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The impact of radiation therapy on lymphocyte count and survival in metastatic cancer patients receiving PD-1 immune checkpoint inhibitors.

Pike LRG, Bang A, Mahal BA, Taylor A, Krishnan M, Spektor A, Cagney DN, Aizer AA, Alexander BM, Rahma O, Balboni T, Ott PA, Hodi FS, Schoenfeld JD.

Int J Radiat Oncol Biol Phys. 2018 Sep 15. pii: S0360-3016(18)33755-6. doi: 10.1016/j.ijrobp.2018.09.010. [Epub ahead of print]


Effects of maternal obesity on maternal and fetal plasma concentrations of adiponectin and expression of adiponectin and its receptor genes in cotyledonary and adipose tissues at mid- and late-gestation in sheep.

Fensterseifer SR, Austin KJ, Ford SP, Alexander BM.

Anim Reprod Sci. 2018 Oct;197:231-239. doi: 10.1016/j.anireprosci.2018.08.033. Epub 2018 Aug 26.


Neurologic Complications of Radiation Therapy.

Tanguturi SK, Alexander BM.

Neurol Clin. 2018 Aug;36(3):599-625. doi: 10.1016/j.ncl.2018.04.012. Epub 2018 Jun 15. Review.


Implications of Screening for Brain Metastases in Patients With Breast Cancer and Non-Small Cell Lung Cancer.

Cagney DN, Martin AM, Catalano PJ, Brown PD, Alexander BM, Lin NU, Aizer AA.

JAMA Oncol. 2018 Jul 1;4(7):1001-1003. doi: 10.1001/jamaoncol.2018.0813. No abstract available.


Validation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma.

Ellingson BM, Abrey LE, Nelson SJ, Kaufmann TJ, Garcia J, Chinot O, Saran F, Nishikawa R, Henriksson R, Mason WP, Wick W, Butowski N, Ligon KL, Gerstner ER, Colman H, de Groot J, Chang S, Mellinghoff I, Young RJ, Alexander BM, Colen R, Taylor JW, Arrillaga-Romany I, Mehta A, Huang RY, Pope WB, Reardon D, Batchelor T, Prados M, Galanis E, Wen PY, Cloughesy TF.

Neuro Oncol. 2018 Aug 2;20(9):1240-1250. doi: 10.1093/neuonc/noy053.


Platform trials arrive on time for glioblastoma.

Alexander BM, Cloughesy TF.

Neuro Oncol. 2018 May 18;20(6):723-725. doi: 10.1093/neuonc/noy040. No abstract available.


Hazards of Hazard Ratios - Deviations from Model Assumptions in Immunotherapy.

Alexander BM, Schoenfeld JD, Trippa L.

N Engl J Med. 2018 Mar 22;378(12):1158-1159. doi: 10.1056/NEJMc1716612. No abstract available.


The clinical trials landscape for glioblastoma: is it adequate to develop new treatments?

Vanderbeek AM, Rahman R, Fell G, Ventz S, Chen T, Redd R, Parmigiani G, Cloughesy TF, Wen PY, Trippa L, Alexander BM.

Neuro Oncol. 2018 Jul 5;20(8):1034-1043. doi: 10.1093/neuonc/noy027.


Impact of pemetrexed on intracranial disease control and radiation necrosis in patients with brain metastases from non-small cell lung cancer receiving stereotactic radiation.

Cagney DN, Martin AM, Catalano PJ, Reitman ZJ, Mezochow GA, Lee EQ, Wen PY, Weiss SE, Brown PD, Ahluwalia MS, Arvold ND, Tanguturi SK, Haas-Kogan DA, Alexander BM, Redig AJ, Aizer AA.

Radiother Oncol. 2018 Mar;126(3):511-518. doi: 10.1016/j.radonc.2018.01.005. Epub 2018 Feb 3.


Immunotherapy and Symptomatic Radiation Necrosis in Patients With Brain Metastases Treated With Stereotactic Radiation.

Martin AM, Cagney DN, Catalano PJ, Alexander BM, Redig AJ, Schoenfeld JD, Aizer AA.

JAMA Oncol. 2018 Aug 1;4(8):1123-1124. doi: 10.1001/jamaoncol.2017.3993. No abstract available.


Clinical trial design for local therapies for brain metastases: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group.

Alexander BM, Brown PD, Ahluwalia MS, Aoyama H, Baumert BG, Chang SM, Gaspar LE, Kalkanis SN, Macdonald DR, Mehta MP, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Lee EQ, Wen PY; Response Assessment in Neuro-Oncology (RANO) group.

