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Transcription factor-mediated regulation of the BCRP/ABCG2 efflux transporter: a review across tissues and species.

Gorczyca L, Aleksunes LM.

Expert Opin Drug Metab Toxicol. 2020 Feb 20. doi: 10.1080/17425255.2020.1732348. [Epub ahead of print]


Mechanism-driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data.

Zhao L, Russo DP, Wang W, Aleksunes LM, Zhu H.

Toxicol Sci. 2020 Feb 19. pii: kfaa005. doi: 10.1093/toxsci/kfaa005. [Epub ahead of print]


Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.

Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE.

Drug Metab Dispos. 2019 Oct;47(10):1080-1092. doi: 10.1124/dmd.119.086603. Epub 2019 Aug 9.


Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling.

You D, Wen X, Gorczyca L, Morris A, Richardson JR, Aleksunes LM.

Mol Neurobiol. 2019 Oct;56(10):6986-7002. doi: 10.1007/s12035-019-1565-7. Epub 2019 Apr 8.


Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across.

Russo DP, Strickland J, Karmaus AL, Wang W, Shende S, Hartung T, Aleksunes LM, Zhu H.

Environ Health Perspect. 2019 Apr;127(4):47001. doi: 10.1289/EHP3614.


Brain region-specific regulation of histone acetylation and efflux transporters in mice.

You D, Shin HM, Mosaad F, Richardson JR, Aleksunes LM.

J Biochem Mol Toxicol. 2019 Mar 21:e22318. doi: 10.1002/jbt.22318. [Epub ahead of print]


Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.

Wen X, Baker AA, Klaassen CD, Corton JC, Richardson JR, Aleksunes LM.

Toxicology. 2019 Mar 15;416:15-22. doi: 10.1016/j.tox.2019.01.014. Epub 2019 Jan 24.


Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.

Szilagyi JT, Composto-Wahler GM, Joseph LB, Wang B, Rosen T, Laskin JD, Aleksunes LM.

Pharmacol Res. 2019 Mar;141:331-342. doi: 10.1016/j.phrs.2019.01.002. Epub 2019 Jan 2.


Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone.

Szilagyi JT, Gorczyca L, Brinker A, Buckley B, Laskin JD, Aleksunes LM.

Toxicol Sci. 2019 Apr 1;168(2):394-404. doi: 10.1093/toxsci/kfy303.


Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase.

Szilagyi JT, Fussell KC, Wang Y, Jan YH, Mishin V, Richardson JR, Heck DE, Yang S, Aleksunes LM, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2018 Nov 15;359:102-107. doi: 10.1016/j.taap.2018.09.011. Epub 2018 Sep 15.


Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates.

Memon N, Griffin IJ, Lee CW, Herdt A, Weinberger BI, Hegyi T, Carayannopoulos MO, Aleksunes LM, Guo GL.

J Matern Fetal Neonatal Med. 2020 Mar;33(6):987-992. doi: 10.1080/14767058.2018.1513483. Epub 2018 Oct 29.


Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor.

Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC.

PLoS One. 2018 Aug 16;13(8):e0200004. doi: 10.1371/journal.pone.0200004. eCollection 2018.


Interindividual Regulation of the Breast Cancer Resistance Protein/ABCG2 Transporter in Term Human Placentas.

Bircsak KM, Moscovitz JE, Wen X, Archer F, Yuen PYS, Mohammed M, Memon N, Weinberger BI, Saba LM, Vetrano AM, Aleksunes LM.

Drug Metab Dispos. 2018 May;46(5):619-627. doi: 10.1124/dmd.117.079228. Epub 2018 Jan 31.


Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy.

George B, Joy MS, Aleksunes LM.

Exp Biol Med (Maywood). 2018 Feb;243(3):272-282. doi: 10.1177/1535370217745302. Epub 2017 Dec 12. Review.


Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier.

Blundell C, Yi YS, Ma L, Tess ER, Farrell MJ, Georgescu A, Aleksunes LM, Huh D.

Adv Healthc Mater. 2018 Jan;7(2). doi: 10.1002/adhm.201700786. Epub 2017 Nov 9.


The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis.

Schumacher JD, Kong B, Pan Y, Zhan L, Sun R, Aa J, Rizzolo D, Richardson JR, Chen A, Goedken M, Aleksunes LM, Laskin DL, Guo GL.

Toxicol Appl Pharmacol. 2017 Sep 1;330:1-8. doi: 10.1016/j.taap.2017.06.023. Epub 2017 Jul 1.


Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin.

Chang C, Hu Y, Hogan SL, Mercke N, Gomez M, O'Bryant C, Bowles DW, George B, Wen X, Aleksunes LM, Joy MS.

