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Items: 1 to 50 of 234

1.

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells.

Brinkmann K, Ng AP, de Graaf CA, Di Rago L, Hyland CD, Morelli E, Rautela J, Huntington ND, Strasser A, Alexander WS, Herold MJ.

Cell Death Differ. 2019 Oct 7. doi: 10.1038/s41418-019-0430-6. [Epub ahead of print]

PMID:
31591473
2.

Membrane-Associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Ra).

Babon JJ, Stockwell D, DiRago L, Zhang JG, Laktyushin A, Villadangos J, Ching A, Ishido S, Hilton DJ, Alexander WS, Nicola NA.

Biochem J. 2019 Sep 5. pii: BCJ20190577. doi: 10.1042/BCJ20190577. [Epub ahead of print]

PMID:
31488575
3.

Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome.

Ishihara K, Shimizu R, Takata K, Kawashita E, Amano K, Shimohata A, Low D, Nabe T, Sago H, Alexander WS, Ginhoux F, Yamakawa K, Akiba S.

Brain Pathol. 2019 Jun 17. doi: 10.1111/bpa.12758. [Epub ahead of print]

PMID:
31206867
4.

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.

McRae HM, Garnham AL, Hu Y, Witkowski MT, Corbett MA, Dixon MP, May RE, Sheikh BN, Chiang W, Kueh AJ, Nguyen TA, Man K, Gloury R, Aubrey BJ, Policheni A, Di Rago L, Alexander WS, Gray DHD, Strasser A, Hawkins ED, Wilcox S, Gécz J, Kallies A, McCormack MP, Smyth GK, Voss AK, Thomas T.

Blood. 2019 Apr 18;133(16):1729-1741. doi: 10.1182/blood-2018-07-860726. Epub 2019 Feb 12.

5.

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans.

Choi J, Baldwin TM, Wong M, Bolden JE, Fairfax KA, Lucas EC, Cole R, Biben C, Morgan C, Ramsay KA, Ng AP, Kauppi M, Corcoran LM, Shi W, Wilson N, Wilson MJ, Alexander WS, Hilton DJ, de Graaf CA.

Nucleic Acids Res. 2019 Jan 8;47(D1):D780-D785. doi: 10.1093/nar/gky1020.

6.

Cytokine control of megakaryopoiesis.

Behrens K, Alexander WS.

Growth Factors. 2018 Aug;36(3-4):89-103. doi: 10.1080/08977194.2018.1498487. Epub 2018 Oct 15. Review.

PMID:
30318940
7.

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.

Michalak EM, Milevskiy MJG, Joyce RM, Dekkers JF, Jamieson PR, Pal B, Dawson CA, Hu Y, Orkin SH, Alexander WS, Lindeman GJ, Smyth GK, Visvader JE.

PLoS Biol. 2018 Aug 6;16(8):e2004986. doi: 10.1371/journal.pbio.2004986. eCollection 2018 Aug.

8.

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML.

Sanders MA, Chew E, Flensburg C, Zeilemaker A, Miller SE, Al Hinai AS, Bajel A, Luiken B, Rijken M, Mclennan T, Hoogenboezem RM, Kavelaars FG, Fröhling S, Blewitt ME, Bindels EM, Alexander WS, Löwenberg B, Roberts AW, Valk PJM, Majewski IJ.

Blood. 2018 Oct 4;132(14):1526-1534. doi: 10.1182/blood-2018-05-852566. Epub 2018 Jul 26.

9.

Identification of a Siglec-F+ granulocyte-macrophage progenitor.

Bolden JE, Lucas EC, Zhou G, O'Sullivan JA, de Graaf CA, McKenzie MD, Di Rago L, Baldwin TM, Shortt J, Alexander WS, Bochner BS, Ritchie ME, Hilton DJ, Fairfax KA.

J Leukoc Biol. 2018 Jul;104(1):123-133. doi: 10.1002/JLB.1MA1217-475R. Epub 2018 Apr 12.

10.

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted.