Lancet Oncol. 2018 Jan;19(1):e33-e42. doi: 10.1016/S1470-2045(17)30692-7. Review.


The FDA NIH Biomarkers, EndpointS, and other Tools (BEST) resource in neuro-oncology.

Cagney DN, Sul J, Huang RY, Ligon KL, Wen PY, Alexander BM.

Neuro Oncol. 2018 Aug 2;20(9):1162-1172. doi: 10.1093/neuonc/nox242.


Future cancer research priorities in the USA: a Lancet Oncology Commission.

Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A.

Lancet Oncol. 2017 Nov;18(11):e653-e706. doi: 10.1016/S1470-2045(17)30698-8. Epub 2017 Oct 31. Review.


Radiographic prediction of meningioma grade by semantic and radiomic features.

Coroller TP, Bi WL, Huynh E, Abedalthagafi M, Aizer AA, Greenwald NF, Parmar C, Narayan V, Wu WW, Miranda de Moura S, Gupta S, Beroukhim R, Wen PY, Al-Mefty O, Dunn IF, Santagata S, Alexander BM, Huang RY, Aerts HJWL.

PLoS One. 2017 Nov 16;12(11):e0187908. doi: 10.1371/journal.pone.0187908. eCollection 2017.


Sun exposure in pigs increases the vitamin D nutritional quality of pork.

Larson-Meyer DE, Ingold BC, Fensterseifer SR, Austin KJ, Wechsler PJ, Hollis BW, Makowski AJ, Alexander BM.

PLoS One. 2017 Nov 14;12(11):e0187877. doi: 10.1371/journal.pone.0187877. eCollection 2017.


The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity.

Jimenez RB, Alexander BM, Mahadevan A, Niemierko A, Rajakesari S, Arvold ND, Floyd SR, Oh KS, Loeffler JS, Shih HA.

Adv Radiat Oncol. 2017 Jun 6;2(3):391-397. doi: 10.1016/j.adro.2017.05.008. eCollection 2017 Jul-Sep.


Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine.

Kramer AC, Mirto AJ, Austin KJ, Roselli CE, Alexander BM.

Anim Reprod Sci. 2017 Dec;187:152-158. doi: 10.1016/j.anireprosci.2017.10.019. Epub 2017 Oct 31.


Evaluation of an improved prototype mini-baghouse to control the release of respirable crystalline silica from sand movers.

Alexander BM, Esswein EJ, Gressel MG, Kratzer JL, Feng HA, Miller AL, Cauda E, Heil G.

J Occup Environ Hyg. 2018 Jan;15(1):24-37. doi: 10.1080/15459624.2017.1376068.


Innovation Incentives and Biomarkers.

Stern AD, Alexander BM, Chandra A.

Clin Pharmacol Ther. 2018 Jan;103(1):34-36. doi: 10.1002/cpt.876. Epub 2017 Oct 16.


Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone.

Arvold ND, Shi DD, Aizer AA, Norden AD, Reardon DA, Lee EQ, Nayak L, Dunn IF, Golby AJ, Johnson MD, Claus EB, Chiocca EA, Ligon KL, Wen PY, Alexander BM.

J Neurooncol. 2017 Dec;135(3):581-591. doi: 10.1007/s11060-017-2611-9. Epub 2017 Oct 3.


Whole brain radiotherapy after stereotactic radiosurgery or surgical resection among patients with one to three brain metastases and favorable prognoses: a secondary analysis of EORTC 22952-26001.

Churilla TM, Handorf E, Collette S, Collette L, Dong Y, Aizer AA, Kocher M, Soffietti R, Alexander BM, Weiss SE.

Ann Oncol. 2017 Oct 1;28(10):2588-2594. doi: 10.1093/annonc/mdx332.


Prophylactic cranial irradiation in patients with extensive-stage small cell lung cancer.

Aizer AA, Mak R, Alexander BM.

Neuro Oncol. 2017 Aug 1;19(8):1015-1016. doi: 10.1093/neuonc/nox113. No abstract available.


Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE.

Alexander BM, Ba S, Berger MS, Berry DA, Cavenee WK, Chang SM, Cloughesy TF, Jiang T, Khasraw M, Li W, Mittman R, Poste GH, Wen PY, Yung WKA, Barker AD; GBM AGILE Network.

Clin Cancer Res. 2018 Feb 15;24(4):737-743. doi: 10.1158/1078-0432.CCR-17-0764. Epub 2017 Aug 16. Review.


The cost and value of glioblastoma therapy.

Cagney DN, Alexander BM.

