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Items: 45

1.

Association of In Utero Exposure to Polybrominated Diphenyl Ethers With the Risk of Hypospadias.

Poon S, Koren G, Carnevale A, Aleksa K, Ling J, Ozsarfati J, Kapur BM, Bagli D.

JAMA Pediatr. 2018 Sep 1;172(9):851-856. doi: 10.1001/jamapediatrics.2018.1492.

PMID:
30073326
2.

Exposure to polybrominated diphenyl ethers and phthalates in healthy men living in the greater Montreal area: A study of hormonal balance and semen quality.

Albert O, Huang JY, Aleksa K, Hales BF, Goodyer CG, Robaire B, Chevrier J, Chan P.

Environ Int. 2018 Jul;116:165-175. doi: 10.1016/j.envint.2018.04.012. Epub 2018 Apr 24.

PMID:
29684825
3.

Erratum: "A Case-Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations".

Goodyer CG, Poon S, Aleksa K, Hou L, Atehortua V, Carnevale A, Koren G, Jednak R, Emil S, Bagli D, Dave S, Hales BF, Chevrier J.

Environ Health Perspect. 2018 Mar 29;126(3):039001. doi: 10.1289/EHP3577.

4.

A Case-Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations.

Goodyer CG, Poon S, Aleksa K, Hou L, Atehortua V, Carnevale A, Koren G, Jednak R, Emil S, Bagli D, Dave S, Hales BF, Chevrier J.

Environ Health Perspect. 2017 May 26;125(5):057004. doi: 10.1289/EHP522. Erratum in: Environ Health Perspect. 2018 Mar 29;126(3):039001.

5.

Oral morphine dosing predictions based on single dose in healthy children undergoing surgery.

Dawes JM, Cooke EM, Hannam JA, Brand KA, Winton P, Jimenez-Mendez R, Aleksa K, Lauder GR, Carleton BC, Koren G, Rieder MJ, Anderson BJ, Montgomery CJ.

Paediatr Anaesth. 2017 Jan;27(1):28-36. doi: 10.1111/pan.13020. Epub 2016 Oct 25.

PMID:
27779356
6.

Examining the transplacental passage of apixaban using the dually perfused human placenta.

Bapat P, Pinto LS, Lubetsky A, Aleksa K, Berger H, Koren G, Ito S.

J Thromb Haemost. 2016 Jul;14(7):1436-41. doi: 10.1111/jth.13353. Epub 2016 Jun 8.

7.

A Compartmental Analysis for Morphine and Its Metabolites in Young Children After a Single Oral Dose.

Velez de Mendizabal N, Jimenez-Mendez R, Cooke E, Montgomery CJ, Dawes J, Rieder MJ, Aleksa K, Koren G, Jacobo-Cabral CO, Gonzalez-Ramirez R, CastaƱeda-Hernandez G, Carleton BC.

Clin Pharmacokinet. 2015 Oct;54(10):1083-90. doi: 10.1007/s40262-015-0256-4.

PMID:
25773480
8.

Evaluating external contamination of polybrominated diphenyl ethers in human hair: clinical and research implications.

Poon S, Aleksa K, Carnevale A, Kapur B, Goodyer C, Koren G.

Ther Drug Monit. 2015 Apr;37(2):270-4. doi: 10.1097/FTD.0000000000000137.

PMID:
25768972
9.

Glyburide transport across the human placenta.

Schwartz RA, Rosenn B, Aleksa K, Koren G.

Obstet Gynecol. 2015 Mar;125(3):583-8. doi: 10.1097/AOG.0000000000000672.

PMID:
25730219
10.

Hair as a biomarker of systemic exposure to polybrominated diphenyl ethers.

Poon S, Wade MG, Aleksa K, Rawn DF, Carnevale A, Gaertner DW, Sadler A, Breton F, Koren G, Ernest SR, Lalancette C, Robaire B, Hales BF, Goodyer CG.

Environ Sci Technol. 2014 Dec 16;48(24):14650-8. doi: 10.1021/es502789h. Epub 2014 Nov 26.

PMID:
25387207
11.

Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach.

Elamin E, Masclee A, Troost F, Pieters HJ, Keszthelyi D, Aleksa K, Dekker J, Jonkers D.

PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.

12.

Transfer of dabigatran and dabigatran etexilate mesylate across the dually perfused human placenta.

Bapat P, Kedar R, Lubetsky A, Matlow JN, Aleksa K, Berger H, Koren G.

