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Items: 46

1.

Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning.

Keul P, van Borren MM, Ghanem A, Müller FU, Baartscheer A, Verkerk AO, Stümpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heusch G, Schäfers M, Peters SL, Chun J, Levkau B.

J Am Heart Assoc. 2016 May 20;5(5). pii: e003393. doi: 10.1161/JAHA.116.003393.

2.

Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.

van Hooren KW, Spijkers LJ, van Breevoort D, Fernandez-Borja M, Bierings R, van Buul JD, Alewijnse AE, Peters SL, Voorberg J.

PLoS One. 2014 Mar 14;9(3):e91346. doi: 10.1371/journal.pone.0091346. eCollection 2014.

3.

Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats.

van den Elsen LW, Spijkers LJ, van den Akker RF, van Winssen AM, Balvers M, Wijesinghe DS, Chalfant CE, Garssen J, Willemsen LE, Alewijnse AE, Peters SL.

J Hypertens. 2014 May;32(5):1050-8; discussion 1058. doi: 10.1097/HJH.0000000000000131.

4.

Sphingosine-1-phosphate receptor-1 controls venous endothelial barrier integrity in zebrafish.

Tobia C, Chiodelli P, Nicoli S, Dell'era P, Buraschi S, Mitola S, Foglia E, van Loenen PB, Alewijnse AE, Presta M.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):e104-16. doi: 10.1161/ATVBAHA.112.250035. Epub 2012 Jul 26.

PMID:
22837470
5.

FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.

Spijkers LJ, Alewijnse AE, Peters SL.

Br J Pharmacol. 2012 Jun;166(4):1411-8. doi: 10.1111/j.1476-5381.2012.01865.x.

6.

Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats.

Spijkers LJ, Janssen BJ, Nelissen J, Meens MJ, Wijesinghe D, Chalfant CE, De Mey JG, Alewijnse AE, Peters SL.

PLoS One. 2011;6(12):e29222. doi: 10.1371/journal.pone.0029222. Epub 2011 Dec 15.

7.

G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide.

Meens MJ, Mattheij NJ, van Loenen PB, Spijkers LJ, Lemkens P, Nelissen J, Compeer MG, Alewijnse AE, De Mey JG.

Br J Pharmacol. 2012 May;166(1):297-308. doi: 10.1111/j.1476-5381.2011.01774.x.

8.

Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide.

Spijkers LJ, van den Akker RF, Janssen BJ, Debets JJ, De Mey JG, Stroes ES, van den Born BJ, Wijesinghe DS, Chalfant CE, MacAleese L, Eijkel GB, Heeren RM, Alewijnse AE, Peters SL.

PLoS One. 2011;6(7):e21817. doi: 10.1371/journal.pone.0021817. Epub 2011 Jul 19.

9.

Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor.

van Loenen PB, de Graaf C, Verzijl D, Leurs R, Rognan D, Peters SL, Alewijnse AE.

Eur J Pharmacol. 2011 Sep 30;667(1-3):105-12. doi: 10.1016/j.ejphar.2011.05.071. Epub 2011 Jun 6.

PMID:
21663738
10.

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions.

Van Doorn R, Van Horssen J, Verzijl D, Witte M, Ronken E, Van Het Hof B, Lakeman K, Dijkstra CD, Van Der Valk P, Reijerkerk A, Alewijnse AE, Peters SL, De Vries HE.

Glia. 2010 Sep;58(12):1465-76. doi: 10.1002/glia.21021.

PMID:
20648639
11.

Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications.

Verzijl D, Peters SL, Alewijnse AE.

Mol Cells. 2010 Feb 28;29(2):99-104. doi: 10.1007/s10059-010-0041-z. Epub 2010 Jan 29. Review.

12.

Sphingolipids and the orchestration of endothelium-derived vasoactive factors: when endothelial function demands greasing.

Spijkers LJ, Alewijnse AE, Peters SL.

Mol Cells. 2010 Feb 28;29(2):105-11. doi: 10.1007/s10059-010-0042-y. Epub 2010 Jan 29. Review.

13.

Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells.

van Borren MM, Verkerk AO, Wilders R, Hajji N, Zegers JG, Bourier J, Tan HL, Verheijck EE, Peters SL, Alewijnse AE, Ravesloot JH.

Basic Res Cardiol. 2010 Jan;105(1):73-87. doi: 10.1007/s00395-009-0048-9. Epub 2009 Jul 29.

14.

LPS differentially affects vasoconstrictor responses: a potential role for RGS16?