Expert Rev Anticancer Ther. 2017 Aug;17(8):657-659. doi: 10.1080/14737140.2017.1351355. Epub 2017 Jul 13. No abstract available.


Adult Glioblastoma.

Alexander BM, Cloughesy TF.

J Clin Oncol. 2017 Jul 20;35(21):2402-2409. doi: 10.1200/JCO.2017.73.0119. Epub 2017 Jun 22. Review.


Designing Clinical Trials That Accept New Arms: An Example in Metastatic Breast Cancer.

Ventz S, Alexander BM, Parmigiani G, Gelber RD, Trippa L.

J Clin Oncol. 2017 Sep 20;35(27):3160-3168. doi: 10.1200/JCO.2016.70.1169. Epub 2017 May 22.


Erratum to: Rapid progression of intracranial melanoma metastases controlled with combined BRAF/MEK inhibition after discontinuation of therapy: a clinical challenge.

Cagney DN, Alexander BM, Hodi FS, Buchbinder EI, Ott PA, Aizer AA.

J Neurooncol. 2017 May;133(1):221. doi: 10.1007/s11060-017-2485-x. No abstract available.


Quantitative imaging biomarkers for risk stratification of patients with recurrent glioblastoma treated with bevacizumab.

Grossmann P, Narayan V, Chang K, Rahman R, Abrey L, Reardon DA, Schwartz LH, Wen PY, Alexander BM, Huang R, Aerts HJWL.

Neuro Oncol. 2017 Nov 29;19(12):1688-1697. doi: 10.1093/neuonc/nox092.


Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.

Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA.

Neuro Oncol. 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077.


Whole brain radiotherapy for non-small cell lung cancer.

Cagney DN, Alexander BM, Aizer AA.

Lancet. 2017 Apr 8;389(10077):1394-1395. doi: 10.1016/S0140-6736(17)30895-4. No abstract available.


Fos Expression in the Olfactory Pathway of High- and Low-Sexually Performing Rams Exposed to Urine from Estrous or Ovariectomized Ewes.

Mirto AJ, Austin KJ, Uthlaut VA, Roselli CE, Alexander BM.

Appl Anim Behav Sci. 2017 Jan;186:22-28. doi: 10.1016/j.applanim.2015.09.001. Epub 2015 Sep 21.


Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma.

Tanguturi SK, Trippa L, Ramkissoon SH, Pelton K, Knoff D, Sandak D, Lindeman NI, Ligon AH, Beroukhim R, Parmigiani G, Wen PY, Ligon KL, Alexander BM.

Neuro Oncol. 2017 Jul 1;19(7):908-917. doi: 10.1093/neuonc/now312.


How economics can shape precision medicines.

Stern AD, Alexander BM, Chandra A.

Science. 2017 Mar 17;355(6330):1131-1133. doi: 10.1126/science.aai8707. Epub 2017 Mar 16. No abstract available.


Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study.

Martin AM, Cagney DN, Catalano PJ, Warren LE, Bellon JR, Punglia RS, Claus EB, Lee EQ, Wen PY, Haas-Kogan DA, Alexander BM, Lin NU, Aizer AA.

JAMA Oncol. 2017 Aug 1;3(8):1069-1077. doi: 10.1001/jamaoncol.2017.0001.


Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas.

Shankar GM, Abedalthagafi M, Vaubel RA, Merrill PH, Nayyar N, Gill CM, Brewster R, Bi WL, Agarwalla PK, Thorner AR, Reardon DA, Al-Mefty O, Wen PY, Alexander BM, van Hummelen P, Batchelor TT, Ligon KL, Ligon AH, Meyerson M, Dunn IF, Beroukhim R, Louis DN, Perry A, Carter SL, Giannini C, Curry WT Jr, Cahill DP, Barker FG 2nd, Brastianos PK, Santagata S.

Neuro Oncol. 2017 Apr 1;19(4):535-545. doi: 10.1093/neuonc/now235.


Bayesian Baskets: A Novel Design for Biomarker-Based Clinical Trials.

Trippa L, Alexander BM.

J Clin Oncol. 2017 Feb 20;35(6):681-687. doi: 10.1200/JCO.2016.68.2864. Epub 2017 Jan 3.


Sunlight exposure increases vitamin D sufficiency in growing pigs fed a diet formulated to exceed requirements.

Alexander BM, Ingold BC, Young JL, Fensterseifer SR, Wechsler PJ, Austin KJ, Larson-Meyer DE.

