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Items: 25


Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells.

Stagno MJ, Zacharopoulou N, Bochem J, Tsapara A, Pelzl L, Al-Maghout T, Kallergi G, Alkahtani S, Alevizopoulos K, Dimas K, Calogeropoulou T, Warmann SW, Lang F, Schmid E, Stournaras C.

Cell Physiol Biochem. 2017;42(4):1366-1376. doi: 10.1159/000479200. Epub 2017 Jul 14.


Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor.

Alevizopoulos K, Dimas K, Papadopoulou N, Schmidt EM, Tsapara A, Alkahtani S, Honisch S, Prousis KC, Alarifi S, Calogeropoulou T, Lang F, Stournaras C.

Oncotarget. 2016 Apr 26;7(17):24415-28. doi: 10.18632/oncotarget.8329.


Membrane androgen receptor down-regulates c-src-activity and beta-catenin transcription and triggers GSK-3beta-phosphorylation in colon tumor cells.

Gu S, Honisch S, Kounenidakis M, Alkahtani S, Alarifi S, Alevizopoulos K, Stournaras C, Lang F.

Cell Physiol Biochem. 2014;34(4):1402-12. doi: 10.1159/000366346. Epub 2014 Oct 3.


Na+/K+ ATPase inhibitors in cancer.

Alevizopoulos K, Calogeropoulou T, Lang F, Stournaras C.

Curr Drug Targets. 2014;15(10):988-1000. Review.


A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells.

Honisch S, Alkahtani S, Kounenidakis M, Liu G, Alarifi S, Al-Yahya H, Dimas K, AlKahtane AA, Prousis KC, Al-Dahmash B, Calogeropoulou T, Alevizopoulos K, Lang F, Stournaras C.

Anticancer Agents Med Chem. 2014;14(8):1161-8.


Steroidal cardiac Na+/K+ ATPase inhibitors exhibit strong anti-cancer potential in vitro and in prostate and lung cancer xenografts in vivo.

Dimas K, Papadopoulou N, Baskakis C, Prousis KC, Tsakos M, Alkahtani S, Honisch S, Lang F, Calogeropoulou T, Alevizopoulos K, Stournaras C.

Anticancer Agents Med Chem. 2014 Jun;14(5):762-70.


Targeting membrane androgen receptors in tumors.

Lang F, Alevizopoulos K, Stournaras C.

Expert Opin Ther Targets. 2013 Aug;17(8):951-63. doi: 10.1517/14728222.2013.806491. Epub 2013 Jun 8. Review.


Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells.

Gu S, Kounenidakis M, Schmidt EM, Deshpande D, Alkahtani S, Alarifi S, Föller M, Alevizopoulos K, Lang F, Stournaras C.

Cell Signal. 2013 Jan;25(1):66-73.


Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.

Schmidt EM, Gu S, Anagnostopoulou V, Alevizopoulos K, Föller M, Lang F, Stournaras C.

FEBS J. 2012 Apr;279(7):1231-42. doi: 10.1111/j.1742-4658.2012.08515.x. Epub 2012 Feb 24.


The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action.

Mahaira LG, Tsimplouli C, Sakellaridis N, Alevizopoulos K, Demetzos C, Han Z, Pantazis P, Dimas K.

Eur J Pharmacol. 2011 Sep;666(1-3):173-82. doi: 10.1016/j.ejphar.2011.04.065. Epub 2011 May 20.


Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling.

Gu S, Papadopoulou N, Nasir O, Föller M, Alevizopoulos K, Lang F, Stournaras C.

Mol Med. 2011 Jan-Feb;17(1-2):48-58. doi: 10.2119/molmed.2010.00120. Epub 2010 Oct 15.


Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo.

Gu S, Papadopoulou N, Gehring EM, Nasir O, Dimas K, Bhavsar SK, Föller M, Alevizopoulos K, Lang F, Stournaras C.

Mol Cancer. 2009 Dec 1;8:114. doi: 10.1186/1476-4598-8-114.


Membrane androgen receptor activation in prostate and breast tumor cells: molecular signaling and clinical impact.

Papadopoulou N, Papakonstanti EA, Kallergi G, Alevizopoulos K, Stournaras C.

IUBMB Life. 2009 Jan;61(1):56-61. doi: 10.1002/iub.150. Review.


Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells.

Papadopoulou N, Charalampopoulos I, Anagnostopoulou V, Konstantinidis G, Föller M, Gravanis A, Alevizopoulos K, Lang F, Stournaras C.

Mol Cancer. 2008 Dec 3;7:88. doi: 10.1186/1476-4598-7-88.


Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells.

Papadopoulou N, Charalampopoulos I, Alevizopoulos K, Gravanis A, Stournaras C.

Exp Cell Res. 2008 Oct 15;314(17):3162-74. doi: 10.1016/j.yexcr.2008.07.012. Epub 2008 Jul 25.


Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice.

Dimas K, Hatziantoniou S, Tseleni S, Khan H, Georgopoulos A, Alevizopoulos K, Wyche JH, Pantazis P, Demetzos C.

Apoptosis. 2007 Apr;12(4):685-94.


Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs.

Dimas K, Papadaki M, Tsimplouli C, Hatziantoniou S, Alevizopoulos K, Pantazis P, Demetzos C.

Biomed Pharmacother. 2006 Apr;60(3):127-33. Epub 2006 Feb 21.


Recruitment of TRRAP required for oncogenic transformation by E1A.

Deleu L, Shellard S, Alevizopoulos K, Amati B, Land H.

Oncogene. 2001 Dec 13;20(57):8270-5.


NF-kappaB signals induce the expression of c-FLIP.

Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J.

Mol Cell Biol. 2001 Aug;21(16):5299-305.


Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.

Schneider P, Street SL, Gaide O, Hertig S, Tardivel A, Tschopp J, Runkel L, Alevizopoulos K, Ferguson BM, Zonana J.

J Biol Chem. 2001 Jun 1;276(22):18819-27. Epub 2001 Mar 14.


A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).

Alevizopoulos K, Catarin B, Vlach J, Amati B.

EMBO J. 1998 Oct 15;17(20):5987-97.


Myc and the cell cycle.

Amati B, Alevizopoulos K, Vlach J.

Front Biosci. 1998 Feb 15;3:d250-68. Review.


Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

Vlach J, Hennecke S, Alevizopoulos K, Conti D, Amati B.

EMBO J. 1996 Dec 2;15(23):6595-604.

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