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Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults.

Pun BT, Balas MC, Barnes-Daly MA, Thompson JL, Aldrich JM, Barr J, Byrum D, Carson SS, Devlin JW, Engel HJ, Esbrook CL, Hargett KD, Harmon L, Hielsberg C, Jackson JC, Kelly TL, Kumar V, Millner L, Morse A, Perme CS, Posa PJ, Puntillo KA, Schweickert WD, Stollings JL, Tan A, D'Agostino McGowan L, Ely EW.

Crit Care Med. 2018 Oct 18. doi: 10.1097/CCM.0000000000003482. [Epub ahead of print]


E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases.

Babiker HM, Byron SA, Hendricks WPD, Elmquist WF, Gampa G, Vondrak J, Aldrich J, Cuyugan L, Adkins J, De Luca V, Tibes R, Borad MJ, Marceau K, Myers TJ, Paradiso LJ, Liang WS, Korn RL, Cridebring D, Von Hoff DD, Carpten JD, Craig DW, Trent JM, Gordon MS.

Invest New Drugs. 2018 Sep 28. doi: 10.1007/s10637-018-0668-8. [Epub ahead of print]


Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis.

Hendricks WPD, Zismann V, Sivaprakasam K, Legendre C, Poorman K, Tembe W, Perdigones N, Kiefer J, Liang W, DeLuca V, Stark M, Ruhe A, Froman R, Duesbery NS, Washington M, Aldrich J, Neff MW, Huentelman MJ, Hayward N, Brown K, Thamm D, Post G, Khanna C, Davis B, Breen M, Sekulic A, Trent JM.

PLoS Genet. 2018 Sep 6;14(9):e1007589. doi: 10.1371/journal.pgen.1007589. eCollection 2018 Sep.


Motives for and impairment associated with alcohol and marijuana use among college students.

Skalisky J, Wielgus MD, Aldrich JT, Mezulis AH.

Addict Behav. 2019 Jan;88:137-143. doi: 10.1016/j.addbeh.2018.08.028. Epub 2018 Aug 29.


Improving Health Care for Critically Ill Patients Using an Evidence-Based Collaborative Approach to ABCDEF Bundle Dissemination and Implementation.

Barnes-Daly MA, Pun BT, Harmon LA, Byrum DG, Kumar VK, Devlin JW, Stollings JL, Puntillo KA, Engel HJ, Posa PJ, Barr J, Schweickert WD, Esbrook CL, Hargett KD, Carson SS, Aldrich JM, Ely EW, Balas MC.

Worldviews Evid Based Nurs. 2018 Jun;15(3):206-216. doi: 10.1111/wvn.12290. Epub 2018 May 5.


Essential oil and monensin affect ruminal fermentation and the protozoal population in continuous culture.

Ye D, Karnati SKR, Wagner B, Firkins JL, Eastridge ML, Aldrich JM.

J Dairy Sci. 2018 Jun;101(6):5069-5081. doi: 10.3168/jds.2017-13646. Epub 2018 Mar 28.


Non-Invasive Electromagnetic Skin Patch Sensor to Measure Intracranial Fluid-Volume Shifts.

Griffith J, Cluff K, Eckerman B, Aldrich J, Becker R, Moore-Jansen P, Patterson J.

Sensors (Basel). 2018 Mar 29;18(4). pii: E1022. doi: 10.3390/s18041022.


Interprofessional Care and Teamwork in the ICU.

Donovan AL, Aldrich JM, Gross AK, Barchas DM, Thornton KC, Schell-Chaple HM, Gropper MA, Lipshutz AKM; University of California, San Francisco Critical Care Innovations Group.

Crit Care Med. 2018 Jun;46(6):980-990. doi: 10.1097/CCM.0000000000003067.


Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution.

Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD.

Am J Med Qual. 2018 May/Jun;33(3):329. doi: 10.1177/1062860618758609. Epub 2018 Feb 23. No abstract available.


Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl).

Fang WJ, Murray TF, Aldrich JV.

