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Items: 1 to 50 of 241

1.

Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen.

Mueller A, Starobova H, Morgan M, Dekan Z, Cheneval O, Schroeder CI, Alewood PF, Deuis JR, Vetter I.

Pain. 2019 Aug;160(8):1766-1780. doi: 10.1097/j.pain.0000000000001567.

PMID:
31335646
2.

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels.

Jin AH, Cristofori-Armstrong B, Rash LD, Román-González SA, Espinosa RA, Lewis RJ, Alewood PF, Vetter I.

Biochem Pharmacol. 2019 Jun;164:342-348. doi: 10.1016/j.bcp.2019.04.025. Epub 2019 Apr 24.

PMID:
31028742
3.

Investigation of the estuarine stonefish (Synanceia horrida) venom composition.

Ziegman R, Undheim EAB, Baillie G, Jones A, Alewood PF.

J Proteomics. 2019 Jun 15;201:12-26. doi: 10.1016/j.jprot.2019.04.002. Epub 2019 Apr 4.

PMID:
30953730
4.

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen.

Mueller A, Starobova H, Morgan M, Dekan Z, Cheneval O, Schroeder CI, Alewood PF, Deuis JR, Vetter I.

Pain. 2019 Mar 21. doi: 10.1097/j.pain.0000000000001567. [Epub ahead of print]

PMID:
30908355
5.

Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis.

Jin AH, Dutertre S, Dutt M, Lavergne V, Jones A, Lewis RJ, Alewood PF.

Mar Drugs. 2019 Mar 19;17(3). pii: E177. doi: 10.3390/md17030177.

6.

'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency.

Ziegman R, Brust A, Jha P, Cardoso FC, Lewis RJ, Alewood PF.

Mar Drugs. 2019 Mar 14;17(3). pii: E165. doi: 10.3390/md17030165.

7.

Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa.

Dutt M, Dutertre S, Jin AH, Lavergne V, Alewood PF, Lewis RJ.

Mar Drugs. 2019 Jan 21;17(1). pii: E71. doi: 10.3390/md17010071.

8.

Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding.

Kakumanu R, Hodgson WC, Ravi R, Alagon A, Harris RJ, Brust A, Alewood PF, Kemp-Harper BK, Fry BG.

Toxins (Basel). 2019 Jan 8;11(1). pii: E26. doi: 10.3390/toxins11010026.

9.

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.

10.

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF.

Biomedicines. 2018 Aug 28;6(3). pii: E90. doi: 10.3390/biomedicines6030090.

11.

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target.

Ma L, Chin YKY, Dekan Z, Herzig V, Chow CY, Heighway J, Lam SW, Guillemin GJ, Alewood PF, King GF.

Biochem Pharmacol. 2018 Dec;158:60-72. doi: 10.1016/j.bcp.2018.08.038. Epub 2018 Aug 25.

PMID:
30149017
12.

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold.

Madio B, Peigneur S, Chin YKY, Hamilton BR, Henriques ST, Smith JJ, Cristofori-Armstrong B, Dekan Z, Boughton BA, Alewood PF, Tytgat J, King GF, Undheim EAB.

Cell Mol Life Sci. 2018 Dec;75(24):4511-4524. doi: 10.1007/s00018-018-2897-6. Epub 2018 Aug 14.

PMID:
30109357
13.

Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation.

Ikonomopoulou MP, Fernandez-Rojo MA, Pineda SS, Cabezas-Sainz P, Winnen B, Morales RAV, Brust A, Sánchez L, Alewood PF, Ramm GA, Miles JJ, King GF.

Sci Rep. 2018 Aug 1;8(1):11519. doi: 10.1038/s41598-018-29826-4.

14.

Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter.

Brust A, Wang CA, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5203. doi: 10.1002/anie.201803138. No abstract available.

PMID:
29701320
15.

Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells.

Fernandez-Rojo MA, Deplazes E, Pineda SS, Brust A, Marth T, Wilhelm P, Martel N, Ramm GA, Mancera RL, Alewood PF, Woods GM, Belov K, Miles JJ, King GF, Ikonomopoulou MP.

Cell Death Discov. 2018 Feb 14;4:19. doi: 10.1038/s41420-018-0030-0. eCollection 2018 Dec.

16.

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.

17.

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976. doi: 10.1002/anie.201708927. Epub 2017 Oct 24.

PMID:
28984021
18.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.

19.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

20.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.