Stutz MD, Ojaimi S, Allison C, Preston S, Arandjelovic P, Hildebrand JM, Sandow JJ, Webb AI, Silke J, Alexander WS, Pellegrini M.

Cell Death Differ. 2018 May;25(5):951-965. doi: 10.1038/s41418-017-0031-1. Epub 2017 Dec 11.

11.

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.

Au AE, Lebois M, Sim SA, Cannon P, Corbin J, Gangatirkar P, Hyland CD, Moujalled D, Rutgersson A, Yassinson F, Kile BT, Mason KD, Ng AP, Alexander WS, Josefsson EC.

Sci Rep. 2017 Nov 2;7(1):14953. doi: 10.1038/s41598-017-15023-2.

12.

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice.

Brinkmann K, Grabow S, Hyland CD, Teh CE, Alexander WS, Herold MJ, Strasser A.

Cell Death Differ. 2017 Dec;24(12):2032-2043. doi: 10.1038/cdd.2017.125. Epub 2017 Aug 11.

13.

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.

Delbridge AR, Aubrey BJ, Hyland C, Bernardini JP, Di Rago L, Garnier JM, Lessene G, Strasser A, Alexander WS, Grabow S.

Cell Death Dis. 2017 Jul 6;8(7):e2914. doi: 10.1038/cddis.2017.304.

14.

ROBUST HYPERPARAMETER ESTIMATION PROTECTS AGAINST HYPERVARIABLE GENES AND IMPROVES POWER TO DETECT DIFFERENTIAL EXPRESSION.

Phipson B, Lee S, Majewski IJ, Alexander WS, Smyth GK.

Ann Appl Stat. 2016 Jun;10(2):946-963. doi: 10.1214/16-AOAS920. Epub 2016 Jul 22.

15.

A non-canonical function of Ezh2 preserves immune homeostasis.

Vasanthakumar A, Xu D, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS.

EMBO Rep. 2017 Apr;18(4):619-631. doi: 10.15252/embr.201643237. Epub 2017 Feb 21.

16.

Haematopoietic stem cells: past, present and future.

Ng AP, Alexander WS.

Cell Death Discov. 2017 Feb 6;3:17002. doi: 10.1038/cddiscovery.2017.2. eCollection 2017. Review.

17.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.

18.

Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.

Ushiki T, Huntington ND, Glaser SP, Kiu H, Georgiou A, Zhang JG, Metcalf D, Nicola NA, Roberts AW, Alexander WS.

PLoS One. 2016 Sep 1;11(9):e0162111. doi: 10.1371/journal.pone.0162111. eCollection 2016.

19.

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Alvarez-Diaz S, Dillon CP, Lalaoui N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O'Reilly LA, Silke J, Alexander WS, Green DR, Strasser A.

Immunity. 2016 Sep 20;45(3):513-526. doi: 10.1016/j.immuni.2016.07.016. Epub 2016 Aug 11.

20.

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells.

de Graaf CA, Choi J, Baldwin TM, Bolden JE, Fairfax KA, Robinson AJ, Biben C, Morgan C, Ramsay K, Ng AP, Kauppi M, Kruse EA, Sargeant TJ, Seidenman N, D'Amico A, D'Ombrain MC, Lucas EC, Koernig S, Baz Morelli A, Wilson MJ, Dower SK, Williams B, Heazlewood SY, Hu Y, Nilsson SK, Wu L, Smyth GK, Alexander WS, Hilton DJ.

Stem Cell Reports. 2016 Sep 13;7(3):571-582. doi: 10.1016/j.stemcr.2016.07.007. Epub 2016 Aug 4.

21.

Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.

Lebois M, Dowling MR, Gangatirkar P, Hodgkin PD, Kile BT, Alexander WS, Josefsson EC.

J Thromb Haemost. 2016 Sep;14(9):1882-7. doi: 10.1111/jth.13397. Epub 2016 Aug 11.

22.

CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, Burns CJ, Carotta S, Gray DH, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND.

Nat Immunol. 2016 Jul;17(7):816-24. doi: 10.1038/ni.3470. Epub 2016 May 23.

