.

PLoS One. 2016 Dec 9;11(12):e0166291. doi: 10.1371/journal.pone.0166291. eCollection 2016.

14.

Long-term treatment with the beta-3 adrenoceptor agonist, mirabegron ameliorates detrusor overactivity and restores cyclic adenosine monophosphate (cAMP) levels in obese mice.

Calmasini FB, de Oliveira MG, Alexandre EC, da Silva FH, da Silva CPV, Candido TZ, Antunes E, Mónica FZ.

Neurourol Urodyn. 2017 Aug;36(6):1511-1518. doi: 10.1002/nau.23171. Epub 2016 Oct 29.

PMID:
27794199
15.

A case-case study on sinonasal cancer prevention: effect from dust reduction in woodworking and risk of mastic/solvents in shoemaking.

Emanuelli E, Alexandre E, Cazzador D, Comiati V, Volo T, Zanon A, Scapellato ML, Carrieri M, Martini A, Mastrangelo G.

J Occup Med Toxicol. 2016 Jul 21;11:35. doi: 10.1186/s12995-016-0124-7. eCollection 2016.

16.

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.

Sison-Young RL, Lauschke VM, Johann E, Alexandre E, Antherieu S, Aerts H, Gerets HHJ, Labbe G, Hoët D, Dorau M, Schofield CA, Lovatt CA, Holder JC, Stahl SH, Richert L, Kitteringham NR, Jones RP, Elmasry M, Weaver RJ, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Park BK.

Arch Toxicol. 2017 Mar;91(3):1385-1400. doi: 10.1007/s00204-016-1745-4. Epub 2016 Jun 25.

17.

Therapy with resveratrol attenuates obesity-associated allergic airway inflammation in mice.

André DM, Calixto MC, Sollon C, Alexandre EC, Leiria LO, Tobar N, Anhê GF, Antunes E.

Int Immunopharmacol. 2016 Sep;38:298-305. doi: 10.1016/j.intimp.2016.06.017. Epub 2016 Jun 22.

PMID:
27344038
18.

Chronic treatment with resveratrol improves overactive bladder in obese mice via antioxidant activity.

Alexandre EC, Calmasini FB, de Oliveira MG, Silva FH, da Silva CPV, André DM, Leonardo FC, Delbin MA, Antunes E.

Eur J Pharmacol. 2016 Oct 5;788:29-36. doi: 10.1016/j.ejphar.2016.06.017. Epub 2016 Jun 15.

PMID:
27316789
19.

Soluble Guanylate Cyclase Modulators, BAY 41-2272 and BAY 60-2770, Inhibit Human and Rabbit Prostate Contractility.

Calmasini FB, Alexandre EC, Silva FH, De Nucci G, Antunes E, D'Ancona CA, Mónica FZ.

Urology. 2016 Aug;94:312.e9-312.e15. doi: 10.1016/j.urology.2016.04.023. Epub 2016 Apr 27.

PMID:
27131967
20.

Activation of soluble guanylyl cyclase by BAY 58-2667 improves bladder function in cyclophosphamide-induced cystitis in mice.

de Oliveira MG, Calmasini FB, Alexandre EC, De Nucci G, Mónica FZ, Antunes E.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F85-93. doi: 10.1152/ajprenal.00041.2016. Epub 2016 Apr 27.

21.

Implication of Rho-kinase and soluble guanylyl cyclase enzymes in prostate smooth muscle dysfunction in middle-aged rats.

Calmasini FB, Silva FH, Alexandre EC, Rodrigues RL, Barbosa AP, Ferrucci DL, Carvalho HF, Anhê GF, Pupo AS, Antunes E.

Neurourol Urodyn. 2017 Mar;36(3):589-596. doi: 10.1002/nau.22990. Epub 2016 Mar 21.

PMID:
26999618
22.

Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade.

Alexandre EC, Kiguti LR, Calmasini FB, Silva FH, da Silva KP, Ferreira R, Ribeiro CA, Mónica FZ, Pupo AS, Antunes E.

Br J Pharmacol. 2016 Feb;173(3):415-28. doi: 10.1111/bph.13367. Epub 2016 Jan 15.

23.

Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice.

Claudino MA, Leiria LO, da Silva FH, Alexandre EC, Renno A, Mónica FZ, de Nucci G, Fertrin KY, Antunes E, Costa FF, Franco-Penteado CF.

PLoS One. 2015 Aug 4;10(8):e0133996. doi: 10.1371/journal.pone.0133996. eCollection 2015.

24.

Treatment With Metformin Improves Erectile Dysfunction in a Murine Model of Obesity Associated With Insulin Resistance.

Silva FH, Alexandre EC, Calmasini FB, Calixto MC, Antunes E.

Urology. 2015 Aug;86(2):423.e1-6. doi: 10.1016/j.urology.2015.04.035. Epub 2015 Jul 18.