Hendriks-Balk MC, Tjon-Atsoi M, Hajji N, Alewijnse AE, Peters SL.

J Physiol Biochem. 2009 Mar;65(1):71-83.

PMID:
19588733
15.

Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells.

Hendriks-Balk MC, Hajji N, van Loenen PB, Michel MC, Peters SL, Alewijnse AE.

Eur J Pharmacol. 2009 Mar 15;606(1-3):25-31. doi: 10.1016/j.ejphar.2009.01.018. Epub 2009 Jan 21.

PMID:
19374869
16.

Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)).

Jongsma M, van Unen J, van Loenen PB, Michel MC, Peters SL, Alewijnse AE.

Br J Pharmacol. 2009 Apr;156(8):1305-11. doi: 10.1111/j.1476-5381.2009.00134.x. Epub 2009 Mar 20.

17.

Do gene polymorphisms alone or in combination affect the function of human beta3-adrenoceptors?

Vrydag W, Alewijnse AE, Michel MC.

Br J Pharmacol. 2009 Jan;156(1):127-34. doi: 10.1111/j.1476-5381.2008.00014.x.

18.

The effect of bladder outlet obstruction on alpha1- and beta-adrenoceptor expression and function.

Barendrecht MM, Frazier EP, Vrydag W, Alewijnse AE, Peters SL, Michel MC.

Neurourol Urodyn. 2009;28(4):349-55. doi: 10.1002/nau.20642.

PMID:
19034955
19.

Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner?

Hahntow IN, Mairuhu G, van Valkengoed IG, Baas F, Alewijnse AE, Koopmans RP, Michel MC.

Am J Hypertens. 2009 Jan;22(1):80-6. doi: 10.1038/ajh.2008.310. Epub 2008 Nov 20.

PMID:
19023274
20.

S1P receptor signalling and RGS proteins; expression and function in vascular smooth muscle cells and transfected CHO cells.

Hendriks-Balk MC, van Loenen PB, Hajji N, Michel MC, Peters SL, Alewijnse AE.

Eur J Pharmacol. 2008 Dec 14;600(1-3):1-9. doi: 10.1016/j.ejphar.2008.09.041. Epub 2008 Oct 7.

PMID:
18854184
21.

Activation of sphingosine kinase by muscarinic receptors enhances NO-mediated and attenuates EDHF-mediated vasorelaxation.

Mulders AC, Mathy MJ, Meyer zu Heringdorf D, ter Braak M, Hajji N, Olthof DC, Michel MC, Alewijnse AE, Peters SL.

Basic Res Cardiol. 2009 Jan;104(1):50-9. doi: 10.1007/s00395-008-0744-x. Epub 2008 Sep 5.

PMID:
18777003
22.

Sphingolipid signalling in the cardiovascular system: good, bad or both?

Alewijnse AE, Peters SL.

Eur J Pharmacol. 2008 May 13;585(2-3):292-302. doi: 10.1016/j.ejphar.2008.02.089. Epub 2008 Mar 15. Review.

PMID:
18420192
23.

Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins.

Hendriks-Balk MC, Peters SL, Michel MC, Alewijnse AE.

Eur J Pharmacol. 2008 May 13;585(2-3):278-91. doi: 10.1016/j.ejphar.2008.02.088. Epub 2008 Mar 15. Review.

PMID:
18410914
24.

Ligand-directed signaling: 50 ways to find a lover.

Michel MC, Alewijnse AE.

Mol Pharmacol. 2007 Nov;72(5):1097-9. Epub 2007 Aug 23.

PMID:
17717108
25.

From the H(2) receptor gene to reclassification of the H(2) receptor antagonists.

Alewijnse AE.

Inflammopharmacology. 1998;6(2):179-92.

PMID:
17694373
26.

Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors.

Jongsma M, Florczyk UM, Hendriks-Balk MC, Michel MC, Peters SL, Alewijnse AE.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):329-36. Epub 2007 May 12.

27.

Vascular effects of sphingolipids.

Michel MC, Mulders AC, Jongsma M, Alewijnse AE, Peters SL.

Acta Paediatr. 2007 Apr;96(455):44-8. Review.

PMID:
17391441
28.

Pitfalls in the normalization of real-time polymerase chain reaction data.

Hendriks-Balk MC, Michel MC, Alewijnse AE.

Basic Res Cardiol. 2007 May;102(3):195-7.

29.

Sphingosine-1-phosphate signaling in the cardiovascular system.

Peters SL, Alewijnse AE.

