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Immunogenicity of high-dose influenza vaccination in patients with primary central nervous system malignancy.

Strowd RE, Russell G, Hsu FC, Carter AF, Chan M, Tatter SB, Laxton AW, Alexander-Miller MA, High K, Lesser GJ.

Neurooncol Pract. 2018 Aug;5(3):176-183. doi: 10.1093/nop/npx035. Epub 2018 Jan 6.


Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq.

Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W.

Cancer Med. 2019 Jun;8(6):3072-3085. doi: 10.1002/cam4.2113. Epub 2019 Apr 29.


The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells.

Westcott MM, Clemens EA, Holbrook BC, King SB, Alexander-Miller MA.

Vaccine. 2018 Feb 21;36(9):1174-1182. doi: 10.1016/j.vaccine.2018.01.035.


A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling.

Blevins LK, Parsonage D, Oliver MB, Domzalski E, Swords WE, Alexander-Miller MA.

Front Immunol. 2017 Nov 27;8:1610. doi: 10.3389/fimmu.2017.01610. eCollection 2017.


Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6months in a nonhuman primate neonate model.

Holbrook BC, D'Agostino RB Jr, Tyler Aycock S, Jorgensen MJ, Hadimani MB, Bruce King S, Alexander-Miller MA.

Vaccine. 2017 Oct 27;35(45):6137-6142. doi: 10.1016/j.vaccine.2017.09.054. Epub 2017 Sep 28.


An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non-human primate neonates.

Holbrook BC, Aycock ST, Machiele E, Clemens E, Gries D, Jorgensen MJ, Hadimani MB, King SB, Alexander-Miller MA.

Immunology. 2018 Mar;153(3):357-367. doi: 10.1111/imm.12845. Epub 2017 Oct 24.


Potential therapeutic action of nitrite in sickle cell disease.

Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB.

Redox Biol. 2017 Aug;12:1026-1039. doi: 10.1016/j.redox.2017.05.006. Epub 2017 May 10.


Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes.

Grayson KM, Blevins LK, Oliver MB, Ornelles DA, Swords WE, Alexander-Miller MA.

Pathog Dis. 2017 Mar 1;75(2). doi: 10.1093/femspd/ftx008.


Pneumococcal Neuraminidase A (NanA) Promotes Biofilm Formation and Synergizes with Influenza A Virus in Nasal Colonization and Middle Ear Infection.

Wren JT, Blevins LK, Pang B, Basu Roy A, Oliver MB, Reimche JL, Wozniak JE, Alexander-Miller MA, Swords WE.

Infect Immun. 2017 Mar 23;85(4). pii: e01044-16. doi: 10.1128/IAI.01044-16. Print 2017 Apr.


In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.

Shewale SV, Brown AL, Bi X, Boudyguina E, Sawyer JK, Alexander-Miller MA, Parks JS.

J Lipid Res. 2017 Jan;58(1):236-246. doi: 10.1194/jlr.M072769. Epub 2016 Nov 3.


Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model.

Holbrook BC, D'Agostino RB Jr, Parks GD, Alexander-Miller MA.

Vaccine. 2016 Sep 7;34(39):4712-4717. doi: 10.1016/j.vaccine.2016.08.010. Epub 2016 Aug 8.


A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model.

Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB Jr, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA.

J Immunol. 2016 Jul 15;197(2):555-64. doi: 10.4049/jimmunol.1600497. Epub 2016 Jun 8.


Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates.

Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino RB Jr, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA.

J Virol. 2015 Jul;89(14):7291-303. doi: 10.1128/JVI.00549-15. Epub 2015 May 6.


Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection.

Holbrook BC, Hayward SL, Blevins LK, Kock N, Aycock T, Parks GD, Alexander-Miller MA.

Virology. 2015 Feb;476:124-133. doi: 10.1016/j.virol.2014.12.007. Epub 2014 Dec 24.


Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges.

Alexander-Miller MA.

J Immunol. 2014 Dec 1;193(11):5363-9. doi: 10.4049/jimmunol.1401410. Review.


Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8⁺ T cell response.

Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA.

J Immunol. 2014 Nov 15;193(10):5076-87. doi: 10.4049/jimmunol.1400529. Epub 2014 Oct 13.


Influenza A virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation.

Wren JT, Blevins LK, Pang B, King LB, Perez AC, Murrah KA, Reimche JL, Alexander-Miller MA, Swords WE.

Infect Immun. 2014 Nov;82(11):4802-12. doi: 10.1128/IAI.01856-14. Epub 2014 Aug 25.


CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals.

Shiner EK, Holbrook BC, Alexander-Miller MA.

PLoS One. 2014 Jun 18;9(6):e100175. doi: 10.1371/journal.pone.0100175. eCollection 2014.


Paramyxovirus activation and inhibition of innate immune responses.

Parks GD, Alexander-Miller MA.