PMID:
26199165
25.

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.

Sison-Young RL, Mitsa D, Jenkins RE, Mottram D, Alexandre E, Richert L, Aerts H, Weaver RJ, Jones RP, Johann E, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Kitteringham NR, Park BK.

Toxicol Sci. 2015 Oct;147(2):412-24. doi: 10.1093/toxsci/kfv136. Epub 2015 Jul 8.

26.

Increased airway reactivity and hyperinsulinemia in obese mice are linked by ERK signaling in brain stem cholinergic neurons.

Leiria LOS, Arantes-Costa FM, Calixto MC, Alexandre EC, Moura RF, Folli F, Prado CM, Prado MA, Prado VF, Velloso LA, Donato J Jr, Antunes E, Martins MA, Saad MJA.

Cell Rep. 2015 May 12;11(6):934-943. doi: 10.1016/j.celrep.2015.04.012. Epub 2015 Apr 30.

27.

Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency.

Calmasini FB, Leiria LO, Alves Junior MJ, Báu FR, Alexandre EC, Silva FH, Mónica FZ, Antunes E.

Eur J Pharmacol. 2015 Jul 5;758:24-30. doi: 10.1016/j.ejphar.2015.03.057. Epub 2015 Mar 30.

28.

Prediction of drug induced liver injury using molecular and biological descriptors.

Muller C, Pekthong D, Alexandre E, Marcou G, Horvath D, Richert L, Varnek A.

Comb Chem High Throughput Screen. 2015;18(3):315-22.

PMID:
25747442
29.

Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure.

Broeders JJ, Parmentier C, Truisi GL, Jossé R, Alexandre E, Savary CC, Hewitt PG, Mueller SO, Guillouzo A, Richert L, van Eijkeren JC, Hermens JL, Blaauboer BJ.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):52-61. doi: 10.1016/j.tiv.2014.08.012. Epub 2014 Nov 4.

PMID:
25458484
30.

Impact of pH on the phytochemical profile of pasteurized peach purée during storage.

Oliveira A, Gomes MH, Alexandre EM, Almeida DP, Pintado M.

J Agric Food Chem. 2014 Dec 17;62(50):12075-81. doi: 10.1021/jf503913t. Epub 2014 Dec 4.

PMID:
25426547
31.

The beta-3 adrenoceptor agonist, mirabegron relaxes isolated prostate from human and rabbit: new therapeutic indication?

Calmasini FB, Candido TZ, Alexandre EC, D'Ancona CA, Silva D, de Oliveira MA, De Nucci G, Antunes E, Mónica FZ.

Prostate. 2015 Mar 1;75(4):440-7. doi: 10.1002/pros.22930. Epub 2014 Nov 21.

PMID:
25417911
32.

Incorporation of strawberries preparation in yoghurt: impact on phytochemicals and milk proteins.

Oliveira A, Alexandre EM, Coelho M, Lopes C, Almeida DP, Pintado M.

Food Chem. 2015 Mar 15;171:370-8. doi: 10.1016/j.foodchem.2014.08.107. Epub 2014 Sep 6.

PMID:
25308682
33.

Phytochemicals preservation in strawberry as affected by pH modulation.

Oliveira A, Gomes MH, Alexandre EM, Poças F, Almeida DP, Pintado M.

Food Chem. 2015 Mar 1;170:74-83. doi: 10.1016/j.foodchem.2014.07.156. Epub 2014 Aug 10.

PMID:
25306319
34.

Prolonged therapy with the soluble guanylyl cyclase activator BAY 60-2770 restores the erectile function in obese mice.

Silva FH, Leiria LO, Alexandre EC, Davel AP, Mónica FZ, De Nucci G, Antunes E.

J Sex Med. 2014 Nov;11(11):2661-70. doi: 10.1111/jsm.12682. Epub 2014 Sep 5.

PMID:
25196910
35.

Soluble guanylyl cyclase (sGC) degradation and impairment of nitric oxide-mediated responses in urethra from obese mice: reversal by the sGC activator BAY 60-2770.

Alexandre EC, Leiria LO, Silva FH, Mendes-Silvério CB, Calmasini FB, Davel AP, Mónica FZ, De Nucci G, Antunes E.

J Pharmacol Exp Ther. 2014 Apr;349(1):2-9. doi: 10.1124/jpet.113.211029. Epub 2014 Jan 13.

36.

Predictability of sentences used in the assessment of speech intelligibility in dysarthria.

Alexandre E, Barreto Sdos S, Ortiz KZ.

Codas. 2013;25(5):399. doi: 10.1590/S2317-17822013000500002. English, Portuguese. No abstract available.

37.

The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice.

Leiria LO, Silva FH, Davel AP, Alexandre EC, Calixto MC, De Nucci G, Mónica FZ, Antunes E.