Int J Mol Sci. 2017 Jun 22;18(7). pii: E1333. doi: 10.3390/ijms18071333.


Localization of the placental BCRP/ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity.

Szilagyi JT, Vetrano AM, Laskin JD, Aleksunes LM.

Placenta. 2017 Jul;55:29-36. doi: 10.1016/j.placenta.2017.04.006. Epub 2017 Apr 12.


Efflux Transporters Regulate Arsenite-Induced Genotoxicity in Double Negative and Double Positive T Cells.

Xu H, Medina S, Lauer FT, Douillet C, Liu KJ, Hudson LG, Stýblo M, Aleksunes LM, Burchiel SW.

Toxicol Sci. 2017 Jul 1;158(1):127-139. doi: 10.1093/toxsci/kfx075.


In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants.

Wen X, Joy MS, Aleksunes LM.

Pharm Res. 2017 Aug;34(8):1637-1647. doi: 10.1007/s11095-017-2160-0. Epub 2017 Apr 12.


Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.


Down-regulation of the placental BCRP/ABCG2 transporter in response to hypoxia signaling.

Francois LN, Gorczyca L, Du J, Bircsak KM, Yen E, Wen X, Tu MJ, Yu AM, Illsley NP, Zamudio S, Aleksunes LM.

Placenta. 2017 Mar;51:57-63. doi: 10.1016/j.placenta.2017.01.125. Epub 2017 Jan 24.


Xenobiotic transporters and kidney injury.

George B, You D, Joy MS, Aleksunes LM.

Adv Drug Deliv Rev. 2017 Jul 1;116:73-91. doi: 10.1016/j.addr.2017.01.005. Epub 2017 Jan 20. Review.


Differential regulation of intestinal efflux transporters by pregnancy in mice.

Moscovitz JE, Yarmush G, Herrera-Garcia G, Guo GL, Aleksunes LM.

Xenobiotica. 2017 Nov;47(11):989-997. doi: 10.1080/00498254.2016.1250292. Epub 2017 Jan 3.


Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-dependent Changes in the Absence of Clinical Nephrotoxicity.

George B, Wen X, Mercke N, Gomez M, O'Bryant C, Bowles DW, Hu Y, Hogan SL, Joy MS, Aleksunes LM.

Clin Pharmacol Ther. 2017 Apr;101(4):510-518. doi: 10.1002/cpt.606. Epub 2017 Feb 14.


Regulation of the placental BCRP transporter by PPAR gamma.

Lin Y, Bircsak KM, Gorczyca L, Wen X, Aleksunes LM.

J Biochem Mol Toxicol. 2017 May;31(5). doi: 10.1002/jbt.21880. Epub 2016 Nov 23.


Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation.

Bright AS, Herrera-Garcia G, Moscovitz JE, You D, Guo GL, Aleksunes LM.

Nucl Receptor Res. 2016;3. pii: 101193.


Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064.

Moscovitz JE, Kong B, Buckley K, Buckley B, Guo GL, Aleksunes LM.

Toxicol Appl Pharmacol. 2016 Nov 1;310:60-67. doi: 10.1016/j.taap.2016.08.021. Epub 2016 Sep 5.


Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

Atilano-Roque A, Aleksunes LM, Joy MS.

Toxicol Lett. 2016 Sep 30;259:52-59. doi: 10.1016/j.toxlet.2016.07.021. Epub 2016 Jul 29.


Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting.

Brunetti L, Sanchez-Catanese B, Kagan L, Wen X, Liu M, Buckley B, Luyendyk JP, Aleksunes LM.

Thromb J. 2016 May 6;14:10. doi: 10.1186/s12959-016-0084-2. eCollection 2016.


Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.

Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, Heindel ND, Laskin DL, Laskin JD.

Toxicol Sci. 2016 May;151(1):150-9. doi: 10.1093/toxsci/kfw031. Epub 2016 Feb 14.


Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers.

Moscovitz JE, Nahar MS, Shalat SL, Slitt AL, Dolinoy DC, Aleksunes LM.

Drug Metab Dispos. 2016 Jul;44(7):1061-5. doi: 10.1124/dmd.115.068668. Epub 2016 Feb 5.


Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter.

Bircsak KM, Gupta V, Yuen PY, Gorczyca L, Weinberger BI, Vetrano AM, Aleksunes LM.

J Pharmacol Exp Ther. 2016 Apr;357(1):103-13. doi: 10.1124/jpet.115.230185. Epub 2016 Feb 5.


Nrf2 activators as potential modulators of injury in human kidney cells.

Atilano-Roque A, Wen X, Aleksunes LM, Joy MS.

Toxicol Rep. 2016 Jan 12;3:153-159. doi: 10.1016/j.toxrep.2016.01.006. eCollection 2016.