Obstet Gynecol. 2014 Jun;123(6):1256-61. doi: 10.1097/AOG.0000000000000277.

PMID:
24807346
13.

Investigating the use of hair to assess polybrominated diphenyl ether exposure retrospectively.

Carnevale A, Aleksa K, Goodyer CG, Koren G.

Ther Drug Monit. 2014 Apr;36(2):244-51. doi: 10.1097/FTD.0b013e3182a69a8b.

PMID:
24625542
14.

The transfer of ethyl glucuronide across the dually perfused human placenta.

Matlow JN, Lubetsky A, Aleksa K, Berger H, Koren G.

Placenta. 2013 Apr;34(4):369-73. doi: 10.1016/j.placenta.2012.12.016. Epub 2013 Jan 31.

PMID:
23375233
15.
16.

Essay for the 2011 CIHR/CMAJ award: Motherisk--caring for mothers, protecting the unborn.

Koren G, Nulman I, Aleksa K, Gareri J, Einarson A, Ito S; Motherisk Program.

CMAJ. 2012 Feb 7;184(2):E155-7. doi: 10.1503/cmaj.112128. Epub 2012 Jan 23. No abstract available.

17.

Hair as a biomarker of polybrominated diethyl ethers' exposure in infants, children and adults.

Aleksa K, Liesivuori J, Koren G.

Toxicol Lett. 2012 Apr 25;210(2):198-202. doi: 10.1016/j.toxlet.2011.12.010. Epub 2011 Dec 29.

PMID:
22227573
18.

Detection of polybrominated biphenyl ethers (PBDEs) in pediatric hair as a tool for determining in utero exposure.

Aleksa K, Carnevale A, Goodyer C, Koren G.

Forensic Sci Int. 2012 May 10;218(1-3):37-43. doi: 10.1016/j.forsciint.2011.10.003. Epub 2011 Nov 10.

PMID:
22079498
19.

Simultaneous detection of seventeen drugs of abuse and metabolites in hair using solid phase micro extraction (SPME) with GC/MS.

Aleksa K, Walasek P, Fulga N, Kapur B, Gareri J, Koren G.

Forensic Sci Int. 2012 May 10;218(1-3):31-6. doi: 10.1016/j.forsciint.2011.10.002. Epub 2011 Nov 1.

PMID:
22047752
20.

Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite.

Gunness P, Aleksa K, Bend J, Koren G.

Transl Res. 2011 Nov;158(5):290-301. doi: 10.1016/j.trsl.2011.07.002. Epub 2011 Aug 3.

PMID:
22005269
21.

Acyclovir is a substrate for the human breast cancer resistance protein (BCRP/ABCG2): implications for renal tubular transport and acyclovir-induced nephrotoxicity.

Gunness P, Aleksa K, Koren G.

Can J Physiol Pharmacol. 2011 Sep;89(9):675-80. doi: 10.1139/Y11-045. Epub 2011 Aug 22.

PMID:
21859328
22.

N-acetylcysteine as a novel prophylactic treatment for ifosfamide-induced nephrotoxicity in children: translational pharmacokinetics.

Hanly LN, Chen N, Aleksa K, Cutler M, Bajcetic M, Palassery R, Regueira O, Turner C, Baw B, Malkin B, Freeman D, Rieder MJ, Vasylyeva TL, Koren G.

J Clin Pharmacol. 2012 Jan;52(1):55-64. doi: 10.1177/0091270010391790. Epub 2011 Jan 24.

PMID:
21263015
23.

The effect of acyclovir on the tubular secretion of creatinine in vitro.

Gunness P, Aleksa K, Koren G.

J Transl Med. 2010 Dec 30;8:139. doi: 10.1186/1479-5876-8-139.

24.

An improved method for rapidly quantifying fatty acid ethyl esters in meconium suitable for prenatal alcohol screening.

Hutson JR, Rao C, Fulga N, Aleksa K, Koren G.

Alcohol. 2011 Mar;45(2):193-9. doi: 10.1016/j.alcohol.2010.07.005. Epub 2010 Aug 12.

PMID:
20705417
25.

Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.

Gunness P, Aleksa K, Kosuge K, Ito S, Koren G.

Can J Physiol Pharmacol. 2010 Apr;88(4):448-55. doi: 10.1139/y10-023. Erratum in: Can J Physiol Pharmacol. 2011 Oct;89(10):767.

PMID:
20555413
26.

Solid-phase microextraction for the detection of codeine, morphine and 6-monoacetylmorphine in human hair by gas chromatography-mass spectrometry.

