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Ancestral reconstruction of protein interaction networks.

Liebeskind BJ, Aldrich RW, Marcotte EM.

PLoS Comput Biol. 2019 Oct 28;15(10):e1007396. doi: 10.1371/journal.pcbi.1007396. eCollection 2019 Oct.


Non-Additive Effects of Binding Site Mutations in Calmodulin.

Edington SC, Halling DB, Bennett SM, Middendorf TR, Aldrich RW, Baiz CR.

Biochemistry. 2019 Jun 18;58(24):2730-2739. doi: 10.1021/acs.biochem.9b00096. Epub 2019 Jun 4.


A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo.

Scott LL, Iyer S, Philpo AE, Avalos MN, Wu NS, Shi T, Prakash BA, Nguyen TT, Mihic SJ, Aldrich RW, Pierce JT.

J Pharmacol Exp Ther. 2018 Nov;367(2):282-290. doi: 10.1124/jpet.118.251918. Epub 2018 Aug 29.


Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.

Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT.

Biochemistry. 2018 May 8;57(18):2733-2743. doi: 10.1021/acs.biochem.8b00292. Epub 2018 Apr 17.


Coordination to lanthanide ions distorts binding site conformation in calmodulin.

Edington SC, Gonzalez A, Middendorf TR, Halling DB, Aldrich RW, Baiz CR.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3126-E3134. doi: 10.1073/pnas.1722042115. Epub 2018 Mar 15.


Influences: Growing up in Yale Physiology.

Aldrich RW.

J Gen Physiol. 2018 Feb 5;150(2):177-179. doi: 10.1085/jgp.201711990. Epub 2018 Jan 23. No abstract available.


International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.

Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H.

Pharmacol Rev. 2017 Jan;69(1):1-11. doi: 10.1124/pr.116.012864. Epub 2016 Nov 15. Review.


A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus.

Scott LL, Brecht EJ, Philpo A, Iyer S, Wu NS, Mihic SJ, Aldrich RW, Pierce J, Walton JP.

Sci Rep. 2017 Feb 14;7:42433. doi: 10.1038/srep42433.


Structural identifiability of equilibrium ligand-binding parameters.

Middendorf TR, Aldrich RW.

J Gen Physiol. 2017 Jan;149(1):105-119. doi: 10.1085/jgp.201611702. Epub 2016 Dec 19.


The structure of binding curves and practical identifiability of equilibrium ligand-binding parameters.

Middendorf TR, Aldrich RW.

J Gen Physiol. 2017 Jan;149(1):121-147. doi: 10.1085/jgp.201611703. Epub 2016 Dec 19.


Closed state-coupled C-type inactivation in BK channels.

Yan J, Li Q, Aldrich RW.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6991-6. doi: 10.1073/pnas.1607584113. Epub 2016 Jun 13.


Conserved properties of individual Ca2+-binding sites in calmodulin.

Halling DB, Liebeskind BJ, Hall AW, Aldrich RW.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1216-25. doi: 10.1073/pnas.1600385113. Epub 2016 Feb 16.


A new standard: A review of Handbook of Ion Channels.

Aldrich RW.

J Gen Physiol. 2015 Aug;146(2):119-21. doi: 10.1085/jgp.201511461. No abstract available.


Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.


Analyzing single-molecule time series via nonparametric Bayesian inference.

Hines KE, Bankston JR, Aldrich RW.

Biophys J. 2015 Feb 3;108(3):540-56. doi: 10.1016/j.bpj.2014.12.016.


Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach.

Hines KE, Middendorf TR, Aldrich RW.

J Gen Physiol. 2014 Mar;143(3):401-16. doi: 10.1085/jgp.201311116. Epub 2014 Feb 10.


Calcium-dependent stoichiometries of the KCa2.2 (SK) intracellular domain/calmodulin complex in solution.

Halling DB, Kenrick SA, Riggs AF, Aldrich RW.

J Gen Physiol. 2014 Feb;143(2):231-52. doi: 10.1085/jgp.201311007. Epub 2014 Jan 13.


BK channel opening involves side-chain reorientation of multiple deep-pore residues.

Chen X, Yan J, Aldrich RW.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E79-88. doi: 10.1073/pnas.1321697111. Epub 2013 Dec 23.


BK potassium channel modulation by leucine-rich repeat-containing proteins.

Yan J, Aldrich RW.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7917-22. doi: 10.1073/pnas.1205435109. Epub 2012 Apr 30.


Intragenic alternative splicing coordination is essential for Caenorhabditis elegans slo-1 gene function.

Glauser DA, Johnson BE, Aldrich RW, Goodman MB.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20790-5. doi: 10.1073/pnas.1116712108. Epub 2011 Nov 14.


Alternatively spliced domains interact to regulate BK potassium channel gating.

Johnson BE, Glauser DA, Dan-Glauser ES, Halling DB, Aldrich RW, Goodman MB.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20784-9. doi: 10.1073/pnas.1116795108. Epub 2011 Nov 2.


Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.

Chen X, Aldrich RW.

J Gen Physiol. 2011 Aug;138(2):137-54. doi: 10.1085/jgp.201110632. Epub 2011 Jul 11.


Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca2+ activated K+ channels.

Li W, Aldrich RW.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5946-53. doi: 10.1073/pnas.1103090108. Epub 2011 Mar 21.


