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Items: 1 to 50 of 380

1.

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader.

Tovell H, Testa A, Maniaci C, Zhou H, Prescott AR, Macartney T, Ciulli A, Alessi DR.

ACS Chem Biol. 2019 Apr 22. doi: 10.1021/acschembio.8b01016. [Epub ahead of print]

PMID:
30978004
2.

The osmotic effect of hyper-saline hydraulic fracturing fluid on rainbow trout, Oncorhynchus mykiss.

Delompré PLM, Blewett TA, Snihur KN, Flynn SL, Alessi DS, Glover CN, Goss GG.

Aquat Toxicol. 2019 Mar 14;211:1-10. doi: 10.1016/j.aquatox.2019.03.009. [Epub ahead of print]

PMID:
30901626
3.

Green remediation of As and Pb contaminated soil using cement-free clay-based stabilization/solidification.

Wang L, Cho DW, Tsang DCW, Cao X, Hou D, Shen Z, Alessi DS, Ok YS, Poon CS.

Environ Int. 2019 May;126:336-345. doi: 10.1016/j.envint.2019.02.057. Epub 2019 Feb 28.

4.

Selective adsorption and irreversible fixation behavior of cesium onto 2:1 layered clay mineral: A mini review.

Park SM, Alessi DS, Baek K.

J Hazard Mater. 2019 May 5;369:569-576. doi: 10.1016/j.jhazmat.2019.02.061. Epub 2019 Feb 18.

PMID:
30818121
5.

Inhibition of naphthalene leaching from municipal carbonaceous waste by a magnetic organophilic clay.

Safari S, Alam MS, von Gunten K, Samborsky S, Alessi DS.

J Hazard Mater. 2019 Apr 15;368:578-583. doi: 10.1016/j.jhazmat.2019.01.088. Epub 2019 Jan 26.

PMID:
30711706
6.

Redox chemistry of vanadium in soils and sediments: Interactions with colloidal materials, mobilization, speciation, and relevant environmental implications- A review.

Shaheen SM, Alessi DS, Tack FMG, Ok YS, Kim KH, Gustafsson JP, Sparks DL, Rinklebe J.

Adv Colloid Interface Sci. 2019 Mar;265:1-13. doi: 10.1016/j.cis.2019.01.002. Epub 2019 Jan 14. Review.

PMID:
30685738
7.

Multifunctional iron-biochar composites for the removal of potentially toxic elements, inherent cations, and hetero-chloride from hydraulic fracturing wastewater.

Sun Y, Yu IKM, Tsang DCW, Cao X, Lin D, Wang L, Graham NJD, Alessi DS, Komárek M, Ok YS, Feng Y, Li XD.

Environ Int. 2019 Mar;124:521-532. doi: 10.1016/j.envint.2019.01.047. Epub 2019 Jan 24.

8.

Association between maternal education and survival after childhood cancer.

Isaevska E, Popovic M, Alessi D, Mosso ML, Sacerdote C, Magnani C, Pastore G, Rosso T, Zengarini N, Dockerty J, Merletti F, Maule M.

Pediatr Blood Cancer. 2019 May;66(5):e27616. doi: 10.1002/pbc.27616. Epub 2019 Jan 24.

PMID:
30677232
9.

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR.

EMBO J. 2019 Jan 15;38(2). pii: e101237. doi: 10.15252/embj.2018101237. No abstract available.

10.

Assessment of impacts of diphenyl phosphate on groundwater and near-surface environments: Sorption and toxicity.

Funk SP, Duffin L, He Y, McMullen C, Sun C, Utting N, Martin JW, Goss GG, Alessi DS.

J Contam Hydrol. 2019 Feb;221:50-57. doi: 10.1016/j.jconhyd.2019.01.002. Epub 2019 Jan 7.

PMID:
30642690
11.

Crystal structure of the WD40 domain dimer of LRRK2.

Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1579-1584. doi: 10.1073/pnas.1817889116. Epub 2019 Jan 11.

12.

Cell surface characterization and trace metal adsorptive properties of anaerobic ammonium-oxidizing (anammox) consortia.

Liu Y, Xu W, Bao L, Li Y, Liu S, Zhang Q, Alessi DS, Konhauser KO, Zhao H.