Domest Anim Endocrinol. 2017 Apr;59:37-43. doi: 10.1016/j.domaniend.2016.10.006. Epub 2016 Nov 11.


Vitamin D and Weight Cycling: Impact on Injury, Illness, and Inflammation in Collegiate Wrestlers.

Barcal JN, Thomas JT, Hollis BW, Austin KJ, Alexander BM, Larson-Meyer DE.

Nutrients. 2016 Nov 30;8(12). pii: E775.


The Radiation Oncology Job Market: The Economics and Policy of Workforce Regulation.

Falit BP, Pan HY, Smith BD, Alexander BM, Zietman AL.

Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):501-10. doi: 10.1016/j.ijrobp.2016.05.029. Epub 2016 Jun 8. Review.


Rapid progression of intracranial melanoma metastases controlled with combined BRAF/MEK inhibition after discontinuation of therapy: a clinical challenge.

Cagney DN, Alexander BM, Hodi FS, Buchbinder EI, Ott PA, Aizer AA.

J Neurooncol. 2016 Sep;129(3):389-393. doi: 10.1007/s11060-016-2196-8. Epub 2016 Jul 11. Erratum in: J Neurooncol. 2017 May 19;:.


Updates in the management of brain metastases.

Arvold ND, Lee EQ, Mehta MP, Margolin K, Alexander BM, Lin NU, Anders CK, Soffietti R, Camidge DR, Vogelbaum MA, Dunn IF, Wen PY.

Neuro Oncol. 2016 Aug;18(8):1043-65. doi: 10.1093/neuonc/now127. Review.


Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas.

Zhang B, Chang K, Ramkissoon S, Tanguturi S, Bi WL, Reardon DA, Ligon KL, Alexander BM, Wen PY, Huang RY.

Neuro Oncol. 2017 Jan;19(1):109-117. doi: 10.1093/neuonc/now121. Epub 2016 Jun 26.


Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year?

Larson-Meyer DE, Schueler J, Kyle E, Austin KJ, Hart AM, Alexander BM.

J Obes. 2016;2016:7532926. doi: 10.1155/2016/7532926. Epub 2016 May 23.


Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.

Ni J, Ramkissoon SH, Xie S, Goel S, Stover DG, Guo H, Luu V, Marco E, Ramkissoon LA, Kang YJ, Hayashi M, Nguyen QD, Ligon AH, Du R, Claus EB, Alexander BM, Yuan GC, Wang ZC, Iglehart JD, Krop IE, Roberts TM, Winer EP, Lin NU, Ligon KL, Zhao JJ.

Nat Med. 2016 Jul;22(7):723-6. doi: 10.1038/nm.4120. Epub 2016 Jun 6.


MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma.

Miller MB, Bi WL, Ramkissoon LA, Kang YJ, Abedalthagafi M, Knoff DS, Agarwalla PK, Wen PY, Reardon DA, Alexander BM, Laws ER Jr, Dunn IF, Beroukhim R, Ligon KL, Ramkissoon SH.

Oncotarget. 2016 Jun 14;7(24):37054-37063. doi: 10.18632/oncotarget.9244.


Flame-retardant contamination of firefighter personal protective clothing - A potential health risk for firefighters.

Alexander BM, Baxter CS.

J Occup Environ Hyg. 2016 Sep;13(9):D148-55. doi: 10.1080/15459624.2016.1183016.


No Effect of Exercise Intensity on Appetite in Highly-Trained Endurance Women.

Howe SM, Hand TM, Larson-Meyer DE, Austin KJ, Alexander BM, Manore MM.

Nutrients. 2016 Apr 18;8(4):223. doi: 10.3390/nu8040223.


The development and testing of a prototype mini-baghouse to control the release of respirable crystalline silica from sand movers.

Alexander BM, Esswein EJ, Gressel MG, Kratzer JL, Feng HA, King B, Miller AL, Cauda E.

J Occup Environ Hyg. 2016 Aug;13(8):628-38. doi: 10.1080/15459624.2016.1168239.


A randomized, placebo-controlled pilot trial of armodafinil for fatigue in patients with gliomas undergoing radiotherapy.

Lee EQ, Muzikansky A, Drappatz J, Kesari S, Wong ET, Fadul CE, Reardon DA, Norden AD, Nayak L, Rinne ML, Alexander BM, Arvold ND, Doherty L, Stefanik J, LaFrankie D, Ruland SF, Pulverenti J, Smith KH, Gaffey SC, Hammond S, Wen PY.

Neuro Oncol. 2016 Jun;18(6):849-54. doi: 10.1093/neuonc/now007. Epub 2016 Feb 21.

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