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Items: 1 to 50 of 90

1.

RNA sequencing for research and diagnostics in clinical oncology.

Buzdin A, Sorokin M, Garazha A, Glusker A, Aleshin A, Poddubskaya E, Sekacheva M, Kim E, Gaifullin N, Giese A, Seryakov A, Rumiantsev P, Moshkovskii S, Moiseev A.

Semin Cancer Biol. 2019 Aug 11. pii: S1044-579X(19)30209-3. doi: 10.1016/j.semcancer.2019.07.010. [Epub ahead of print] Review.

PMID:
31412295
2.

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer.

Reinert T, Henriksen TV, Christensen E, Sharma S, Salari R, Sethi H, Knudsen M, Nordentoft I, Wu HT, Tin AS, Heilskov Rasmussen M, Vang S, Shchegrova S, Frydendahl Boll Johansen A, Srinivasan R, Assaf Z, Balcioglu M, Olson A, Dashner S, Hafez D, Navarro S, Goel S, Rabinowitz M, Billings P, Sigurjonsson S, Dyrskjøt L, Swenerton R, Aleshin A, Laurberg S, Husted Madsen A, Kannerup AS, Stribolt K, Palmelund Krag S, Iversen LH, Gotschalck Sunesen K, Lin CJ, Zimmermann BG, Lindbjerg Andersen C.

JAMA Oncol. 2019 May 9. doi: 10.1001/jamaoncol.2019.0528. [Epub ahead of print] Erratum in: JAMA Oncol. 2019 Jun 13;:.

3.

Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.

Christensen E, Birkenkamp-Demtröder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, Wu HT, Knudsen M, Lamy P, Lindskrog SV, Taber A, Balcioglu M, Vang S, Assaf Z, Sharma S, Tin AS, Srinivasan R, Hafez D, Reinert T, Navarro S, Olson A, Ram R, Dashner S, Rabinowitz M, Billings P, Sigurjonsson S, Andersen CL, Swenerton R, Aleshin A, Zimmermann B, Agerbæk M, Lin CJ, Jensen JB, Dyrskjøt L.

J Clin Oncol. 2019 Jun 20;37(18):1547-1557. doi: 10.1200/JCO.18.02052. Epub 2019 May 6.

PMID:
31059311
4.

Hemostatic Effect of Aminated Multiwalled Carbon Nanotubes/Oxidized Regenerated Cellulose Nanocomposites.

Zhang B, Chakoli AN, He JM, Huang YD, Aleshin AN.

J Nanosci Nanotechnol. 2019 Nov 1;19(11):7410-7415. doi: 10.1166/jnn.2019.16617.

PMID:
31039905
5.

Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence.

Coombes RC, Page K, Salari R, Hastings RK, Armstrong A, Ahmed S, Ali S, Cleator S, Kenny L, Stebbing J, Rutherford M, Sethi H, Boydell A, Swenerton R, Fernandez-Garcia D, Gleason KLT, Goddard K, Guttery DS, Assaf ZJ, Wu HT, Natarajan P, Moore DA, Primrose L, Dashner S, Tin AS, Balcioglu M, Srinivasan R, Shchegrova SV, Olson A, Hafez D, Billings P, Aleshin A, Rehman F, Toghill BJ, Hills A, Louie MC, Lin CJ, Zimmermann BG, Shaw JA.

Clin Cancer Res. 2019 Jul 15;25(14):4255-4263. doi: 10.1158/1078-0432.CCR-18-3663. Epub 2019 Apr 16.

PMID:
30992300
6.

Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report.

Poddubskaya EV, Baranova MP, Allina DO, Sekacheva MI, Makovskaia LA, Kamashev DE, Suntsova MV, Barbara VS, Kochergina-Nikitskaya IN, Aleshin AA.

Cold Spring Harb Mol Case Stud. 2019 Apr 1;5(2). pii: a003434. doi: 10.1101/mcs.a003434. Print 2019 Apr.

7.

Molecular pathophysiology of the myelodysplastic syndromes: insights for targeted therapy.

Aleshin A, Greenberg PL.

Blood Adv. 2018 Oct 23;2(20):2787-2797. doi: 10.1182/bloodadvances.2018015834. Review.

