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Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N.

Neurobiol Dis. 2018 Sep 5;120:76-87. doi: 10.1016/j.nbd.2018.09.003. [Epub ahead of print]


Assessing long-term stability of cadmium and lead in a soil washing residue amended with MgO-based binders using quantitative accelerated ageing.

Shen Z, Hou D, Xu W, Zhang J, Jin F, Zhao B, Pan S, Peng T, Alessi DS.

Sci Total Environ. 2018 Dec 1;643:1571-1578. doi: 10.1016/j.scitotenv.2018.06.321. Epub 2018 Jul 4.


Enhanced irreversible fixation of cesium by wetting and drying cycles in soil.

Park SM, Yang JS, Tsang DCW, Alessi DS, Baek K.

Environ Geochem Health. 2018 Aug 24. doi: 10.1007/s10653-018-0174-0. [Epub ahead of print]


PP1 Phosphatase Complexes: Undruggable No Longer.

Vagnarelli P, Alessi DR.

Cell. 2018 Aug 23;174(5):1049-1051. doi: 10.1016/j.cell.2018.08.007.


Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS.

ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31.


LRRK2 activation in idiopathic Parkinson's disease.

Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaar5429. doi: 10.1126/scitranslmed.aar5429.


Electron donor-driven bacterial and archaeal community patterns along forest ring edges in Ontario, Canada.

von Gunten K, Hamilton SM, Zhong C, Nesbø C, Li J, Muehlenbachs K, Konhauser KO, Alessi DS.

Environ Microbiol Rep. 2018 Jul 16. doi: 10.1111/1758-2229.12678. [Epub ahead of print]


Removal of hexavalent chromium in aqueous solutions using biochar: Chemical and spectroscopic investigations.

Rajapaksha AU, Alam MS, Chen N, Alessi DS, Igalavithana AD, Tsang DCW, Ok YS.

Sci Total Environ. 2018 Jun 1;625:1567-1573. doi: 10.1016/j.scitotenv.2017.12.195. Epub 2018 Jan 12.


Effect of dissolved organic carbon from sludge, Rice straw and spent coffee ground biochar on the mobility of arsenic in soil.

Kim HB, Kim SH, Jeon EK, Kim DH, Tsang DCW, Alessi DS, Kwon EE, Baek K.

Sci Total Environ. 2018 Sep 15;636:1241-1248. doi: 10.1016/j.scitotenv.2018.04.406. Epub 2018 May 9.


LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.

Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG.

EMBO J. 2018 Jun 15;37(12). pii: e98694. doi: 10.15252/embj.201798694. Epub 2018 May 22.


Thermodynamic Analysis of Nickel(II) and Zinc(II) Adsorption to Biochar.

Alam MS, Gorman-Lewis D, Chen N, Flynn SL, Ok YS, Konhauser KO, Alessi DS.

Environ Sci Technol. 2018 Jun 5;52(11):6246-6255. doi: 10.1021/acs.est.7b06261. Epub 2018 May 21.


The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.

Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR.

Biochem J. 2018 Jun 6;475(11):1861-1883. doi: 10.1042/BCJ20180248.


LRRK2 kinase in Parkinson's disease.

Alessi DR, Sammler E.

Science. 2018 Apr 6;360(6384):36-37. doi: 10.1126/science.aar5683. No abstract available.


Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations.

Tomczak A, Mortensen JM, Winnenburg R, Liu C, Alessi DT, Swamy V, Vallania F, Lofgren S, Haynes W, Shah NH, Musen MA, Khatri P.

Sci Rep. 2018 Mar 23;8(1):5115. doi: 10.1038/s41598-018-23395-2.


Comparison of nickel adsorption on biochars produced from mixed softwood and Miscanthus straw.

Shen Z, Zhang Y, Jin F, Alessi DS, Zhang Y, Wang F, McMillan O, Al-Tabbaa A.

Environ Sci Pollut Res Int. 2018 May;25(15):14626-14635. doi: 10.1007/s11356-018-1674-2. Epub 2018 Mar 12.


The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries.

Grabow D, Kaiser M, Hjorth L, Byrne J, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Bright CJ, de Vathaire F, Feijen EAM, Garwicz S, Hagberg O, Haupt R, Hawkins MM, Jakab Z, Kremer LCM, Kuehni CE, Kuonen R, Lähteenmäki PM, Reulen RC, Ronckers CM, Sacerdote C, Vu-Bezin G, Wesenberg F, Wiebe T, Winter DL, Winther JF, Zaletel LZ, Kaatsch P; PanCareSurFup Consortium.

Eur J Epidemiol. 2018 Mar;33(3):335-349. doi: 10.1007/s10654-018-0370-3. Epub 2018 Mar 2.


Selection criteria for oxidation method in total organic carbon measurement.

Yoon G, Park SM, Yang H, Tsang DCW, Alessi DS, Baek K.

Chemosphere. 2018 May;199:453-458. doi: 10.1016/j.chemosphere.2018.02.074. Epub 2018 Feb 12.


Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR.