Chemosphere. 2019 Apr;221:11-20. doi: 10.1016/j.chemosphere.2019.01.025. Epub 2019 Jan 6.

PMID:
30634144
13.

Characterization and implications of solids associated with hydraulic fracturing flowback and produced water from the Duvernay Formation, Alberta, Canada.

Flynn SL, von Gunten K, Warchola T, Snihur K, Forbes TZ, Goss GG, Gingras MK, Konhauser KO, Alessi DS.

Environ Sci Process Impacts. 2019 Feb 21;21(2):242-255. doi: 10.1039/c8em00404h.

PMID:
30556566
14.

Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1.

Osborne J, Birchall K, Tsagris DJ, Lewis SJ, Smiljanic-Hurley E, Taylor DL, Levy A, Alessi DR, McIver EG.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):668-673. doi: 10.1016/j.bmcl.2018.11.058. Epub 2018 Dec 1.

15.

Synthesis of MgO-coated corncob biochar and its application in lead stabilization in a soil washing residue.

Shen Z, Zhang J, Hou D, Tsang DCW, Ok YS, Alessi DS.

Environ Int. 2019 Jan;122:357-362. doi: 10.1016/j.envint.2018.11.045. Epub 2018 Nov 28.

16.

Effect of production temperature on lead removal mechanisms by rice straw biochars.

Shen Z, Hou D, Jin F, Shi J, Fan X, Tsang DCW, Alessi DS.

Sci Total Environ. 2019 Mar 10;655:751-758. doi: 10.1016/j.scitotenv.2018.11.282. Epub 2018 Nov 20.

PMID:
30476855
17.

Accuracy of methods for reporting inorganic element concentrations and radioactivity in oil and gas wastewaters from the Appalachian Basin, U.S. based on an inter-laboratory comparison.

Tasker TL, Burgos WD, Ajemigbitse MA, Lauer NE, Gusa AV, Kuatbek M, May D, Landis JD, Alessi DS, Johnsen AM, Kaste JM, Headrick KL, Wilke FDH, McNeal M, Engle M, Jubb AM, Vidic RD, Vengosh A, Warner NR.

Environ Sci Process Impacts. 2019 Feb 21;21(2):224-241. doi: 10.1039/c8em00359a.

PMID:
30452047
18.

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

Dhekne HS, Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR.

Elife. 2018 Nov 6;7. pii: e40202. doi: 10.7554/eLife.40202.

19.

In vitro assessment of endocrine disrupting potential of organic fractions extracted from hydraulic fracturing flowback and produced water (HF-FPW).

He Y, Zhang Y, Martin JW, Alessi DS, Giesy JP, Goss GG.

Environ Int. 2018 Dec;121(Pt 1):824-831. doi: 10.1016/j.envint.2018.10.014. Epub 2018 Oct 17.

20.

Mechanisms of the Removal of U(VI) from Aqueous Solution Using Biochar: A Combined Spectroscopic and Modeling Approach.

Alam MS, Gorman-Lewis D, Chen N, Safari S, Baek K, Konhauser KO, Alessi DS.

Environ Sci Technol. 2018 Nov 20;52(22):13057-13067. doi: 10.1021/acs.est.8b01715. Epub 2018 Nov 1.

PMID:
30339395
21.

The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer.

Byrne J, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Bright CJ, Brown M, Diallo I, Feijen EAML, Fidler MM, Frey E, Garwicz S, Grabow D, Gudmundsdottir T, Hagberg O, Harila-Saari A, Hau EM, Haupt R, Hawkins MM, Jakab Z, Jankovic M, Kaatsch P, Kaiser M, Kremer LCM, Kuehni CE, Kuonen R, Ladenstein R, Lähteenmäki PM, Levitt G, Linge H, LLanas D, Michel G, Morsellino V, Mulder RL, Reulen RC, Ronckers CM, Sacerdote C, Skinner R, Steliarova-Foucher E, van der Pal HJ, de Vathaire F, Vũ Bezin G, Wesenberg F, Wiebe T, Winter DL, Falck Winther J, Witthoff E, Zadravec Zaletel L, Hjorth L.

Eur J Cancer. 2018 Nov;103:238-248. doi: 10.1016/j.ejca.2018.08.017. Epub 2018 Oct 1.

PMID:
30286417
22.

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N.