21.

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities.

Dekan Z, Headey SJ, Scanlon M, Baldo BA, Lee TH, Aguilar MI, Deuis JR, Vetter I, Elliott AG, Amado M, Cooper MA, Alewood D, Alewood PF.

Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8495-8499. doi: 10.1002/anie.201703360. Epub 2017 Jun 13.

PMID:
28513074
22.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD.

Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0.

23.

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.

Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ.

Sci Rep. 2017 Mar 31;7:45466. doi: 10.1038/srep45466.

24.

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

Di Giglio MG, Muttenthaler M, Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood PF, Gloriam DE, Gruber CW.

Sci Rep. 2017 Feb 1;7:41002. doi: 10.1038/srep41002.

25.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.

26.

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix.

Ikonomopoulou MP, Smith JJ, Herzig V, Pineda SS, Dziemborowicz S, Er SY, Durek T, Gilchrist J, Alewood PF, Nicholson GM, Bosmans F, King GF.

Toxicon. 2016 Dec 1;123:62-70. doi: 10.1016/j.toxicon.2016.10.013. Epub 2016 Oct 26.

27.

The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus).

Yang DC, Deuis JR, Dashevsky D, Dobson J, Jackson TN, Brust A, Xie B, Koludarov I, Debono J, Hendrikx I, Hodgson WC, Josh P, Nouwens A, Baillie GJ, Bruxner TJ, Alewood PF, Lim KK, Frank N, Vetter I, Fry BG.

Toxins (Basel). 2016 Oct 18;8(10). pii: E303.

28.

Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.

Touchard A, Brust A, Cardoso FC, Chin YK, Herzig V, Jin AH, Dejean A, Alewood PF, King GF, Orivel J, Escoubas P.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2553-2562. doi: 10.1016/j.bbagen.2016.07.027. Epub 2016 Jul 28.

PMID:
27474999
29.

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I.

J Biol Chem. 2016 May 27;291(22):11829-42. doi: 10.1074/jbc.M116.721662. Epub 2016 Mar 29.

30.

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

Deuis JR, Wingerd JS, Winter Z, Durek T, Dekan Z, Sousa SR, Zimmermann K, Hoffmann T, Weidner C, Nassar MA, Alewood PF, Lewis RJ, Vetter I.

Toxins (Basel). 2016 Mar 17;8(3). pii: E78. doi: 10.3390/toxins8030078.

31.

Peptide-Decorated Dendrimers and Their Bioapplications.

Wan J, Alewood PF.

Angew Chem Int Ed Engl. 2016 Apr 18;55(17):5124-34. doi: 10.1002/anie.201508428. Epub 2016 Mar 16. Review.

PMID:
26990715
32.

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers.

Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF.

J Pept Sci. 2016 May;22(5):280-9. doi: 10.1002/psc.2857. Epub 2016 Feb 22.

PMID:
26910400
33.

Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.

Brust A, Croker DE, Colless B, Ragnarsson L, Andersson Å, Jain K, Garcia-Caraballo S, Castro J, Brierley SM, Alewood PF, Lewis RJ.

J Med Chem. 2016 Mar 24;59(6):2381-95. doi: 10.1021/acs.jmedchem.5b00911. Epub 2016 Feb 22.

PMID:
26859603
34.

Deep venomics of the Pseudonaja genus reveals inter- and intra-specific variation.

Reeks T, Lavergne V, Sunagar K, Jones A, Undheim E, Dunstan N, Fry B, Alewood PF.

J Proteomics. 2016 Feb 5;133:20-32. doi: 10.1016/j.jprot.2015.11.019. Epub 2015 Nov 26.

PMID:
26632978
35.

The role of defensive ecological interactions in the evolution of conotoxins.

Prashanth JR, Dutertre S, Jin AH, Lavergne V, Hamilton B, Cardoso FC, Griffin J, Venter DJ, Alewood PF, Lewis RJ.

Mol Ecol. 2016 Jan;25(2):598-615. doi: 10.1111/mec.13504. Epub 2016 Jan 20.

PMID:
26614983
36.

Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom.

Jin AH, Vetter I, Himaya SW, Alewood PF, Lewis RJ, Dutertre S.

Proteomics. 2015 Dec;15(23-24):4030-40. doi: 10.1002/pmic.201500220. Epub 2015 Nov 17.

PMID:
26506909
37.

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.

