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Items: 24


Transcriptomic Signatures Predict Regulators of Drug Synergy and Clinical Regimen Efficacy against Tuberculosis.

Ma S, Jaipalli S, Larkins-Ford J, Lohmiller J, Aldridge BB, Sherman DR, Chandrasekaran S.

mBio. 2019 Nov 12;10(6). pii: e02627-19. doi: 10.1128/mBio.02627-19.


Targeting drugs for tuberculosis.

Smith TC 2nd, Aldridge BB.

Science. 2019 Jun 28;364(6447):1234-1235. doi: 10.1126/science.aay0211. No abstract available.


Prediction of ultra-high-order antibiotic combinations based on pairwise interactions.

Katzir I, Cokol M, Aldridge BB, Alon U.

PLoS Comput Biol. 2019 Jan 30;15(1):e1006774. doi: 10.1371/journal.pcbi.1006774. eCollection 2019 Jan.


Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action.

Boot M, Commandeur S, Subudhi AK, Bahira M, Smith TC 2nd, Abdallah AM, van Gemert M, Lelièvre J, Ballell L, Aldridge BB, Pain A, Speer A, Bitter W.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00083-18. doi: 10.1128/AAC.00083-18. Print 2018 Jul.


Stable Regulation of Cell Cycle Events in Mycobacteria: Insights From Inherently Heterogeneous Bacterial Populations.

Logsdon MM, Aldridge BB.

Front Microbiol. 2018 Mar 21;9:514. doi: 10.3389/fmicb.2018.00514. eCollection 2018. Review.


Stress-Induced Reorganization of the Mycobacterial Membrane Domain.

Hayashi JM, Richardson K, Melzer ES, Sandler SJ, Aldridge BB, Siegrist MS, Morita YS.

mBio. 2018 Jan 23;9(1). pii: e01823-17. doi: 10.1128/mBio.01823-17.


Engineered cell and tissue models of pulmonary fibrosis.

Sundarakrishnan A, Chen Y, Black LD, Aldridge BB, Kaplan DL.

Adv Drug Deliv Rev. 2018 Apr;129:78-94. doi: 10.1016/j.addr.2017.12.013. Epub 2017 Dec 18. Review.


Influence of Stress and Antibiotic Resistance on Cell-Length Distribution in Mycobacterium tuberculosis Clinical Isolates.

Vijay S, Vinh DN, Hai HT, Ha VTN, Dung VTM, Dinh TD, Nhung HN, Tram TTB, Aldridge BB, Hanh NT, Thu DDA, Phu NH, Thwaites GE, Thuong NTT.

Front Microbiol. 2017 Nov 21;8:2296. doi: 10.3389/fmicb.2017.02296. eCollection 2017.


Rv0004 is a new essential member of the mycobacterial DNA replication machinery.

Mann KM, Huang DL, Hooppaw AJ, Logsdon MM, Richardson K, Lee HJ, Kimmey JM, Aldridge BB, Stallings CL.

PLoS Genet. 2017 Nov 27;13(11):e1007115. doi: 10.1371/journal.pgen.1007115. eCollection 2017 Nov.


A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization.

Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB.

Curr Biol. 2017 Nov 6;27(21):3367-3374.e7. doi: 10.1016/j.cub.2017.09.046. Epub 2017 Oct 26.


Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis.

Cokol M, Kuru N, Bicak E, Larkins-Ford J, Aldridge BB.

Sci Adv. 2017 Oct 11;3(10):e1701881. doi: 10.1126/sciadv.1701881. eCollection 2017 Oct.


Temporal and intrinsic factors of rifampicin tolerance in mycobacteria.

Richardson K, Bennion OT, Tan S, Hoang AN, Cokol M, Aldridge BB.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8302-7. doi: 10.1073/pnas.1600372113. Epub 2016 Jun 29.


Spatially distinct and metabolically active membrane domain in mycobacteria.

Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5400-5. doi: 10.1073/pnas.1525165113. Epub 2016 Apr 25.


The Spectrum of Drug Susceptibility in Mycobacteria.

Aldridge BB, Keren I, Fortune SM.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.MGM2-0031-2013. Review.


Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection.

Sukumar N, Tan S, Aldridge BB, Russell DG.

PLoS Pathog. 2014 Sep 18;10(9):e1004394. doi: 10.1371/journal.ppat.1004394. eCollection 2014 Sep.


Microbial metabolomics: innovation, application, insight.

Aldridge BB, Rhee KY.

Curr Opin Microbiol. 2014 Jun;19:90-96. doi: 10.1016/j.mib.2014.06.009. Epub 2014 Jul 11.


Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria.

Chao MC, Kieser KJ, Minami S, Mavrici D, Aldridge BB, Fortune SM, Alber T, Rubin EJ.

PLoS Pathog. 2013 Feb;9(2):e1003197. doi: 10.1371/journal.ppat.1003197. Epub 2013 Feb 28.


Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.

Wirth SE, Krywy JA, Aldridge BB, Fortune SM, Fernandez-Suarez M, Gray TA, Derbyshire KM.

Mol Microbiol. 2012 Feb;83(3):654-64. doi: 10.1111/j.1365-2958.2011.07958.x. Epub 2012 Jan 11.


Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility.

Aldridge BB, Fernandez-Suarez M, Heller D, Ambravaneswaran V, Irimia D, Toner M, Fortune SM.

Science. 2012 Jan 6;335(6064):100-4. doi: 10.1126/science.1216166. Epub 2011 Dec 15.


Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.

Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK.

Mol Syst Biol. 2011 Nov 22;7:553. doi: 10.1038/msb.2011.85.


Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.

Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA.

PLoS Comput Biol. 2009 Apr;5(4):e1000340. doi: 10.1371/journal.pcbi.1000340. Epub 2009 Apr 3.


Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.

Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK.

Mol Cell. 2008 Apr 11;30(1):11-25. doi: 10.1016/j.molcel.2008.02.012.


Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour.

Aldridge BB, Haller G, Sorger PK, Lauffenburger DA.

Syst Biol (Stevenage). 2006 Nov;153(6):425-32.


Physicochemical modelling of cell signalling pathways.

Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK.

Nat Cell Biol. 2006 Nov;8(11):1195-203. Review.


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