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Items: 1 to 50 of 309

1.

The implementation of newborn screening for spinal muscular atrophy: the Australian experience.

Kariyawasam DST, Russell JS, Wiley V, Alexander IE, Farrar MA.

Genet Med. 2019 Oct 14. doi: 10.1038/s41436-019-0673-0. [Epub ahead of print]

PMID:
31607747
2.

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition.

Conley RB, Adib G, Adler RA, Akesson KE, Alexander IM, Amenta KC, Blank RD, Brox WT, Carmody EE, Chapman-Novakofski K, Clarke BL, Cody KM, Cooper C, Crandall CJ, Dirschl DR, Eagen TJ, Elderkin AL, Fujita M, Greenspan SL, Halbout P, Hochberg MC, Javaid M, Jeray KJ, Kearns AE, King T, Koinis TF, Koontz JS, Kuzma M, Lindsey C, Lorentzon M, Lyritis GP, Michaud LB, Miciano A, Morin SN, Mujahid N, Napoli N, Olenginski TP, Puzas JE, Rizou S, Rosen CJ, Saag K, Thompson E, Tosi LL, Tracer H, Khosla S, Kiel D.

J Bone Miner Res. 2019 Sep 20. doi: 10.1002/jbmr.3877. [Epub ahead of print]

PMID:
31538675
3.

Systemic AAV8-mediated delivery of a functional copy of muscle glycogen phosphorylase (Pygm) ameliorates disease in a murine model of McArdle disease.

McNamara EL, Taylor RL, Clayton JS, Goullee H, Dilworth KL, Pinós T, Brull A, Alexander IE, Lisowski L, Ravenscroft G, Laing NG, Nowak KJ.

Hum Mol Genet. 2019 Sep 12. pii: ddz214. doi: 10.1093/hmg/ddz214. [Epub ahead of print]

PMID:
31511858
4.

Sleep-Wake Disturbance Related to Ocular Disease: A Systematic Review of Phase-Shifting Pharmaceutical Therapies.

Andrews CD, Foster RG, Alexander I, Vasudevan S, Downes SM, Heneghan C, Plüddemann A.

Transl Vis Sci Technol. 2019 Jun 26;8(3):49. doi: 10.1167/tvst.8.3.49. eCollection 2019 May. Review.

5.

Insights into Gene Therapy for Urea Cycle Defects by Mathematical Modeling.

Kok CY, Cunningham SC, Kuchel PW, Alexander IE.

Hum Gene Ther. 2019 Nov;30(11):1385-1394. doi: 10.1089/hum.2019.053. Epub 2019 Jul 17.

PMID:
31215258
6.

Impact of Diabetic Retinopathy on Sleep, Mood, and Quality of Life.

Morjaria R, Alexander I, Purbrick RMJ, Safa R, Chong NV, Wulff K, Foster RG, Downes SM; SOMNUS Study Group.

Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2304-2310. doi: 10.1167/iovs.18-26108. Erratum in: Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3421.

7.

Prevention of Cholestatic Liver Disease and Reduced Tumorigenicity in a Murine Model of PFIC Type 3 Using Hybrid AAV-piggyBac Gene Therapy.

Siew SM, Cunningham SC, Zhu E, Tay SS, Venuti E, Bolitho C, Alexander IE.

Hepatology. 2019 May 17. doi: 10.1002/hep.30773. [Epub ahead of print]

PMID:
31099022
8.

AAV-Mediated Gene Delivery to the Mouse Liver.

Cunningham SC, Alexander IE.

Methods Mol Biol. 2019;1937:213-219. doi: 10.1007/978-1-4939-9065-8_12.

PMID:
30706398
9.

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality.

Cabanes-Creus M, Ginn SL, Amaya AK, Liao SHY, Westhaus A, Hallwirth CV, Wilmott P, Ward J, Dilworth KL, Santilli G, Rybicki A, Nakai H, Thrasher AJ, Filip AC, Alexander IE, Lisowski L.