J Mol Biol. 2013 Dec 13;425(24):4872-92. doi: 10.1016/j.jmb.2013.09.015. Epub 2013 Sep 20. Review.


In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection.

Holbrook BC, Yammani RD, Blevins LK, Alexander-Miller MA.

Viral Immunol. 2013 Oct;26(5):302-13. doi: 10.1089/vim.2013.0042. Epub 2013 Aug 24.


High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion.

Amoah S, Holbrook BC, Yammani RD, Alexander-Miller MA.

J Immunol. 2013 May 15;190(10):5020-9. doi: 10.4049/jimmunol.1200971. Epub 2013 Apr 15.


Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions.

Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2122-30. doi: 10.1161/ATVBAHA.112.253435. Epub 2012 Jul 19.


CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation.

Beauchamp NM, Yammani RD, Alexander-Miller MA.

J Virol. 2012 Oct;86(19):10640-50. doi: 10.1128/JVI.01413-12. Epub 2012 Jul 18.


Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization.

Johnson JB, Lyles DS, Alexander-Miller MA, Parks GD.

J Virol. 2012 Sep;86(18):9929-40. doi: 10.1128/JVI.01154-12. Epub 2012 Jul 3.


Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.

Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA.

J Immunol. 2012 Jul 15;189(2):638-45. doi: 10.4049/jimmunol.1102579. Epub 2012 Jun 15.


Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction.

Sharma SK, Alexander-Miller MA.

Immunology. 2011 Jul;133(3):307-17. doi: 10.1111/j.1365-2567.2011.03440.x. Epub 2011 Apr 19.


Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung.

Busick RY, Yammani RD, Alexander-Miller MA.

Am J Respir Cell Mol Biol. 2011 May;44(5):597-605. doi: 10.1165/rcmb.2010-0377OC. Epub 2011 Jan 7.


Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection.

Beauchamp NM, Busick RY, Alexander-Miller MA.

J Virol. 2010 Oct;84(19):10191-9. doi: 10.1128/JVI.00892-10. Epub 2010 Jul 21.


IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment.

Palmer EM, Holbrook BC, Arimilli S, Parks GD, Alexander-Miller MA.

Virology. 2010 Sep 1;404(2):225-30. doi: 10.1016/j.virol.2010.05.004.


Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1.

Arimilli S, Sharma SK, Yammani R, Reid SD, Parks GD, Alexander-Miller MA.

J Leukoc Biol. 2010 Jun;87(6):977-88. doi: 10.1189/jlb.0809575. Epub 2010 Jan 26.


Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function.

Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD.

J Virol. 2008 Nov;82(22):10975-85. doi: 10.1128/JVI.01288-08. Epub 2008 Sep 10.


Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus.

Yates NL, Yammani RD, Alexander-Miller MA.

Virus Res. 2008 Nov;137(2):198-205. doi: 10.1016/j.virusres.2008.07.010. Epub 2008 Aug 23.


Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus.

Yammani RD, Pejawar-Gaddy S, Gurley TC, Weimer ET, Hiltbold EM, Alexander-Miller MA.

Virology. 2008 Aug 15;378(1):142-50. doi: 10.1016/j.virol.2008.05.031. Epub 2008 Jun 30.


Loss of function in virus-specific lung effector T cells is independent of infection.

Arimilli S, Palmer EM, Alexander-Miller MA.

J Leukoc Biol. 2008 Mar;83(3):564-74. Epub 2007 Dec 13.


Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter.

Kroger CJ, Alexander-Miller MA.

Immunology. 2007 Oct;122(2):167-78. Epub 2007 May 2.


TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways.

Arimilli S, Johnson JB, Alexander-Miller MA, Parks GD.

Virology. 2007 Aug 15;365(1):144-56. Epub 2007 Apr 24.


Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5.

Pejawar-Gaddy S, Gitiban-Vaghefi N, Parks GD, Alexander-Miller MA.

Viral Immunol. 2007 Spring;20(1):76-87.


Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes.

Pejawar-Gaddy S, Alexander-Miller MA.

J Immunol. 2006 Oct 1;177(7):4495-502.


Transferable anticancer innate immunity in spontaneous regression/complete resistance mice.

Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7753-8. Epub 2006 May 8.


Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection.

Gray PM, Parks GD, Alexander-Miller MA.

Cell Immunol. 2004 Sep-Oct;231(1-2):14-9. Epub 2005 Jan 20.


Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract.

Gray PM, Arimilli S, Palmer EM, Parks GD, Alexander-Miller MA.

J Virol. 2005 Mar;79(6):3339-49.


High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors.

Alexander-Miller MA.

Immunol Res. 2005;31(1):13-24. Review.


Molecular mechanisms and biological significance of CTL avidity.

Snyder JT, Alexander-Miller MA, Berzofskyl JA, Belyakov IM.

Curr HIV Res. 2003 Jul;1(3):287-94. Review.


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