8.

Personalized prescription of tyrosine kinase inhibitors in unresectable metastatic cholangiocarcinoma.

Poddubskaya EV, Baranova MP, Allina DO, Smirnov PY, Albert EA, Kirilchev AP, Aleshin AA, Sekacheva MI, Suntsova MV.

Exp Hematol Oncol. 2018 Sep 6;7:21. doi: 10.1186/s40164-018-0113-x. eCollection 2018.

9.

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα.

Chen L, Aleshin AE, Alitongbieke G, Zhou Y, Zhang X, Ye X, Hu M, Ren G, Chen Z, Ma Y, Zhang D, Liu S, Gao W, Cai L, Wu L, Zeng Z, Jiang F, Liu J, Zhou H, Cadwell G, Liddington RC, Su Y, Zhang XK.

Nat Commun. 2017 Jul 17;8:16066. doi: 10.1038/ncomms16066.

10.

IDH2 Mutation in a Patient with Metastatic Colon Cancer.

Zhang BM, Aleshin A, Lin CY, Ford J, Zehnder JL, Suarez CJ.

N Engl J Med. 2017 May 18;376(20):1991-2. doi: 10.1056/NEJMc1701072. No abstract available.

PMID:
28514606
11.

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.

Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.

12.

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.

Grandjean G, de Jong PR, James B, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby K, Powis G.

Cancer Res. 2016 Jul 15;76(14):4259-4269. doi: 10.1158/0008-5472.CAN-16-0401. Epub 2016 Jun 3.

13.

Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers.

Finn RS, Aleshin A, Slamon DJ.

Breast Cancer Res. 2016 Feb 9;18(1):17. doi: 10.1186/s13058-015-0661-5. Review.

14.

Chemoradiotherapy for squamous cell carcinoma of the anal canal: Comparison of one versus two cycles mitomycin-C.

White EC, Goldman K, Aleshin A, Lien WW, Rao AR.

Radiother Oncol. 2015 Nov;117(2):240-5. doi: 10.1016/j.radonc.2015.08.015. Epub 2015 Sep 4.

PMID:
26347494
15.

TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response.

Rozanov D, Cheltsov A, Sergienko E, Vasile S, Golubkov V, Aleshin AE, Levin T, Traer E, Hann B, Freimuth J, Alexeev N, Alekseyev MA, Budko SP, Bächinger HP, Spellman P.

PLoS One. 2015 Jun 15;10(6):e0129566. doi: 10.1371/journal.pone.0129566. eCollection 2015.

16.

Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery.

Rodionova IA, Zuccola HJ, Sorci L, Aleshin AE, Kazanov MD, Ma CT, Sergienko E, Rubin EJ, Locher CP, Osterman AL.

J Biol Chem. 2015 Mar 20;290(12):7693-706. doi: 10.1074/jbc.M114.628016. Epub 2015 Jan 28.

17.

Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.

Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y.

Chem Biol. 2014 May 22;21(5):596-607. doi: 10.1016/j.chembiol.2014.02.017. Epub 2014 Apr 3.

18.

Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island.

Shiryaev SA, Aleshin AE, Muranaka N, Kukreja M, Routenberg DA, Remacle AG, Liddington RC, Cieplak P, Kozlov IA, Strongin AY.

FEBS J. 2014 Jun;281(11):2487-502. doi: 10.1111/febs.12804. Epub 2014 Apr 22.

19.

Crystal structure of a glucose/H+ symporter and its mechanism of action.

Iancu CV, Zamoon J, Woo SB, Aleshin A, Choe JY.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17862-7. doi: 10.1073/pnas.1311485110. Epub 2013 Oct 14.

20.

Molecular subtype and response to dasatinib, an Src/Abl small molecule kinase inhibitor, in hepatocellular carcinoma cell lines in vitro.

Finn RS, Aleshin A, Dering J, Yang P, Ginther C, Desai A, Zhao D, von Euw E, Busuttil RW, Slamon DJ.

Hepatology. 2013 May;57(5):1838-46. doi: 10.1002/hep.26223. Epub 2013 Apr 1.

PMID:
23299860
21.

