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Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients.

Kishimoto T, Fujimoto N, Ebara T, Omori T, Oguri T, Niimi A, Yokoyama T, Kato M, Usami I, Nishio M, Yoshikawa K, Tokuyama T, Tamura M, Yokoyama Y, Tsuboi K, Matsuo Y, Xu J, Takahashi S, Abdelgied M, Alexander WT, Alexander DB, Tsuda H.

BMC Cancer. 2019 Dec 10;19(1):1204. doi: 10.1186/s12885-019-6419-1.


Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration.

Abdelgied M, El-Gazzar AM, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Abdou KA, Takahashi S, Alexander DB, Tsuda H.

Part Fibre Toxicol. 2019 Sep 2;16(1):34. doi: 10.1186/s12989-019-0316-2.


Evaluation of a biomarker for the diagnosis of pancreas cancer using an animal model.

Fukamachi K, Hagiwara Y, Futakuchi M, Alexander DB, Tsuda H, Suzui M.

J Toxicol Pathol. 2019 Jul;32(3):135-141. doi: 10.1293/tox.2018-0062. Epub 2019 Apr 4.


MWCNT-7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats.

Numano T, Higuchi H, Alexander DB, Alexander WT, Abdelgied M, El-Gazzar AM, Saleh D, Takase H, Hirose A, Naiki-Ito A, Suzuki S, Takahashi S, Tsuda H.

Cancer Sci. 2019 Aug;110(8):2485-2492. doi: 10.1111/cas.14121. Epub 2019 Jul 25.


Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats.

Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Tsuda H, Takahashi S.

Arch Toxicol. 2019 Apr;93(4):909-920. doi: 10.1007/s00204-019-02410-z. Epub 2019 Feb 13.


Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats.

El-Gazzar AM, Abdelgied M, Alexander DB, Alexander WT, Numano T, Iigo M, Naiki A, Takahashi S, Takase H, Hirose A, Kannno J, Elokle OS, Nazem AM, Tsuda H.

Arch Toxicol. 2019 Jan;93(1):49-59. doi: 10.1007/s00204-018-2336-3. Epub 2018 Oct 19.


The RECK tumor-suppressor protein binds and stabilizes ADAMTS10.

Matsuzaki T, Kitayama H, Omura A, Nishimoto E, Alexander DB, Noda M.

Biol Open. 2018 Oct 4;7(10). pii: bio033985. doi: 10.1242/bio.033985.


Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.

Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H.

Chem Res Toxicol. 2018 Oct 15;31(10):1025-1031. doi: 10.1021/acs.chemrestox.8b00067. Epub 2018 Sep 13.


Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats.

Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Tsuda H, Takahashi S.

Cancer Sci. 2018 Jul;109(7):2164-2177. doi: 10.1111/cas.13643. Epub 2018 Jun 22.


Lactoferrin researchers descend on Nagoya Castle.

Alexander DB, Vogel HJ, Tsuda H.

Biochem Cell Biol. 2017 Feb;95(1):1-4. doi: 10.1139/bcb-2017-0009. No abstract available.


Bovine lactoferrin and Crohn's disease: a case study.

Alexander DB, Iigo M, Abdelgied M, Ozeki K, Tanida S, Joh T, Takahashi S, Tsuda H.

Biochem Cell Biol. 2017 Feb;95(1):133-141. doi: 10.1139/bcb-2016-0107. Epub 2016 Nov 30.


Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors.

Suzui M, Futakuchi M, Fukamachi K, Numano T, Abdelgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Alexander WT, Jiegou X, Tsuda H.

Cancer Sci. 2016 Jul;107(7):924-35. doi: 10.1111/cas.12954. Epub 2016 Jun 23.


The " NF-ĸ B interacting long noncoding RNA" ( NKILA) transcript is antisense to cancer-associated gene PMEPA1.

Dijkstra JM, Alexander DB.

F1000Res. 2015 Apr 22;4:96. doi: 10.12688/f1000research.6400.1. eCollection 2015.


Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study.

Xu J, Alexander DB, Iigo M, Hamano H, Takahashi S, Yokoyama T, Kato M, Usami I, Tokuyama T, Tsutsumi M, Tamura M, Oguri T, Niimi A, Hayashi Y, Yokoyama Y, Tonegawa K, Fukamachi K, Futakuchi M, Sakai Y, Suzui M, Kamijima M, Hisanaga N, Omori T, Nakae D, Hirose A, Kanno J, Tsuda H.

Cancer Sci. 2015 Jul;106(7):825-32. doi: 10.1111/cas.12687. Epub 2015 Jun 5.


Rat N-ERC/mesothelin as a marker for in vivo screening of drugs against pancreas cancer.

Fukamachi K, Iigo M, Hagiwara Y, Shibata K, Futakuchi M, Alexander DB, Hino O, Suzui M, Tsuda H.