Neurobiol Dis. 2018 Dec;120:76-87. doi: 10.1016/j.nbd.2018.09.003. Epub 2018 Sep 5.

23.

Assessing long-term stability of cadmium and lead in a soil washing residue amended with MgO-based binders using quantitative accelerated ageing.

Shen Z, Hou D, Xu W, Zhang J, Jin F, Zhao B, Pan S, Peng T, Alessi DS.

Sci Total Environ. 2018 Dec 1;643:1571-1578. doi: 10.1016/j.scitotenv.2018.06.321. Epub 2018 Jul 4.

PMID:
30189573
24.

Enhanced irreversible fixation of cesium by wetting and drying cycles in soil.

Park SM, Yang JS, Tsang DCW, Alessi DS, Baek K.

Environ Geochem Health. 2019 Feb;41(1):149-157. doi: 10.1007/s10653-018-0174-0. Epub 2018 Aug 24.

PMID:
30143907
25.

PP1 Phosphatase Complexes: Undruggable No Longer.

Vagnarelli P, Alessi DR.

Cell. 2018 Aug 23;174(5):1049-1051. doi: 10.1016/j.cell.2018.08.007.

PMID:
30142342
26.

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS.

ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31.

PMID:
30102854
27.

LRRK2 activation in idiopathic Parkinson's disease.

Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaar5429. doi: 10.1126/scitranslmed.aar5429.

28.

Electron donor-driven bacterial and archaeal community patterns along forest ring edges in Ontario, Canada.

von Gunten K, Hamilton SM, Zhong C, Nesbø C, Li J, Muehlenbachs K, Konhauser KO, Alessi DS.

Environ Microbiol Rep. 2018 Dec;10(6):663-672. doi: 10.1111/1758-2229.12678. Epub 2018 Sep 9.

PMID:
30014579
29.

Removal of hexavalent chromium in aqueous solutions using biochar: Chemical and spectroscopic investigations.

Rajapaksha AU, Alam MS, Chen N, Alessi DS, Igalavithana AD, Tsang DCW, Ok YS.

Sci Total Environ. 2018 Jun 1;625:1567-1573. doi: 10.1016/j.scitotenv.2017.12.195. Epub 2018 Jan 12.

PMID:
29996453
30.

Effect of dissolved organic carbon from sludge, Rice straw and spent coffee ground biochar on the mobility of arsenic in soil.

Kim HB, Kim SH, Jeon EK, Kim DH, Tsang DCW, Alessi DS, Kwon EE, Baek K.

Sci Total Environ. 2018 Sep 15;636:1241-1248. doi: 10.1016/j.scitotenv.2018.04.406. Epub 2018 May 9.

PMID:
29913586
31.

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.

Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG.

EMBO J. 2018 Jun 15;37(12). pii: e98694. doi: 10.15252/embj.201798694. Epub 2018 May 22.

32.

Thermodynamic Analysis of Nickel(II) and Zinc(II) Adsorption to Biochar.

Alam MS, Gorman-Lewis D, Chen N, Flynn SL, Ok YS, Konhauser KO, Alessi DS.

Environ Sci Technol. 2018 Jun 5;52(11):6246-6255. doi: 10.1021/acs.est.7b06261. Epub 2018 May 21.

PMID:
29746774
33.

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.

Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR.

Biochem J. 2018 Jun 6;475(11):1861-1883. doi: 10.1042/BCJ20180248.

34.

LRRK2 kinase in Parkinson's disease.

Alessi DR, Sammler E.

Science. 2018 Apr 6;360(6384):36-37. doi: 10.1126/science.aar5683. No abstract available.

PMID:
29622645
35.

Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations.

Tomczak A, Mortensen JM, Winnenburg R, Liu C, Alessi DT, Swamy V, Vallania F, Lofgren S, Haynes W, Shah NH, Musen MA, Khatri P.

Sci Rep. 2018 Mar 23;8(1):5115. doi: 10.1038/s41598-018-23395-2.

36.

Comparison of nickel adsorption on biochars produced from mixed softwood and Miscanthus straw.

Shen Z, Zhang Y, Jin F, Alessi DS, Zhang Y, Wang F, McMillan O, Al-Tabbaa A.

Environ Sci Pollut Res Int. 2018 May;25(15):14626-14635. doi: 10.1007/s11356-018-1674-2. Epub 2018 Mar 12.