Activity, specificity, and probe design for the smallpox virus protease K7L.

Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.

J Biol Chem. 2012 Nov 16;287(47):39470-9. doi: 10.1074/jbc.M112.388678. Epub 2012 Sep 25.

22.

Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

Aleshin AE, DiScipio RG, Stec B, Liddington RC.

J Biol Chem. 2012 Jun 1;287(23):19642-52. doi: 10.1074/jbc.M112.361121. Epub 2012 Apr 12.

23.

Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

Aleshin AE, Schraufstatter IU, Stec B, Bankston LA, Liddington RC, DiScipio RG.

J Biol Chem. 2012 Mar 23;287(13):10210-22. doi: 10.1074/jbc.M111.327809. Epub 2012 Jan 20.

24.

Morphological Changes and Immunohistochemical Expression of RAGE and its Ligands in the Sciatic Nerve of Hyperglycemic Pig (Sus Scrofa).

Juranek JK, Aleshin A, Rattigan EM, Johnson L, Qu W, Song F, Ananthakrishnan R, Quadri N, Yan SD, Ramasamy R, Schmidt AM, Geddis MS.

Biochem Insights. 2010 Sep 1;2010(3):47-59.

25.

Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.

Shiryaev SA, Cieplak P, Aleshin AE, Sun Q, Zhu W, Motamedchaboki K, Sloutsky A, Strongin AY.

FEBS J. 2011 Sep;278(18):3277-86. doi: 10.1111/j.1742-4658.2011.08244.x. Epub 2011 Aug 8.

26.

Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.

Golubkov VS, Aleshin AE, Strongin AY.

J Biol Chem. 2011 Jun 10;286(23):20970-6. doi: 10.1074/jbc.M111.237669. Epub 2011 Apr 25.

27.

The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.

Shiryaev SA, Chernov AV, Shiryaeva TN, Aleshin AE, Strongin AY.

Arch Virol. 2011 Feb;156(2):313-8. doi: 10.1007/s00705-010-0838-2. Epub 2010 Oct 27.

28.

The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.

Golubkov VS, Chekanov AV, Cieplak P, Aleshin AE, Chernov AV, Zhu W, Radichev IA, Zhang D, Dong PD, Strongin AY.

J Biol Chem. 2010 Nov 12;285(46):35740-9. doi: 10.1074/jbc.M110.165159. Epub 2010 Sep 13.

29.

SRC: a century of science brought to the clinic.

Aleshin A, Finn RS.

Neoplasia. 2010 Aug;12(8):599-607. Review.

30.

p27Kip1 mediates addiction of ovarian cancer cells to MYCC (c-MYC) and their dependence on MYC paralogs.

Prathapam T, Aleshin A, Guan Y, Gray JW, Martin GS.

J Biol Chem. 2010 Oct 15;285(42):32529-38. doi: 10.1074/jbc.M110.151902. Epub 2010 Jul 20.

31.

Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.

Golubkov VS, Cieplak P, Chekanov AV, Ratnikov BI, Aleshin AE, Golubkova NV, Postnova TI, Radichev IA, Rozanov DV, Zhu W, Motamedchaboki K, Strongin AY.

J Biol Chem. 2010 Sep 3;285(36):27726-36. doi: 10.1074/jbc.M110.135442. Epub 2010 Jul 6.

32.

Recombination-associated sequence homogenization of neighboring Alu elements: signature of nonallelic gene conversion.

Aleshin A, Zhi D.

Mol Biol Evol. 2010 Oct;27(10):2300-11. doi: 10.1093/molbev/msq116. Epub 2010 May 7.

33.

Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.

Cheltsov AV, Aoyagi M, Aleshin A, Yu EC, Gilliland T, Zhai D, Bobkov AA, Reed JC, Liddington RC, Abagyan R.

J Med Chem. 2010 May 27;53(10):3899-906. doi: 10.1021/jm901446n.

34.

Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.

Shiryaev SA, Radichev IA, Ratnikov BI, Aleshin AE, Gawlik K, Stec B, Frisch C, Knappik A, Strongin AY.

Biochem J. 2010 Apr 14;427(3):369-76. doi: 10.1042/BJ20100074.

35.

