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Items: 15


Lipids lead the way.

Aldrich LN.

Nat Chem Biol. 2019 Jul;15(7):653-654. doi: 10.1038/s41589-019-0309-3. No abstract available.


Systematic Diversity-Oriented Synthesis of Reduced Flavones from γ-Pyrones to Probe Biological Performance Diversity.

Gerlach EM, Korkmaz MA, Pavlinov I, Gao Q, Aldrich LN.

ACS Chem Biol. 2019 Jul 19;14(7):1536-1545. doi: 10.1021/acschembio.9b00294. Epub 2019 Jun 21.


Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity.

Pavlinov I, Gerlach EM, Aldrich LN.

Org Biomol Chem. 2019 Feb 13;17(7):1608-1623. doi: 10.1039/c8ob02327a. Review.


Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition.

Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, Aldrich LN, Fuchs JR, Burdette JE.

Mol Cancer Ther. 2018 Oct;17(10):2123-2135. doi: 10.1158/1535-7163.MCT-17-1195. Epub 2018 Jul 17.


Microwave-Assisted, Asymmetric Synthesis of 3-Amino-2,3-Dihydrobenzofuran Flavonoid Derivatives from Chalcones.

Helgren TR, Xu LL, Sotelo D, Mehta YR, Korkmaz MA, Pavlinov I, Aldrich LN.

Chemistry. 2018 Mar 26;24(18):4509-4514. doi: 10.1002/chem.201705984. Epub 2018 Mar 8.


Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dančík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, Xavier RJ.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7. doi: 10.1073/pnas.1512289112. Epub 2015 Jul 20.


The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.

Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, Sharpe AH, Shaw SY, Xavier RJ.

Elife. 2015 May 22;4. doi: 10.7554/eLife.05920.


Discovery of a Small-Molecule Probe for V-ATPase Function.

Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ.

J Am Chem Soc. 2015 Apr 29;137(16):5563-8. doi: 10.1021/jacs.5b02150. Epub 2015 Apr 20.


Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model.

Aldrich LN, Berry CB, Bates BS, Konkol LC, So M, Lindsley CW.

European J Org Chem. 2013 Jul 1;2013(20). doi: 10.1002/ejoc.201300643.


Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ.

ACS Chem Biol. 2013 Dec 20;8(12):2724-2733. doi: 10.1021/cb400352d. Epub 2013 Oct 29.


Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ.

Gastroenterology. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21.


Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation.

Panarese JD, Konkol LC, Berry CB, Bates BS, Aldrich LN, Lindsley CW.

Tetrahedron Lett. 2013 May 1;54(18):2231-2234.


Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.

Aldrich LN, Stoops SL, Crews BC, Marnett LJ, Lindsley CW.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5207-11. doi: 10.1016/j.bmcl.2010.06.154. Epub 2010 Jul 23.


Evaluation of the biosynthetic proposal for the synthesis of marineosins A and B.

Aldrich LN, Dawson ES, Lindsley CW.

Org Lett. 2010 Mar 5;12(5):1048-51. doi: 10.1021/ol100034p.


MAOS ls for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines.

Aldrich LN, Lebois EP, Lewis LM, Nalywajko NT, Niswender CM, Weaver CD, Conn PJ, Lindsley CW.

Tetrahedron Lett. 2009 Jan 14;50(2):212-215.

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