Mol Ther Methods Clin Dev. 2018 Nov 1;12:71-84. doi: 10.1016/j.omtm.2018.10.016. eCollection 2019 Mar 15.

10.

The American Academy of Nursing on policy proposed healthcare policy changes threaten women's health.

Roye CF, Johnson-Mallard V, Burke P, Alexander IM, Taylor D, Greenberg CS, Czubaruk K.

Nurs Outlook. 2018 Nov;66(6):586-589. doi: 10.1016/j.outlook.2018.09.005. Epub 2018 Sep 18. No abstract available.

PMID:
30509405
11.

Directed Evolution of Adeno-Associated Virus Vectors in Human Cardiomyocytes for Cardiac Gene Therapy.

Kok CY, Alexander I, Lisowski L, Kizana E.

Heart Lung Circ. 2018 Nov;27(11):1270-1273. doi: 10.1016/j.hlc.2018.08.014. No abstract available.

PMID:
30274736
12.

Thymocyte self-renewal and oncogenic risk in immunodeficient mouse models: relevance for human gene therapy clinical trials targeting haematopoietic stem cell populations?

Ginn SL, McCormack MP, Alexander IE.

Mamm Genome. 2018 Dec;29(11-12):771-776. doi: 10.1007/s00335-018-9780-5. Epub 2018 Sep 4. Review.

PMID:
30182300
13.

Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction.

Paul-Heng M, Leong M, Cunningham E, Bunker DLJ, Bremner K, Wang Z, Wang C, Tay SS, McGuffog C, Logan GJ, Alexander IE, Hu M, Alexander SI, Sparwasser TD, Bertolino P, Bowen DG, Bishop GA, Sharland A.

JCI Insight. 2018 Aug 9;3(15). pii: 97500. doi: 10.1172/jci.insight.97500. eCollection 2018 Aug 9.

14.

An Examination of Applicants and Factors Associated with Matriculation to Complex General Surgical Oncology Fellowship Training Programs.

Wach MM, Ruff SM, Ayabe RI, Martin SP, Diggs LP, Alexander IA, Steinberg SM, Davis JL, Hernandez JM.

Ann Surg Oncol. 2018 Nov;25(12):3436-3442. doi: 10.1245/s10434-018-6674-4. Epub 2018 Jul 27.

15.

Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort.

Perocheau DP, Cunningham S, Lee J, Antinao Diaz J, Waddington SN, Gilmour K, Eaglestone S, Lisowski L, Thrasher AJ, Alexander IE, Gissen P, Baruteau J.

Hum Gene Ther. 2019 Jan;30(1):79-87. doi: 10.1089/hum.2018.098. Epub 2018 Oct 19.

16.

Managing sexually transmitted infections: Beyond the 2015 guidelines.

Johnson-Mallard V, Curry K, Chandler R, Alexander I, Kostas-Polston E, Orsega S, Woods NF.

Nurse Pract. 2018 Aug;43(8):28-34. doi: 10.1097/01.NPR.0000541464.23795.5b.

PMID:
29985197
17.

The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.

DeWald LE, Dyall J, Sword JM, Torzewski L, Zhou H, Postnikova E, Kollins E, Alexander I, Gross R, Cong Y, Gerhardt DM, Johnson RF, Olinger GG Jr, Holbrook MR, Hensley LE, Jahrling PB.

J Infect Dis. 2018 Nov 22;218(suppl_5):S588-S591. doi: 10.1093/infdis/jiy332.

PMID:
29982632
18.

Assessing exposure factors in the smartphone generation: Design and evaluation of a smartphone app that collects use patterns of cosmetics and household chemicals.

Natalie VG, Elena GH, Charles B, Klaus F, Remo F, Alexander I.

Food Chem Toxicol. 2018 Aug;118:532-540. doi: 10.1016/j.fct.2018.05.060. Epub 2018 May 31.

PMID:
29860016
19.

Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.

Chen X, Ma J, Kwan T, Stribos EGD, Messchendorp AL, Loh YW, Wang X, Paul M, Cunningham EC, Habib M, Alexander IE, Sharland AF, Chadban SJ, Wu H.