PMID:
27213690
23.

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions.

Behrens K, Triviai I, Schwieger M, Tekin N, Alawi M, Spohn M, Indenbirken D, Ziegler M, Müller U, Alexander WS, Stocking C.

Blood. 2016 Jun 30;127(26):3369-81. doi: 10.1182/blood-2015-09-668129. Epub 2016 Apr 13.

PMID:
27076172
24.

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

Xu Z, Sharp PP, Yao Y, Segal D, Ang CH, Khaw SL, Aubrey BJ, Gong J, Kelly GL, Herold MJ, Strasser A, Roberts AW, Alexander WS, Burns CJ, Huang DC, Glaser SP.

Leukemia. 2016 Jul;30(7):1531-41. doi: 10.1038/leu.2016.52. Epub 2016 Mar 8.

PMID:
27055867
25.

Tribute to Donald Metcalf.

Murphy A, Murphy MJ, Begley CG, Stanley ER, Migliaccio AR, Kaushansky K, Ng AP, Alexander WS, Hilton DJ, Nicola NA.

Stem Cells. 2015 Dec;33(12):3397-421. doi: 10.1002/stem.2237.

26.

In vivo at last: Demonstrating the biological credentials and clinical potential of GM-CSF.

Alexander WS.

Exp Hematol. 2016 Aug;44(8):669-73. doi: 10.1016/j.exphem.2016.01.006. Epub 2016 Feb 1. Review.

PMID:
26835837
27.

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Delconte RB, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, Kolesnik TB, Rankin LC, Mielke LA, Zhang JG, Busslinger M, Smyth MJ, Hutchinson DS, Nutt SL, Nicholson SE, Alexander WS, Corcoran LM, Vivier E, Belz GT, Carotta S, Huntington ND.

Immunity. 2016 Jan 19;44(1):103-115. doi: 10.1016/j.immuni.2015.12.007. Epub 2016 Jan 12.

28.

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a.

Shields BJ, Jackson JT, Metcalf D, Shi W, Huang Q, Garnham AL, Glaser SP, Beck D, Pimanda JE, Bogue CW, Smyth GK, Alexander WS, McCormack MP.

Genes Dev. 2016 Jan 1;30(1):78-91. doi: 10.1101/gad.268425.115.

29.

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.

Lawrenson ID, Krebs DL, Linossi EM, Zhang JG, McLennan TJ, Collin C, McRae HM, Kolesnik TB, Koh K, Britto JM, Kueh AJ, Sheikh BN, El-Saafin F, Nicola NA, Tan SS, Babon JJ, Nicholson SE, Alexander WS, Thomas T, Voss AK.

Cereb Cortex. 2017 Jan 1;27(1):576-588. doi: 10.1093/cercor/bhv253.

PMID:
26503265
30.

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.

Tanzer MC, Tripaydonis A, Webb AI, Young SN, Varghese LN, Hall C, Alexander WS, Hildebrand JM, Silke J, Murphy JM.

Biochem J. 2015 Oct 15;471(2):255-65. doi: 10.1042/BJ20150678. Epub 2015 Aug 17.

PMID:
26283547
31.

In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology.

Nicola NA, Alexander WS, Hilton DJ, Ng AP.

Exp Hematol. 2015 Jun;43(6):425-7. No abstract available.

PMID:
26247071
32.

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.

Lee SC, Miller S, Hyland C, Kauppi M, Lebois M, Di Rago L, Metcalf D, Kinkel SA, Josefsson EC, Blewitt ME, Majewski IJ, Alexander WS.

Blood. 2015 Jul 9;126(2):167-75. doi: 10.1182/blood-2014-12-615898. Epub 2015 Jun 2.

PMID:
26036803
33.

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.

Potts KS, Sargeant TJ, Dawson CA, Josefsson EC, Hilton DJ, Alexander WS, Taoudi S.

Blood. 2015 Aug 6;126(6):807-16. doi: 10.1182/blood-2014-12-616607. Epub 2015 May 20.

PMID:
25995324
34.