EMBO J. 2018 Jan 4;37(1):1-18. doi: 10.15252/embj.201798099. Epub 2017 Dec 6.


Biochar application for the remediation of heavy metal polluted land: A review of in situ field trials.

O'Connor D, Peng T, Zhang J, Tsang DCW, Alessi DS, Shen Z, Bolan NS, Hou D.

Sci Total Environ. 2018 Apr 1;619-620:815-826. doi: 10.1016/j.scitotenv.2017.11.132. Epub 2017 Nov 29.


Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.

Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen EAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LC, Hjorth L, Reulen RC; PanCareSurFup Consortium.

J Natl Cancer Inst. 2018 Jun 1;110(6):649-660. doi: 10.1093/jnci/djx235.


Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.

Malik N, Macartney T, Hornberger A, Anderson KE, Tovell H, Prescott AR, Alessi DR.

Biochem J. 2018 Jan 2;475(1):117-135. doi: 10.1042/BCJ20170650.


Stability of heavy metals in soil washing residue with and without biochar addition under accelerated ageing.

Shen Z, Hou D, Zhao B, Xu W, Ok YS, Bolan NS, Alessi DS.

Sci Total Environ. 2018 Apr 1;619-620:185-193. doi: 10.1016/j.scitotenv.2017.11.038. Epub 2017 Nov 29.


Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase.

Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR.

Biochem J. 2018 Jan 2;475(1):1-22. doi: 10.1042/BCJ20170802.


Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.

Fan Y, Howden AJM, Sarhan AR, Lis P, Ito G, Martinez TN, Brockmann K, Gasser T, Alessi DR, Sammler EM.

Biochem J. 2018 Jan 2;475(1):23-44. doi: 10.1042/BCJ20170803.


Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M.

Elife. 2017 Nov 10;6. pii: e31012. doi: 10.7554/eLife.31012.


USP7 small-molecule inhibitors interfere with ubiquitin binding.

Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE.

Nature. 2017 Oct 26;550(7677):534-538. doi: 10.1038/nature24006. Epub 2017 Oct 18.


Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

Maniaci C, Hughes SJ, Testa A, Chen W, Lamont DJ, Rocha S, Alessi DR, Romeo R, Ciulli A.

Nat Commun. 2017 Oct 10;8(1):830. doi: 10.1038/s41467-017-00954-1.


Cadmium bioaccumulates after acute exposure but has no effect on locomotion or shelter-seeking behaviour in the invasive green shore crab (Carcinus maenas).

Blewett TA, Newton D, Flynn SL, Alessi DS, Goss GG, Hamilton TJ.

Conserv Physiol. 2017 Sep 28;5(1):cox057. doi: 10.1093/conphys/cox057. eCollection 2017.


Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.

Cervantes-Perez LG, Castaneda-Bueno M, Jimenez JV, Vazquez N, Rojas-Vega L, Alessi DR, Bobadilla NA, Gamba G.

J Hypertens. 2018 Feb;36(2):361-367. doi: 10.1097/HJH.0000000000001554.


Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5.

Gilbert AS, Seoane PI, Sephton-Clark P, Bojarczuk A, Hotham R, Giurisato E, Sarhan AR, Hillen A, Velde GV, Gray NS, Alessi DR, Cunningham DL, Tournier C, Johnston SA, May RC.

Sci Adv. 2017 Aug 16;3(8):e1700898. doi: 10.1126/sciadv.1700898. eCollection 2017 Aug.


Comment on Piscitelli et al. Hospitalizations in Pediatric and Adult Patients for All Cancer Type in Italy: The EPIKIT Study under the E.U. COHEIRS Project on Environment and Health. Int. J. Environ. Res. Public Health 2017, 14, 495.

Terracini B, Alessi D, Isaevska E, Macerata V, Magnani C, Manasievska M, Maule M, Merletti F, Mosso ML, Rosso T, Sacerdote C.

Int J Environ Res Public Health. 2017 Aug 16;14(8). pii: E919. doi: 10.3390/ijerph14080919.


Role of defects in laser-induced modifications of silica coatings and fused silica using picosecond pulses at 1053 nm: II. Scaling laws and the density of precursors.

Laurence TA, Negres RA, Ly S, Shen N, Carr CW, Alessi DA, Rigatti A, Bude JD.

Opt Express. 2017 Jun 26;25(13):15381-15401. doi: 10.1364/OE.25.015381.


The role of defects in laser-induced modifications of silica coatings and fused silica using picosecond pulses at 1053 nm: I. Damage morphology.

Ly S, Shen N, Negres RA, Carr CW, Alessi DA, Bude JD, Rigatti A, Laurence TA.

Opt Express. 2017 Jun 26;25(13):15161-15178. doi: 10.1364/OE.25.015161.


Cancer incidence rates and trends among children and adolescents in Piedmont, 1967-2011.

Isaevska E, Manasievska M, Alessi D, Mosso ML, Magnani C, Sacerdote C, Pastore G, Fagioli F, Merletti F, Maule M.

PLoS One. 2017 Jul 24;12(7):e0181805. doi: 10.1371/journal.pone.0181805. eCollection 2017.


Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.