PMID:
29532375
37.

The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries.

Grabow D, Kaiser M, Hjorth L, Byrne J, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Bright CJ, de Vathaire F, Feijen EAM, Garwicz S, Hagberg O, Haupt R, Hawkins MM, Jakab Z, Kremer LCM, Kuehni CE, Kuonen R, Lähteenmäki PM, Reulen RC, Ronckers CM, Sacerdote C, Vu-Bezin G, Wesenberg F, Wiebe T, Winter DL, Winther JF, Zaletel LZ, Kaatsch P; PanCareSurFup Consortium.

Eur J Epidemiol. 2018 Mar;33(3):335-349. doi: 10.1007/s10654-018-0370-3. Epub 2018 Mar 2.

38.

Selection criteria for oxidation method in total organic carbon measurement.

Yoon G, Park SM, Yang H, Tsang DCW, Alessi DS, Baek K.

Chemosphere. 2018 May;199:453-458. doi: 10.1016/j.chemosphere.2018.02.074. Epub 2018 Feb 12.

PMID:
29453072
39.

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR.

EMBO J. 2018 Jan 4;37(1):1-18. doi: 10.15252/embj.201798099. Epub 2017 Dec 6. Erratum in: EMBO J. 2019 Jan 15;38(2):.

40.

Biochar application for the remediation of heavy metal polluted land: A review of in situ field trials.

O'Connor D, Peng T, Zhang J, Tsang DCW, Alessi DS, Shen Z, Bolan NS, Hou D.

Sci Total Environ. 2018 Apr 1;619-620:815-826. doi: 10.1016/j.scitotenv.2017.11.132. Epub 2017 Nov 29.

PMID:
29166628
41.

Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.

Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen EAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LC, Hjorth L, Reulen RC; PanCareSurFup Consortium.

J Natl Cancer Inst. 2018 Jun 1;110(6):649-660. doi: 10.1093/jnci/djx235.

42.

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.

Malik N, Macartney T, Hornberger A, Anderson KE, Tovell H, Prescott AR, Alessi DR.

Biochem J. 2018 Jan 2;475(1):117-135. doi: 10.1042/BCJ20170650.

43.

Stability of heavy metals in soil washing residue with and without biochar addition under accelerated ageing.

Shen Z, Hou D, Zhao B, Xu W, Ok YS, Bolan NS, Alessi DS.

Sci Total Environ. 2018 Apr 1;619-620:185-193. doi: 10.1016/j.scitotenv.2017.11.038. Epub 2017 Nov 29.

PMID:
29149742
44.

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase.

Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR.

Biochem J. 2018 Jan 2;475(1):1-22. doi: 10.1042/BCJ20170802.

45.

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.

Fan Y, Howden AJM, Sarhan AR, Lis P, Ito G, Martinez TN, Brockmann K, Gasser T, Alessi DR, Sammler EM.

Biochem J. 2018 Jan 2;475(1):23-44. doi: 10.1042/BCJ20170803.

46.

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M.

Elife. 2017 Nov 10;6. pii: e31012. doi: 10.7554/eLife.31012.

47.

USP7 small-molecule inhibitors interfere with ubiquitin binding.

Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE.

Nature. 2017 Oct 26;550(7677):534-538. doi: 10.1038/nature24006. Epub 2017 Oct 18.

PMID:
29045385
48.

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

Maniaci C, Hughes SJ, Testa A, Chen W, Lamont DJ, Rocha S, Alessi DR, Romeo R, Ciulli A.

Nat Commun. 2017 Oct 10;8(1):830. doi: 10.1038/s41467-017-00954-1.

49.

Cadmium bioaccumulates after acute exposure but has no effect on locomotion or shelter-seeking behaviour in the invasive green shore crab (Carcinus maenas).

Blewett TA, Newton D, Flynn SL, Alessi DS, Goss GG, Hamilton TJ.

Conserv Physiol. 2017 Sep 28;5(1):cox057. doi: 10.1093/conphys/cox057. eCollection 2017.

50.

Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.

Cervantes-Perez LG, Castaneda-Bueno M, Jimenez JV, Vazquez N, Rojas-Vega L, Alessi DR, Bobadilla NA, Gamba G.

J Hypertens. 2018 Feb;36(2):361-367. doi: 10.1097/HJH.0000000000001554.

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