Bioorg Med Chem. 2018 Mar 15;26(6):1157-1161. doi: 10.1016/j.bmc.2017.11.029. Epub 2017 Nov 21.


Understanding heart rate alarm adjustment in the intensive care units through an analytical approach.

Fidler RL, Pelter MM, Drew BJ, Palacios JA, Bai Y, Stannard D, Aldrich JM, Hu X.

PLoS One. 2017 Nov 27;12(11):e0187855. doi: 10.1371/journal.pone.0187855. eCollection 2017.


Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases.

Manojlovic Z, Christofferson A, Liang WS, Aldrich J, Washington M, Wong S, Rohrer D, Jewell S, Kittles RA, Derome M, Auclair D, Craig DW, Keats J, Carpten JD.

PLoS Genet. 2017 Nov 22;13(11):e1007087. doi: 10.1371/journal.pgen.1007087. eCollection 2017 Nov.


Low physiological arousal and high impulsivity as predictors of self-injurious thoughts and behaviors among adolescents.

Aldrich JT, Wielgus MD, Mezulis AH.

J Adolesc. 2018 Jan;62:55-60. doi: 10.1016/j.adolescence.2017.11.006. Epub 2017 Nov 17.


A method to reduce ancestry related germline false positives in tumor only somatic variant calling.

Halperin RF, Carpten JD, Manojlovic Z, Aldrich J, Keats J, Byron S, Liang WS, Russell M, Enriquez D, Claasen A, Cherni I, Awuah B, Oppong J, Wicha MS, Newman LA, Jaigge E, Kim S, Craig DW.

BMC Med Genomics. 2017 Oct 19;10(1):61. doi: 10.1186/s12920-017-0296-8.


Erratum to: Unique sequence organization and small RNA expression of a "selfish" B chromosome.

Li Y, Jing XA, Aldrich JC, Clifford C, Chen J, Akbari OS, Ferree PM.

Chromosoma. 2017 Dec;126(6):781. doi: 10.1007/s00412-017-0642-9. No abstract available.


Unique sequence organization and small RNA expression of a "selfish" B chromosome.

Li Y, Jing XA, Aldrich JC, Clifford C, Chen J, Akbari OS, Ferree PM.

Chromosoma. 2017 Dec;126(6):753-768. doi: 10.1007/s00412-017-0641-x. Epub 2017 Aug 5. Erratum in: Chromosoma. 2017 Aug 19;:.


Macrocyclic peptides decrease c-Myc protein levels and reduce prostate cancer cell growth.

Mukhopadhyay A, Hanold LE, Thayele Purayil H, Gisemba SA, Senadheera SN, Aldrich JV.

Cancer Biol Ther. 2017 Aug 3;18(8):571-583. doi: 10.1080/15384047.2017.1345384. Epub 2017 Jul 10.


A prospective pilot study of genome-wide exome and transcriptome profiling in patients with small cell lung cancer progressing after first-line therapy.

Weiss GJ, Byron SA, Aldrich J, Sangal A, Barilla H, Kiefer JA, Carpten JD, Craig DW, Whitsett TG.

PLoS One. 2017 Jun 6;12(6):e0179170. doi: 10.1371/journal.pone.0179170. eCollection 2017.


Physiological Self-Regulation Buffers the Relationship between Impulsivity and Externalizing Behaviors among Nonclinical Adolescents.

Kuhn MA, Ahles JJ, Aldrich JT, Wielgus MD, Mezulis AH.

J Youth Adolesc. 2018 Apr;47(4):829-841. doi: 10.1007/s10964-017-0689-1. Epub 2017 May 12.


Genome Silencing and Elimination: Insights from a "Selfish" B Chromosome.

Aldrich JC, Ferree PM.

Front Genet. 2017 Apr 25;8:50. doi: 10.3389/fgene.2017.00050. eCollection 2017. Review.


Alanine scan of the opioid peptide dynorphin B amide.

Joshi AA, Murray TF, Aldrich JV.