Sci Rep. 2018 May 29;8(1):8319. doi: 10.1038/s41598-018-26637-5.

20.

The Effect of Perioperative Fluid Management on Intraocular Pressure during Gynecologic Laparoscopic Pelvic Surgery.

Alexander I, Ahmad S, Inbar BS, Joseph P.

J Ophthalmol. 2018 Mar 15;2018:1457851. doi: 10.1155/2018/1457851. eCollection 2018.

21.

Partial pancreatic transdifferentiation of primary human hepatocytes in the livers of a humanised mouse model.

Ren B, La QT, O'Brien BA, Nassif NT, Tan Y, Gerace D, Martiniello-Wilks R, Torpy F, Dane AP, Alexander IE, Simpson AM.

J Gene Med. 2018 May;20(5):e3017. doi: 10.1002/jgm.3017. Epub 2018 Apr 16.

PMID:
29578255
22.

Gene therapy clinical trials worldwide to 2017: An update.

Ginn SL, Amaya AK, Alexander IE, Edelstein M, Abedi MR.

J Gene Med. 2018 May;20(5):e3015. doi: 10.1002/jgm.3015. Epub 2018 Apr 19. Review.

PMID:
29575374
23.

Clinical Trial of MGMT(P140K) Gene Therapy in the Treatment of Pediatric Patients with Brain Tumors.

Kramer B, Singh R, Wischusen J, Dent R, Rush A, Middlemiss S, Ching YW, Alexander IE, McCowage G.

Hum Gene Ther. 2018 Aug;29(8):874-885. doi: 10.1089/hum.2017.235. Epub 2018 Mar 23.

PMID:
29385852
24.

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization.

Tu L, Wang JH, Barathi VA, Prea SM, He Z, Lee JH, Bender J, King AE, Logan GJ, Alexander IE, Bee YS, Tai MH, Dusting GJ, Bui BV, Zhong J, Liu GS.

Angiogenesis. 2018 Feb;21(1):95-109. doi: 10.1007/s10456-017-9591-4. Epub 2018 Jan 9.

PMID:
29318471
25.

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

Paulk NK, Pekrun K, Zhu E, Nygaard S, Li B, Xu J, Chu K, Leborgne C, Dane AP, Haft A, Zhang Y, Zhang F, Morton C, Valentine MB, Davidoff AM, Nathwani AC, Mingozzi F, Grompe M, Alexander IE, Lisowski L, Kay MA.

Mol Ther. 2018 Jan 3;26(1):289-303. doi: 10.1016/j.ymthe.2017.09.021. Epub 2017 Sep 25.

26.

Animal Health Surveillance.

Alexander I, Kloeze H.

Can Vet J. 2017 Oct;58(10):1017-1019. No abstract available.

27.

Unintended pregnancy: a framework for prevention and options for midlife women in the US.

Johnson-Mallard V, Kostas-Polston EA, Woods NF, Simmonds KE, Alexander IM, Taylor D.

Womens Midlife Health. 2017 Sep 15;3:8. doi: 10.1186/s40695-017-0027-5. eCollection 2017.

28.

Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Logan GJ, Dane AP, Hallwirth CV, Smyth CM, Wilkie EE, Amaya AK, Zhu E, Khandekar N, Ginn SL, Liao SHY, Cunningham SC, Sasaki N, Cabanes-Creus M, Tam PPL, Russell DW, Lisowski L, Alexander IE.

Nat Genet. 2017 Aug;49(8):1267-1273. doi: 10.1038/ng.3893. Epub 2017 Jun 19.

PMID:
28628105
29.

Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data.

Kamboj A, Hallwirth CV, Alexander IE, McCowage GB, Kramer B.

BMC Bioinformatics. 2017 Jun 17;18(1):305. doi: 10.1186/s12859-017-1719-4.

30.

Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.

Baruteau J, Waddington SN, Alexander IE, Gissen P.

J Inherit Metab Dis. 2017 Jul;40(4):497-517. doi: 10.1007/s10545-017-0053-3. Epub 2017 May 31. Review.