J Urol. 2014 Feb;191(2):539-47. doi: 10.1016/j.juro.2013.09.020. Epub 2013 Sep 17.

PMID:
24050894
38.

Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures.

Parmentier C, Truisi GL, Moenks K, Stanzel S, Lukas A, Kopp-Schneider A, Alexandre E, Hewitt PG, Mueller SO, Richert L.

Drug Metab Dispos. 2013 Oct;41(10):1835-42. doi: 10.1124/dmd.113.052415. Epub 2013 Aug 2.

39.

Improvement in clinical signs and cellular immunity of dogs with visceral leishmaniasis using the immunomodulator P-MAPA.

Santiago ME, Neto LS, Alexandre EC, Munari DP, Andrade MM, Somenzari MA, Ciarlini PC, de Lima VM.

Acta Trop. 2013 Sep;127(3):174-80. doi: 10.1016/j.actatropica.2013.04.005. Epub 2013 Apr 29.

40.

Increased survival despite failure of transplanted human hepatocyte implantation into liver parenchyma of nude mice with repeated lethal Jo2-induced liver deficiency.

Vidal I, Blanchard N, Chenard-Neu MP, Bachellier P, Heyd B, Staedtler F, Schumacher M, Alexandre E, Richert L.

Cell Transplant. 2014;23(12):1557-72. doi: 10.3727/096368913X667501. Epub 2013 Apr 29.

PMID:
23636101
41.

Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers.

Alexandre E, Baze A, Parmentier C, Desbans C, Pekthong D, Gerin B, Wack C, Bachellier P, Heyd B, Weber JC, Richert L.

Xenobiotica. 2012 Oct;42(10):968-79. doi: 10.3109/00498254.2012.676693. Epub 2012 Apr 19.

PMID:
22515431
42.

[Predictability of sentences used in the assessment of speech intelligibility in dysarthria].

Alexandre E, Barreto Sdos S, Ortiz KZ.

J Soc Bras Fonoaudiol. 2011;23(2):119-23. Portuguese.

PMID:
21829926
43.

Isolation and culture of primary hepatocytes from resected human liver tissue.

Lecluyse EL, Alexandre E.

Methods Mol Biol. 2010;640:57-82. doi: 10.1007/978-1-60761-688-7_3.

PMID:
20645046
44.

Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers - a European Centre for Validation of Alternative Methods (ECVAM) - funded pre-validation study.

Richert L, Abadie C, Bonet A, Heyd B, Mantion G, Alexandre E, Bachellier P, Kingston S, Pattenden C, Illouz S, Dennison A, Hoffmann S, Coecke S.

Toxicol In Vitro. 2010 Feb;24(1):335-45. doi: 10.1016/j.tiv.2009.05.022. Epub 2009 Jun 2.

PMID:
19497361
45.

Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions.

Abadie-Viollon C, Martin H, Blanchard N, Pekthong D, Bachellier P, Mantion G, Heyd B, Schuler F, Coassolo P, Alexandre E, Richert L.

Toxicol In Vitro. 2010 Feb;24(1):346-56. doi: 10.1016/j.tiv.2009.05.021. Epub 2009 Jun 2.

PMID:
19497360
46.

Improved xenogenic hepatocyte implantation into nude mouse liver parenchyma with acute liver failure when followed by repeated anti-Fas antibody (Jo2) treatment.

Vidal I, Blanchard N, Alexandre E, Gandillet A, Chenard-Neu MP, Staedtler F, Schumacher M, Bachellier P, Jaeck D, Firat H, Heyd B, Richert L.

Cell Transplant. 2008;17(5):507-24.

PMID:
18714670
47.

Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes.

Illouz S, Alexandre E, Pattenden C, Mark L, Bachellier P, Webb M, Berry D, Dennison A, Richert L.

Phytother Res. 2008 Dec;22(12):1688-91. doi: 10.1002/ptr.2545.

PMID:
18697189
48.

A metabolic screening study of trichostatin A (TSA) and TSA-like histone deacetylase inhibitors in rat and human primary hepatocyte cultures.

Elaut G, Laus G, Alexandre E, Richert L, Bachellier P, Tourwé D, Rogiers V, Vanhaecke T.

J Pharmacol Exp Ther. 2007 Apr;321(1):400-8. Epub 2007 Jan 11.

49.

On the use of 2-D coding techniques for ECG signals.

Alexandre E, Pena A, Sobreira M.

IEEE Trans Inf Technol Biomed. 2006 Oct;10(4):809-11.

PMID:
17044415
50.

REMOVED: Glutathione prevents cytochrome P450 3A induction by dexamethasone in primary cultures of rat hepatocytes.

Richert L, Binda D, Alexandre E, Bars R, Martin H, Lasserre-Bigot D.

Toxicol In Vitro. 2006 Aug 1. [Epub ahead of print]

PMID:
16978831

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