PLoS One. 2014 Oct 27;9(10):e111481. doi: 10.1371/journal.pone.0111481. eCollection 2014.


Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine.

Iigo M, Alexander DB, Xu J, Futakuchi M, Suzui M, Kozu T, Akasu T, Saito D, Kakizoe T, Yamauchi K, Abe F, Takase M, Sekine K, Tsuda H.

Biometals. 2014 Oct;27(5):1017-29. doi: 10.1007/s10534-014-9747-2. Epub 2014 May 28.


MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents.

Ohba T, Xu J, Alexander DB, Yamada A, Kanno J, Hirose A, Tsuda H, Imaizumi Y.

J Toxicol Sci. 2014 Jun;39(3):499-505.


Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes.

Xu J, Alexander DB, Futakuchi M, Numano T, Fukamachi K, Suzui M, Omori T, Kanno J, Hirose A, Tsuda H.

Cancer Sci. 2014 Jul;105(7):763-9. doi: 10.1111/cas.12437. Epub 2014 Jul 1.


Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro.

Numano T, Xu J, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Kanno J, Hirose A, Tsuda H, Suzui M.

Asian Pac J Cancer Prev. 2014;15(2):929-35.


Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles.

Xu J, Futakuchi M, Alexander DB, Fukamachi K, Numano T, Suzui M, Shimizu H, Omori T, Kanno J, Hirose A, Tsuda H.

Arch Toxicol. 2014 Jan;88(1):65-75. doi: 10.1007/s00204-013-1086-5. Epub 2013 Jul 6.


Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.

Yabushita S, Fukamachi K, Kikuchi F, Ozaki M, Miyata K, Sukata T, Deguchi Y, Tanaka H, Kakehashi A, Kawamura S, Uwagawa S, Wanibuchi H, Suzui M, Alexander DB, Tsuda H.

Pancreas. 2013 Aug;42(6):1034-9. doi: 10.1097/MPA.0b013e3182883624.


Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.

Yabushita S, Fukamachi K, Tanaka H, Fukuda T, Sumida K, Deguchi Y, Mikata K, Nishioka K, Kawamura S, Uwagawa S, Suzui M, Alexander DB, Tsuda H.

Carcinogenesis. 2013 Jun;34(6):1251-9. doi: 10.1093/carcin/bgt053. Epub 2013 Feb 7.


A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination.

Fukamachi K, Tanaka H, Sakai Y, Alexander DB, Futakuchi M, Tsuda H, Suzui M.

Genesis. 2013 Apr;51(4):268-74. doi: 10.1002/dvg.22371. Epub 2013 Feb 25.


The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.

Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M.

Biol Open. 2012 May 15;1(5):458-66. doi: 10.1242/bio.2012638. Epub 2012 Mar 27.


Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats.

Xu J, Futakuchi M, Shimizu H, Alexander DB, Yanagihara K, Fukamachi K, Suzui M, Kanno J, Hirose A, Ogata A, Sakamoto Y, Nakae D, Omori T, Tsuda H.

Cancer Sci. 2012 Dec;103(12):2045-50. doi: 10.1111/cas.12005. Epub 2012 Oct 10.


Lactoferrin: an alternative view of its role in human biological fluids.

Alexander DB, Iigo M, Yamauchi K, Suzui M, Tsuda H.

Biochem Cell Biol. 2012 Jun;90(3):279-306. doi: 10.1139/o2012-013. Epub 2012 May 3. Review.


Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats.

Xu J, Sagawa Y, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Ikarashi Y, Uchino T, Nishimura T, Morita A, Suzui M, Tsuda H.

Food Chem Toxicol. 2011 Jun;49(6):1298-302. doi: 10.1016/j.fct.2011.03.011. Epub 2011 Mar 23.


Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice.

Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J, Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y, Matsuzaki T, Noda M.

BMC Dev Biol. 2010 Aug 6;10:84. doi: 10.1186/1471-213X-10-84.


Cancer prevention by bovine lactoferrin: from animal studies to human trial.

Tsuda H, Kozu T, Iinuma G, Ohashi Y, Saito Y, Saito D, Akasu T, Alexander DB, Futakuchi M, Fukamachi K, Xu J, Kakizoe T, Iigo M.

Biometals. 2010 Jun;23(3):399-409. doi: 10.1007/s10534-010-9331-3. Epub 2010 Apr 21. Review.


Involvement of macrophage inflammatory protein 1alpha (MIP1alpha) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying.

Xu J, Futakuchi M, Iigo M, Fukamachi K, Alexander DB, Shimizu H, Sakai Y, Tamano S, Furukawa F, Uchino T, Tokunaga H, Nishimura T, Hirose A, Kanno J, Tsuda H.

Carcinogenesis. 2010 May;31(5):927-35. doi: 10.1093/carcin/bgq029. Epub 2010 Feb 25.


Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy.

Long N, Hardiville S, Pierce A, Fukamachi K, Futakuchi M, Alexander DB, Shirai T, Tsuda H.

Asian Pac J Cancer Prev. 2009;10(5):939-60.


Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.

Tanaka H, Fukamachi K, Futakuchi M, Alexander DB, Long N, Tamamushi S, Minami K, Seino S, Ohara H, Joh T, Tsuda H.

Cancer Sci. 2010 Feb;101(2):341-6. doi: 10.1111/j.1349-7006.2009.01410.x. Epub 2009 Oct 22.


Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial.

Kozu T, Iinuma G, Ohashi Y, Saito Y, Akasu T, Saito D, Alexander DB, Iigo M, Kakizoe T, Tsuda H.

Cancer Prev Res (Phila). 2009 Nov;2(11):975-83. doi: 10.1158/1940-6207.CAPR-08-0208. Epub 2009 Oct 27.


An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas.

Fukamachi K, Tanaka H, Hagiwara Y, Ohara H, Joh T, Iigo M, Alexander DB, Xu J, Long N, Takigahira M, Yanagihara K, Hino O, Saito I, Tsuda H.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):636-41. doi: 10.1016/j.bbrc.2009.10.019. Epub 2009 Oct 8.


The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts.

Morioka Y, Monypenny J, Matsuzaki T, Shi S, Alexander DB, Kitayama H, Noda M.

Oncogene. 2009 Mar 19;28(11):1454-64. doi: 10.1038/onc.2008.486. Epub 2009 Jan 26.


Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine.

Iigo M, Alexander DB, Long N, Xu J, Fukamachi K, Futakuchi M, Takase M, Tsuda H.

Biochimie. 2009 Jan;91(1):86-101. doi: 10.1016/j.biochi.2008.06.012. Epub 2008 Jun 27.


Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes.

Goldberg GS, Kunimoto T, Alexander DB, Suenaga K, Ishidate F, Miyamoto K, Ushijima T, Teng CT, Yokota J, Ohta T, Tsuda H.

Med Chem. 2005 Jan;1(1):57-64.


Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas.

Ueda S, Fukamachi K, Matsuoka Y, Takasuka N, Takeshita F, Naito A, Iigo M, Alexander DB, Moore MA, Saito I, Ochiya T, Tsuda H.

Carcinogenesis. 2006 Dec;27(12):2497-510. Epub 2006 Jun 13.


Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.

Oh J, Takahashi R, Adachi E, Kondo S, Kuratomi S, Noma A, Alexander DB, Motoda H, Okada A, Seiki M, Itoh T, Itohara S, Takahashi C, Noda M.

Oncogene. 2004 Jun 24;23(29):5041-8.


Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity.

Alexander DB, Ichikawa H, Bechberger JF, Valiunas V, Ohki M, Naus CC, Kunimoto T, Tsuda H, Miller WT, Goldberg GS.

Cancer Res. 2004 Feb 15;64(4):1347-58.


Sleep and adjustment in preschool children: sleep diary reports by mothers relate to behavior reports by teachers.

Bates JE, Viken RJ, Alexander DB, Beyers J, Stockton L.

Child Dev. 2002 Jan-Feb;73(1):62-74.


Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.

Iigo M, Shimamura M, Matsuda E, Fujita K, Nomoto H, Satoh J, Kojima S, Alexander DB, Moore MA, Tsuda H.

Cytokine. 2004 Jan 7;25(1):36-44.


Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells.

Goldberg GS, Alexander DB, Pellicena P, Zhang ZY, Tsuda H, Miller WT.

J Biol Chem. 2003 Nov 21;278(47):46533-40. Epub 2003 Sep 11.


Transfer of biologically important molecules between cells through gap junction channels.

Alexander DB, Goldberg GS.

Curr Med Chem. 2003 Oct;10(19):2045-58. Review.


The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.

Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB, Ide C, Horan TP, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C, Noda M.

Cell. 2001 Dec 14;107(6):789-800.


Cytotoxicity and mutagenicity of UVB assessed using cultured rat fibroblast.

Akiyama N, Murata S, Alexander DB, Yaoita H, Aoki Y, Noda M.

J Epidemiol. 1999 Dec;9(6 Suppl):S72-7. Review.


Transforming growth factor-alpha abrogates glucocorticoid-stimulated tight junction formation and growth suppression in rat mammary epithelial tumor cells.

Buse P, Woo PL, Alexander DB, Cha HH, Reza A, Sirota ND, Firestone GL.

J Biol Chem. 1995 Mar 24;270(12):6505-14.


Regulation of methylthioribose kinase by methionine in Klebsiella pneumoniae.

Tower PA, Alexander DB, Johnson LL, Riscoe MK.

J Gen Microbiol. 1993 May;139(5):1027-31.


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