Curr Opin Pharmacol. 2007 Apr;7(2):186-92. Epub 2007 Feb 5. Review.

PMID:
17280869
30.

Comparison of three radioligands for the labelling of human beta-adrenoceptor subtypes.

Niclauss N, Michel-Reher MB, Alewijnse AE, Michel MC.

Naunyn Schmiedebergs Arch Pharmacol. 2006 Nov;374(2):99-105. Epub 2006 Oct 7.

PMID:
17028849
31.

BML-241 fails to display selective antagonism at the sphingosine-1-phosphate receptor, S1P(3).

Jongsma M, Hendriks-Balk MC, Michel MC, Peters SL, Alewijnse AE.

Br J Pharmacol. 2006 Oct;149(3):277-82. Epub 2006 Aug 29.

32.

Sphingosine kinase-dependent activation of endothelial nitric oxide synthase by angiotensin II.

Mulders AC, Hendriks-Balk MC, Mathy MJ, Michel MC, Alewijnse AE, Peters SL.

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2043-8. Epub 2006 Jul 20.

PMID:
16857953
33.

Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?

Alewijnse AE, Michel MC.

Br J Pharmacol. 2006 Feb;147(4):347-8.

34.

Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites.

Alewijnse AE, Peters SL, Michel MC.

Br J Pharmacol. 2004 Nov;143(6):666-84. Epub 2004 Oct 25. Review.

35.

Methods to determine the constitutive activity of histamine H2 receptors.

Leurs R, Hoffmann M, Alewijnse AE, Smit MJ, Timmerman H.

Methods Enzymol. 2002;343:405-16. No abstract available.

PMID:
11665581
36.

Recombinant Semliki Forest virus for over-expression and pharmacological characterisation of the histamine H(2) receptor in mammalian cells.

Hoffmann M, Verzijl D, Lundstrom K, Simmen U, Alewijnse AE, Timmerman H, Leurs R.

Eur J Pharmacol. 2001 Sep 14;427(2):105-14.

PMID:
11557261
37.

Constitutive activity of G protein coupled receptors and drug action.

Leurs R, Rodriguez Pena MS, Bakker RA, Alewijnse AE, Timmerman H.

Pharm Acta Helv. 2000 Mar;74(2-3):327-31. Review. No abstract available.

PMID:
10812977
38.

The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor.

Alewijnse AE, Timmerman H, Jacobs EH, Smit MJ, Roovers E, Cotecchia S, Leurs R.

Mol Pharmacol. 2000 May;57(5):890-8.

PMID:
10779371
39.

Agonist-independent regulation of constitutively active G-protein-coupled receptors.

Leurs R, Smit MJ, Alewijnse AE, Timmerman H.

Trends Biochem Sci. 1998 Nov;23(11):418-22. Review.

PMID:
9852759
40.

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

van der Pouw Kraan TC, Snijders A, Boeije LC, de Groot ER, Alewijnse AE, Leurs R, Aarden LA.

J Clin Invest. 1998 Nov 15;102(10):1866-73.

41.

Constitutive activity and structural instability of the wild-type human H2 receptor.

Alewijnse AE, Smit MJ, Hoffmann M, Verzijl D, Timmerman H, Leurs R.

J Neurochem. 1998 Aug;71(2):799-807.

42.

From histamine H2 receptor regulation to reclassification of H2 antagonists; inverse agonism as the basis for H2 receptor upregulation.

Smit MJ, Timmerman H, Alewijnse AE, Leurs R.

Receptors Channels. 1998;5(2):99-102. No abstract available.

PMID:
9606714
43.

Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active G(S)-coupled receptors.

Alewijnse AE, Smit MJ, Rodriguez Pena MS, Verzijl D, Timmerman H, Leurs R.

FEBS Lett. 1997 Dec 15;419(2-3):171-4.

44.

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

Smit MJ, Leurs R, Alewijnse AE, Blauw J, Van Nieuw Amerongen GP, Van De Vrede Y, Roovers E, Timmerman H.

Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6802-7.

45.

Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists.

Smit MJ, Roovers E, Timmerman H, van de Vrede Y, Alewijnse AE, Leurs R.

J Biol Chem. 1996 Mar 29;271(13):7574-82.

46.

Visualization of agonist-induced internalization of histamine H2 receptors.

Smit MJ, Timmerman H, Alewijnse AE, Punin M, van den Nieuwenhof I, Blauw J, van Minnen J, Leurs R.

Biochem Biophys Res Commun. 1995 Sep 25;214(3):1138-45.

PMID:
7575521

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