Moller M, Aleksa K, Walasek P, Karaskov T, Koren G.

Forensic Sci Int. 2010 Mar 20;196(1-3):64-9. doi: 10.1016/j.forsciint.2009.12.046. Epub 2010 Jan 18.

PMID:
20083362
27.

The effect of hair pigment on the incorporation of fatty acid ethyl esters (FAEE).

Kulaga V, Velazquez-Armenta Y, Aleksa K, Vergee Z, Koren G.

Alcohol Alcohol. 2009 May-Jun;44(3):287-92. doi: 10.1093/alcalc/agn114. Epub 2009 Jan 16.

PMID:
19151159
28.

Detection and quantification of fatty acid ethyl esters in meconium by headspace-solid-phase microextraction and gas chromatography-mass spectrometry.

Hutson JR, Aleksa K, Pragst F, Koren G.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 1;877(1-2):8-12. doi: 10.1016/j.jchromb.2008.10.056. Epub 2008 Nov 12.

PMID:
19056326
29.

Detection and quantification of (R) and (S)-dechloroethylifosfamide metabolites in plasma from children by enantioselective LC/MS/MS.

Aleksa K, Nava-Ocampo A, Koren G.

Chirality. 2009 Jul;21(7):674-80. doi: 10.1002/chir.20662.

PMID:
18825700
30.

N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G.

Br J Pharmacol. 2008 Apr;153(7):1364-72. doi: 10.1038/bjp.2008.15. Epub 2008 Feb 18.

31.

A simple and rapid HPLC method for the detection of glyburide in plasma original research communication (analytical).

Gedeon C, Kapur B, Aleksa K, Koren G.

Clin Biochem. 2008 Feb;41(3):167-73. Epub 2007 Aug 17.

PMID:
18061587
32.

Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.

Madadi P, Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder JS, Teitelbaum R, Karaskov T, Aleksa K.

Can Fam Physician. 2007 Jan;53(1):33-5.

33.

Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G.

Can J Clin Pharmacol. 2007 Summer;14(2):e246-50. Epub 2007 Jul 24. Review.

PMID:
17652768
34.

The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G.

Transl Res. 2007 Jul;150(1):51-7. Epub 2007 May 23.

PMID:
17585863
35.

Drug-induced nephrotoxicity in children: pharmacologically based prevention of long-term impairment.

Koren G, Chen N, Aleksa K.

Paediatr Drugs. 2007;9(3):139-42. No abstract available.

PMID:
17523693
36.

Enantioselective metabolism of ifosfamide by the kidney.

Aleksa K, Ito S, Koren G.

Chirality. 2006 Jun;18(6):398-405.

PMID:
16575879
37.

Ontogeny of drug elimination by the human kidney.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G.

Pediatr Nephrol. 2006 Feb;21(2):160-8. Epub 2005 Dec 6. Review.

PMID:
16331517
38.

A tubule cell model for ifosfamide nephrotoxicity.

Aleksa K, Halachmi N, Ito S, Koren G.

Can J Physiol Pharmacol. 2005 Jun;83(6):499-508.

PMID:
16049550
39.

Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse.

Ivakine EA, Fox CJ, Paterson AD, Mortin-Toth SM, Canty A, Walton DS, Aleksa K, Ito S, Danska JS.

J Immunol. 2005 Jun 1;174(11):7129-40.

40.

Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity.

Aleksa K, Matsell D, Krausz K, Gelboin H, Ito S, Koren G.

Pediatr Nephrol. 2005 Jul;20(7):872-85. Epub 2005 May 4.

PMID:
15875221
41.

Renal ontogeny of ifosfamide nephrotoxicity.

Aleksa K, Halachmi N, Ito S, Koren G.

J Lab Clin Med. 2004 Dec;144(6):285-93.

PMID:
15614250
43.

Ethical issues in including pediatric cancer patients in drug development trials.

Aleksa K, Koren G.

Paediatr Drugs. 2002;4(4):257-65. Review.

PMID:
11960514
44.

Young age and the risk for ifosfamide-induced nephrotoxicity: a critical review of two opposing studies.

Aleksa K, Woodland C, Koren G.

Pediatr Nephrol. 2001 Dec;16(12):1153-8. Review.

PMID:
11793120
45.

Entitlements, the deficit, and spending caps.

Gist JR, Aleksa K.

J Aging Soc Policy. 1994;6(1-2):95-118. No abstract available.

PMID:
10186863

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