Ultrastructural features of retinal capillary basement membrane thickening in diabetic swine.

Lee SE, Ma W, Rattigan EM, Aleshin A, Chen L, Johnson LL, D'Agati VD, Schmidt AM, Barile GR.

Ultrastruct Pathol. 2010 Feb;34(1):35-41. doi: 10.3109/01913120903308583.

36.

Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.

Aleshin AE, Gramatikova S, Hura GL, Bobkov A, Strongin AY, Stec B, Tainer JA, Liddington RC, Smith JW.

Structure. 2009 Nov 11;17(11):1465-75. doi: 10.1016/j.str.2009.09.009.

37.

Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.

Rozanov DV, Savinov AY, Golubkov VS, Rozanova OL, Postnova TI, Sergienko EA, Vasile S, Aleshin AE, Rega MF, Pellecchia M, Strongin AY.

Mol Cancer Ther. 2009 Jun;8(6):1515-25. doi: 10.1158/1535-7163.MCT-09-0202. Epub 2009 Jun 9.

38.

NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus.

Shiryaev SA, Chernov AV, Aleshin AE, Shiryaeva TN, Strongin AY.

J Gen Virol. 2009 Sep;90(Pt 9):2081-5. doi: 10.1099/vir.0.012864-0. Epub 2009 May 27.

39.

The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.

Chernov AV, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

J Biol Chem. 2008 Jun 20;283(25):17270-8. doi: 10.1074/jbc.M801719200. Epub 2008 Apr 28.

40.

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.

Radichev I, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

J Gen Virol. 2008 Mar;89(Pt 3):636-41. doi: 10.1099/vir.0.83359-0.

PMID:
18272753
41.

RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model.

Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, Song F, Bakr S, Szabolcs M, D'Agati V, Liu R, Homma S, Schmidt AM, Yan SF, Ramasamy R.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1823-32. doi: 10.1152/ajpheart.01210.2007. Epub 2008 Feb 1.

42.

Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.

Golubkov VS, Chekanov AV, Shiryaev SA, Aleshin AE, Ratnikov BI, Gawlik K, Radichev I, Motamedchaboki K, Smith JW, Strongin AY.

J Biol Chem. 2007 Dec 14;282(50):36283-91. Epub 2007 Oct 15.

43.

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.

Aleshin AE, Shiryaev SA, Strongin AY, Liddington RC.

Protein Sci. 2007 May;16(5):795-806. Epub 2007 Mar 30.

44.

Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.

Shiryaev SA, Ratnikov BI, Aleshin AE, Kozlov IA, Nelson NA, Lebl M, Smith JW, Liddington RC, Strongin AY.

J Virol. 2007 May;81(9):4501-9. Epub 2007 Feb 14.

45.

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.

Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

Protein Expr Purif. 2007 Apr;52(2):334-9. Epub 2006 Dec 1.

46.

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.

Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC.

Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22.

47.

Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets.

Memon IA, Sawa Y, Fukushima N, Matsumiya G, Miyagawa S, Taketani S, Sakakida SK, Kondoh H, Aleshin AN, Shimizu T, Okano T, Matsuda H.

J Thorac Cardiovasc Surg. 2005 Nov;130(5):1333-41.

48.

150-kDa oxygen-regulated protein attenuates myocardial ischemia-reperfusion injury in rat heart.

Aleshin AN, Sawa Y, Kitagawa-Sakakida S, Bando Y, Ono M, Memon IA, Tohyama M, Ogawa S, Matsuda H.

J Mol Cell Cardiol. 2005 Mar;38(3):517-25.

PMID:
15733911
49.

Dispersion and current-voltage characteristics of helical polyacetylene single fibers.

Lee HJ, Jin ZX, Aleshin AN, Lee JY, Goh MJ, Akagi K, Kim YS, Kim DW, Park YW.

J Am Chem Soc. 2004 Dec 29;126(51):16722-3.

PMID:
15612700
50.

One-dimensional transport in polymer nanofibers.

Aleshin AN, Lee HJ, Park YW, Akagi K.

Phys Rev Lett. 2004 Nov 5;93(19):196601. Epub 2004 Nov 4.

PMID:
15600860

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