Tissue-specific N terminus of the HCN4 channel affects channel activation.

Liu H, Aldrich RW.

J Biol Chem. 2011 Apr 22;286(16):14209-14. doi: 10.1074/jbc.M110.215640. Epub 2011 Mar 3.


LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium.

Yan J, Aldrich RW.

Nature. 2010 Jul 22;466(7305):513-6. doi: 10.1038/nature09162. Epub 2010 Jul 7.


Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction.

Girouard H, Bonev AD, Hannah RM, Meredith A, Aldrich RW, Nelson MT.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3811-6. doi: 10.1073/pnas.0914722107. Epub 2010 Feb 2.


EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK-calmodulin interaction.

Li W, Halling DB, Hall AW, Aldrich RW.

J Gen Physiol. 2009 Oct;134(4):281-93. doi: 10.1085/jgp.200910295. Epub 2009 Sep 14.


Activation of the SK potassium channel-calmodulin complex by nanomolar concentrations of terbium.

Li W, Aldrich RW.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1075-80. doi: 10.1073/pnas.0812008106. Epub 2009 Jan 14.


The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels.

Imlach WL, Finch SC, Dunlop J, Meredith AL, Aldrich RW, Dalziel JE.

J Pharmacol Exp Ther. 2008 Dec;327(3):657-64. doi: 10.1124/jpet.108.143933. Epub 2008 Sep 18.


Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel.

Brown SM, Bentcheva-Petkova LM, Liu L, Hristov KL, Chen M, Kellett WF, Meredith AL, Aldrich RW, Nelson MT, Petkov GV.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1149-57. doi: 10.1152/ajprenal.00440.2007. Epub 2008 Aug 13.


Convergent evolution of alternative splices at domain boundaries of the BK channel.

Fodor AA, Aldrich RW.

Annu Rev Physiol. 2009;71:19-36. doi: 10.1146/annurev.physiol.010908.163124. Review.


Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity.

Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS.

Mol Cell Proteomics. 2008 Nov;7(11):2188-98. doi: 10.1074/mcp.M800063-MCP200. Epub 2008 Jun 23.


Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction.

Werner ME, Meredith AL, Aldrich RW, Nelson MT.

Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R181-8. doi: 10.1152/ajpregu.00173.2008. Epub 2008 May 14.


Cochlear function in mice lacking the BK channel alpha, beta1, or beta4 subunits.

Pyott SJ, Meredith AL, Fodor AA, Vázquez AE, Yamoah EN, Aldrich RW.

J Biol Chem. 2007 Feb 2;282(5):3312-24. Epub 2006 Nov 29.


Local potassium signaling couples neuronal activity to vasodilation in the brain.

Filosa JA, Bonev AD, Straub SV, Meredith AL, Wilkerson MK, Aldrich RW, Nelson MT.

Nat Neurosci. 2006 Nov;9(11):1397-1403.


State-dependent block of BK channels by synthesized shaker ball peptides.

Li W, Aldrich RW.

J Gen Physiol. 2006 Oct;128(4):423-41. Epub 2006 Sep 11.


State-independent block of BK channels by an intracellular quaternary ammonium.

Wilkens CM, Aldrich RW.

J Gen Physiol. 2006 Sep;128(3):347-64.


Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels.

Werner ME, Knorn AM, Meredith AL, Aldrich RW, Nelson MT.

Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R616-24. Epub 2006 Aug 24.


BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output.

Meredith AL, Wiler SW, Miller BH, Takahashi JS, Fodor AA, Ruby NF, Aldrich RW.

Nat Neurosci. 2006 Aug;9(8):1041-9. Epub 2006 Jul 16. Erratum in: Nat Neurosci. 2006 Sep;9(9):1193.


Relationship between pore occupancy and gating in BK potassium channels.

Piskorowski RA, Aldrich RW.

J Gen Physiol. 2006 May;127(5):557-76.


Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons.

Misonou H, Menegola M, Buchwalder L, Park EW, Meredith A, Rhodes KJ, Aldrich RW, Trimmer JS.

J Comp Neurol. 2006 May 20;496(3):289-302.


BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures.

Brenner R, Chen QH, Vilaythong A, Toney GM, Noebels JL, Aldrich RW.

Nat Neurosci. 2005 Dec;8(12):1752-9. Epub 2005 Oct 30.


Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel.

Werner ME, Zvara P, Meredith AL, Aldrich RW, Nelson MT.

J Physiol. 2005 Sep 1;567(Pt 2):545-56. Epub 2005 Jul 14.


Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder.

Thorneloe KS, Meredith AL, Knorn AM, Aldrich RW, Nelson MT.

Am J Physiol Renal Physiol. 2005 Sep;289(3):F604-10. Epub 2005 Apr 12.


Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells.

Pyott SJ, Glowatzki E, Trimmer JS, Aldrich RW.

J Neurosci. 2004 Oct 27;24(43):9469-74.


Unique inner pore properties of BK channels revealed by quaternary ammonium block.

Li W, Aldrich RW.

J Gen Physiol. 2004 Jul;124(1):43-57. Epub 2004 Jun 14.


Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel.

Meredith AL, Thorneloe KS, Werner ME, Nelson MT, Aldrich RW.

J Biol Chem. 2004 Aug 27;279(35):36746-52. Epub 2004 Jun 7.

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