31.

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.

Kanthan A, Fahmy P, Rao R, Pouliopoulos J, Alexander IE, Thomas SP, Kizana E.

Heart Lung Circ. 2018 Jan;27(1):114-121. doi: 10.1016/j.hlc.2017.02.010. Epub 2017 Mar 21.

PMID:
28457700
32.

Loss in lung volume and changes in the immune response demonstrate disease progression in African green monkeys infected by small-particle aerosol and intratracheal exposure to Nipah virus.

Cong Y, Lentz MR, Lara A, Alexander I, Bartos C, Bohannon JK, Hammoud D, Huzella L, Jahrling PB, Janosko K, Jett C, Kollins E, Lackemeyer M, Mollura D, Ragland D, Rojas O, Solomon J, Xu Z, Munster V, Holbrook MR.

PLoS Negl Trop Dis. 2017 Apr 7;11(4):e0005532. doi: 10.1371/journal.pntd.0005532. eCollection 2017 Apr.

33.

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency.

Ginn SL, Hallwirth CV, Liao SH, Teber ET, Arthur JW, Wu J, Lee HC, Tay SS, Hu M, Reddel RR, McCormack MP, Thrasher AJ, Cavazzana M, Alexander SI, Alexander IE.

Mol Ther Nucleic Acids. 2017 Mar 17;6:1-14. doi: 10.1016/j.omtn.2016.11.011. Epub 2016 Dec 10.

34.

Delivering efficient liver-directed AAV-mediated gene therapy.

Baruteau J, Waddington SN, Alexander IE, Gissen P.

Gene Ther. 2017 May;24(5):263-264. doi: 10.1038/gt.2016.90. Epub 2017 Jan 12. No abstract available.

PMID:
28079048
35.

Effect of Direct Ligament Repair and Tenodesis Reconstruction on Simulated Subtalar Joint Instability.

Choisne J, Hoch MC, Alexander I, Ringleb SI.

Foot Ankle Int. 2017 Mar;38(3):324-330. doi: 10.1177/1071100716674997. Epub 2016 Nov 14.

PMID:
27923217
36.

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus.

Cong Y, Dyall J, Hart BJ, DeWald LE, Johnson JC, Postnikova E, Zhou H, Gross R, Rojas O, Alexander I, Josleyn N, Zhang T, Michelotti J, Janosko K, Glass PJ, Flint M, McMullan LK, Spiropoulou CF, Mierzwa T, Guha R, Shinn P, Michael S, Klumpp-Thomas C, McKnight C, Thomas C, Eakin AE, O'Loughlin KG, Green CE, Catz P, Mirsalis JC, Honko AN, Olinger GG Jr, Bennett RS, Holbrook MR, Hensley LE, Jahrling PB.

PLoS One. 2016 Nov 30;11(11):e0166318. doi: 10.1371/journal.pone.0166318. eCollection 2016.

37.

Developing Quality Improvement capacity and capability across the Children in Fife partnership.

Morris C, Alexander I.

BMJ Qual Improv Rep. 2016 Sep 30;5(1). pii: u212664.w5045. eCollection 2016.

38.

Synthetic certified DNA reference material for analysis of human erythropoietin transgene and transcript in gene doping and gene therapy.

Baoutina A, Bhat S, Zheng M, Partis L, Dobeson M, Alexander IE, Emslie KR.

Gene Ther. 2016 Oct;23(10):708-717. doi: 10.1038/gt.2016.47. Epub 2016 Jun 7.

PMID:
27439362
39.

[Responsabilité sociale au mésoniveau: Au sein de la communauté].

Woollard R, Buchman S, Meili R, Strasser R, Alexander I, Goel R.

Can Fam Physician. 2016 Jul;62(7):547-50. French. No abstract available.

40.

Social accountability at the meso level: Into the community.

Woollard R, Buchman S, Meili R, Strasser R, Alexander I, Goel R.

Can Fam Physician. 2016 Jul;62(7):538-40. No abstract available.

41.

Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus.