Biopolymers. 2017 Sep;108(5). doi: 10.1002/bip.23026.


Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer.

Pierobon M, Ramos C, Wong S, Hodge KA, Aldrich J, Byron S, Anthony SP, Robert NJ, Northfelt DW, Jahanzeb M, Vocila L, Wulfkuhle J, Gambara G, Gallagher RI, Dunetz B, Hoke N, Dong T, Craig DW, Cristofanilli M, Leyland-Jones B, Liotta LA, O'Shaughnessy JA, Carpten JD, Petricoin EF.

Clin Cancer Res. 2017 Aug 15;23(16):4919-4928. doi: 10.1158/1078-0432.CCR-16-2656. Epub 2017 Apr 26.


A 'selfish' B chromosome induces genome elimination by disrupting the histone code in the jewel wasp Nasonia vitripennis.

Aldrich JC, Leibholz A, Cheema MS, Ausiό J, Ferree PM.

Sci Rep. 2017 Feb 13;7:42551. doi: 10.1038/srep42551.


Production responses of Holstein dairy cows when fed supplemental fat containing saturated free fatty acids: a meta-analysis.

Hu W, Boerman JP, Aldrich JM.

Asian-Australas J Anim Sci. 2017 Aug;30(8):1105-1116. doi: 10.5713/ajas.16.0611. Epub 2017 Feb 1.


Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib.

Bryce AH, Borad MJ, Egan JB, Condjella RM, Liang WS, Fonseca R, McCullough AE, Hunt KS, Ritacca NR, Barrett MT, Patel MD, Young SW, Silva AC, Ho TH, Halfdanarson TR, Stanton ML, Cheville J, Swanson S, Schneider DE, McWilliams RR, Baker A, Aldrich J, Kurdoglu A, Izatt T, Christoforides A, Cherni I, Nasser S, Reiman R, Cuyugan L, McDonald J, Adkins J, Mastrian SD, Von Hoff DD, Craig DW, Stewart AK, Carpten JD.

Clin Genitourin Cancer. 2017 Aug;15(4):e727-e734. doi: 10.1016/j.clgc.2016.11.001. Epub 2016 Dec 1. No abstract available.


Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies.

Zhrebker L, Cherni I, Gross LM, Hinshelwood MM, Reese M, Aldrich J, Guileyardo JM, Roberts WC, Craig D, Von Hoff DD, Mennel RG, Carpten JD.

BMC Cancer. 2017 Jan 5;17(1):17. doi: 10.1186/s12885-016-3000-z.


Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers.

Borad MJ, Egan JB, Condjella RM, Liang WS, Fonseca R, Ritacca NR, McCullough AE, Barrett MT, Hunt KS, Champion MD, Patel MD, Young SW, Silva AC, Ho TH, Halfdanarson TR, McWilliams RR, Lazaridis KN, Ramanathan RK, Baker A, Aldrich J, Kurdoglu A, Izatt T, Christoforides A, Cherni I, Nasser S, Reiman R, Cuyugan L, McDonald J, Adkins J, Mastrian SD, Valdez R, Jaroszewski DE, Von Hoff DD, Craig DW, Stewart AK, Carpten JD, Bryce AH.

Sci Rep. 2016 Dec 23;6(1):25. doi: 10.1038/s41598-016-0021-4.


Corrigendum: The abundant marine bacterium Pelagibacter simultaneously catabolizes dimethylsulfoniopropionate to the gases dimethyl sulfide and methanethiol.

Sun J, Todd JD, Thrash JC, Qian Y, Qian MC, Temperton B, Guo J, Fowler EK, Aldrich JT, Nicora CD, Lipton MS, Smith RD, De Leenheer P, Payne SH, Johnston AW, Davie-Martin CL, Halsey KH, Giovannoni SJ.

Nat Microbiol. 2016 Oct 3;1(11):16210. doi: 10.1038/nmicrobiol.2016.210. No abstract available.


Volatiles Mediating Parasitism of Euschistus conspersus and Halyomorpha halys Eggs by Telenomus podisi and Trissolcus erugatus.

