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Items: 11

1.

Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines.

Chorvat RJ, Bakthavatchalam R, Beck JP, Gilligan PJ, Wilde RG, Cocuzza AJ, Hobbs FW, Cheeseman RS, Curry M, Rescinito JP, Krenitsky P, Chidester D, Yarem JA, Klaczkiewicz JD, Hodge CN, Aldrich PE, Wasserman ZR, Fernandez CH, Zaczek R, Fitzgerald LW, Huang SM, Shen HL, Wong YN, Chien BM, Arvanitis A, et al.

J Med Chem. 1999 Mar 11;42(5):833-48.

PMID:
10072681
2.

Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies.

Hodge CN, Aldrich PE, Wasserman ZR, Fernandez CH, Nemeth GA, Arvanitis A, Cheeseman RS, Chorvat RJ, Ciganek E, Christos TE, Gilligan PJ, Krenitsky P, Scholfield E, Strucely P.

J Med Chem. 1999 Mar 11;42(5):819-32.

PMID:
10072680
3.

Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.

De Lucca GV, Liang J, Aldrich PE, Calabrese J, Cordova B, Klabe RM, Rayner MM, Chang CH.

J Med Chem. 1997 May 23;40(11):1707-9.

PMID:
9171880
4.

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al.

J Med Chem. 1996 Aug 30;39(18):3514-25.

PMID:
8784449
5.

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.

Hodge CN, Aldrich PE, Bacheler LT, Chang CH, Eyermann CJ, Garber S, Grubb M, Jackson DA, Jadhav PK, Korant B, Lam PY, Maurin MB, Meek JL, Otto MJ, Rayner MM, Reid C, Sharpe TR, Shum L, Winslow DL, Erickson-Viitanen S.

Chem Biol. 1996 Apr;3(4):301-14.

6.
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8.

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

Carini DJ, Duncia JV, Aldrich PE, Chiu AT, Johnson AL, Pierce ME, Price WA, Santella JB 3rd, Wells GJ, Wexler RR, et al.

J Med Chem. 1991 Aug;34(8):2525-47.

PMID:
1875348
9.

[3H]DUP 753, a highly potent and specific radioligand for the angiotensin II-1 receptor subtype.

Chiu AT, McCall DE, Aldrich PE, Timmermans PB.

Biochem Biophys Res Commun. 1990 Nov 15;172(3):1195-202.

PMID:
2244903
10.

Antiviral agents. 2. Structure-activity relationships of compounds related to 1-adamantanamine.

Aldrich PE, Hermann EC, Meier WE, Paulshock M, Prichard WW, Snyder JA, Watts JC.

J Med Chem. 1971 Jun;14(6):535-43. No abstract available.

PMID:
5091970
11.

Total synthesis of yohimbine.

van Tamelen EE, Shamma M, Burgstahler AW, Wolinsky J, Tamm R, Aldrich PE.

J Am Chem Soc. 1969 Dec 17;91(26):7315-33. No abstract available.

PMID:
5358617

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