Smith RH, Hallwirth CV, Westerman M, Hetherington NA, Tseng YS, Cecchini S, Virag T, Ziegler ML, Rogozin IB, Koonin EV, Agbandje-McKenna M, Kotin RM, Alexander IE.

Sci Rep. 2016 Jul 5;6:28965. doi: 10.1038/srep28965.

42.

Tumor-derived circulating endothelial cell clusters in colorectal cancer.

Cima I, Kong SL, Sengupta D, Tan IB, Phyo WM, Lee D, Hu M, Iliescu C, Alexander I, Goh WL, Rahmani M, Suhaimi NA, Vo JH, Tai JA, Tan JH, Chua C, Ten R, Lim WJ, Chew MH, Hauser CA, van Dam RM, Lim WY, Prabhakar S, Lim B, Koh PK, Robson P, Ying JY, Hillmer AM, Tan MH.

Sci Transl Med. 2016 Jun 29;8(345):345ra89. doi: 10.1126/scitranslmed.aad7369.

PMID:
27358499
43.

Chromatic Perceptual Learning but No Category Effects without Linguistic Input.

Grandison A, Sowden PT, Drivonikou VG, Notman LA, Alexander I, Davies IR.

Front Psychol. 2016 May 25;7:731. doi: 10.3389/fpsyg.2016.00731. eCollection 2016.

44.

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication.

Yeo CQX, Alexander I, Lin Z, Lim S, Aning OA, Kumar R, Sangthongpitag K, Pendharkar V, Ho VHB, Cheok CF.

Cell Rep. 2016 Apr 5;15(1):132-146. doi: 10.1016/j.celrep.2016.03.011. Epub 2016 Mar 24.

45.

Tibiotalocalcaneal Fusion for Severe Deformity and Bone Loss.

Asomugha EU, Den Hartog BD, Junko JT, Alexander IJ.

J Am Acad Orthop Surg. 2016 Mar;24(3):125-34. doi: 10.5435/JAAOS-D-14-00102. Review.

PMID:
26829585
46.

Adeno-associated virus serotypes for gene therapeutics.

Lisowski L, Tay SS, Alexander IE.

Curr Opin Pharmacol. 2015 Oct;24:59-67. doi: 10.1016/j.coph.2015.07.006. Epub 2015 Aug 25. Review.

PMID:
26291407
47.

Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus.

Dane AP, Cunningham SC, Kok CY, Logan GJ, Alexander IE.

Gene Ther. 2015 Nov;22(11):917-22. doi: 10.1038/gt.2015.66. Epub 2015 Jul 30.

PMID:
26224361
48.

Methyl-Guanine-Methyl-Transferase Transgenic Bone Marrow Transplantation Allows N,N-bis(2-chloroethyl)-Nitrosourea Driven Donor Mixed-Chimerism Without Graft-Versus-Host Disease, and With Donor-Specific Allograft Tolerance.

Hu M, Kramer B, Zhang GY, Wang YM, Watson D, Howden B, McCowage G, Alexander IE, Gunning P, Alexander SI.

Transplantation. 2015 Dec;99(12):2476-84. doi: 10.1097/TP.0000000000000825.

PMID:
26177088
49.

Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions.

Hallwirth CV, Garg G, Peters TJ, Kramer BA, Malani NV, Hyman J, Ruan X, Ginn SL, Hetherington NA, Veeravalli L, Shahab A, Ranganathan S, Wei CL, Liddle C, Thrasher AJ, Bushman FD, Buckley MJ, Alexander IE.

Mol Ther Methods Clin Dev. 2015 Apr 29;2:15015. doi: 10.1038/mtm.2015.15. eCollection 2015.

50.

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system.

Cunningham SC, Siew SM, Hallwirth CV, Bolitho C, Sasaki N, Garg G, Michael IP, Hetherington NA, Carpenter K, de Alencastro G, Nagy A, Alexander IE.

Hepatology. 2015 Aug;62(2):417-28. doi: 10.1002/hep.27842. Epub 2015 May 23.

PMID:
26011400

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