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

Ng AP, Hu Y, Metcalf D, Hyland CD, Ierino H, Phipson B, Wu D, Baldwin TM, Kauppi M, Kiu H, Di Rago L, Hilton DJ, Smyth GK, Alexander WS.

PLoS Genet. 2015 May 14;11(5):e1005211. doi: 10.1371/journal.pgen.1005211. eCollection 2015 May.

35.

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi: 10.1073/pnas.1507812112. Epub 2015 May 8. No abstract available.

36.

BCL-2 is dispensable for thrombopoiesis and platelet survival.

Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC.

Cell Death Dis. 2015 Apr 16;6:e1721. doi: 10.1038/cddis.2015.97.

37.

Brief Report: Factors Released by Megakaryocytes Thrombin Cleave Osteopontin to Negatively Regulate Hematopoietic Stem Cells.

Storan MJ, Heazlewood SY, Heazlewood CK, Haylock DN, Alexander WS, Neaves RJ, Oteiza A, Nilsson SK.

Stem Cells. 2015 Jul;33(7):2351-7. doi: 10.1002/stem.2038. Epub 2015 May 15.

38.

Donald Metcalf (1929-2014).

Hilton DJ, Nicola NA, Alexander WS, Roberts AW, Dunn AR.

Cell. 2015 Jan 29;160(3):361-2. No abstract available.

39.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.

40.

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

Kinkel SA, Galeev R, Flensburg C, Keniry A, Breslin K, Gilan O, Lee S, Liu J, Chen K, Gearing LJ, Moore DL, Alexander WS, Dawson M, Majewski IJ, Oshlack A, Larsson J, Blewitt ME.

Blood. 2015 Mar 19;125(12):1890-900. doi: 10.1182/blood-2014-10-603969. Epub 2015 Feb 2.

41.

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.

Sheikh BN, Lee SC, El-Saafin F, Vanyai HK, Hu Y, Pang SH, Grabow S, Strasser A, Nutt SL, Alexander WS, Smyth GK, Voss AK, Thomas T.

Blood. 2015 Mar 19;125(12):1910-21. doi: 10.1182/blood-2014-08-594655. Epub 2015 Jan 20.

42.

A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis.

Jackson JT, Nasa C, Shi W, Huntington ND, Bogue CW, Alexander WS, McCormack MP.

Blood. 2015 Jan 29;125(5):803-14. doi: 10.1182/blood-2014-06-579813. Epub 2014 Dec 3.

PMID:
25472970
43.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03464.

44.

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.

Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. doi: 10.1073/pnas.1408987111. Epub 2014 Oct 6.

45.

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.

Shields BJ, Alserihi R, Nasa C, Bogue C, Alexander WS, McCormack MP.

Leukemia. 2015 Apr;29(4):927-38. doi: 10.1038/leu.2014.292. Epub 2014 Oct 6.

PMID:
25283843
46.

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo.

Potts KS, Sargeant TJ, Markham JF, Shi W, Biben C, Josefsson EC, Whitehead LW, Rogers KL, Liakhovitskaia A, Smyth GK, Kile BT, Medvinsky A, Alexander WS, Hilton DJ, Taoudi S.

Blood. 2014 Oct 23;124(17):2725-9. doi: 10.1182/blood-2014-02-559468. Epub 2014 Jul 25.

PMID:
25079356
47.

Asymptomatic facial papules.

Alexander WS, Hossler EW.

J Am Acad Dermatol. 2014 Aug;71(2):412-4. doi: 10.1016/j.jaad.2012.10.027. No abstract available.

PMID:
25037799
48.

Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.

Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP.

Arthritis Rheumatol. 2014 Sep;66(9):2391-402. doi: 10.1002/art.38701.

49.

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.

50.

Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis.

Cheung LC, Strickland DH, Howlett M, Ford J, Charles AK, Lyons KM, Brigstock DR, Goldschmeding R, Cole CH, Alexander WS, Kees UR.

Haematologica. 2014 Jul;99(7):1149-56. doi: 10.3324/haematol.2013.102327. Epub 2014 Apr 11.

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