Cefoxitin Plasma and Subcutaneous Adipose Tissue Concentration in Patients Undergoing Sleeve Gastrectomy.

Brunetti L, Kagan L, Forrester G, Aleksunes LM, Lin H, Buyske S, Nahass RG.

Clin Ther. 2016 Jan 1;38(1):204-10. doi: 10.1016/j.clinthera.2015.11.009. Epub 2015 Dec 11.


Inherited disorders of bilirubin clearance.

Memon N, Weinberger BI, Hegyi T, Aleksunes LM.

Pediatr Res. 2016 Mar;79(3):378-86. doi: 10.1038/pr.2015.247. Epub 2015 Nov 23. Review.


Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1).

Udasin RG, Wen X, Bircsak KM, Aleksunes LM, Shakarjian MP, Kong AN, Heck DE, Laskin DL, Laskin JD.

Toxicol Sci. 2016 Jan;149(1):202-12. doi: 10.1093/toxsci/kfv226. Epub 2015 Oct 9.


Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells.

Xu H, Zhou X, Wen X, Lauer FT, Liu KJ, Hudson LG, Aleksunes LM, Burchiel SW.

Toxicol Sci. 2016 Jan;149(1):31-41. doi: 10.1093/toxsci/kfv211. Epub 2015 Oct 5.


Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).

Oshida K, Vasani N, Thomas RS, Applegate D, Gonzalez FJ, Aleksunes LM, Klaassen CD, Corton JC.

Toxicology. 2015 Oct 2;336:99-112. doi: 10.1016/j.tox.2015.07.005. Epub 2015 Jul 26.


Interaction of Isoflavones with the BCRP/ABCG2 Drug Transporter.

Bircsak KM, Aleksunes LM.

Curr Drug Metab. 2015;16(2):124-40. Review.


Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators.

Baker AA, Guo GL, Aleksunes LM, Richardson JR.

J Biochem Mol Toxicol. 2015 Dec;29(12):545-51. doi: 10.1002/jbt.21725. Epub 2015 Jul 15.


Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.

Brouwer KL, Aleksunes LM, Brandys B, Giacoia GP, Knipp G, Lukacova V, Meibohm B, Nigam SK, Rieder M, de Wildt SN; Pediatric Transporter Working Group.

Clin Pharmacol Ther. 2015 Sep;98(3):266-87. doi: 10.1002/cpt.176. Review.


In Vitro Screening of Environmental Chemicals Identifies Zearalenone as a Novel Substrate of the Placental BCRP/ABCG2 Transporter.

Xiao J, Wang Q, Bircsak KM, Wen X, Aleksunes LM.

Toxicol Res (Camb). 2015 May 1;4(3):695-706.


Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.

Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter DR, Aleksunes LM, Thomas RS, Applegate D, Klaassen CD, Corton JC.

Nucl Recept Signal. 2015 Apr 27;13:e002. doi: 10.1621/nrs.13002. eCollection 2015.


Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.

Oshida K, Vasani N, Thomas RS, Applegate D, Rosen M, Abbott B, Lau C, Guo G, Aleksunes LM, Klaassen C, Corton JC.

PLoS One. 2015 Feb 17;10(2):e0112655. doi: 10.1371/journal.pone.0112655. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0124224.


Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor.

Wen X, Thorne G, Hu L, Joy MS, Aleksunes LM.

J Biochem Mol Toxicol. 2015 Jun;29(6):261-6. doi: 10.1002/jbt.21693. Epub 2015 Feb 12.


Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice.

Rudraiah S, Moscovitz JE, Donepudi AC, Campion SN, Slitt AL, Aleksunes LM, Manautou JE.

Toxicology. 2014 Nov 5;325:85-95. doi: 10.1016/j.tox.2014.08.013. Epub 2014 Sep 2.


MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells.

Wen X, Gibson CJ, Yang I, Buckley B, Goedken MJ, Richardson JR, Aleksunes LM.

Toxicol Sci. 2014 Oct;141(2):475-83. doi: 10.1093/toxsci/kfu141. Epub 2014 Jul 11.


Fibroblast growth factor 15 deficiency impairs liver regeneration in mice.

Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, Aleksunes LM, Richardson JR, Apte U, Rudnick DA, Guo GL.

Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G893-902. doi: 10.1152/ajpgi.00337.2013. Epub 2014 Apr 3.


Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice.

Wen X, Buckley B, McCandlish E, Goedken MJ, Syed S, Pelis R, Manautou JE, Aleksunes LM.

Am J Pathol. 2014 May;184(5):1299-308. doi: 10.1016/j.ajpath.2014.01.025. Epub 2014 Mar 15.

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