Tognon R, Sant'Ana J, Zhang QH, Millar JG, Aldrich JR, Zalom FG.

J Chem Ecol. 2016 Oct;42(10):1016-1027. Epub 2016 Sep 8.


The abundant marine bacterium Pelagibacter simultaneously catabolizes dimethylsulfoniopropionate to the gases dimethyl sulfide and methanethiol.

Sun J, Todd JD, Thrash JC, Qian Y, Qian MC, Temperton B, Guo J, Fowler EK, Aldrich JT, Nicora CD, Lipton MS, Smith RD, De Leenheer P, Payne SH, Johnston AW, Davie-Martin CL, Halsey KH, Giovannoni SJ.

Nat Microbiol. 2016 May 16;1(8):16065. doi: 10.1038/nmicrobiol.2016.65. Erratum in: Nat Microbiol. 2016 Oct 03;1(11):16210.


Comparative Community Proteomics Demonstrates the Unexpected Importance of Actinobacterial Glycoside Hydrolase Family 12 Protein for Crystalline Cellulose Hydrolysis.

Hiras J, Wu YW, Deng K, Nicora CD, Aldrich JT, Frey D, Kolinko S, Robinson EW, Jacobs JM, Adams PD, Northen TR, Simmons BA, Singer SW.

MBio. 2016 Aug 23;7(4). pii: e01106-16. doi: 10.1128/mBio.01106-16.


Respiratory sinus arrhythmia as a predictor of self-injurious thoughts and behaviors among adolescents.

Wielgus MD, Aldrich JT, Mezulis AH, Crowell SE.

Int J Psychophysiol. 2016 Aug;106:127-34. doi: 10.1016/j.ijpsycho.2016.05.005. Epub 2016 May 20.


Soybean Roots Grown under Heat Stress Show Global Changes in Their Transcriptional and Proteomic Profiles.

Valdés-López O, Batek J, Gomez-Hernandez N, Nguyen CT, Isidra-Arellano MC, Zhang N, Joshi T, Xu D, Hixson KK, Weitz KK, Aldrich JT, Paša-Tolić L, Stacey G.

Front Plant Sci. 2016 Apr 25;7:517. doi: 10.3389/fpls.2016.00517. eCollection 2016.


Male-Killing Spiroplasma Alters Behavior of the Dosage Compensation Complex during Drosophila melanogaster Embryogenesis.

Cheng B, Kuppanda N, Aldrich JC, Akbari OS, Ferree PM.

Curr Biol. 2016 May 23;26(10):1339-45. doi: 10.1016/j.cub.2016.03.050. Epub 2016 May 5.


Species differences in the effects of the κ-opioid receptor antagonist zyklophin.

Sirohi S, Aldrich JV, Walker BM.

Alcohol. 2016 Mar;51:43-9. doi: 10.1016/j.alcohol.2015.11.012. Epub 2016 Jan 29.


Chemical Ecology of Neuroptera.

Aldrich JR, Zhang QH.

Annu Rev Entomol. 2016;61:197-218. doi: 10.1146/annurev-ento-010715-023507. Review.


Source of carbohydrate and metabolizable lysine and methionine in the diet of recently weaned dairy calves on digestion and growth.

Hill TM, Quigley JD, Bateman HG 2nd, Aldrich JM, Schlotterbeck RL.

J Dairy Sci. 2016 Apr;99(4):2788-2796. doi: 10.3168/jds.2015-10571. Epub 2016 Feb 3.


Pharmacophagy in green lacewings (Neuroptera: Chrysopidae: Chrysopa spp.)?

Aldrich JR, Chauhan K, Zhang QH.

PeerJ. 2016 Jan 18;4:e1564. doi: 10.7717/peerj.1564. eCollection 2016.


Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests.

Huang P, Yakovleva T, Aldrich JV, Tunis J, Parry C, Liu-Chen LY.

Neurosci Lett. 2016 Feb 26;615:15-20. doi: 10.1016/j.neulet.2016.01.017. Epub 2016 Jan 15.


Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin.

Joshi AA, Murray TF, Aldrich JV.

J Med Chem. 2015 Nov 25;58(22):8783-95. doi: 10.1021/jm501827k. Epub 2015 Nov 16.


North American Invasion of the Tawny Crazy Ant (Nylanderia fulva) Is Enabled by Pheromonal Synergism from Two Separate Glands.

Zhang QH, McDonald DL, Hoover DR, Aldrich JR, Schneidmiller RG.

J Chem Ecol. 2015 Sep;41(9):853-8. doi: 10.1007/s10886-015-0622-6. Epub 2015 Aug 28.


Inclusion of tallow and soybean oil to calf starters fed to dairy calves from birth to four months of age on calf performance and digestion.

Hill TM, Bateman HG 2nd, Aldrich JM, Quigley JD, Schlotterbeck RL.

J Dairy Sci. 2015 Jul;98(7):4882-8. doi: 10.3168/jds.2015-9376. Epub 2015 Apr 23.


Transgenerational inheritance of diet-induced genome rearrangements in Drosophila.

Aldrich JC, Maggert KA.

PLoS Genet. 2015 Apr 17;11(4):e1005148. doi: 10.1371/journal.pgen.1005148. eCollection 2015 Apr.


Behavioral responses of the invasive Halyomorpha halys (Stål) to traps baited with stereoisomeric mixtures of 10,11-epoxy-1-bisabolen-3-OL.

Leskey TC, Khrimian A, Weber DC, Aldrich JC, Short BD, Lee DH, Morrison WR 3rd.

J Chem Ecol. 2015 Apr;41(4):418-29. doi: 10.1007/s10886-015-0566-x. Epub 2015 Apr 9.


An integrated framework for reporting clinically relevant biomarkers from paired tumor/normal genomic and transcriptomic sequencing data in support of clinical trials in personalized medicine.

Nasser S, Kurdolgu AA, Izatt T, Aldrich J, Russell ML, Christoforides A, Tembe W, Keifer JA, Corneveaux JJ, Byron SA, Forman KM, Zuccaro C, Keats JJ, Lorusso PM, Carpten JD, Trent JM, Craig DW.

Pac Symp Biocomput. 2015:56-67.


Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes.

Sekar S, McDonald J, Cuyugan L, Aldrich J, Kurdoglu A, Adkins J, Serrano G, Beach TG, Craig DW, Valla J, Reiman EM, Liang WS.

Neurobiol Aging. 2015 Feb;36(2):583-91. doi: 10.1016/j.neurobiolaging.2014.09.027. Epub 2014 Oct 2.


Determination of the stereochemistry of the aggregation pheromone of harlequin bug, Murgantia histrionica.

Khrimian A, Shirali S, Vermillion KE, Siegler MA, Guzman F, Chauhan K, Aldrich JR, Weber DC.

J Chem Ecol. 2014 Dec;40(11-12):1260-8. doi: 10.1007/s10886-014-0521-2. Epub 2014 Nov 19.


Simple quantitative PCR approach to reveal naturally occurring and mutation-induced repetitive sequence variation on the Drosophila Y chromosome.

Aldrich JC, Maggert KA.

PLoS One. 2014 Oct 6;9(10):e109906. doi: 10.1371/journal.pone.0109906. eCollection 2014.


Aromatic inhibitors derived from ammonia-pretreated lignocellulose hinder bacterial ethanologenesis by activating regulatory circuits controlling inhibitor efflux and detoxification.

Keating DH, Zhang Y, Ong IM, McIlwain S, Morales EH, Grass JA, Tremaine M, Bothfeld W, Higbee A, Ulbrich A, Balloon AJ, Westphall MS, Aldrich J, Lipton MS, Kim J, Moskvin OV, Bukhman YV, Coon JJ, Kiley PJ, Bates DM, Landick R.

Front Microbiol. 2014 Aug 13;5:402. doi: 10.3389/fmicb.2014.00402. eCollection 2014.

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