Himaya SW, Jin AH, Dutertre S, Giacomotto J, Mohialdeen H, Vetter I, Alewood PF, Lewis RJ.

J Proteome Res. 2015 Oct 2;14(10):4372-81. doi: 10.1021/acs.jproteome.5b00630. Epub 2015 Sep 10.

PMID:
26322961
38.

Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia.

Deuis JR, Whately E, Brust A, Inserra MC, Asvadi NH, Lewis RJ, Alewood PF, Cabot PJ, Vetter I.

ACS Chem Neurosci. 2015 Oct 21;6(10):1751-8. doi: 10.1021/acschemneuro.5b00113. Epub 2015 Aug 12.

PMID:
26225903
39.

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails.

Jin AH, Israel MR, Inserra MC, Smith JJ, Lewis RJ, Alewood PF, Vetter I, Dutertre S.

Proc Biol Sci. 2015 Jul 22;282(1811). pii: 20150817. doi: 10.1098/rspb.2015.0817.

40.

Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.

Lavergne V, Harliwong I, Jones A, Miller D, Taft RJ, Alewood PF.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3782-91. doi: 10.1073/pnas.1501334112. Epub 2015 Jul 6. Erratum in: Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6253.

41.

Ancient Venom Systems: A Review on Cnidaria Toxins.

Jouiaei M, Yanagihara AA, Madio B, Nevalainen TJ, Alewood PF, Fry BG.

Toxins (Basel). 2015 Jun 18;7(6):2251-71. doi: 10.3390/toxins7062251. Review.

42.

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.

Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ.

Mol Pharmacol. 2015 Aug;88(2):291-303. doi: 10.1124/mol.115.098178. Epub 2015 May 15.

PMID:
25979003
43.

Evolution of an ancient venom: recognition of a novel family of cnidarian toxins and the common evolutionary origin of sodium and potassium neurotoxins in sea anemone.

Jouiaei M, Sunagar K, Federman Gross A, Scheib H, Alewood PF, Moran Y, Fry BG.

Mol Biol Evol. 2015 Jun;32(6):1598-610. doi: 10.1093/molbev/msv050. Epub 2015 Mar 9.

PMID:
25757852
44.

A defined α-helix in the bifunctional O-glycosylated natriuretic peptide TcNPa from the venom of Tropidechis carinatus.

Reeks T, Jones A, Brust A, Sridharan S, Corcilius L, Wilkinson BL, Thaysen-Andersen M, Payne RJ, Kini RM, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4828-31. doi: 10.1002/anie.201411914. Epub 2015 Mar 3.

PMID:
25735823
45.

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors.

Wan J, Huang JX, Vetter I, Mobli M, Lawson J, Tae HS, Abraham N, Paul B, Cooper MA, Adams DJ, Lewis RJ, Alewood PF.

J Am Chem Soc. 2015 Mar 11;137(9):3209-12. doi: 10.1021/jacs.5b00244. Epub 2015 Mar 3.

PMID:
25710197
46.

Privileged frameworks from snake venom.

Reeks TA, Fry BG, Alewood PF.

Cell Mol Life Sci. 2015 May;72(10):1939-58. doi: 10.1007/s00018-015-1844-z. Epub 2015 Feb 19. Review.

PMID:
25693678
47.

α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors.

Mueller A, Starobova H, Inserra MC, Jin AH, Deuis JR, Dutertre S, Lewis RJ, Alewood PF, Daly NL, Vetter I.

Biochem Pharmacol. 2015 Mar 15;94(2):155-63. doi: 10.1016/j.bcp.2015.01.011. Epub 2015 Jan 31.

PMID:
25646788
48.

High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury.

Murali SS, Napier IA, Mohammadi SA, Alewood PF, Lewis RJ, Christie MJ.

J Neurophysiol. 2015 Mar 1;113(5):1511-9. doi: 10.1152/jn.00608.2014. Epub 2014 Dec 10.

49.

Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic.

Gori A, Wang CI, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A.

Angew Chem Int Ed Engl. 2015 Jan 19;54(4):1361-4. doi: 10.1002/anie.201409678. Epub 2014 Dec 5.

PMID:
25483297
50.

Editorial overview: synthetic biomolecules.

Kent SB, Alewood PF.

Curr Opin Chem Biol. 2014 Oct;22:viii-xi. doi: 10.1016/j.cbpa.2014.09.037. Epub 2014 Oct 16. No abstract available.

PMID:
25438804

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