Wang L, Fan J, Francis JM, Georghiou G, Hergert S, Li S, Gambe R, Zhou CW, Yang C, Xiao S, Cin PD, Bowden M, Kotliar D, Shukla SA, Brown JR, Neuberg D, Alessi DR, Zhang CZ, Kharchenko PV, Livak KJ, Wu CJ.

Genome Res. 2017 Aug;27(8):1300-1311. doi: 10.1101/gr.217331.116. Epub 2017 Jul 5.


Modified sequential extraction for biochar and petroleum coke: Metal release potential and its environmental implications.

von Gunten K, Alam MS, Hubmann M, Ok YS, Konhauser KO, Alessi DS.

Bioresour Technol. 2017 Jul;236:106-110. doi: 10.1016/j.biortech.2017.03.162. Epub 2017 Mar 29.


Small-Molecule Inhibitors of LRRK2.

Hatcher JM, Choi HG, Alessi DR, Gray NS.

Adv Neurobiol. 2017;14:241-264. doi: 10.1007/978-3-319-49969-7_13.


Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains.

Lopez-Guerrero AM, Tomas-Martin P, Pascual-Caro C, Macartney T, Rojas-Fernandez A, Ball G, Alessi DR, Pozo-Guisado E, Martin-Romero FJ.

Sci Rep. 2017 Mar 24;7(1):383. doi: 10.1038/s41598-017-00331-4.


Chemical and toxicological characterizations of hydraulic fracturing flowback and produced water.

He Y, Flynn SL, Folkerts EJ, Zhang Y, Ruan D, Alessi DS, Martin JW, Goss GG.

Water Res. 2017 May 1;114:78-87. doi: 10.1016/j.watres.2017.02.027. Epub 2017 Feb 14.


Sublethal and Reproductive Effects of Acute and Chronic Exposure to Flowback and Produced Water from Hydraulic Fracturing on the Water Flea Daphnia magna.

Blewett TA, Delompré PL, He Y, Folkerts EJ, Flynn SL, Alessi DS, Goss GG.

Environ Sci Technol. 2017 Mar 7;51(5):3032-3039. doi: 10.1021/acs.est.6b05179. Epub 2017 Feb 13.


Active cooling of pulse compression diffraction gratings for high energy, high average power ultrafast lasers.

Alessi DA, Rosso PA, Nguyen HT, Aasen MD, Britten JA, Haefner C.

Opt Express. 2016 Dec 26;24(26):30015-30023. doi: 10.1364/OE.24.030015.


Effects on Biotransformation, Oxidative Stress, and Endocrine Disruption in Rainbow Trout (Oncorhynchus mykiss) Exposed to Hydraulic Fracturing Flowback and Produced Water.

He Y, Folkerts EJ, Zhang Y, Martin JW, Alessi DS, Goss GG.

Environ Sci Technol. 2017 Jan 17;51(2):940-947. doi: 10.1021/acs.est.6b04695. Epub 2016 Dec 27.


B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice.

Jayachandran N, Landego I, Hou S, Alessi DR, Marshall AJ.

Eur J Immunol. 2017 Feb;47(2):280-290. doi: 10.1002/eji.201646596. Epub 2016 Dec 21.


The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR.

EMBO J. 2016 Oct 17;35(20):2263. No abstract available.


Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT.

Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986.


Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup.

Feijen EA, Font-Gonzalez A, van Dalen EC, van der Pal HJ, Reulen RC, Winter DL, Kuehni CE, Haupt R, Alessi D, Byrne J, Bardi E, Jakab Z, Grabow D, Garwicz S, Jankovic M, Levitt GA, Skinner R, Zadravec Zaletel L, Hjorth L, Tissing WJ, de Vathaire F, Hawkins MM, Kremer LC; PanCareSurFup consortium.

PLoS One. 2016 Sep 19;11(9):e0162778. doi: 10.1371/journal.pone.0162778. eCollection 2016.


The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR.

EMBO J. 2016 Sep 1;35(17):1902-22. doi: 10.15252/embj.201693929. Epub 2016 Aug 1. Erratum in: EMBO J. 2016 Oct 17;35(20):2263.


Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

Ito G, Katsemonova K, Tonelli F, Lis P, Baptista MA, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi DR.

Biochem J. 2016 Sep 1;473(17):2671-85. doi: 10.1042/BCJ20160557. Epub 2016 Jul 29.


PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Castel P, Ellis H, Bago R, Toska E, Razavi P, Carmona FJ, Kannan S, Verma CS, Dickler M, Chandarlapaty S, Brogi E, Alessi DR, Baselga J, Scaltriti M.

Cancer Cell. 2016 Aug 8;30(2):229-242. doi: 10.1016/j.ccell.2016.06.004. Epub 2016 Jul 21.


Surviving a childhood cancer: impact on education and employment.

Maule M, Zugna D, Migliore E, Alessi D, Merletti F, Onorati R, Zengarini N, Costa G, Spadea T.

Eur J Cancer Prev. 2017 Jul;26(4):351-356. doi: 10.1097/CEJ.0000000000000258.

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